Definition Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome chromosome I, complete sequence.
Accession NC_010602
Length 3,599,677

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The map label for this gene is clpA [H]

Identifier: 183221237

GI number: 183221237

Start: 1941403

End: 1943673

Strand: Reverse

Name: clpA [H]

Synonym: LEPBI_I1852

Alternate gene names: 183221237

Gene position: 1943673-1941403 (Counterclockwise)

Preceding gene: 183221238

Following gene: 183221234

Centisome position: 54.0

GC content: 40.51

Gene sequence:

>2271_bases
ATGAACTTTTCGACCGATTTAGAAAAAACATTGGAATTGGCACATATTGAGGCCAGCAAATACCATCATGAGTTTATCAC
ATTAGAACATTTGTTATATGGGTTAACGTTTAACGAAAAAACAAAGGAAGTGCTGGTTAACGTTGGATGTGATTTGGATT
TACTTCGCAAAGAATTATTAGAATACTTTGAAGATGACTTATCCTCCATCGCGGTTCCCAATTTAAAAATCCAACCGAAG
TACACTGTAGGTGTACAATTTGTAATTCAGTTTGCAGCCTTTCATGTTCAAAACTCAGGCAAAGAAGAGGTGGATGGAAA
TAATGTACTTGTCGCATTATTTCGAGAAGAGGATAGCCAGGCCTGTTATTTACTCGCCAAACAAGATATCAAACGGCTTG
ATGTGATCAAATTTATTTCACATGGAGTGAAAAAAGAATCGAGCCCGATAGACCCTAATTTTTCTCCATCGGAAGAAGAG
TTAGAGGAAGAAGCGGAAGGGAAATCAAAACAATCTGCATTGGAAAAGTTTTGTGTGAATCTTACCGAAAGGGCAAAACT
TGGGAAACTAGATCCATGTATCGGAAGGGATACGGAAATCCAAAGGACAATTCACATCCTTTCCAGGCGTAGAAAAAACA
ATCCAATATTTGTAGGAGAAGCTGGTGTTGGCAAAACCTCTATTGTAGAGGGGATCGCCTTGCGGGTAGTCAATGGAAAA
GTTCCCAAAAGTTTACTTGGACTAGAAATTTACTCACTCGATATGGGACTAGTGATGGCAGGAACCAAATTTAGAGGAGA
ATTTGAGGAAAGACTCAAGGCCATCTTGCAAGAATTAGTTGGCAAACCCGAAAAAGTGATTTTTATTGATGAAATTCATA
CCATCGTAGGTGCAGGTGCCGTTTCTGGAGGGAGTTTAGACGCCTCTAACCTAATGAAACCAGCACTTGCCAATGGAGAA
CTCAAATGCATTGGAACCACAACTTACAAAGAATACAAATCAATCTTTGAAAAAGACCATGCACTTTCCAGAAGGTTTCA
AAAAATTGAAGTTTCGGAACCATCCAGGGAAGACGCCATACAGATATTAAATGGATTAAAGCCCAAATACGAATCATTTC
ATGGTGTCCATTATAGCATTAAAGCAATCGAAGCATGCGTTGATTTATCCACTTTGCATCTAAGGGATCGTTTTTTACCA
GACAAAGCCATCGACTTACTAGATGAAGCGGGTGCCTTTGTCAAACTCCGGGATGAAAACAAAGAAAAAGCCAAAAAGAC
GGTGGGGATTTTTGAAATCGAAAGTCTAGTGGCAAAGATTGCGAAGATTCCAGAGAAAACAGTTAAGGCAGATGATAAAA
AGAAATTAGAATCTCTTGATTTAGAAATCAAAACCGTTGTCTTCGGCCAGGACCATGCCATCGAACAAATCGTCGATGCC
ATCCATTACTCTCGGTCGGGCCTTGGGGACGAAGGGAAACCGATTGGTAGTTTTTTATTTGTAGGACCTACTGGAGTTGG
GAAAACGGAAGTGGCCAAAACGTTAGCCGAGAAAATGGGAGTTGAGTTCCTACGATTTGACATGAGTGAGTATATGGAAA
AACATTCTGTATCCCGGCTCATTGGTAGCCCTCCAGGTTATGTGGGGTATGACCAAGGTGGCCAACTCACAGATGCGATT
GCCAAAACCCCTCACTGTGTATTACTTTTTGACGAAATTGAAAAGGCCCATGAGGATATTTATAACATCCTTTTACAAGT
GATGGATCATGCCACTCTGACCGATAGCACTGGAAAAAAAGCGGATTTTCGAAATGTCATTCTAATTCTCACCACAAACA
CAGGTGCCCAGGAAAGTGCAAAACCAATGCTTGGTTTTGATACGGATCGATATGATGACAGATCAATGAAAGCGATTGAA
CGAACTTTCACACCTGAATTTCGTAACCGTCTAACGGCTGTCATTGAATTTAATCCACTTTCGATTCCCATTGTAGAACT
AGTCGTAAAACGAATGTTTAAAACATTACAGTCCAAGGCCAAAGACAAAGGAATTCAGTTGGAGATTTCCGAAAGGTGCG
TCCGTTACCTCGCAGAAAATGGCTATGATAAAGCGATGGGGGCAAGGCCCATCCAAAGGATCTTAAATACCGAAATAGGA
AAACCTTTGTCCAAAAAGATATTATTCCATAAGGACAAAGTGACCTCATACTTAGTGGACGTAGTGGTAGAGCAGGGCAA
ATCCAAATTAGACATCATTCCGGTGATGTAA

Upstream 100 bases:

>100_bases
ATTCACTCGATATTGCACGCACAAAAGTAGCTGAAGTGCATAAATTAGCAGATGATGCGGGACACCCTTTACAATGCCAG
TTGGCAAAGGAGGAAGAGGA

Downstream 100 bases:

>100_bases
AAATAAGAAAGTGTTTTGGAAATTTTGGAACAATCCACAAGTTAGTGGCGGAATTCAAAAGGATTTTGAAAACACTTCGT
CTTCTTTTTTAAAGCTCAAG

Product: ATP-dependent Clp protease ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MNFSTDLEKTLELAHIEASKYHHEFITLEHLLYGLTFNEKTKEVLVNVGCDLDLLRKELLEYFEDDLSSIAVPNLKIQPK
YTVGVQFVIQFAAFHVQNSGKEEVDGNNVLVALFREEDSQACYLLAKQDIKRLDVIKFISHGVKKESSPIDPNFSPSEEE
LEEEAEGKSKQSALEKFCVNLTERAKLGKLDPCIGRDTEIQRTIHILSRRRKNNPIFVGEAGVGKTSIVEGIALRVVNGK
VPKSLLGLEIYSLDMGLVMAGTKFRGEFEERLKAILQELVGKPEKVIFIDEIHTIVGAGAVSGGSLDASNLMKPALANGE
LKCIGTTTYKEYKSIFEKDHALSRRFQKIEVSEPSREDAIQILNGLKPKYESFHGVHYSIKAIEACVDLSTLHLRDRFLP
DKAIDLLDEAGAFVKLRDENKEKAKKTVGIFEIESLVAKIAKIPEKTVKADDKKKLESLDLEIKTVVFGQDHAIEQIVDA
IHYSRSGLGDEGKPIGSFLFVGPTGVGKTEVAKTLAEKMGVEFLRFDMSEYMEKHSVSRLIGSPPGYVGYDQGGQLTDAI
AKTPHCVLLFDEIEKAHEDIYNILLQVMDHATLTDSTGKKADFRNVILILTTNTGAQESAKPMLGFDTDRYDDRSMKAIE
RTFTPEFRNRLTAVIEFNPLSIPIVELVVKRMFKTLQSKAKDKGIQLEISERCVRYLAENGYDKAMGARPIQRILNTEIG
KPLSKKILFHKDKVTSYLVDVVVEQGKSKLDIIPVM

Sequences:

>Translated_756_residues
MNFSTDLEKTLELAHIEASKYHHEFITLEHLLYGLTFNEKTKEVLVNVGCDLDLLRKELLEYFEDDLSSIAVPNLKIQPK
YTVGVQFVIQFAAFHVQNSGKEEVDGNNVLVALFREEDSQACYLLAKQDIKRLDVIKFISHGVKKESSPIDPNFSPSEEE
LEEEAEGKSKQSALEKFCVNLTERAKLGKLDPCIGRDTEIQRTIHILSRRRKNNPIFVGEAGVGKTSIVEGIALRVVNGK
VPKSLLGLEIYSLDMGLVMAGTKFRGEFEERLKAILQELVGKPEKVIFIDEIHTIVGAGAVSGGSLDASNLMKPALANGE
LKCIGTTTYKEYKSIFEKDHALSRRFQKIEVSEPSREDAIQILNGLKPKYESFHGVHYSIKAIEACVDLSTLHLRDRFLP
DKAIDLLDEAGAFVKLRDENKEKAKKTVGIFEIESLVAKIAKIPEKTVKADDKKKLESLDLEIKTVVFGQDHAIEQIVDA
IHYSRSGLGDEGKPIGSFLFVGPTGVGKTEVAKTLAEKMGVEFLRFDMSEYMEKHSVSRLIGSPPGYVGYDQGGQLTDAI
AKTPHCVLLFDEIEKAHEDIYNILLQVMDHATLTDSTGKKADFRNVILILTTNTGAQESAKPMLGFDTDRYDDRSMKAIE
RTFTPEFRNRLTAVIEFNPLSIPIVELVVKRMFKTLQSKAKDKGIQLEISERCVRYLAENGYDKAMGARPIQRILNTEIG
KPLSKKILFHKDKVTSYLVDVVVEQGKSKLDIIPVM
>Mature_756_residues
MNFSTDLEKTLELAHIEASKYHHEFITLEHLLYGLTFNEKTKEVLVNVGCDLDLLRKELLEYFEDDLSSIAVPNLKIQPK
YTVGVQFVIQFAAFHVQNSGKEEVDGNNVLVALFREEDSQACYLLAKQDIKRLDVIKFISHGVKKESSPIDPNFSPSEEE
LEEEAEGKSKQSALEKFCVNLTERAKLGKLDPCIGRDTEIQRTIHILSRRRKNNPIFVGEAGVGKTSIVEGIALRVVNGK
VPKSLLGLEIYSLDMGLVMAGTKFRGEFEERLKAILQELVGKPEKVIFIDEIHTIVGAGAVSGGSLDASNLMKPALANGE
LKCIGTTTYKEYKSIFEKDHALSRRFQKIEVSEPSREDAIQILNGLKPKYESFHGVHYSIKAIEACVDLSTLHLRDRFLP
DKAIDLLDEAGAFVKLRDENKEKAKKTVGIFEIESLVAKIAKIPEKTVKADDKKKLESLDLEIKTVVFGQDHAIEQIVDA
IHYSRSGLGDEGKPIGSFLFVGPTGVGKTEVAKTLAEKMGVEFLRFDMSEYMEKHSVSRLIGSPPGYVGYDQGGQLTDAI
AKTPHCVLLFDEIEKAHEDIYNILLQVMDHATLTDSTGKKADFRNVILILTTNTGAQESAKPMLGFDTDRYDDRSMKAIE
RTFTPEFRNRLTAVIEFNPLSIPIVELVVKRMFKTLQSKAKDKGIQLEISERCVRYLAENGYDKAMGARPIQRILNTEIG
KPLSKKILFHKDKVTSYLVDVVVEQGKSKLDIIPVM

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=170, Percent_Identity=44.1176470588235, Blast_Score=152, Evalue=1e-36,
Organism=Escherichia coli, GI1787109, Length=729, Percent_Identity=51.5775034293553, Blast_Score=783, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=256, Percent_Identity=55.078125, Blast_Score=290, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6320464, Length=326, Percent_Identity=47.8527607361963, Blast_Score=272, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6323002, Length=348, Percent_Identity=41.0919540229885, Blast_Score=245, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84610; Mature: 84610

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFSTDLEKTLELAHIEASKYHHEFITLEHLLYGLTFNEKTKEVLVNVGCDLDLLRKELL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHH
EYFEDDLSSIAVPNLKIQPKYTVGVQFVIQFAAFHVQNSGKEEVDGNNVLVALFREEDSQ
HHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCC
ACYLLAKQDIKRLDVIKFISHGVKKESSPIDPNFSPSEEELEEEAEGKSKQSALEKFCVN
CEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHH
LTERAKLGKLDPCIGRDTEIQRTIHILSRRRKNNPIFVGEAGVGKTSIVEGIALRVVNGK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHEEEECCC
VPKSLLGLEIYSLDMGLVMAGTKFRGEFEERLKAILQELVGKPEKVIFIDEIHTIVGAGA
CCHHHHCCEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCC
VSGGSLDASNLMKPALANGELKCIGTTTYKEYKSIFEKDHALSRRFQKIEVSEPSREDAI
CCCCCCCHHHHHCHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
QILNGLKPKYESFHGVHYSIKAIEACVDLSTLHLRDRFLPDKAIDLLDEAGAFVKLRDEN
HHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCC
KEKAKKTVGIFEIESLVAKIAKIPEKTVKADDKKKLESLDLEIKTVVFGQDHAIEQIVDA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHCCCEEEEEEECCCHHHHHHHHH
IHYSRSGLGDEGKPIGSFLFVGPTGVGKTEVAKTLAEKMGVEFLRFDMSEYMEKHSVSRL
HHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
IGSPPGYVGYDQGGQLTDAIAKTPHCVLLFDEIEKAHEDIYNILLQVMDHATLTDSTGKK
HCCCCCCCCCCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ADFRNVILILTTNTGAQESAKPMLGFDTDRYDDRSMKAIERTFTPEFRNRLTAVIEFNPL
CCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHCCEEEEEEECCC
SIPIVELVVKRMFKTLQSKAKDKGIQLEISERCVRYLAENGYDKAMGARPIQRILNTEIG
CCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHC
KPLSKKILFHKDKVTSYLVDVVVEQGKSKLDIIPVM
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
>Mature Secondary Structure
MNFSTDLEKTLELAHIEASKYHHEFITLEHLLYGLTFNEKTKEVLVNVGCDLDLLRKELL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHH
EYFEDDLSSIAVPNLKIQPKYTVGVQFVIQFAAFHVQNSGKEEVDGNNVLVALFREEDSQ
HHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCC
ACYLLAKQDIKRLDVIKFISHGVKKESSPIDPNFSPSEEELEEEAEGKSKQSALEKFCVN
CEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHH
LTERAKLGKLDPCIGRDTEIQRTIHILSRRRKNNPIFVGEAGVGKTSIVEGIALRVVNGK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHEEEECCC
VPKSLLGLEIYSLDMGLVMAGTKFRGEFEERLKAILQELVGKPEKVIFIDEIHTIVGAGA
CCHHHHCCEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCC
VSGGSLDASNLMKPALANGELKCIGTTTYKEYKSIFEKDHALSRRFQKIEVSEPSREDAI
CCCCCCCHHHHHCHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
QILNGLKPKYESFHGVHYSIKAIEACVDLSTLHLRDRFLPDKAIDLLDEAGAFVKLRDEN
HHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCC
KEKAKKTVGIFEIESLVAKIAKIPEKTVKADDKKKLESLDLEIKTVVFGQDHAIEQIVDA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHCCCEEEEEEECCCHHHHHHHHH
IHYSRSGLGDEGKPIGSFLFVGPTGVGKTEVAKTLAEKMGVEFLRFDMSEYMEKHSVSRL
HHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
IGSPPGYVGYDQGGQLTDAIAKTPHCVLLFDEIEKAHEDIYNILLQVMDHATLTDSTGKK
HCCCCCCCCCCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ADFRNVILILTTNTGAQESAKPMLGFDTDRYDDRSMKAIERTFTPEFRNRLTAVIEFNPL
CCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHCCEEEEEEECCC
SIPIVELVVKRMFKTLQSKAKDKGIQLEISERCVRYLAENGYDKAMGARPIQRILNTEIG
CCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHC
KPLSKKILFHKDKVTSYLVDVVVEQGKSKLDIIPVM
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]