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The map label for this gene is 183220375

Identifier: 183220375

GI number: 183220375

Start: 1007198

End: 1008022

Strand: Direct

Name: 183220375

Synonym: LEPBI_I0971

Alternate gene names: NA

Gene position: 1007198-1008022 (Clockwise)

Preceding gene: 183220374

Following gene: 183220379

Centisome position: 27.98

GC content: 41.33

Gene sequence:

>825_bases
TTGGTAATGTGGTTCGTTAAAACGAAAGCAATCCAAATTTCCTTCCTGGGAATTTACTTTTTATTGGGGGTATTTGTTTC
CGGATGCCAAAGGCAAATTGTTTCGGAATCTCCAAACCAAGTGACCTTTCCTGGATCAATTACAAAGTTATCAGAGAATT
CTTCACCCCAACATTTAGAGTGGATCAAAATCAAAGAGACGGTTTGGATCCACAAAAGTTTTGGTAATTTTTTAGGGAAA
ACCTATGAATCCAATGGCCTTGTGGTCCTTTCGAGTCGGGGAGTTGTTGTCATTGATACCCCATGGACAGAGTCACAAAC
GGAAGAACTGTTTGAGGGTATCAAAACCAAATTCCAAAAAGAAATTTTATTCCTGATTGTGACACATGCGCATGACGACC
GTATGGCGGGAGTCACACAATTCCAAAACCGAAACATCCCTGTATATAGCACTTCTTTAACTTCAAAATTGGCAAAGGAA
AAAGGACTTGGAAAAACAAATCCCATCTTGGATCTGCAAACAAGAGTTTCAGCGGGGAATGTTTCTGTAGAAATCTTTTT
TCCAGGGCATGGGCACTCACCCGATAATATTGTGGTTTGGTTACCAAACACTCATATTCTTTTTGGTGGTTGCCTTGTGA
AGGCTATCGATGCAACAGACTTGGGAAATGTGAAGGATGCAAATTTATTGGAATGGGAAAATGCAGTGAAACGAGTGTTA
TCTCGTTACCCTGACGCAGAAGTTGTGGTGCCAGGGCATGGGAACTGGGGGAAACTGGATTTACTCCGCCATACGATACG
ATTACTTGTTTCTACGAACCACTAA

Upstream 100 bases:

>100_bases
AAGTGGTGGTGACAGACGATACTGTTCTGAAAAAAGAAGCACCCATTACAATTTTAAAGGGTGATATCGAAAAGATCGCT
TAAAAAAAAGAAATGTTACT

Downstream 100 bases:

>100_bases
GATGGACAGTTTTTCCATGGGATTTGTGAGATTTCGTTCGCGCCCGAGGGAACTCATCTTTTTGGCAATGGCAAGTAACA
TCTGTCTAGAAGAACTTGGC

Product: putative beta-lactamase II

Products: NA

Alternate protein names: Beta-lactamase II; Penicillinase [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MVMWFVKTKAIQISFLGIYFLLGVFVSGCQRQIVSESPNQVTFPGSITKLSENSSPQHLEWIKIKETVWIHKSFGNFLGK
TYESNGLVVLSSRGVVVIDTPWTESQTEELFEGIKTKFQKEILFLIVTHAHDDRMAGVTQFQNRNIPVYSTSLTSKLAKE
KGLGKTNPILDLQTRVSAGNVSVEIFFPGHGHSPDNIVVWLPNTHILFGGCLVKAIDATDLGNVKDANLLEWENAVKRVL
SRYPDAEVVVPGHGNWGKLDLLRHTIRLLVSTNH

Sequences:

>Translated_274_residues
MVMWFVKTKAIQISFLGIYFLLGVFVSGCQRQIVSESPNQVTFPGSITKLSENSSPQHLEWIKIKETVWIHKSFGNFLGK
TYESNGLVVLSSRGVVVIDTPWTESQTEELFEGIKTKFQKEILFLIVTHAHDDRMAGVTQFQNRNIPVYSTSLTSKLAKE
KGLGKTNPILDLQTRVSAGNVSVEIFFPGHGHSPDNIVVWLPNTHILFGGCLVKAIDATDLGNVKDANLLEWENAVKRVL
SRYPDAEVVVPGHGNWGKLDLLRHTIRLLVSTNH
>Mature_274_residues
MVMWFVKTKAIQISFLGIYFLLGVFVSGCQRQIVSESPNQVTFPGSITKLSENSSPQHLEWIKIKETVWIHKSFGNFLGK
TYESNGLVVLSSRGVVVIDTPWTESQTEELFEGIKTKFQKEILFLIVTHAHDDRMAGVTQFQNRNIPVYSTSLTSKLAKE
KGLGKTNPILDLQTRVSAGNVSVEIFFPGHGHSPDNIVVWLPNTHILFGGCLVKAIDATDLGNVKDANLLEWENAVKRVL
SRYPDAEVVVPGHGNWGKLDLLRHTIRLLVSTNH

Specific function: Can hydrolyze carbapenem compounds [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001018
- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 30621; Mature: 30621

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00744 BETA_LACTAMASE_B_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMWFVKTKAIQISFLGIYFLLGVFVSGCQRQIVSESPNQVTFPGSITKLSENSSPQHLE
CEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEECCCCCCCCEEE
WIKIKETVWIHKSFGNFLGKTYESNGLVVLSSRGVVVIDTPWTESQTEELFEGIKTKFQK
EEEEEEEEEEEHHHHHHHCCEECCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHH
EILFLIVTHAHDDRMAGVTQFQNRNIPVYSTSLTSKLAKEKGLGKTNPILDLQTRVSAGN
EEEEEEEEECCCCCCCCHHHHCCCCCCEEEHHHHHHHHHHCCCCCCCCEEEEEEEECCCC
VSVEIFFPGHGHSPDNIVVWLPNTHILFGGCLVKAIDATDLGNVKDANLLEWENAVKRVL
EEEEEEECCCCCCCCCEEEECCCCEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
SRYPDAEVVVPGHGNWGKLDLLRHTIRLLVSTNH
HHCCCCEEEECCCCCCCHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MVMWFVKTKAIQISFLGIYFLLGVFVSGCQRQIVSESPNQVTFPGSITKLSENSSPQHLE
CEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEECCCCCCCCEEE
WIKIKETVWIHKSFGNFLGKTYESNGLVVLSSRGVVVIDTPWTESQTEELFEGIKTKFQK
EEEEEEEEEEEHHHHHHHCCEECCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHH
EILFLIVTHAHDDRMAGVTQFQNRNIPVYSTSLTSKLAKEKGLGKTNPILDLQTRVSAGN
EEEEEEEEECCCCCCCCHHHHCCCCCCEEEHHHHHHHHHHCCCCCCCCEEEEEEEECCCC
VSVEIFFPGHGHSPDNIVVWLPNTHILFGGCLVKAIDATDLGNVKDANLLEWENAVKRVL
EEEEEEECCCCCCCCCEEEECCCCEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
SRYPDAEVVVPGHGNWGKLDLLRHTIRLLVSTNH
HHCCCCEEEECCCCCCCHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3938474 [H]