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The map label for this gene is adk

Identifier: 183221327

GI number: 183221327

Start: 2030921

End: 2031481

Strand: Reverse

Name: adk

Synonym: LEPBI_I1944

Alternate gene names: 183221327

Gene position: 2031481-2030921 (Counterclockwise)

Preceding gene: 183221328

Following gene: 183221326

Centisome position: 56.44

GC content: 45.28

Gene sequence:

>561_bases
ATGAAGAGACTCATATTTATGGGCCCTCCAGGTGCTGGAAAGGGAACACAAGCTGACATCATCAAAGAGAAATACAATAT
CCCTCAGATTTCCACAGGTGATATCCTCCGTGCGGCTGTAAAAAATGGCACCGCTATGGGGATTGAAGCAAAAAAATATA
TGGACGCTGGAGACCTTGTTCCAGATGCTGTCGTTATAGGCATTATCCGCGACCGTTTGGTCGAAGCTGATTGTGCAAAT
GGATTCATTTTGGATGGATTTCCTAGGACGGTGGAGCAAGCAAAGGCTCTCTCGGAAATCCTCAAAGAGCTTCACATGGA
GCTCGACTCCGTTGTCAACCTAGACGTTCCTGACGAAGAACTCGTCAAACGGTTGCTAGGTAGAGCGATCAAAGAAGGAC
GCTCGGATGACAACGAAGAGACCATCAAAAACCGTCTGCATACTTACAACACCAAGACGTTGCCCCTCATTGACTTTTAT
AAAGCCACAGGGATCCTTCGGCAAATCAATGGTTTGGGAAGTATGGAAGAAATCACTAACACTATTTTAAAATCAATCTA
G

Upstream 100 bases:

>100_bases
TGTGGCACTCGAAACCTTAAAACAGATCGAAGCCCAACTCCTCATGAGAAATTACGAAGGTTTCATGAAAAAGACTAAAA
TCAAGGGAAGAGTGTAACGA

Downstream 100 bases:

>100_bases
TAGGAGATAGACCCTGGCTAAGGAAGAAGCAATCACTATTGACGGAACCGTTTTAGAACCTTTACCAAATGCGATGTTCC
GTGTGGAACTAGAGAATGGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MKRLIFMGPPGAGKGTQADIIKEKYNIPQISTGDILRAAVKNGTAMGIEAKKYMDAGDLVPDAVVIGIIRDRLVEADCAN
GFILDGFPRTVEQAKALSEILKELHMELDSVVNLDVPDEELVKRLLGRAIKEGRSDDNEETIKNRLHTYNTKTLPLIDFY
KATGILRQINGLGSMEEITNTILKSI

Sequences:

>Translated_186_residues
MKRLIFMGPPGAGKGTQADIIKEKYNIPQISTGDILRAAVKNGTAMGIEAKKYMDAGDLVPDAVVIGIIRDRLVEADCAN
GFILDGFPRTVEQAKALSEILKELHMELDSVVNLDVPDEELVKRLLGRAIKEGRSDDNEETIKNRLHTYNTKTLPLIDFY
KATGILRQINGLGSMEEITNTILKSI
>Mature_186_residues
MKRLIFMGPPGAGKGTQADIIKEKYNIPQISTGDILRAAVKNGTAMGIEAKKYMDAGDLVPDAVVIGIIRDRLVEADCAN
GFILDGFPRTVEQAKALSEILKELHMELDSVVNLDVPDEELVKRLLGRAIKEGRSDDNEETIKNRLHTYNTKTLPLIDFY
KATGILRQINGLGSMEEITNTILKSI

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=211, Percent_Identity=38.8625592417062, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI4502013, Length=211, Percent_Identity=38.8625592417062, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI4502011, Length=182, Percent_Identity=39.010989010989, Blast_Score=137, Evalue=4e-33,
Organism=Homo sapiens, GI19923437, Length=200, Percent_Identity=32.5, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI7706497, Length=186, Percent_Identity=31.7204301075269, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI310110345, Length=196, Percent_Identity=33.6734693877551, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI53832003, Length=196, Percent_Identity=33.6734693877551, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI8051579, Length=196, Percent_Identity=33.6734693877551, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI53832001, Length=196, Percent_Identity=33.6734693877551, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI28144897, Length=186, Percent_Identity=30.1075268817204, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI28144899, Length=186, Percent_Identity=30.1075268817204, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI22749187, Length=129, Percent_Identity=31.0077519379845, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI209915597, Length=181, Percent_Identity=25.414364640884, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1786680, Length=185, Percent_Identity=47.5675675675676, Blast_Score=166, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17552384, Length=207, Percent_Identity=41.5458937198068, Blast_Score=157, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=40, Blast_Score=147, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17533833, Length=171, Percent_Identity=32.1637426900585, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17550688, Length=188, Percent_Identity=30.8510638297872, Blast_Score=106, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17537943, Length=191, Percent_Identity=28.2722513089005, Blast_Score=73, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI25147457, Length=172, Percent_Identity=25, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=197, Percent_Identity=41.1167512690355, Blast_Score=158, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=34.3589743589744, Blast_Score=109, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322828, Length=186, Percent_Identity=30.1075268817204, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI22026816, Length=205, Percent_Identity=39.0243902439024, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI221459597, Length=185, Percent_Identity=31.3513513513514, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21356893, Length=185, Percent_Identity=31.3513513513514, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI17737899, Length=201, Percent_Identity=31.3432835820896, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24645822, Length=201, Percent_Identity=31.3432835820896, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24663208, Length=161, Percent_Identity=31.6770186335404, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17647141, Length=161, Percent_Identity=31.6770186335404, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_LEPBA (B0SA26)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962974.1
- ProteinModelPortal:   B0SA26
- SMR:   B0SA26
- GeneID:   6389787
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_1892
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK14528
- BioCyc:   LBIF355278:LBF_1892-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20494; Mature: 20494

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLIFMGPPGAGKGTQADIIKEKYNIPQISTGDILRAAVKNGTAMGIEAKKYMDAGDLV
CCCEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCC
PDAVVIGIIRDRLVEADCANGFILDGFPRTVEQAKALSEILKELHMELDSVVNLDVPDEE
HHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LVKRLLGRAIKEGRSDDNEETIKNRLHTYNTKTLPLIDFYKATGILRQINGLGSMEEITN
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
TILKSI
HHHHCC
>Mature Secondary Structure
MKRLIFMGPPGAGKGTQADIIKEKYNIPQISTGDILRAAVKNGTAMGIEAKKYMDAGDLV
CCCEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCC
PDAVVIGIIRDRLVEADCANGFILDGFPRTVEQAKALSEILKELHMELDSVVNLDVPDEE
HHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LVKRLLGRAIKEGRSDDNEETIKNRLHTYNTKTLPLIDFYKATGILRQINGLGSMEEITN
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
TILKSI
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA