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The map label for this gene is hisC [H]

Identifier: 183221232

GI number: 183221232

Start: 1938131

End: 1939225

Strand: Direct

Name: hisC [H]

Synonym: LEPBI_I1846

Alternate gene names: 183221232

Gene position: 1938131-1939225 (Clockwise)

Preceding gene: 183221231

Following gene: 183221235

Centisome position: 53.84

GC content: 41.19

Gene sequence:

>1095_bases
ATGGATTCTTCGAAACAAAACTTCAATCCAGAATCGTTCATTCGAAAAGAACTCATTTCGTTTTCTCCATATACACCAGG
AGAACAACCAGCTCTTTCCACATCCACAATCAAACTCAATACAAACGAAAACCCCTATCCACCTTCACCTAAGATCCAGA
AGGCGGTAGAAGAAGTCATTCAAAAGGGACTCCTACGCAAATACCCAAATTACCATTCCCGAACATTACAAGAACTCATT
GCCAAAGATTATGATTTGGACCCAAACCAAATCCTTGTCACAAATGGTTCTGATGAAGCCTTACGCCTGTTATTCCAAAC
CTTCGTGGGACCAGGGGATGTTGTTGTGGCACCTGATCCCACCTATTCCTATTATCCCGTCCTCACCGAACAAATGATGG
TGGGTGCAAAATACCAGCCCATCCCCCTTTTGGAAAATCTACACTTTGATTTTGAATCTCTGAAAAAGAGTAAAGGAAAA
CTGCTTTGTTTTGCACACCCAAATGCTCCGACGGGAATTGAAGAACCAAAAGAAACCTTACTCGAACTCGTACAAACCTT
TCCAGGACTTGTGCTCTCTGATGAAGCTTACATTGATTTTACAAACGAAACCGCAAGTCTCATCCCCGATACGAAAGACC
ATCCCAATTTACTCGTTTCCCGAACGTTTTCGAAATCGTTTGCACTCGCAGGACTACGTGTAGGGTATCTCGTAGGGTCA
CTCCAAACAATTTCCTGGATACGCAAACTGAAAGACTCCTATAATGTGGGAATTCTCGACCAAGTGATTGCGGAAACTTC
TTATGCAGATAAAGAATACTTCAAGGAAAAACGAAATTTGGTTCTCACGGAGCGTTCCCGTCTGAAATCCAATTTAGAAT
CTCTTGGGTTTTGGATCCCAGAATCTTCGACCAATTTTTTATTTTGTAAACCAAAACCTGGGGTCTCTCCCGAAGAGTTA
TATCTTTCCTTAAAAGAAAAAAATATCCTCATTCGGTATTTCTCGTATGGTGTTTCCAAAGATTACATCCGGATCACCAT
TGGGACAAAAGAAGAAAATGACACCCTTTTCCAAACAATTCAGACTCTATTATAA

Upstream 100 bases:

>100_bases
GGAGTCAGGCGAAAGGCGAGTCGTAGGAAAAGGAGATTCCACCGATATCATTGAAGCTTGTGCCAAAGCCTATATCAATG
CATTGAACCGGTTGTAAATC

Downstream 100 bases:

>100_bases
AAGAAACCCAACAAAACAACTGTTCTGTTGGGTGATTAATATTTCGTTCACTGATGTTTCCATTCAAAATTTCCGATTGT
CACTTCAAAATCTTTAAAAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MDSSKQNFNPESFIRKELISFSPYTPGEQPALSTSTIKLNTNENPYPPSPKIQKAVEEVIQKGLLRKYPNYHSRTLQELI
AKDYDLDPNQILVTNGSDEALRLLFQTFVGPGDVVVAPDPTYSYYPVLTEQMMVGAKYQPIPLLENLHFDFESLKKSKGK
LLCFAHPNAPTGIEEPKETLLELVQTFPGLVLSDEAYIDFTNETASLIPDTKDHPNLLVSRTFSKSFALAGLRVGYLVGS
LQTISWIRKLKDSYNVGILDQVIAETSYADKEYFKEKRNLVLTERSRLKSNLESLGFWIPESSTNFLFCKPKPGVSPEEL
YLSLKEKNILIRYFSYGVSKDYIRITIGTKEENDTLFQTIQTLL

Sequences:

>Translated_364_residues
MDSSKQNFNPESFIRKELISFSPYTPGEQPALSTSTIKLNTNENPYPPSPKIQKAVEEVIQKGLLRKYPNYHSRTLQELI
AKDYDLDPNQILVTNGSDEALRLLFQTFVGPGDVVVAPDPTYSYYPVLTEQMMVGAKYQPIPLLENLHFDFESLKKSKGK
LLCFAHPNAPTGIEEPKETLLELVQTFPGLVLSDEAYIDFTNETASLIPDTKDHPNLLVSRTFSKSFALAGLRVGYLVGS
LQTISWIRKLKDSYNVGILDQVIAETSYADKEYFKEKRNLVLTERSRLKSNLESLGFWIPESSTNFLFCKPKPGVSPEEL
YLSLKEKNILIRYFSYGVSKDYIRITIGTKEENDTLFQTIQTLL
>Mature_364_residues
MDSSKQNFNPESFIRKELISFSPYTPGEQPALSTSTIKLNTNENPYPPSPKIQKAVEEVIQKGLLRKYPNYHSRTLQELI
AKDYDLDPNQILVTNGSDEALRLLFQTFVGPGDVVVAPDPTYSYYPVLTEQMMVGAKYQPIPLLENLHFDFESLKKSKGK
LLCFAHPNAPTGIEEPKETLLELVQTFPGLVLSDEAYIDFTNETASLIPDTKDHPNLLVSRTFSKSFALAGLRVGYLVGS
LQTISWIRKLKDSYNVGILDQVIAETSYADKEYFKEKRNLVLTERSRLKSNLESLGFWIPESSTNFLFCKPKPGVSPEEL
YLSLKEKNILIRYFSYGVSKDYIRITIGTKEENDTLFQTIQTLL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=359, Percent_Identity=28.6908077994429, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788722, Length=304, Percent_Identity=25.3289473684211, Blast_Score=75, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6322075, Length=384, Percent_Identity=27.0833333333333, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41304; Mature: 41304

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSSKQNFNPESFIRKELISFSPYTPGEQPALSTSTIKLNTNENPYPPSPKIQKAVEEVI
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
QKGLLRKYPNYHSRTLQELIAKDYDLDPNQILVTNGSDEALRLLFQTFVGPGDVVVAPDP
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEECCCC
TYSYYPVLTEQMMVGAKYQPIPLLENLHFDFESLKKSKGKLLCFAHPNAPTGIEEPKETL
CCCCHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHCCCCCEEEEECCCCCCCCCCHHHHH
LELVQTFPGLVLSDEAYIDFTNETASLIPDTKDHPNLLVSRTFSKSFALAGLRVGYLVGS
HHHHHHCCCEEECCCEEEEECCCCHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
LQTISWIRKLKDSYNVGILDQVIAETSYADKEYFKEKRNLVLTERSRLKSNLESLGFWIP
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHCCEEEEHHHHHHHHHHHHCEECC
ESSTNFLFCKPKPGVSPEELYLSLKEKNILIRYFSYGVSKDYIRITIGTKEENDTLFQTI
CCCCCEEEECCCCCCCHHHHEEEECCCCEEEEEEECCCCCCEEEEEECCCCCCHHHHHHH
QTLL
HHHC
>Mature Secondary Structure
MDSSKQNFNPESFIRKELISFSPYTPGEQPALSTSTIKLNTNENPYPPSPKIQKAVEEVI
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
QKGLLRKYPNYHSRTLQELIAKDYDLDPNQILVTNGSDEALRLLFQTFVGPGDVVVAPDP
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEECCCC
TYSYYPVLTEQMMVGAKYQPIPLLENLHFDFESLKKSKGKLLCFAHPNAPTGIEEPKETL
CCCCHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHCCCCCEEEEECCCCCCCCCCHHHHH
LELVQTFPGLVLSDEAYIDFTNETASLIPDTKDHPNLLVSRTFSKSFALAGLRVGYLVGS
HHHHHHCCCEEECCCEEEEECCCCHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
LQTISWIRKLKDSYNVGILDQVIAETSYADKEYFKEKRNLVLTERSRLKSNLESLGFWIP
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHCCEEEEHHHHHHHHHHHHCEECC
ESSTNFLFCKPKPGVSPEELYLSLKEKNILIRYFSYGVSKDYIRITIGTKEENDTLFQTI
CCCCCEEEECCCCCCCHHHHEEEECCCCEEEEEEECCCCCCEEEEEECCCCCCHHHHHHH
QTLL
HHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA