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The map label for this gene is guaA [H]

Identifier: 183221002

GI number: 183221002

Start: 1688207

End: 1690006

Strand: Direct

Name: guaA [H]

Synonym: LEPBI_I1615

Alternate gene names: 183221002

Gene position: 1688207-1690006 (Clockwise)

Preceding gene: 183220998

Following gene: 183221006

Centisome position: 46.9

GC content: 42.78

Gene sequence:

>1800_bases
ATGACAAGTGATAAAAAAATCGCAGTCGTCGATTTCGGCGGCCAGTATGCTCATCTCATTGCTTCCCGTATCCGAAGGTT
AGGAGCCTATACCGAAATCCTATCCAATGAAGAACCCTTGTCTCGCTACGAGTCCTATGCGGGTATCATCCTTTCAGGAG
GACCAAGCAGCGTCTATGAAACGGGAGCACCGCTTTTGCCAGCTGGTTTTTTTGATACTTCCGTTCCTGTGCTAGGAATT
TGTTACGGCCACCAGCTCATGATGAAGACACTCGGTGGCGAAGTGGTTTCAGCGAGCACAAAAGAATACGGACCGGCGAT
CCTTGAAATTGAAAATCCAAATTCACCCTTGTCCCAATCACTTTCTCTAAAAACAAAGGTTTGGATGAGTCATGGTGATG
AGGTGGTTCGATTACCAAATGATTTCCAGGTGATTGCAAAGTCAGATCACTGCCGTTATGCGTTTGTCTCTCATCCTTCT
AAAAACCTTTTTGGCATCCAATTCCACCCAGAGGTGACGCATTCCGAAGAAGGAGAAATTTTACTAAAAAACTTTGTGGA
GTTATGTGGGGCTTCTGGTACTTGGAGCATCCAACATTTTTTGGACGAACAAATCCAAAGTTTACAGAAAAAAGTTCCAG
AAGGGAAAAATGTATTTTTACTCGTTTCCGGTGGAGTGGACTCATCTGTCGCATACCTTTTACTGGCAAAGGCACTTGGA
AAGGACCGGGTGAAGGGATTACTCGTTGATACAGGGTTTATGCGTAAAAATGAAGTGAAGGACCTAATGGATAATTTACA
CCATGTAGGATTTGACCTTACCATTTGGGATGAAAGTGAAGTATTTTACAAATCCCTACAAAATGAATTTGAACCCGAGA
AAAAAAGAAGGATTGTTGGGGATTTATTTTTAGAGGCACAAGGAAAAGCCACCACATCTCTTGGACTTGACGCCGAACAC
TGGTTACTTGGCCAAGGAACGATTTACCCGGATACCATCGAATCAGGTGGAACCAAACATTCTCATAAAATCAAAACACA
CCACAATCGTGTCCCTCAAATTGAAGCCCTGATCCGCGAAGGCAAAATTGTGGAACCCATCGCCGATCTTTATAAAGACG
AGGTGAGAGAACTTGGCCGAACACTAGGCCTTCCGGAAAGGTGGATTGAACGCCATCCCTTTCCAGGACCTGGACTTGTC
GTGCGAATGATTGCCAGTCCCAGAACAAGTCCCCCCAATATTGATTTTAGCATTTGGAAAGAAAAAATCCCAAAGGCCGA
AATCCAAATATTACCCATTCTTTCAGTGGGAGTCCAAGGAGACCAAAGGAGTTACGCACATTGTGCTGTACTCAGTGACT
TCACATCAGATTGGAAGGAATTAGACAATTTGTCTGTTGAAATTACCAATACCAAAAAAGAGATCAATCGAGTGGTACTG
GCACCAGGGATCACTCATTTTGAAAAAGATTTCTTTTATACAAAACTAACCTTAGACAAAACTCATGCTGATATTTTGCG
AGATGCTGATGCGATCGTGAATCAGATTTTATATGATGAGTCCATTCATAATCAAATTTGGCAGATGCCAGTCGTACTTG
TGCCTGTGGGATTACGAGAAAATTCCTACGGTGTGGTTTTACGTCCTGTAGAATCCACAGAAGCGATGACTGCTAATTTT
TACCAAATGAATCGTAATATTTTAGCAAGGATCACAAAGGAACTCTTGGAACTTCCTCAGATTTCACTTGTGATGTATGA
TCTTACCCACAAACCCCCAGGAACCATTGAATGGGAATAG

Upstream 100 bases:

>100_bases
AAGCCGGGATATGGTCTTGTTTGTCCTCATAAGAAGATTCTGATTTTTTTTCCGACATTTGTTTACCCCGACATAAACAA
AATTATTTTGGAACCATCCC

Downstream 100 bases:

>100_bases
GGGTGGGGGTTTTAGATTAGGTTGATTCGGGCGCTTTTTTGATTCGAAACCGACTCTGATTAAGGGAGAAGGATCCAAAG
TAAAGCCATTCCACCCATTG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MTSDKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPLSRYESYAGIILSGGPSSVYETGAPLLPAGFFDTSVPVLGI
CYGHQLMMKTLGGEVVSASTKEYGPAILEIENPNSPLSQSLSLKTKVWMSHGDEVVRLPNDFQVIAKSDHCRYAFVSHPS
KNLFGIQFHPEVTHSEEGEILLKNFVELCGASGTWSIQHFLDEQIQSLQKKVPEGKNVFLLVSGGVDSSVAYLLLAKALG
KDRVKGLLVDTGFMRKNEVKDLMDNLHHVGFDLTIWDESEVFYKSLQNEFEPEKKRRIVGDLFLEAQGKATTSLGLDAEH
WLLGQGTIYPDTIESGGTKHSHKIKTHHNRVPQIEALIREGKIVEPIADLYKDEVRELGRTLGLPERWIERHPFPGPGLV
VRMIASPRTSPPNIDFSIWKEKIPKAEIQILPILSVGVQGDQRSYAHCAVLSDFTSDWKELDNLSVEITNTKKEINRVVL
APGITHFEKDFFYTKLTLDKTHADILRDADAIVNQILYDESIHNQIWQMPVVLVPVGLRENSYGVVLRPVESTEAMTANF
YQMNRNILARITKELLELPQISLVMYDLTHKPPGTIEWE

Sequences:

>Translated_599_residues
MTSDKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPLSRYESYAGIILSGGPSSVYETGAPLLPAGFFDTSVPVLGI
CYGHQLMMKTLGGEVVSASTKEYGPAILEIENPNSPLSQSLSLKTKVWMSHGDEVVRLPNDFQVIAKSDHCRYAFVSHPS
KNLFGIQFHPEVTHSEEGEILLKNFVELCGASGTWSIQHFLDEQIQSLQKKVPEGKNVFLLVSGGVDSSVAYLLLAKALG
KDRVKGLLVDTGFMRKNEVKDLMDNLHHVGFDLTIWDESEVFYKSLQNEFEPEKKRRIVGDLFLEAQGKATTSLGLDAEH
WLLGQGTIYPDTIESGGTKHSHKIKTHHNRVPQIEALIREGKIVEPIADLYKDEVRELGRTLGLPERWIERHPFPGPGLV
VRMIASPRTSPPNIDFSIWKEKIPKAEIQILPILSVGVQGDQRSYAHCAVLSDFTSDWKELDNLSVEITNTKKEINRVVL
APGITHFEKDFFYTKLTLDKTHADILRDADAIVNQILYDESIHNQIWQMPVVLVPVGLRENSYGVVLRPVESTEAMTANF
YQMNRNILARITKELLELPQISLVMYDLTHKPPGTIEWE
>Mature_598_residues
TSDKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPLSRYESYAGIILSGGPSSVYETGAPLLPAGFFDTSVPVLGIC
YGHQLMMKTLGGEVVSASTKEYGPAILEIENPNSPLSQSLSLKTKVWMSHGDEVVRLPNDFQVIAKSDHCRYAFVSHPSK
NLFGIQFHPEVTHSEEGEILLKNFVELCGASGTWSIQHFLDEQIQSLQKKVPEGKNVFLLVSGGVDSSVAYLLLAKALGK
DRVKGLLVDTGFMRKNEVKDLMDNLHHVGFDLTIWDESEVFYKSLQNEFEPEKKRRIVGDLFLEAQGKATTSLGLDAEHW
LLGQGTIYPDTIESGGTKHSHKIKTHHNRVPQIEALIREGKIVEPIADLYKDEVRELGRTLGLPERWIERHPFPGPGLVV
RMIASPRTSPPNIDFSIWKEKIPKAEIQILPILSVGVQGDQRSYAHCAVLSDFTSDWKELDNLSVEITNTKKEINRVVLA
PGITHFEKDFFYTKLTLDKTHADILRDADAIVNQILYDESIHNQIWQMPVVLVPVGLRENSYGVVLRPVESTEAMTANFY
QMNRNILARITKELLELPQISLVMYDLTHKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=674, Percent_Identity=35.459940652819, Blast_Score=362, Evalue=1e-100,
Organism=Escherichia coli, GI1788854, Length=512, Percent_Identity=37.3046875, Blast_Score=312, Evalue=4e-86,
Organism=Escherichia coli, GI1789760, Length=141, Percent_Identity=34.0425531914894, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=699, Percent_Identity=32.761087267525, Blast_Score=325, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI133901714, Length=699, Percent_Identity=32.761087267525, Blast_Score=325, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI71992710, Length=699, Percent_Identity=32.761087267525, Blast_Score=324, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6323873, Length=492, Percent_Identity=40.4471544715447, Blast_Score=332, Evalue=7e-92,
Organism=Drosophila melanogaster, GI281365319, Length=670, Percent_Identity=35.3731343283582, Blast_Score=365, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 67188; Mature: 67057

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPLSRYESYAGIILSGGPSSVYE
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCCHHHH
TGAPLLPAGFFDTSVPVLGICYGHQLMMKTLGGEVVSASTKEYGPAILEIENPNSPLSQS
CCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCHHEECCCCCCCCEEEEECCCCCCHHHC
LSLKTKVWMSHGDEVVRLPNDFQVIAKSDHCRYAFVSHPSKNLFGIQFHPEVTHSEEGEI
CCHHEEEECCCCCCEEECCCCEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCH
LLKNFVELCGASGTWSIQHFLDEQIQSLQKKVPEGKNVFLLVSGGVDSSVAYLLLAKALG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHC
KDRVKGLLVDTGFMRKNEVKDLMDNLHHVGFDLTIWDESEVFYKSLQNEFEPEKKRRIVG
HHHHCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHH
DLFLEAQGKATTSLGLDAEHWLLGQGTIYPDTIESGGTKHSHKIKTHHNRVPQIEALIRE
HHHEECCCCEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHC
GKIVEPIADLYKDEVRELGRTLGLPERWIERHPFPGPGLVVRMIASPRTSPPNIDFSIWK
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHH
EKIPKAEIQILPILSVGVQGDQRSYAHCAVLSDFTSDWKELDNLSVEITNTKKEINRVVL
HHCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCEEEE
APGITHFEKDFFYTKLTLDKTHADILRDADAIVNQILYDESIHNQIWQMPVVLVPVGLRE
CCCCHHHHHCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
NSYGVVLRPVESTEAMTANFYQMNRNILARITKELLELPQISLVMYDLTHKPPGTIEWE
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TSDKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPLSRYESYAGIILSGGPSSVYE
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCCHHHH
TGAPLLPAGFFDTSVPVLGICYGHQLMMKTLGGEVVSASTKEYGPAILEIENPNSPLSQS
CCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCHHEECCCCCCCCEEEEECCCCCCHHHC
LSLKTKVWMSHGDEVVRLPNDFQVIAKSDHCRYAFVSHPSKNLFGIQFHPEVTHSEEGEI
CCHHEEEECCCCCCEEECCCCEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCH
LLKNFVELCGASGTWSIQHFLDEQIQSLQKKVPEGKNVFLLVSGGVDSSVAYLLLAKALG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHC
KDRVKGLLVDTGFMRKNEVKDLMDNLHHVGFDLTIWDESEVFYKSLQNEFEPEKKRRIVG
HHHHCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHH
DLFLEAQGKATTSLGLDAEHWLLGQGTIYPDTIESGGTKHSHKIKTHHNRVPQIEALIRE
HHHEECCCCEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHC
GKIVEPIADLYKDEVRELGRTLGLPERWIERHPFPGPGLVVRMIASPRTSPPNIDFSIWK
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHH
EKIPKAEIQILPILSVGVQGDQRSYAHCAVLSDFTSDWKELDNLSVEITNTKKEINRVVL
HHCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCEEEE
APGITHFEKDFFYTKLTLDKTHADILRDADAIVNQILYDESIHNQIWQMPVVLVPVGLRE
CCCCHHHHHCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
NSYGVVLRPVESTEAMTANFYQMNRNILARITKELLELPQISLVMYDLTHKPPGTIEWE
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA