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The map label for this gene is argH

Identifier: 183220993

GI number: 183220993

Start: 1680667

End: 1682103

Strand: Direct

Name: argH

Synonym: LEPBI_I1606

Alternate gene names: 183220993

Gene position: 1680667-1682103 (Clockwise)

Preceding gene: 183220992

Following gene: 183220994

Centisome position: 46.69

GC content: 40.22

Gene sequence:

>1437_bases
ATGAAAGAAAAAAAATTATGGGGTGGGCGTTTTGATGCAGCACCATCTTCGCTAATGATCCGCATTGGTGAATCAATCAG
CTTTGATCAGGAACTCTATCGCCATGACATCGAAGGATCCATTTCTCATTCAAGAATGTTGAGGCGGATCGGAATCCTTT
CGGAATCAGAACAACGTAAAATTGAAACGGGTCTTGGCCAAATCAAAAAAGAAATCGATTCTGGGAAATTTGAATTTAAA
ATTGAAAACGAAGACATTCATATGTCGATCGAATCTCGCCTAACGGAACTTTTAGGTGATTTAGGAAAAAAACTCCACAC
AGGTAGAAGTCGAAATGACCAAGTCTCACAAGACGTTCGATTGTACATCAAATCCGAAATGCATTCGATTTTAATATTGG
TATATGATCTCCTAACGGTTTGGTTAAAAAAAGCAGAAGCCCATACAAAAACCATCATTCCTGGTTACACCCATTTACAA
ATTGCACAACCTATCCGTGCGTCTCATTATTTTTTGTCACATTTTTGGGCCAATGTGCGGGACTTTGAAGACTTTTATTC
TGCCTTTGAAAGAGCCGATGAGCTCGTGTTAGGTTCTGGTGCACTCGCTGGAGTCAATTATGAAACCGATCGGGAGTATT
TAAGAAAGGATTTGAATCTGGCAAGAATGTCTGAGAATTCAATGGATGCCGTAAGCCAAAGAGACCACATTTTTAAATTT
TTATTTGCTTCTTCCCAGTTTATGGTCCATGCCTCAAGGTTTTGTGAAGAAATCATATTGTACACTTCCCAAGAATTCAG
TTATTTTAAATTGCCTGACCATTTAACAACTGGTTCGTCGATCATGCCGCAGAAAAAAAATCCGGATGTGGCAGAACTGA
TTCGAGGGAAGGCCGGCCGAGTGATTGGAAACCTCACTCACCTTCTTGTGATGTTAAAGGGAACACCTCTTTCTTATAAT
CGAGACTTCCAAGAAGACAAAATCCCTCTCTTCGACACGGTGAAACAAATCAAAATTTGTACGGAAGGAATCCGTGATAT
GGTGGAAGGGATCCAAATTTTTCCAGAAAATGCAACACGAAGTTTACGCAATGGTTTTTCGACAGCGACTGATCTTGCAG
ACTGGCTTGTGAGTGCCAAAGGAATCCCTTTCCGATCGGCCCATGAAATTGTAGGCGAACTTGTGAAACATTGTTCTATG
AAAGGTTATGATTTATTTACCATCCCGAGTGGGGAAAGAGGCCAAATCCATGCCGTATTAACTGACCCAGGATACGAAGC
TGCCATTTCTCTAGAAACTTCCTGTGACAAAAAAGATGTGTTTGGCGGAACCGCACTCCCAAGACAAAAAGAACAAATCA
AACGAGCGAAAGCCAAGTTAAACGAATTGACCAAAAAATTAAAACAAATAGAATCCAAAGGTAAAAAAACAATATGA

Upstream 100 bases:

>100_bases
CACCCAAGGATTATCTCCTTTTACACCCTAGTGCCAATTTGTCTGAAAAGGACAAAGAAATCTTAAAAAACTGGGCAAAC
GCTTTCAGTGAGGATTCGGA

Downstream 100 bases:

>100_bases
AACAGTTTTTCTTTTCCCGTATCAAATCTCTGGCACTGGCACTTCTTTTGTTAAGCCAAACCGTTTTCTGTAGTGACCAA
ACTTTTAAAAAAATCACGTA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MKEKKLWGGRFDAAPSSLMIRIGESISFDQELYRHDIEGSISHSRMLRRIGILSESEQRKIETGLGQIKKEIDSGKFEFK
IENEDIHMSIESRLTELLGDLGKKLHTGRSRNDQVSQDVRLYIKSEMHSILILVYDLLTVWLKKAEAHTKTIIPGYTHLQ
IAQPIRASHYFLSHFWANVRDFEDFYSAFERADELVLGSGALAGVNYETDREYLRKDLNLARMSENSMDAVSQRDHIFKF
LFASSQFMVHASRFCEEIILYTSQEFSYFKLPDHLTTGSSIMPQKKNPDVAELIRGKAGRVIGNLTHLLVMLKGTPLSYN
RDFQEDKIPLFDTVKQIKICTEGIRDMVEGIQIFPENATRSLRNGFSTATDLADWLVSAKGIPFRSAHEIVGELVKHCSM
KGYDLFTIPSGERGQIHAVLTDPGYEAAISLETSCDKKDVFGGTALPRQKEQIKRAKAKLNELTKKLKQIESKGKKTI

Sequences:

>Translated_478_residues
MKEKKLWGGRFDAAPSSLMIRIGESISFDQELYRHDIEGSISHSRMLRRIGILSESEQRKIETGLGQIKKEIDSGKFEFK
IENEDIHMSIESRLTELLGDLGKKLHTGRSRNDQVSQDVRLYIKSEMHSILILVYDLLTVWLKKAEAHTKTIIPGYTHLQ
IAQPIRASHYFLSHFWANVRDFEDFYSAFERADELVLGSGALAGVNYETDREYLRKDLNLARMSENSMDAVSQRDHIFKF
LFASSQFMVHASRFCEEIILYTSQEFSYFKLPDHLTTGSSIMPQKKNPDVAELIRGKAGRVIGNLTHLLVMLKGTPLSYN
RDFQEDKIPLFDTVKQIKICTEGIRDMVEGIQIFPENATRSLRNGFSTATDLADWLVSAKGIPFRSAHEIVGELVKHCSM
KGYDLFTIPSGERGQIHAVLTDPGYEAAISLETSCDKKDVFGGTALPRQKEQIKRAKAKLNELTKKLKQIESKGKKTI
>Mature_478_residues
MKEKKLWGGRFDAAPSSLMIRIGESISFDQELYRHDIEGSISHSRMLRRIGILSESEQRKIETGLGQIKKEIDSGKFEFK
IENEDIHMSIESRLTELLGDLGKKLHTGRSRNDQVSQDVRLYIKSEMHSILILVYDLLTVWLKKAEAHTKTIIPGYTHLQ
IAQPIRASHYFLSHFWANVRDFEDFYSAFERADELVLGSGALAGVNYETDREYLRKDLNLARMSENSMDAVSQRDHIFKF
LFASSQFMVHASRFCEEIILYTSQEFSYFKLPDHLTTGSSIMPQKKNPDVAELIRGKAGRVIGNLTHLLVMLKGTPLSYN
RDFQEDKIPLFDTVKQIKICTEGIRDMVEGIQIFPENATRSLRNGFSTATDLADWLVSAKGIPFRSAHEIVGELVKHCSM
KGYDLFTIPSGERGQIHAVLTDPGYEAAISLETSCDKKDVFGGTALPRQKEQIKRAKAKLNELTKKLKQIESKGKKTI

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=464, Percent_Identity=41.8103448275862, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI68303542, Length=464, Percent_Identity=41.8103448275862, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI68303549, Length=464, Percent_Identity=39.6551724137931, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI68303547, Length=464, Percent_Identity=39.6551724137931, Blast_Score=313, Evalue=3e-85,
Organism=Escherichia coli, GI1790398, Length=457, Percent_Identity=40.2625820568928, Blast_Score=343, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6321806, Length=463, Percent_Identity=40.3887688984881, Blast_Score=329, Evalue=7e-91,
Organism=Drosophila melanogaster, GI221473854, Length=465, Percent_Identity=36.1290322580645, Blast_Score=304, Evalue=9e-83,
Organism=Drosophila melanogaster, GI78706858, Length=465, Percent_Identity=36.1290322580645, Blast_Score=304, Evalue=9e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_LEPBA (B0SHK4)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962643.1
- ProteinModelPortal:   B0SHK4
- SMR:   B0SHK4
- GeneID:   6389640
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_1555
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- ProtClustDB:   PRK00855
- BioCyc:   LBIF355278:LBF_1555-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 54371; Mature: 54371

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKKLWGGRFDAAPSSLMIRIGESISFDQELYRHDIEGSISHSRMLRRIGILSESEQRK
CCCCCCCCCCCCCCCCHHEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHH
IETGLGQIKKEIDSGKFEFKIENEDIHMSIESRLTELLGDLGKKLHTGRSRNDQVSQDVR
HHHHHHHHHHHHCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LYIKSEMHSILILVYDLLTVWLKKAEAHTKTIIPGYTHLQIAQPIRASHYFLSHFWANVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHHHCHHHHHHHHHHHHHHHHH
DFEDFYSAFERADELVLGSGALAGVNYETDREYLRKDLNLARMSENSMDAVSQRDHIFKF
HHHHHHHHHHHHHHEEECCCCEECCCCHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHH
LFASSQFMVHASRFCEEIILYTSQEFSYFKLPDHLTTGSSIMPQKKNPDVAELIRGKAGR
HHHCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCH
VIGNLTHLLVMLKGTPLSYNRDFQEDKIPLFDTVKQIKICTEGIRDMVEGIQIFPENATR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCHHHH
SLRNGFSTATDLADWLVSAKGIPFRSAHEIVGELVKHCSMKGYDLFTIPSGERGQIHAVL
HHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEE
TDPGYEAAISLETSCDKKDVFGGTALPRQKEQIKRAKAKLNELTKKLKQIESKGKKTI
ECCCCCEEEEECCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKEKKLWGGRFDAAPSSLMIRIGESISFDQELYRHDIEGSISHSRMLRRIGILSESEQRK
CCCCCCCCCCCCCCCCHHEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHH
IETGLGQIKKEIDSGKFEFKIENEDIHMSIESRLTELLGDLGKKLHTGRSRNDQVSQDVR
HHHHHHHHHHHHCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LYIKSEMHSILILVYDLLTVWLKKAEAHTKTIIPGYTHLQIAQPIRASHYFLSHFWANVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHHHCHHHHHHHHHHHHHHHHH
DFEDFYSAFERADELVLGSGALAGVNYETDREYLRKDLNLARMSENSMDAVSQRDHIFKF
HHHHHHHHHHHHHHEEECCCCEECCCCHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHH
LFASSQFMVHASRFCEEIILYTSQEFSYFKLPDHLTTGSSIMPQKKNPDVAELIRGKAGR
HHHCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCH
VIGNLTHLLVMLKGTPLSYNRDFQEDKIPLFDTVKQIKICTEGIRDMVEGIQIFPENATR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCHHHH
SLRNGFSTATDLADWLVSAKGIPFRSAHEIVGELVKHCSMKGYDLFTIPSGERGQIHAVL
HHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEE
TDPGYEAAISLETSCDKKDVFGGTALPRQKEQIKRAKAKLNELTKKLKQIESKGKKTI
ECCCCCEEEEECCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA