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The map label for this gene is pepP [H]

Identifier: 183221174

GI number: 183221174

Start: 1866084

End: 1867403

Strand: Reverse

Name: pepP [H]

Synonym: LEPBI_I1788

Alternate gene names: 183221174

Gene position: 1867403-1866084 (Counterclockwise)

Preceding gene: 183221175

Following gene: 183221173

Centisome position: 51.88

GC content: 35.53

Gene sequence:

>1320_bases
ATGAAACTACCGGTTATGAAATCGAATGAATTCGATGCAGGACTATTTCAAAAACGAATTCGGAAAGTCCAAAAAAAGCT
AAAAAAGGGCGAAATATTAATCTTATTTGCAGCAACTCACAAAATTAGAAATCGAGACGTTGAATATAAATTCAGACAAA
ATTCCGATTTTTATTACCTAACAGGGGTTAGAGAAGAGGATTCAATTTTTGTTTTAACTTCTGATGCAGTTGGGATGTTC
TGTTTGCCCAAAGACAAAGAAAGGGAAATTTGGACAGGGATTCGTTTAGGCAAAGATAAAATCAAATCCATGTTAGATTT
GGATTTTACATATGATTTGAACGATTGGGACAAACAAAAATCAGCAATTCTCATTGGGAATCATACCTTATATTATTTTT
TTGGAGAAAATCCCGACAGGGATCGTGAACTATTACAGGAATGTAAAAATCTTTCGGAAAGAGCAAGGGAAGGGAAATTT
GGACCACATCGTATCGAACACCCTTATTTTTTACACGAAGAACGACTCATCAAATCCAAAGAAGAAATCCAAATTCTAAA
AAATGCTGCCGAGATTACAAAATTTGGACATATGCGTATCATGCGAGAAAGTAAACCCGGGTTGTATGAATATGAATTGG
AAGCTTTACTTGAACAAGAATACCTAAAATATGGATCGATTGGTGGTGGGTATGGTCATATTGTAGCATCCGGTAAAAAC
GCATGTATCTTACATTATGTTAATAACGATGATCGTTTGTTAGATGGTGATTTGGTATTAGTGGATTCTGGTGCGGAATG
GAATTATTACACGGCGGACGTAACCCGTGTTTTTCCTGTTGGGAAAAAGTTTTCAGACGCGCAAAAGACAATTTATGAAG
TTGTATTGTATGCTCAAAAGAATGCGATTCGTCAATCCGTAACTGGAATTCCATTCAATGAAGTACATGAAAAAACGGTT
CGTTTCCTTGCAGATTGTTTACGTGAGATGGGTTTTTTAAAAGGGAATCTCGATGAAATTTTAGAAAAAGAAACCTACAA
AAAGTTTTATATGCATCGAACTGGGCATTATTTAGGAATGGATGTCCATGATGTTGGTAGGTATTTTATAGATGGAAAGT
CAAGACCCTTAAAGGATGGGCAAGTGGTCACAGTTGAACCTGGATTGTATTTTGATCCAAGTGATGATTCAATACCAAAA
GAATTTCGGGGCATAGGAATTCGTATTGAAGATGATATCCTCATCAATGGAAAAGAACCAATCAATTTAACAGAATCGAT
TCCAAAAGAAGTTTCTGAAATTGAAGCTTTGAAATCGTAG

Upstream 100 bases:

>100_bases
GCATTCACGGAGGTAGGGTTTGCCCAGAAGGGCATTTTCGGTGTATGTTGGATCAAAATCCAGTACGTATTTTTGAAGCA
CTCGAGGAAGTGATTAAGAC

Downstream 100 bases:

>100_bases
TAGATTCAATCGTTCCATGGCAAGAGAACTCCCAAAACGCTTTCGATCCGTCCGATATTTTGATCGCATTAGTTCTGAAA
TTGCAGACATTGTTCGAACG

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKLPVMKSNEFDAGLFQKRIRKVQKKLKKGEILILFAATHKIRNRDVEYKFRQNSDFYYLTGVREEDSIFVLTSDAVGMF
CLPKDKEREIWTGIRLGKDKIKSMLDLDFTYDLNDWDKQKSAILIGNHTLYYFFGENPDRDRELLQECKNLSERAREGKF
GPHRIEHPYFLHEERLIKSKEEIQILKNAAEITKFGHMRIMRESKPGLYEYELEALLEQEYLKYGSIGGGYGHIVASGKN
ACILHYVNNDDRLLDGDLVLVDSGAEWNYYTADVTRVFPVGKKFSDAQKTIYEVVLYAQKNAIRQSVTGIPFNEVHEKTV
RFLADCLREMGFLKGNLDEILEKETYKKFYMHRTGHYLGMDVHDVGRYFIDGKSRPLKDGQVVTVEPGLYFDPSDDSIPK
EFRGIGIRIEDDILINGKEPINLTESIPKEVSEIEALKS

Sequences:

>Translated_439_residues
MKLPVMKSNEFDAGLFQKRIRKVQKKLKKGEILILFAATHKIRNRDVEYKFRQNSDFYYLTGVREEDSIFVLTSDAVGMF
CLPKDKEREIWTGIRLGKDKIKSMLDLDFTYDLNDWDKQKSAILIGNHTLYYFFGENPDRDRELLQECKNLSERAREGKF
GPHRIEHPYFLHEERLIKSKEEIQILKNAAEITKFGHMRIMRESKPGLYEYELEALLEQEYLKYGSIGGGYGHIVASGKN
ACILHYVNNDDRLLDGDLVLVDSGAEWNYYTADVTRVFPVGKKFSDAQKTIYEVVLYAQKNAIRQSVTGIPFNEVHEKTV
RFLADCLREMGFLKGNLDEILEKETYKKFYMHRTGHYLGMDVHDVGRYFIDGKSRPLKDGQVVTVEPGLYFDPSDDSIPK
EFRGIGIRIEDDILINGKEPINLTESIPKEVSEIEALKS
>Mature_439_residues
MKLPVMKSNEFDAGLFQKRIRKVQKKLKKGEILILFAATHKIRNRDVEYKFRQNSDFYYLTGVREEDSIFVLTSDAVGMF
CLPKDKEREIWTGIRLGKDKIKSMLDLDFTYDLNDWDKQKSAILIGNHTLYYFFGENPDRDRELLQECKNLSERAREGKF
GPHRIEHPYFLHEERLIKSKEEIQILKNAAEITKFGHMRIMRESKPGLYEYELEALLEQEYLKYGSIGGGYGHIVASGKN
ACILHYVNNDDRLLDGDLVLVDSGAEWNYYTADVTRVFPVGKKFSDAQKTIYEVVLYAQKNAIRQSVTGIPFNEVHEKTV
RFLADCLREMGFLKGNLDEILEKETYKKFYMHRTGHYLGMDVHDVGRYFIDGKSRPLKDGQVVTVEPGLYFDPSDDSIPK
EFRGIGIRIEDDILINGKEPINLTESIPKEVSEIEALKS

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=416, Percent_Identity=31.0096153846154, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI149589008, Length=459, Percent_Identity=29.8474945533769, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI260593665, Length=308, Percent_Identity=33.7662337662338, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI260593663, Length=260, Percent_Identity=33.4615384615385, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1789275, Length=428, Percent_Identity=40.1869158878505, Blast_Score=318, Evalue=3e-88,
Organism=Escherichia coli, GI1788728, Length=261, Percent_Identity=27.9693486590038, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790282, Length=466, Percent_Identity=24.2489270386266, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17508215, Length=461, Percent_Identity=29.0672451193059, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71989583, Length=273, Percent_Identity=31.8681318681319, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320922, Length=451, Percent_Identity=30.5986696230599, Blast_Score=206, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6321118, Length=424, Percent_Identity=30.4245283018868, Blast_Score=173, Evalue=6e-44,
Organism=Drosophila melanogaster, GI19920384, Length=419, Percent_Identity=33.1742243436754, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI21357079, Length=453, Percent_Identity=32.8918322295806, Blast_Score=197, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 50904; Mature: 50904

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPVMKSNEFDAGLFQKRIRKVQKKLKKGEILILFAATHKIRNRDVEYKFRQNSDFYYL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECHHHCCCCCEEEEECCCCEEEE
TGVREEDSIFVLTSDAVGMFCLPKDKEREIWTGIRLGKDKIKSMLDLDFTYDLNDWDKQK
EECCCCCCEEEEECCCCEEEECCCCCCCHHHHHHCCCHHHHHHHHCCCEEECCCCCCCCC
SAILIGNHTLYYFFGENPDRDRELLQECKNLSERAREGKFGPHRIEHPYFLHEERLIKSK
CEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHCCH
EEIQILKNAAEITKFGHMRIMRESKPGLYEYELEALLEQEYLKYGSIGGGYGHIVASGKN
HHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
ACILHYVNNDDRLLDGDLVLVDSGAEWNYYTADVTRVFPVGKKFSDAQKTIYEVVLYAQK
EEEEEEECCCCEEEECCEEEEECCCCCCEEECCEEEEEECCCCCCHHHHHHHHHHHHHHH
NAIRQSVTGIPFNEVHEKTVRFLADCLREMGFLKGNLDEILEKETYKKFYMHRTGHYLGM
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEECC
DVHDVGRYFIDGKSRPLKDGQVVTVEPGLYFDPSDDSIPKEFRGIGIRIEDDILINGKEP
CHHHHHHHEECCCCCCCCCCEEEEECCCEEECCCCCCCCHHHCCCCEEEECCEEECCCCC
INLTESIPKEVSEIEALKS
CCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLPVMKSNEFDAGLFQKRIRKVQKKLKKGEILILFAATHKIRNRDVEYKFRQNSDFYYL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECHHHCCCCCEEEEECCCCEEEE
TGVREEDSIFVLTSDAVGMFCLPKDKEREIWTGIRLGKDKIKSMLDLDFTYDLNDWDKQK
EECCCCCCEEEEECCCCEEEECCCCCCCHHHHHHCCCHHHHHHHHCCCEEECCCCCCCCC
SAILIGNHTLYYFFGENPDRDRELLQECKNLSERAREGKFGPHRIEHPYFLHEERLIKSK
CEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHCCH
EEIQILKNAAEITKFGHMRIMRESKPGLYEYELEALLEQEYLKYGSIGGGYGHIVASGKN
HHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
ACILHYVNNDDRLLDGDLVLVDSGAEWNYYTADVTRVFPVGKKFSDAQKTIYEVVLYAQK
EEEEEEECCCCEEEECCEEEEECCCCCCEEECCEEEEEECCCCCCHHHHHHHHHHHHHHH
NAIRQSVTGIPFNEVHEKTVRFLADCLREMGFLKGNLDEILEKETYKKFYMHRTGHYLGM
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEECC
DVHDVGRYFIDGKSRPLKDGQVVTVEPGLYFDPSDDSIPKEFRGIGIRIEDDILINGKEP
CHHHHHHHEECCCCCCCCCCEEEEECCCEEECCCCCCCCHHHCCCCEEEECCEEECCCCC
INLTESIPKEVSEIEALKS
CCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]