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The map label for this gene is ubiB [H]

Identifier: 183221137

GI number: 183221137

Start: 1828109

End: 1829743

Strand: Reverse

Name: ubiB [H]

Synonym: LEPBI_I1751

Alternate gene names: 183221137

Gene position: 1829743-1828109 (Counterclockwise)

Preceding gene: 183221138

Following gene: 183221136

Centisome position: 50.83

GC content: 35.17

Gene sequence:

>1635_bases
ATGAAATCTGATCAAAATCGATCTGTCTCTGTTTATTCATTTGTTCTGAAAACATACATTCAATATTTATATTTATCAAA
AATTTCGAAACGAATCCTTTCCAAAGAAAATTATGAAAACAAACGAATTTCGTTTCTAAAAGCAAAAGGGCTCGAAACAA
AAACTTTGTTCTTTCAGTTAGGTGGCGTTTACATCAAAATTGGACAATTCGTAAGTAATTTGTTCCATATCCTTCCTGAA
GAATTTTTATGGGAATTACAAGACCTTCAAGATAAAATACCACCACGTGAATTTAATGAAATTGATAAACGTTGGCAATT
AGGTTTCGGGAAACCAATGGATCAAATTTTTGCATCATTGGATACAAATGCTTATGCCAGTGCTTCGACCGCTCAAGTTC
ATATTGGAATCTTCCAAAACAAAAAAGTAGCAATCAAAACTTTATATCCAGGCATTGAAGAAACAGCTAAATCGGATTTA
AAAACAATTTCCAAAGTGATATGGCTTGTAGATCGTTTTGTCGTGCGAATTTCAGCAAAGGAAGTCGTGGACCAATTACA
AACCATGATCCATTCTGAATTGGATCTCCGCTCGGAATTAAAAAATCTAAAATTACTCAAACAGATGTTTGCATTGGAAA
AGGACTTTTATATTCCAAATCCAATCGATGAACTTTGTGGTCGACATACATTGGTTACAGAATTCGTAGAGGGGAAAAAA
ATATACGAATTAGAATCGGAACCAATGTTCACCAAACGAAATCCAAATTTGGATAAATTGATCAAAGCTTACATTCTGAT
GATTTTTGATTATCGTTTTTTCCATGCGGACCCACATCCAGGAAATTTAATTTTTATGGAAACTGGGGAACTTTGTCTTA
TTGATTTTGGAGCAGTCCAATCCATTTCCGAGGAAGAAACTCAAATTTTGGAACGAATCTTAGTCGGCGCCATGAGAAAG
GACTACCATCTAGTTTCTGAATCTTTATACGAATTAGGTGCTGTCACCGATTCGCTCACGAAAGAGGAACTCACTCAAAT
TGTAAAATATTCTCTGGAAAAACTAAATCGGATCTTGGCAGACACCAATCATTTTAGAAATTTGAGTTTGGATACTCTTC
GACCGGGAGATGACTTACGATTTCTAAAAGAAATCCAAGTAAGCCTCAAACGTCTGTTATCGAGTCTCAAACTCCCTCCC
AATTTCCTGAGTTTACACCGTGTACTCGCTTTATTACTTGGGAACTTTTCGTTTTTGGACCCAACACGATCGATGATTGA
ATATGCAGAAAAACCGTTTTCTCAAATTGTACTCAAAGGAAGTTCATTCAAAAGGCTTTGGAAAGATGAAGGAGAGGAGT
TTCTAACGAGTTTGTTTTCCCTTCCGAGAGAATTGAATGACTTTTTGTACAAATGGAACCGAGGGGAATTTACAGCCAAA
GAGGACCACAAACAGGAAGAATTGAAACTAAAGGAAATTTTTACCTTTGGTACACTCGGCTCACTATTTTTCTTTTTTGG
AATGTATTATGCGGAAAAATTATGGAAAGAACCAAGCATAATTTTTTATATACTATCAGGACTTTGTTTTTGGTCACTTG
CCAAATCTAGTCTAAGTTATTGGAAACAAAAATAA

Upstream 100 bases:

>100_bases
TCAAAGAAGTATTCCATGGCGAAACAACCAGAATGGAAGCAAGTCTCGCTGACAATATTCAAATTTTAGAAAGTATCGAA
TCCATTTATAGGCAATCAAA

Downstream 100 bases:

>100_bases
ACGGAAAAGATTACAAAACTTCAGTATGAAATTACCAAAAACACCATTTTTCTCTGTCTTTAAACCTGGATATTTGGCCT
TCGTTGCCTTCGGACTATTT

Product: putative protein kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MKSDQNRSVSVYSFVLKTYIQYLYLSKISKRILSKENYENKRISFLKAKGLETKTLFFQLGGVYIKIGQFVSNLFHILPE
EFLWELQDLQDKIPPREFNEIDKRWQLGFGKPMDQIFASLDTNAYASASTAQVHIGIFQNKKVAIKTLYPGIEETAKSDL
KTISKVIWLVDRFVVRISAKEVVDQLQTMIHSELDLRSELKNLKLLKQMFALEKDFYIPNPIDELCGRHTLVTEFVEGKK
IYELESEPMFTKRNPNLDKLIKAYILMIFDYRFFHADPHPGNLIFMETGELCLIDFGAVQSISEEETQILERILVGAMRK
DYHLVSESLYELGAVTDSLTKEELTQIVKYSLEKLNRILADTNHFRNLSLDTLRPGDDLRFLKEIQVSLKRLLSSLKLPP
NFLSLHRVLALLLGNFSFLDPTRSMIEYAEKPFSQIVLKGSSFKRLWKDEGEEFLTSLFSLPRELNDFLYKWNRGEFTAK
EDHKQEELKLKEIFTFGTLGSLFFFFGMYYAEKLWKEPSIIFYILSGLCFWSLAKSSLSYWKQK

Sequences:

>Translated_544_residues
MKSDQNRSVSVYSFVLKTYIQYLYLSKISKRILSKENYENKRISFLKAKGLETKTLFFQLGGVYIKIGQFVSNLFHILPE
EFLWELQDLQDKIPPREFNEIDKRWQLGFGKPMDQIFASLDTNAYASASTAQVHIGIFQNKKVAIKTLYPGIEETAKSDL
KTISKVIWLVDRFVVRISAKEVVDQLQTMIHSELDLRSELKNLKLLKQMFALEKDFYIPNPIDELCGRHTLVTEFVEGKK
IYELESEPMFTKRNPNLDKLIKAYILMIFDYRFFHADPHPGNLIFMETGELCLIDFGAVQSISEEETQILERILVGAMRK
DYHLVSESLYELGAVTDSLTKEELTQIVKYSLEKLNRILADTNHFRNLSLDTLRPGDDLRFLKEIQVSLKRLLSSLKLPP
NFLSLHRVLALLLGNFSFLDPTRSMIEYAEKPFSQIVLKGSSFKRLWKDEGEEFLTSLFSLPRELNDFLYKWNRGEFTAK
EDHKQEELKLKEIFTFGTLGSLFFFFGMYYAEKLWKEPSIIFYILSGLCFWSLAKSSLSYWKQK
>Mature_544_residues
MKSDQNRSVSVYSFVLKTYIQYLYLSKISKRILSKENYENKRISFLKAKGLETKTLFFQLGGVYIKIGQFVSNLFHILPE
EFLWELQDLQDKIPPREFNEIDKRWQLGFGKPMDQIFASLDTNAYASASTAQVHIGIFQNKKVAIKTLYPGIEETAKSDL
KTISKVIWLVDRFVVRISAKEVVDQLQTMIHSELDLRSELKNLKLLKQMFALEKDFYIPNPIDELCGRHTLVTEFVEGKK
IYELESEPMFTKRNPNLDKLIKAYILMIFDYRFFHADPHPGNLIFMETGELCLIDFGAVQSISEEETQILERILVGAMRK
DYHLVSESLYELGAVTDSLTKEELTQIVKYSLEKLNRILADTNHFRNLSLDTLRPGDDLRFLKEIQVSLKRLLSSLKLPP
NFLSLHRVLALLLGNFSFLDPTRSMIEYAEKPFSQIVLKGSSFKRLWKDEGEEFLTSLFSLPRELNDFLYKWNRGEFTAK
EDHKQEELKLKEIFTFGTLGSLFFFFGMYYAEKLWKEPSIIFYILSGLCFWSLAKSSLSYWKQK

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=298, Percent_Identity=27.5167785234899, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI41393593, Length=356, Percent_Identity=25.8426966292135, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI27363457, Length=291, Percent_Identity=26.1168384879725, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI217416386, Length=265, Percent_Identity=25.2830188679245, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI34147522, Length=212, Percent_Identity=24.5283018867925, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI217035081, Length=202, Percent_Identity=28.2178217821782, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI2367309, Length=311, Percent_Identity=27.6527331189711, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32565180, Length=359, Percent_Identity=26.7409470752089, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17559152, Length=286, Percent_Identity=24.8251748251748, Blast_Score=95, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6323282, Length=270, Percent_Identity=28.5185185185185, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=291, Percent_Identity=23.3676975945017, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6325148, Length=443, Percent_Identity=21.4446952595937, Blast_Score=63, Evalue=1e-10,
Organism=Drosophila melanogaster, GI22024280, Length=254, Percent_Identity=25.5905511811024, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24662575, Length=335, Percent_Identity=25.3731343283582, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI18859849, Length=303, Percent_Identity=23.1023102310231, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63537; Mature: 63537

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDQNRSVSVYSFVLKTYIQYLYLSKISKRILSKENYENKRISFLKAKGLETKTLFFQL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHH
GGVYIKIGQFVSNLFHILPEEFLWELQDLQDKIPPREFNEIDKRWQLGFGKPMDQIFASL
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHH
DTNAYASASTAQVHIGIFQNKKVAIKTLYPGIEETAKSDLKTISKVIWLVDRFVVRISAK
CCCCCCCCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVVDQLQTMIHSELDLRSELKNLKLLKQMFALEKDFYIPNPIDELCGRHTLVTEFVEGKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHCCCE
IYELESEPMFTKRNPNLDKLIKAYILMIFDYRFFHADPHPGNLIFMETGELCLIDFGAVQ
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECHHHH
SISEEETQILERILVGAMRKDYHLVSESLYELGAVTDSLTKEELTQIVKYSLEKLNRILA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTNHFRNLSLDTLRPGDDLRFLKEIQVSLKRLLSSLKLPPNFLSLHRVLALLLGNFSFLD
CCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
PTRSMIEYAEKPFSQIVLKGSSFKRLWKDEGEEFLTSLFSLPRELNDFLYKWNRGEFTAK
HHHHHHHHHHCCHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EDHKQEELKLKEIFTFGTLGSLFFFFGMYYAEKLWKEPSIIFYILSGLCFWSLAKSSLSY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
WKQK
HCCC
>Mature Secondary Structure
MKSDQNRSVSVYSFVLKTYIQYLYLSKISKRILSKENYENKRISFLKAKGLETKTLFFQL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHH
GGVYIKIGQFVSNLFHILPEEFLWELQDLQDKIPPREFNEIDKRWQLGFGKPMDQIFASL
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHH
DTNAYASASTAQVHIGIFQNKKVAIKTLYPGIEETAKSDLKTISKVIWLVDRFVVRISAK
CCCCCCCCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVVDQLQTMIHSELDLRSELKNLKLLKQMFALEKDFYIPNPIDELCGRHTLVTEFVEGKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHCCCE
IYELESEPMFTKRNPNLDKLIKAYILMIFDYRFFHADPHPGNLIFMETGELCLIDFGAVQ
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECHHHH
SISEEETQILERILVGAMRKDYHLVSESLYELGAVTDSLTKEELTQIVKYSLEKLNRILA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTNHFRNLSLDTLRPGDDLRFLKEIQVSLKRLLSSLKLPPNFLSLHRVLALLLGNFSFLD
CCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
PTRSMIEYAEKPFSQIVLKGSSFKRLWKDEGEEFLTSLFSLPRELNDFLYKWNRGEFTAK
HHHHHHHHHHCCHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EDHKQEELKLKEIFTFGTLGSLFFFFGMYYAEKLWKEPSIIFYILSGLCFWSLAKSSLSY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
WKQK
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]