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The map label for this gene is cysK1 [H]

Identifier: 183220558

GI number: 183220558

Start: 1209101

End: 1210015

Strand: Direct

Name: cysK1 [H]

Synonym: LEPBI_I1162

Alternate gene names: 183220558

Gene position: 1209101-1210015 (Clockwise)

Preceding gene: 183220557

Following gene: 183220559

Centisome position: 33.59

GC content: 41.64

Gene sequence:

>915_bases
ATGAAATTTAATAGTATTTTAGATGCCATAGGCAATACACCACATATTCGATTGTCTCGTTTATTTGGAACCGATCACGA
AGTATATATGAAGTTAGAGAGACAAAATCCAGGTGGATCCATCAAGGATCGGATTGCTCTTGCGATGATCGAAGACGCAG
AAAAATCTGGAAAATTAAAAAAAGATTCAATCATCGTGGAGCCAACTTCTGGAAATACAGGAATTGGCCTTGCGATGGTT
GCAGCTGTCAAAGGTTATGCGATCACACTTGTGATGCCAGAACATATGTCCGTGGAAAGAAGACGAATCATGGCGGCATA
CGGTGCAAAATTTGAGCTCACTCCAAGAGAGAAAGGTATGCCTGGCGCGATTGCCAAAGCACAAGAAATGGTAGCGGCAA
ATCCAAATGCTTGGATGCCACAACAGTTTGAAAACGAGGCGAATATCCAAGTACACAGAGAAAAAACCGCAGAAGAAATC
GCTAAAGATTTTCCAGATGGTTTGGACTATATCATTACAGGAGTTGGAACTGGTGGGCATATTACTGGTTGTGCAGAAAA
TTTGAAAAAACGTTTTCCAAAACTCAAAGTTTTTGCTGTGGAACCAGAAGGTTCTCCTGTTCTCAGCGGTGGTAAACCCG
GCCCACATCCACTCCAAGGGATTGGTGCTGGTTTCATTCCTAAAAACTGTAAAACTGAATTATTAGATGGAATCATCACT
GTCGGTAAAGAAGAGTCATTTACCATGGCTGTCCTTGCTGCCAAAAAAGAAGGGATCTTCATCGGAACATCGTCCGGCGC
AAGTCTTGCTGCCGTTTCTAAAAAATTAAAAGAAATCCCAGCAGGATCCAAAGTTCTCACTTTCTGTTACGATACAGGAG
AAAGATACTTATCTGTTGAAGGACTTTTCGTTTAA

Upstream 100 bases:

>100_bases
CCTTTCCTTTTTGATTTCGTTTCGTAACCCCTGATTCCCAATGATTTCATTGTGGACAAATCTAGATTTTCTTTCAAAAT
GTGACTGAAACGGAGAAATT

Downstream 100 bases:

>100_bases
TTTTCGTTTGATGGGATTTTAAAATCACCAATCTATTAATTGTCGAATCACCTACAAAAGCGGCAACCATCACTTCTTAT
CTCGGTAAGGATTGGTTGGT

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKFNSILDAIGNTPHIRLSRLFGTDHEVYMKLERQNPGGSIKDRIALAMIEDAEKSGKLKKDSIIVEPTSGNTGIGLAMV
AAVKGYAITLVMPEHMSVERRRIMAAYGAKFELTPREKGMPGAIAKAQEMVAANPNAWMPQQFENEANIQVHREKTAEEI
AKDFPDGLDYIITGVGTGGHITGCAENLKKRFPKLKVFAVEPEGSPVLSGGKPGPHPLQGIGAGFIPKNCKTELLDGIIT
VGKEESFTMAVLAAKKEGIFIGTSSGASLAAVSKKLKEIPAGSKVLTFCYDTGERYLSVEGLFV

Sequences:

>Translated_304_residues
MKFNSILDAIGNTPHIRLSRLFGTDHEVYMKLERQNPGGSIKDRIALAMIEDAEKSGKLKKDSIIVEPTSGNTGIGLAMV
AAVKGYAITLVMPEHMSVERRRIMAAYGAKFELTPREKGMPGAIAKAQEMVAANPNAWMPQQFENEANIQVHREKTAEEI
AKDFPDGLDYIITGVGTGGHITGCAENLKKRFPKLKVFAVEPEGSPVLSGGKPGPHPLQGIGAGFIPKNCKTELLDGIIT
VGKEESFTMAVLAAKKEGIFIGTSSGASLAAVSKKLKEIPAGSKVLTFCYDTGERYLSVEGLFV
>Mature_304_residues
MKFNSILDAIGNTPHIRLSRLFGTDHEVYMKLERQNPGGSIKDRIALAMIEDAEKSGKLKKDSIIVEPTSGNTGIGLAMV
AAVKGYAITLVMPEHMSVERRRIMAAYGAKFELTPREKGMPGAIAKAQEMVAANPNAWMPQQFENEANIQVHREKTAEEI
AKDFPDGLDYIITGVGTGGHITGCAENLKKRFPKLKVFAVEPEGSPVLSGGKPGPHPLQGIGAGFIPKNCKTELLDGIIT
VGKEESFTMAVLAAKKEGIFIGTSSGASLAAVSKKLKEIPAGSKVLTFCYDTGERYLSVEGLFV

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=305, Percent_Identity=37.7049180327869, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI295821200, Length=305, Percent_Identity=37.7049180327869, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI4557415, Length=305, Percent_Identity=37.7049180327869, Blast_Score=201, Evalue=9e-52,
Organism=Escherichia coli, GI1788754, Length=299, Percent_Identity=46.4882943143813, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI2367138, Length=303, Percent_Identity=36.963696369637, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17562970, Length=296, Percent_Identity=39.8648648648649, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=40.2730375426621, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17535051, Length=293, Percent_Identity=39.5904436860068, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI115535073, Length=293, Percent_Identity=43.3447098976109, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17561720, Length=296, Percent_Identity=39.8648648648649, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17534315, Length=315, Percent_Identity=37.7777777777778, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI25147552, Length=313, Percent_Identity=36.4217252396166, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32566672, Length=210, Percent_Identity=38.0952380952381, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17561716, Length=114, Percent_Identity=37.719298245614, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=294, Percent_Identity=35.3741496598639, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=32.8220858895706, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24643623, Length=305, Percent_Identity=35.0819672131148, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI20129101, Length=305, Percent_Identity=35.0819672131148, Blast_Score=165, Evalue=4e-41,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32659; Mature: 32659

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS00901 CYS_SYNTHASE ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFNSILDAIGNTPHIRLSRLFGTDHEVYMKLERQNPGGSIKDRIALAMIEDAEKSGKLK
CCHHHHHHHHCCCCCEEEEEHHCCCCEEEEEEECCCCCCCHHHHEEEEEEHHHHHCCCEE
KDSIIVEPTSGNTGIGLAMVAAVKGYAITLVMPEHMSVERRRIMAAYGAKFELTPREKGM
CCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCEEEECCCCCCC
PGAIAKAQEMVAANPNAWMPQQFENEANIQVHREKTAEEIAKDFPDGLDYIITGVGTGGH
CCHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEHHHHHHHHHHHCCCCCEEEEEECCCCCC
ITGCAENLKKRFPKLKVFAVEPEGSPVLSGGKPGPHPLQGIGAGFIPKNCKTELLDGIIT
CHHHHHHHHHHCCCEEEEEECCCCCEECCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHC
VGKEESFTMAVLAAKKEGIFIGTSSGASLAAVSKKLKEIPAGSKVLTFCYDTGERYLSVE
CCCCCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEE
GLFV
EEEC
>Mature Secondary Structure
MKFNSILDAIGNTPHIRLSRLFGTDHEVYMKLERQNPGGSIKDRIALAMIEDAEKSGKLK
CCHHHHHHHHCCCCCEEEEEHHCCCCEEEEEEECCCCCCCHHHHEEEEEEHHHHHCCCEE
KDSIIVEPTSGNTGIGLAMVAAVKGYAITLVMPEHMSVERRRIMAAYGAKFELTPREKGM
CCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCEEEECCCCCCC
PGAIAKAQEMVAANPNAWMPQQFENEANIQVHREKTAEEIAKDFPDGLDYIITGVGTGGH
CCHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEHHHHHHHHHHHCCCCCEEEEEECCCCCC
ITGCAENLKKRFPKLKVFAVEPEGSPVLSGGKPGPHPLQGIGAGFIPKNCKTELLDGIIT
CHHHHHHHHHHCCCEEEEEECCCCCEECCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHC
VGKEESFTMAVLAAKKEGIFIGTSSGASLAAVSKKLKEIPAGSKVLTFCYDTGERYLSVE
CCCCCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEE
GLFV
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8867384 [H]