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The map label for this gene is cya1 [H]

Identifier: 183220895

GI number: 183220895

Start: 1570386

End: 1572554

Strand: Direct

Name: cya1 [H]

Synonym: LEPBI_I1508

Alternate gene names: 183220895

Gene position: 1570386-1572554 (Clockwise)

Preceding gene: 183220894

Following gene: 183220896

Centisome position: 43.63

GC content: 40.02

Gene sequence:

>2169_bases
ATGAAACAAAATAAAATTCTAATTCCAATCTTTCTAATGGTCGTGATCCCCACGCTGATCACAACTTTCCTTTCTTTTTT
TCGATTTTCAACTACCTTAGATCGTAAACTATCGGATGTTTTTTTTCATCTACTACCCACTCACCATTTTTTTTCAAAAG
ACATCGTCATCATCGACATCGATGAACAAAGTATCGCAAAATATGCCGACCATCCAGAGCTTGGACAATGGCCTTGGAAA
CGTCATATTTATCCAACACTCATTGGTTATACCAAACTTCTCACACCACCAAAGATCACTATCATCGACATCATGTTTAC
AGAACGTTCCGATTATGATGATGCAATTGTTTCAGCAAATGAAAGTTTGGGGGGAATTTCTCATGCAGCAAATTTTCGGA
ATGGAGGGATCGTCATCCCAAGAAAAGGAATGCAATCCATCAGCGAAAAATTCAGTGTCAAACTAGAGACAAGTATCCCT
TTTCCGAACTATGAGAATGTTGCCTTTCCTATCGGCCAAATTGGAGAAACAGCTCCCATGATCCATGTGGTCAACGTGAT
AGCCGATGGAGATGGAATCCTTCGAAGATTTTCTCCTTTTGTGAGATGGAATGGTTTATACTTTCCTACTCTTGCCATGC
AAGCCTTTGCACTTGGAGAAAGATACGATACCTTAACCCAAGAATCGGATTTTTATCTGATCAAAGATGATCTTCGTCGG
CATGTGCCTGTGGGTAAGGACGGACTTGTTCGGGCCTACTTTTATACAGAAGAAGAATTGCGTAATATTCCTCGTTATTC
GGCAGCAGGGATCATTGATTCATTGGAGAAATTGAATACAGGCGAAGTGGAAGATCCGAATTCCTTACTTGTTCCTCCCC
AATTATTTGAAGATAAAATTGTTCTCATTGGGACATCTGCGGCTTCCACTCATGATGATGTTGTCACCCCTCATGGTTTG
TTTCCTGGAGTGATCGCTCAGGCAGTATTTGCTTCTAATCTAAGGGAGGGTCATCTATTAAAGGAATTACCAGAATCGTA
TGGGATTATTTTTACCATTCTGGTTCTACTGATTGGTGTCCTTGTTCTTTTCATCAACCAATGGCATCTTTTGAAAAACC
TATATCCAATCGTTGCGATTTCATTATTCGTTGGTTCCTTTTATTTTCTGTACCGAATGGATTTAGTTTTGTCTACCTAT
TCCTTTGTGTTAGGTTTCCCCATTTCTTATCTATTAGGTTTTGCCTATTTGACATACACGGAAGGAAGGGAAAAAAGAAA
ATTCAATCACATCTTACGGAACTTAGTCGATCCTGAAGTTGTCAGTGTGGCTCTAGAAAATATGGAGTCCCTAAAACAAG
GTGGGGAATGGGAAATCACAGCCTTTTTTTCAGACGTTGCTGGTTTTTCCTCCATCAGCGAAGAGTTAAGTGCGACAGAC
CTTGCCAAATTACTGAATGAATACTTATCTGCAATGACAAAGGTTTTAAAAACCAATGCAGGTACTTTGGATAAATACAT
TGGTGATGCCATTGTGGGAATATTCAGTGCCCCCATCCAAAACAAAGAACATCCAAAACTTGCTTGCAAAACAGCATTGG
AAATGGTGACCGAGCTTGAACATTTAAGAGTGGAATGGAACCGCCGTGGTGATTACACTCCACTTGCCCGTGCGATGGTG
TTTCGCATTGGACTCAATTGTGGACAAGCCAAGGTTGGATTTATGGGAACGGATAGTTTGGCATCCTACACCATGATGGG
TGATACCGTCAATTTAGCCGCCAGGTTAGAAGCCGCAGCCAAAGATTATGGAGTTTCGATTTTGGTTTCAGAAAGCATTC
AGTCCTCATGCAAAGAAGAATTCCATTTTCGTTTCTTAGATTGGATTCGCGTCAAAGGGAAAGAAGCGCCAGTAAAGATC
TATAGTTTAGAATCATTTCAAAAAGATGTTTCGTCACAAATGTTAAAAGCAGAAAAGGAATATGAATCTGGATTTTCTCT
TTATTTGAAACGAAATTGGGAAGGAGCGATCGAACACTTTAAGAATGTTTCTAAAATTTTAGAGAAAGAAGATGTGAGTA
GCCATTTACTCATCAAACGTTGCCAAATGCTTTTCCAAAACCCGCCACCTGTCGACTGGGATGGTGTTTATACTCGCACT
TCAAAATAA

Upstream 100 bases:

>100_bases
TTCGCATCGCAAAACTAGTGTTTATTGAATCTTCTGTACCAACGGAGGGAACTCCTTTTGTTGTGGATCGTTGGAGCGAA
TATAAAAATAAAATCGGCAA

Downstream 100 bases:

>100_bases
TACTATACTAGAATTTCCTTTTTCTAGATTGTCCAGAACAAGGAAAAAGCGGAATGAACGAAGCCAAAATCAAATCATTG
TGTTGGCGGTTGACTCTCGG

Product: adenylate cyclase family protein

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1 [H]

Number of amino acids: Translated: 722; Mature: 722

Protein sequence:

>722_residues
MKQNKILIPIFLMVVIPTLITTFLSFFRFSTTLDRKLSDVFFHLLPTHHFFSKDIVIIDIDEQSIAKYADHPELGQWPWK
RHIYPTLIGYTKLLTPPKITIIDIMFTERSDYDDAIVSANESLGGISHAANFRNGGIVIPRKGMQSISEKFSVKLETSIP
FPNYENVAFPIGQIGETAPMIHVVNVIADGDGILRRFSPFVRWNGLYFPTLAMQAFALGERYDTLTQESDFYLIKDDLRR
HVPVGKDGLVRAYFYTEEELRNIPRYSAAGIIDSLEKLNTGEVEDPNSLLVPPQLFEDKIVLIGTSAASTHDDVVTPHGL
FPGVIAQAVFASNLREGHLLKELPESYGIIFTILVLLIGVLVLFINQWHLLKNLYPIVAISLFVGSFYFLYRMDLVLSTY
SFVLGFPISYLLGFAYLTYTEGREKRKFNHILRNLVDPEVVSVALENMESLKQGGEWEITAFFSDVAGFSSISEELSATD
LAKLLNEYLSAMTKVLKTNAGTLDKYIGDAIVGIFSAPIQNKEHPKLACKTALEMVTELEHLRVEWNRRGDYTPLARAMV
FRIGLNCGQAKVGFMGTDSLASYTMMGDTVNLAARLEAAAKDYGVSILVSESIQSSCKEEFHFRFLDWIRVKGKEAPVKI
YSLESFQKDVSSQMLKAEKEYESGFSLYLKRNWEGAIEHFKNVSKILEKEDVSSHLLIKRCQMLFQNPPPVDWDGVYTRT
SK

Sequences:

>Translated_722_residues
MKQNKILIPIFLMVVIPTLITTFLSFFRFSTTLDRKLSDVFFHLLPTHHFFSKDIVIIDIDEQSIAKYADHPELGQWPWK
RHIYPTLIGYTKLLTPPKITIIDIMFTERSDYDDAIVSANESLGGISHAANFRNGGIVIPRKGMQSISEKFSVKLETSIP
FPNYENVAFPIGQIGETAPMIHVVNVIADGDGILRRFSPFVRWNGLYFPTLAMQAFALGERYDTLTQESDFYLIKDDLRR
HVPVGKDGLVRAYFYTEEELRNIPRYSAAGIIDSLEKLNTGEVEDPNSLLVPPQLFEDKIVLIGTSAASTHDDVVTPHGL
FPGVIAQAVFASNLREGHLLKELPESYGIIFTILVLLIGVLVLFINQWHLLKNLYPIVAISLFVGSFYFLYRMDLVLSTY
SFVLGFPISYLLGFAYLTYTEGREKRKFNHILRNLVDPEVVSVALENMESLKQGGEWEITAFFSDVAGFSSISEELSATD
LAKLLNEYLSAMTKVLKTNAGTLDKYIGDAIVGIFSAPIQNKEHPKLACKTALEMVTELEHLRVEWNRRGDYTPLARAMV
FRIGLNCGQAKVGFMGTDSLASYTMMGDTVNLAARLEAAAKDYGVSILVSESIQSSCKEEFHFRFLDWIRVKGKEAPVKI
YSLESFQKDVSSQMLKAEKEYESGFSLYLKRNWEGAIEHFKNVSKILEKEDVSSHLLIKRCQMLFQNPPPVDWDGVYTRT
SK
>Mature_722_residues
MKQNKILIPIFLMVVIPTLITTFLSFFRFSTTLDRKLSDVFFHLLPTHHFFSKDIVIIDIDEQSIAKYADHPELGQWPWK
RHIYPTLIGYTKLLTPPKITIIDIMFTERSDYDDAIVSANESLGGISHAANFRNGGIVIPRKGMQSISEKFSVKLETSIP
FPNYENVAFPIGQIGETAPMIHVVNVIADGDGILRRFSPFVRWNGLYFPTLAMQAFALGERYDTLTQESDFYLIKDDLRR
HVPVGKDGLVRAYFYTEEELRNIPRYSAAGIIDSLEKLNTGEVEDPNSLLVPPQLFEDKIVLIGTSAASTHDDVVTPHGL
FPGVIAQAVFASNLREGHLLKELPESYGIIFTILVLLIGVLVLFINQWHLLKNLYPIVAISLFVGSFYFLYRMDLVLSTY
SFVLGFPISYLLGFAYLTYTEGREKRKFNHILRNLVDPEVVSVALENMESLKQGGEWEITAFFSDVAGFSSISEELSATD
LAKLLNEYLSAMTKVLKTNAGTLDKYIGDAIVGIFSAPIQNKEHPKLACKTALEMVTELEHLRVEWNRRGDYTPLARAMV
FRIGLNCGQAKVGFMGTDSLASYTMMGDTVNLAARLEAAAKDYGVSILVSESIQSSCKEEFHFRFLDWIRVKGKEAPVKI
YSLESFQKDVSSQMLKAEKEYESGFSLYLKRNWEGAIEHFKNVSKILEKEDVSSHLLIKRCQMLFQNPPPVDWDGVYTRT
SK

Specific function: Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP [H]

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17561800, Length=179, Percent_Identity=27.3743016759777, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17561802, Length=179, Percent_Identity=26.8156424581006, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193207841, Length=179, Percent_Identity=26.8156424581006, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17561810, Length=231, Percent_Identity=25.1082251082251, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI212645052, Length=179, Percent_Identity=26.8156424581006, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193206632, Length=199, Percent_Identity=27.6381909547739, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71982300, Length=195, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71995300, Length=184, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI62484477, Length=236, Percent_Identity=24.5762711864407, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI62484298, Length=236, Percent_Identity=24.5762711864407, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI116008008, Length=236, Percent_Identity=24.5762711864407, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 81651; Mature: 81651

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQNKILIPIFLMVVIPTLITTFLSFFRFSTTLDRKLSDVFFHLLPTHHFFSKDIVIIDI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEC
DEQSIAKYADHPELGQWPWKRHIYPTLIGYTKLLTPPKITIIDIMFTERSDYDDAIVSAN
CHHHHHHHCCCCCCCCCCCHHCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHCCC
ESLGGISHAANFRNGGIVIPRKGMQSISEKFSVKLETSIPFPNYENVAFPIGQIGETAPM
CCCCCHHHHCCCCCCCEEEECHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHCCCCCHH
IHVVNVIADGDGILRRFSPFVRWNGLYFPTLAMQAFALGERYDTLTQESDFYLIKDDLRR
HHHHHHHCCCCHHHHHCCHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHH
HVPVGKDGLVRAYFYTEEELRNIPRYSAAGIIDSLEKLNTGEVEDPNSLLVPPQLFEDKI
CCCCCCCCCEEEEEECHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCHHHCCCCE
VLIGTSAASTHDDVVTPHGLFPGVIAQAVFASNLREGHLLKELPESYGIIFTILVLLIGV
EEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHH
LVLFINQWHLLKNLYPIVAISLFVGSFYFLYRMDLVLSTYSFVLGFPISYLLGFAYLTYT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
EGREKRKFNHILRNLVDPEVVSVALENMESLKQGGEWEITAFFSDVAGFSSISEELSATD
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHH
LAKLLNEYLSAMTKVLKTNAGTLDKYIGDAIVGIFSAPIQNKEHPKLACKTALEMVTELE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
HLRVEWNRRGDYTPLARAMVFRIGLNCGQAKVGFMGTDSLASYTMMGDTVNLAARLEAAA
HHHEEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHCCCHHHHHHHHHHHH
KDYGVSILVSESIQSSCKEEFHFRFLDWIRVKGKEAPVKIYSLESFQKDVSSQMLKAEKE
HHCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
YESGFSLYLKRNWEGAIEHFKNVSKILEKEDVSSHLLIKRCQMLFQNPPPVDWDGVYTRT
HCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEECC
SK
CC
>Mature Secondary Structure
MKQNKILIPIFLMVVIPTLITTFLSFFRFSTTLDRKLSDVFFHLLPTHHFFSKDIVIIDI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEC
DEQSIAKYADHPELGQWPWKRHIYPTLIGYTKLLTPPKITIIDIMFTERSDYDDAIVSAN
CHHHHHHHCCCCCCCCCCCHHCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHCCC
ESLGGISHAANFRNGGIVIPRKGMQSISEKFSVKLETSIPFPNYENVAFPIGQIGETAPM
CCCCCHHHHCCCCCCCEEEECHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHCCCCCHH
IHVVNVIADGDGILRRFSPFVRWNGLYFPTLAMQAFALGERYDTLTQESDFYLIKDDLRR
HHHHHHHCCCCHHHHHCCHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHH
HVPVGKDGLVRAYFYTEEELRNIPRYSAAGIIDSLEKLNTGEVEDPNSLLVPPQLFEDKI
CCCCCCCCCEEEEEECHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCHHHCCCCE
VLIGTSAASTHDDVVTPHGLFPGVIAQAVFASNLREGHLLKELPESYGIIFTILVLLIGV
EEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHH
LVLFINQWHLLKNLYPIVAISLFVGSFYFLYRMDLVLSTYSFVLGFPISYLLGFAYLTYT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
EGREKRKFNHILRNLVDPEVVSVALENMESLKQGGEWEITAFFSDVAGFSSISEELSATD
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHH
LAKLLNEYLSAMTKVLKTNAGTLDKYIGDAIVGIFSAPIQNKEHPKLACKTALEMVTELE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
HLRVEWNRRGDYTPLARAMVFRIGLNCGQAKVGFMGTDSLASYTMMGDTVNLAARLEAAA
HHHEEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHCCCHHHHHHHHHHHH
KDYGVSILVSESIQSSCKEEFHFRFLDWIRVKGKEAPVKIYSLESFQKDVSSQMLKAEKE
HHCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
YESGFSLYLKRNWEGAIEHFKNVSKILEKEDVSSHLLIKRCQMLFQNPPPVDWDGVYTRT
HCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEECC
SK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 1970565 [H]