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The map label for this gene is ppiB [H]

Identifier: 183220994

GI number: 183220994

Start: 1682100

End: 1682981

Strand: Direct

Name: ppiB [H]

Synonym: LEPBI_I1607

Alternate gene names: 183220994

Gene position: 1682100-1682981 (Clockwise)

Preceding gene: 183220993

Following gene: 183220995

Centisome position: 46.73

GC content: 41.38

Gene sequence:

>882_bases
ATGAAACAGTTTTTCTTTTCCCGTATCAAATCTCTGGCACTGGCACTTCTTTTGTTAAGCCAAACCGTTTTCTGTAGTGA
CCAAACTTTTAAAAAAATCACGTATGAACCAGTTACCTATGCACCTACAAAAGTATTGGTAAAACGTGCTGACCAAACAA
CAGTAAAACTACCGGAAAAACCTGCCATCTATGCTGTGATCCAAACCACACAAGGGGATCTAGTGGTTGAATTGTATGAC
ACGGCAGCACCCAAAACCGTACAAAATTTTATCGATCTGGCACAAGGTGAGAAAGAGTTTCGAACAGAAAAAGGTTCCGA
AAGACGACCATTTTATGATGGACTCAAATTCCACCGAGTGATTGAAAATTTTATGGCCCAAGGCGGATGCCCGAGAGGCG
ACGGTACAGGCGGGCCTGGGTTTCAATTCGAGGATGAAATCAATGGAAAGGCATTGGGACTTGATAAATTGAAGGTCAAA
GATGCTCCCCAATACCAAGCACAATTACAAAGAGCCGTTTTATCTGAATTCAATATCAAGTCTCGCCAAGAGTTTGAGGA
AAAAAGGACTGAAGTAGAAAAAGCATACCAGGAAGCAATGGAGTTACCAGTTTTGGAAGTCCTATACCGAGTGGGATATC
GTTTTAACGAAGTTGTACCAAGTAAAAAAGCTACCCGTGGTGCTCTTGCGATGGCAAACGCCGGCCCGAATTCAAATGGT
TCTCAATTTTTTATCAACCAAGTTGACACTCCTCATTTGGATGGACTTCATACAGTGTTTGGTTTTTTAATCACAGGGTA
TGATGTGCTTGACCGAATCATTGAAAAGGGGAATCTTCAAACAACCATTCGTAAGGTTCTCATTTTAGATAAAAGGCAAT
GA

Upstream 100 bases:

>100_bases
CACTCCCAAGACAAAAAGAACAAATCAAACGAGCGAAAGCCAAGTTAAACGAATTGACCAAAAAATTAAAACAAATAGAA
TCCAAAGGTAAAAAAACAAT

Downstream 100 bases:

>100_bases
ACTACTCAGAAGGCATAGAAGTCATTCAAAAATACACATCGGGTTCTTCCGTAGAACCTGTGTTAAAATTCATTATGACT
GTCCCTCACAATGAAGAGGC

Product: putative peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKQFFFSRIKSLALALLLLSQTVFCSDQTFKKITYEPVTYAPTKVLVKRADQTTVKLPEKPAIYAVIQTTQGDLVVELYD
TAAPKTVQNFIDLAQGEKEFRTEKGSERRPFYDGLKFHRVIENFMAQGGCPRGDGTGGPGFQFEDEINGKALGLDKLKVK
DAPQYQAQLQRAVLSEFNIKSRQEFEEKRTEVEKAYQEAMELPVLEVLYRVGYRFNEVVPSKKATRGALAMANAGPNSNG
SQFFINQVDTPHLDGLHTVFGFLITGYDVLDRIIEKGNLQTTIRKVLILDKRQ

Sequences:

>Translated_293_residues
MKQFFFSRIKSLALALLLLSQTVFCSDQTFKKITYEPVTYAPTKVLVKRADQTTVKLPEKPAIYAVIQTTQGDLVVELYD
TAAPKTVQNFIDLAQGEKEFRTEKGSERRPFYDGLKFHRVIENFMAQGGCPRGDGTGGPGFQFEDEINGKALGLDKLKVK
DAPQYQAQLQRAVLSEFNIKSRQEFEEKRTEVEKAYQEAMELPVLEVLYRVGYRFNEVVPSKKATRGALAMANAGPNSNG
SQFFINQVDTPHLDGLHTVFGFLITGYDVLDRIIEKGNLQTTIRKVLILDKRQ
>Mature_293_residues
MKQFFFSRIKSLALALLLLSQTVFCSDQTFKKITYEPVTYAPTKVLVKRADQTTVKLPEKPAIYAVIQTTQGDLVVELYD
TAAPKTVQNFIDLAQGEKEFRTEKGSERRPFYDGLKFHRVIENFMAQGGCPRGDGTGGPGFQFEDEINGKALGLDKLKVK
DAPQYQAQLQRAVLSEFNIKSRQEFEEKRTEVEKAYQEAMELPVLEVLYRVGYRFNEVVPSKKATRGALAMANAGPNSNG
SQFFINQVDTPHLDGLHTVFGFLITGYDVLDRIIEKGNLQTTIRKVLILDKRQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=93, Percent_Identity=44.0860215053763, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=90, Percent_Identity=42.2222222222222, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17506311, Length=87, Percent_Identity=42.5287356321839, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565860, Length=68, Percent_Identity=48.5294117647059, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=79, Percent_Identity=51.8987341772152, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=65, Percent_Identity=46.1538461538462, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922376, Length=65, Percent_Identity=50.7692307692308, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17986117, Length=89, Percent_Identity=38.2022471910112, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 33085; Mature: 33085

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQFFFSRIKSLALALLLLSQTVFCSDQTFKKITYEPVTYAPTKVLVKRADQTTVKLPEK
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHCCCCEEECCCC
PAIYAVIQTTQGDLVVELYDTAAPKTVQNFIDLAQGEKEFRTEKGSERRPFYDGLKFHRV
CCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHH
IENFMAQGGCPRGDGTGGPGFQFEDEINGKALGLDKLKVKDAPQYQAQLQRAVLSEFNIK
HHHHHHCCCCCCCCCCCCCCCEECCCCCCCEECCCHHCCCCCHHHHHHHHHHHHHHCCCC
SRQEFEEKRTEVEKAYQEAMELPVLEVLYRVGYRFNEVVPSKKATRGALAMANAGPNSNG
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHCCCCHHHHCCEEEECCCCCCCC
SQFFINQVDTPHLDGLHTVFGFLITGYDVLDRIIEKGNLQTTIRKVLILDKRQ
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKQFFFSRIKSLALALLLLSQTVFCSDQTFKKITYEPVTYAPTKVLVKRADQTTVKLPEK
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHCCCCEEECCCC
PAIYAVIQTTQGDLVVELYDTAAPKTVQNFIDLAQGEKEFRTEKGSERRPFYDGLKFHRV
CCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHH
IENFMAQGGCPRGDGTGGPGFQFEDEINGKALGLDKLKVKDAPQYQAQLQRAVLSEFNIK
HHHHHHCCCCCCCCCCCCCCCEECCCCCCCEECCCHHCCCCCHHHHHHHHHHHHHHCCCC
SRQEFEEKRTEVEKAYQEAMELPVLEVLYRVGYRFNEVVPSKKATRGALAMANAGPNSNG
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHCCCCHHHHCCEEEECCCCCCCC
SQFFINQVDTPHLDGLHTVFGFLITGYDVLDRIIEKGNLQTTIRKVLILDKRQ
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9317025; 9665876 [H]