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The map label for this gene is hcr [H]

Identifier: 183220302

GI number: 183220302

Start: 918887

End: 920071

Strand: Direct

Name: hcr [H]

Synonym: LEPBI_I0897

Alternate gene names: 183220302

Gene position: 918887-920071 (Clockwise)

Preceding gene: 183220301

Following gene: 183220303

Centisome position: 25.53

GC content: 37.47

Gene sequence:

>1185_bases
ATGTTAGATAACAACCAAAAATTAGAAACAAATATTTTAAACTCAGTTGTTGGATTCCATGATGCAGTTTTAAAAAAAGA
AGATCTAGAGAAAAACGGTTCCGATTTTAGAGAAGGCAAAGGATTGGTCAAAGAAACGATTCGAAGTCTCCATCCAAAAC
GAATCCATTTGCGTGTCGAAAGTATACGCATTGATACACCTTCGACCAAAACATTGGTTATGGTTCCAGTAGATGGAAAT
CGATTACCGCCGTTCCAAGCAGGACAGTACATCAACTTATTTGTTACACTTGCAGGCGTTTTGACAGCAAGACCATATTC
AATATCATCCTCTCCTAAAAACTTACAATCCTATGAACTAACCATCAAACGAGCAGAAGGTGGGTTTGTAAGTCCTTATC
TATTAGATGACGTTAAAATTGGACAAAAATTTGAATCCACGGGGCCAATGGGTTCCTTTCATCATAATCCACTGTTTCAT
GGATTTGATATTGTATTTCTTGCAGGTGGTTCCGGAATTGCTCCTGCTATGAGTATGTTAAAAGCATTTTTGGCAGCGGA
AAATCCCTTTCGTTTTCATATTATTTATTCCAATAGTTACGAAAATGATGTAATTTTTCTAGATGAACTTCGGAACTTAT
CACTTTTACATAAAAACTTCATTTTAACTGAATTCATTTCTCGTGAGGTAAGTCCTGAGTTTAAAGGATTTAAAGGTCGA
TTGGACATTGTCACATTGCAAACGTTATTGTCTGATGTTTCATCTAAAATGTTTTATGTCTGTGGCCCCACTCCGTTTAA
TGAACATTGTGCGAATCTCCTCGCTGATTTAGGTGTTAAATCTGGACGTATATTAATCGAAGGTAATGGTCCACCTCCCA
AACCAGATCAATTAGATGGATGGCCAAGTGAAATTCATCCGTCCTCGGAGGTGAACGTAACAGTAGGAACCCATAAGTCA
TTTAAAGCAAAAGTAGGGGAGCCTCTACTTAACAGTTTAGAACGGAATGGTTATTTTACAGAAAACGCATGTCGTTCCGG
AGAATGTAGCTTATGCCGTGTGAAACTAAAATCGGGAGAAGTATTCAGTCCTAAGGAAGCTAAAATTAGAAAGTCCGATC
GGAAATTTGGTTGGATCCATTCTTGTGTGGCATTTCCAATCACGGATGTTGAAATTCAATTATAA

Upstream 100 bases:

>100_bases
CAACTGCGTCGTAAAAACAAAACTGCTGTCTAGGTCGTGTGCGACCTCAATCACAGTTGGTAGTAGTGCAAAATATTTTA
AATAAGAAAGGAAATACGAT

Downstream 100 bases:

>100_bases
TTAAAAATAGAGAACCAACTAATTGAGAGTTTGGTATGAATGTTTAAAAATCTTTTCTACCAAATTCCGAAAAGGTTTTA
ATTGGGTTCGTGCATTGAAT

Product: putative oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MLDNNQKLETNILNSVVGFHDAVLKKEDLEKNGSDFREGKGLVKETIRSLHPKRIHLRVESIRIDTPSTKTLVMVPVDGN
RLPPFQAGQYINLFVTLAGVLTARPYSISSSPKNLQSYELTIKRAEGGFVSPYLLDDVKIGQKFESTGPMGSFHHNPLFH
GFDIVFLAGGSGIAPAMSMLKAFLAAENPFRFHIIYSNSYENDVIFLDELRNLSLLHKNFILTEFISREVSPEFKGFKGR
LDIVTLQTLLSDVSSKMFYVCGPTPFNEHCANLLADLGVKSGRILIEGNGPPPKPDQLDGWPSEIHPSSEVNVTVGTHKS
FKAKVGEPLLNSLERNGYFTENACRSGECSLCRVKLKSGEVFSPKEAKIRKSDRKFGWIHSCVAFPITDVEIQL

Sequences:

>Translated_394_residues
MLDNNQKLETNILNSVVGFHDAVLKKEDLEKNGSDFREGKGLVKETIRSLHPKRIHLRVESIRIDTPSTKTLVMVPVDGN
RLPPFQAGQYINLFVTLAGVLTARPYSISSSPKNLQSYELTIKRAEGGFVSPYLLDDVKIGQKFESTGPMGSFHHNPLFH
GFDIVFLAGGSGIAPAMSMLKAFLAAENPFRFHIIYSNSYENDVIFLDELRNLSLLHKNFILTEFISREVSPEFKGFKGR
LDIVTLQTLLSDVSSKMFYVCGPTPFNEHCANLLADLGVKSGRILIEGNGPPPKPDQLDGWPSEIHPSSEVNVTVGTHKS
FKAKVGEPLLNSLERNGYFTENACRSGECSLCRVKLKSGEVFSPKEAKIRKSDRKFGWIHSCVAFPITDVEIQL
>Mature_394_residues
MLDNNQKLETNILNSVVGFHDAVLKKEDLEKNGSDFREGKGLVKETIRSLHPKRIHLRVESIRIDTPSTKTLVMVPVDGN
RLPPFQAGQYINLFVTLAGVLTARPYSISSSPKNLQSYELTIKRAEGGFVSPYLLDDVKIGQKFESTGPMGSFHHNPLFH
GFDIVFLAGGSGIAPAMSMLKAFLAAENPFRFHIIYSNSYENDVIFLDELRNLSLLHKNFILTEFISREVSPEFKGFKGR
LDIVTLQTLLSDVSSKMFYVCGPTPFNEHCANLLADLGVKSGRILIEGNGPPPKPDQLDGWPSEIHPSSEVNVTVGTHKS
FKAKVGEPLLNSLERNGYFTENACRSGECSLCRVKLKSGEVFSPKEAKIRKSDRKFGWIHSCVAFPITDVEIQL

Specific function: NADH oxidoreductase acting in concert with HCP [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI84875541, Length=212, Percent_Identity=27.8301886792453, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1787098, Length=339, Percent_Identity=28.6135693215339, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787658, Length=317, Percent_Identity=24.6056782334385, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788903, Length=222, Percent_Identity=27.4774774774775, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323552, Length=208, Percent_Identity=27.8846153846154, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR000951
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 43840; Mature: 43840

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDNNQKLETNILNSVVGFHDAVLKKEDLEKNGSDFREGKGLVKETIRSLHPKRIHLRVE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCEEEEEEEE
SIRIDTPSTKTLVMVPVDGNRLPPFQAGQYINLFVTLAGVLTARPYSISSSPKNLQSYEL
EEEECCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
TIKRAEGGFVSPYLLDDVKIGQKFESTGPMGSFHHNPLFHGFDIVFLAGGSGIAPAMSML
EEEECCCCCCCCCEECCHHHCCHHCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHH
KAFLAAENPFRFHIIYSNSYENDVIFLDELRNLSLLHKNFILTEFISREVSPEFKGFKGR
HHHHHCCCCEEEEEEECCCCCCCEEEEEHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LDIVTLQTLLSDVSSKMFYVCGPTPFNEHCANLLADLGVKSGRILIEGNGPPPKPDQLDG
EEHEEHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCC
WPSEIHPSSEVNVTVGTHKSFKAKVGEPLLNSLERNGYFTENACRSGECSLCRVKLKSGE
CCCCCCCCCCEEEEECCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCC
VFSPKEAKIRKSDRKFGWIHSCVAFPITDVEIQL
EECCCHHHHHHCCCCHHHHHHHHHCCEEEEEEEC
>Mature Secondary Structure
MLDNNQKLETNILNSVVGFHDAVLKKEDLEKNGSDFREGKGLVKETIRSLHPKRIHLRVE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCEEEEEEEE
SIRIDTPSTKTLVMVPVDGNRLPPFQAGQYINLFVTLAGVLTARPYSISSSPKNLQSYEL
EEEECCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
TIKRAEGGFVSPYLLDDVKIGQKFESTGPMGSFHHNPLFHGFDIVFLAGGSGIAPAMSML
EEEECCCCCCCCCEECCHHHCCHHCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHH
KAFLAAENPFRFHIIYSNSYENDVIFLDELRNLSLLHKNFILTEFISREVSPEFKGFKGR
HHHHHCCCCEEEEEEECCCCCCCEEEEEHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LDIVTLQTLLSDVSSKMFYVCGPTPFNEHCANLLADLGVKSGRILIEGNGPPPKPDQLDG
EEHEEHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCC
WPSEIHPSSEVNVTVGTHKSFKAKVGEPLLNSLERNGYFTENACRSGECSLCRVKLKSGE
CCCCCCCCCCEEEEECCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCC
VFSPKEAKIRKSDRKFGWIHSCVAFPITDVEIQL
EECCCHHHHHHCCCCHHHHHHHHHCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10651802 [H]