Click here to switch to the map view.

The map label for this gene is lpxC

Identifier: 183221252

GI number: 183221252

Start: 1958545

End: 1959453

Strand: Direct

Name: lpxC

Synonym: LEPBI_I1868

Alternate gene names: 183221252

Gene position: 1958545-1959453 (Clockwise)

Preceding gene: 183221251

Following gene: 183221253

Centisome position: 54.41

GC content: 47.85

Gene sequence:

>909_bases
ATGCAAACAGTGATCCATCGAAAAACGATCCAAAACTCTGTCACATTGAAGGGAATTGGCGTACATTCAGGGAAAGTGGT
GACTCTCCGCCTCCATCCTGCGGAAGCAAACACTGGTCTCATTTTTTATCTCTACAAAGGCATCCAAAAAATCCGAATTC
CTGTTTCTCTCGACCACGTCGTCGACACAAGTAACGCCACAACCATTGGGGATGGAAGCTCCAACCGAGTCCAAACCATA
GAACACCTTCTTGCCGCAGTCCATACATTGGGAATAACCGATTGTATTTTTGAAATTGATTCCGTGGAAGTTCCGATTAT
GGATGGATCTTCCTTACCGTTTTGGGAAGGAATCCGATCGGCTGGGATCCGAGTCTTAGAAGAAACGATCGAACCAATCA
CCATTACAAACCCAATTTGGGTGGTAGACGGGGACAAATACCTTGTCATGCTCCCTTCTGATGAGCTCAAAGTCACCTAT
AGCATTGATTTCAACCACCCTCTCTTAAGGGGTCAGTCCTACACCACCACACTCGATGAATCCATCCTCGGAACCGACAT
TTTGCCTGCGAGAACCTTTGGGTTTTTGAAGGATGTGGAAGCGCTCCAAGCACGGGGTCTTGCCATGGGGGGATCCCTCG
ACAATGCTGTGGTCCTAACGGATGATGGGTATCTAAACGACCACTTACGTTATGACAATGAATGCGTCCGACATAAAATC
CTCGACCTTGTTGGAGACCTTGCCGTGATGGGACGTCCATTCCGTGGGCACCTCATTGCTTCGAAAGCGGGCCATGCCTT
GGACATTTCTCTTGCCAAATGCATCATGAGCCAAGTCACTGGGAACGAACTCACCCAGTACAAAAGCAAACGGATCCCAC
TTTTTTCCAAAAAAGAAGCCGCAAAGTAA

Upstream 100 bases:

>100_bases
ACCACACTGTTGTAAAAAAGAGACATTTTTTTGACTTGGGGGGACGGTTTTGGAATTGTCCGAGGGCGAATTCCTACAAA
TTTGTAAGTAGGAATTGAAT

Downstream 100 bases:

>100_bases
TCAAAACCGTTTTTTACTTTCCAAACCAGGCCAAAACAAAAGTATTTTTGGCATAGGTTCGGATGGAAGAAAAAACCACA
TTTAAAGGCATCTCTGCCTA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MQTVIHRKTIQNSVTLKGIGVHSGKVVTLRLHPAEANTGLIFYLYKGIQKIRIPVSLDHVVDTSNATTIGDGSSNRVQTI
EHLLAAVHTLGITDCIFEIDSVEVPIMDGSSLPFWEGIRSAGIRVLEETIEPITITNPIWVVDGDKYLVMLPSDELKVTY
SIDFNHPLLRGQSYTTTLDESILGTDILPARTFGFLKDVEALQARGLAMGGSLDNAVVLTDDGYLNDHLRYDNECVRHKI
LDLVGDLAVMGRPFRGHLIASKAGHALDISLAKCIMSQVTGNELTQYKSKRIPLFSKKEAAK

Sequences:

>Translated_302_residues
MQTVIHRKTIQNSVTLKGIGVHSGKVVTLRLHPAEANTGLIFYLYKGIQKIRIPVSLDHVVDTSNATTIGDGSSNRVQTI
EHLLAAVHTLGITDCIFEIDSVEVPIMDGSSLPFWEGIRSAGIRVLEETIEPITITNPIWVVDGDKYLVMLPSDELKVTY
SIDFNHPLLRGQSYTTTLDESILGTDILPARTFGFLKDVEALQARGLAMGGSLDNAVVLTDDGYLNDHLRYDNECVRHKI
LDLVGDLAVMGRPFRGHLIASKAGHALDISLAKCIMSQVTGNELTQYKSKRIPLFSKKEAAK
>Mature_302_residues
MQTVIHRKTIQNSVTLKGIGVHSGKVVTLRLHPAEANTGLIFYLYKGIQKIRIPVSLDHVVDTSNATTIGDGSSNRVQTI
EHLLAAVHTLGITDCIFEIDSVEVPIMDGSSLPFWEGIRSAGIRVLEETIEPITITNPIWVVDGDKYLVMLPSDELKVTY
SIDFNHPLLRGQSYTTTLDESILGTDILPARTFGFLKDVEALQARGLAMGGSLDNAVVLTDDGYLNDHLRYDNECVRHKI
LDLVGDLAVMGRPFRGHLIASKAGHALDISLAKCIMSQVTGNELTQYKSKRIPLFSKKEAAK

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=302, Percent_Identity=37.4172185430464, Blast_Score=199, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_LEPBA (B0S9V0)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962898.1
- ProteinModelPortal:   B0S9V0
- SMR:   B0S9V0
- GeneID:   6387204
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_1813
- HOGENOM:   HBG482342
- OMA:   ATDPAKE
- ProtClustDB:   PRK13186
- BioCyc:   LBIF355278:LBF_1813-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33173; Mature: 33173

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTVIHRKTIQNSVTLKGIGVHSGKVVTLRLHPAEANTGLIFYLYKGIQKIRIPVSLDHV
CCCHHHHHHHCCCEEEEEEEECCCEEEEEEEECCCCCCCEEEEEECCCEEEECCEEEHHE
VDTSNATTIGDGSSNRVQTIEHLLAAVHTLGITDCIFEIDSVEVPIMDGSSLPFWEGIRS
EECCCCEEECCCCCCHHHHHHHHHHHHHHCCHHHHHEEECCEEEEEECCCCCCHHHHHHH
AGIRVLEETIEPITITNPIWVVDGDKYLVMLPSDELKVTYSIDFNHPLLRGQSYTTTLDE
HHHHHHHHHCCCEEECCCEEEEECCEEEEEECCCCEEEEEEEECCCCEECCCCCCCHHHH
SILGTDILPARTFGFLKDVEALQARGLAMGGSLDNAVVLTDDGYLNDHLRYDNECVRHKI
HHCCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECCCCCCCCCCCCHHHHHHHH
LDLVGDLAVMGRPFRGHLIASKAGHALDISLAKCIMSQVTGNELTQYKSKRIPLFSKKEA
HHHHHHHHHHCCCCCCEEEECCCCCEEHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCC
AK
CC
>Mature Secondary Structure
MQTVIHRKTIQNSVTLKGIGVHSGKVVTLRLHPAEANTGLIFYLYKGIQKIRIPVSLDHV
CCCHHHHHHHCCCEEEEEEEECCCEEEEEEEECCCCCCCEEEEEECCCEEEECCEEEHHE
VDTSNATTIGDGSSNRVQTIEHLLAAVHTLGITDCIFEIDSVEVPIMDGSSLPFWEGIRS
EECCCCEEECCCCCCHHHHHHHHHHHHHHCCHHHHHEEECCEEEEEECCCCCCHHHHHHH
AGIRVLEETIEPITITNPIWVVDGDKYLVMLPSDELKVTYSIDFNHPLLRGQSYTTTLDE
HHHHHHHHHCCCEEECCCEEEEECCEEEEEECCCCEEEEEEEECCCCEECCCCCCCHHHH
SILGTDILPARTFGFLKDVEALQARGLAMGGSLDNAVVLTDDGYLNDHLRYDNECVRHKI
HHCCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECCCCCCCCCCCCHHHHHHHH
LDLVGDLAVMGRPFRGHLIASKAGHALDISLAKCIMSQVTGNELTQYKSKRIPLFSKKEA
HHHHHHHHHHCCCCCCEEEECCCCCEEHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCC
AK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA