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The map label for this gene is lspA

Identifier: 183221136

GI number: 183221136

Start: 1827523

End: 1828083

Strand: Reverse

Name: lspA

Synonym: LEPBI_I1750

Alternate gene names: 183221136

Gene position: 1828083-1827523 (Counterclockwise)

Preceding gene: 183221137

Following gene: 183221133

Centisome position: 50.78

GC content: 35.65

Gene sequence:

>561_bases
ATGAAATTACCAAAAACACCATTTTTCTCTGTCTTTAAACCTGGATATTTGGCCTTCGTTGCCTTCGGACTATTTTTAGA
TTTAAGTTCAAAGTACGTCATCATTACAAAAATGTATGCTCATGAAAGTATCCCTGTGTTAGGTGATTTTTTTCGACTTT
CGTTAACGTTTAATACTGGTTTTGTGTTTGGATTATTCCAAGACAATGCTTTGCCTTCTTTATTTGCGACAGGCTTTGCG
ATTGTTTTTTTAATATTTTATCGCTGGGAAAATTCTGACTTAGGCAATGCTTGGGGATGGAATTTTGTGATGGCAGGTGC
TTTCGGAAATTTTTTGGATAAGTTTTTTGTGAAAATTCCAGGCAGTGGATTTCGATTTGGATTCACACCAGAAAAACCAG
GAATTGAATTCATAGGTGTGGTTGACTTTTTGGATTTTGAATGGCCCGATTTTTTATTATTTGATCGATGGCCTGCATTT
AATGTGGCTGATTCCTGTGTCTCCATCGGCATTGTGATTTTACTCTTTACAATGGACTGGAAAGAGATGGATAAAAAATA
A

Upstream 100 bases:

>100_bases
ATTTTTTATATACTATCAGGACTTTGTTTTTGGTCACTTGCCAAATCTAGTCTAAGTTATTGGAAACAAAAATAAACGGA
AAAGATTACAAAACTTCAGT

Downstream 100 bases:

>100_bases
TCCAAATCCCACATACAACTCTGATTCGATCATTGAAAACGAATCCTAAGATTGGATAAAGATTTAATCCTCCAATCTTA
GTTTTGAACTTGAAGTGGTC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MKLPKTPFFSVFKPGYLAFVAFGLFLDLSSKYVIITKMYAHESIPVLGDFFRLSLTFNTGFVFGLFQDNALPSLFATGFA
IVFLIFYRWENSDLGNAWGWNFVMAGAFGNFLDKFFVKIPGSGFRFGFTPEKPGIEFIGVVDFLDFEWPDFLLFDRWPAF
NVADSCVSIGIVILLFTMDWKEMDKK

Sequences:

>Translated_186_residues
MKLPKTPFFSVFKPGYLAFVAFGLFLDLSSKYVIITKMYAHESIPVLGDFFRLSLTFNTGFVFGLFQDNALPSLFATGFA
IVFLIFYRWENSDLGNAWGWNFVMAGAFGNFLDKFFVKIPGSGFRFGFTPEKPGIEFIGVVDFLDFEWPDFLLFDRWPAF
NVADSCVSIGIVILLFTMDWKEMDKK
>Mature_186_residues
MKLPKTPFFSVFKPGYLAFVAFGLFLDLSSKYVIITKMYAHESIPVLGDFFRLSLTFNTGFVFGLFQDNALPSLFATGFA
IVFLIFYRWENSDLGNAWGWNFVMAGAFGNFLDKFFVKIPGSGFRFGFTPEKPGIEFIGVVDFLDFEWPDFLLFDRWPAF
NVADSCVSIGIVILLFTMDWKEMDKK

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_LEPBA (B0S977)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962782.1
- GeneID:   6388803
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_1697
- HOGENOM:   HBG724422
- OMA:   FFYITSH
- ProtClustDB:   PRK14783
- BioCyc:   LBIF355278:LBF_1697-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 21292; Mature: 21292

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 113-113 ACT_SITE 164-164

Signals:

None

Transmembrane regions:

HASH(0x1814448c)-; HASH(0x1a2c4900)-; HASH(0x1b98bef4)-; HASH(0x1b585460)-; HASH(0x1b87d7b4)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPKTPFFSVFKPGYLAFVAFGLFLDLSSKYVIITKMYAHESIPVLGDFFRLSLTFNTG
CCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEEEEEEEECCC
FVFGLFQDNALPSLFATGFAIVFLIFYRWENSDLGNAWGWNFVMAGAFGNFLDKFFVKIP
EEEEEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEEHHHHHHHHHHHEECC
GSGFRFGFTPEKPGIEFIGVVDFLDFEWPDFLLFDRWPAFNVADSCVSIGIVILLFTMDW
CCCEEECCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCH
KEMDKK
HHHCCH
>Mature Secondary Structure
MKLPKTPFFSVFKPGYLAFVAFGLFLDLSSKYVIITKMYAHESIPVLGDFFRLSLTFNTG
CCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEEEEEEEECCC
FVFGLFQDNALPSLFATGFAIVFLIFYRWENSDLGNAWGWNFVMAGAFGNFLDKFFVKIP
EEEEEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEEHHHHHHHHHHHEECC
GSGFRFGFTPEKPGIEFIGVVDFLDFEWPDFLLFDRWPAFNVADSCVSIGIVILLFTMDW
CCCEEECCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCH
KEMDKK
HHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA