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The map label for this gene is acyII [H]

Identifier: 183220271

GI number: 183220271

Start: 884028

End: 886550

Strand: Direct

Name: acyII [H]

Synonym: LEPBI_Ia0863

Alternate gene names: 183220271

Gene position: 884028-886550 (Clockwise)

Preceding gene: 183220270

Following gene: 183220272

Centisome position: 24.56

GC content: 39.99

Gene sequence:

>2523_bases
ATGTTACAGAAAACAAAAAACTTTATCAAGAAGAGACCGATGATCAGTCTCTTCCTTCTTTTAATCCTTTCTTTGCCAGT
TACCTTACACATTTTATTTTGGGGTCTTGTTTCCTTAAAAGCTCCGAGATACCAAGGTGAAATACGCTCAGAAAAACTCT
CCGCAAAAGCGACTGTGATCCGGGACGCAAATGGAATTCCTCACATTGTAGGCGAGGATGCAAAGTCCGCCTATTTTGCA
TTAGGTTTTACGATGGCGCAAGATCGAATTTTCCAAATGGAATTACAAAGGCGGATTGGGAAAGGGGAACTCACTGAAAT
TTTTGGCGAAAAACTCATCCCTTCGGATCAGTTTTTAAAATCACTTTTATTGAAACAAACGGCAGAAGCCTATGCAAACC
AAACCAAACATATTTATCCGGAAGCTTGGGAACAATTGGATTGGTTTTTGGATGGTGTGAACCATTTTTTAGAAACGGAA
GCCCTACCAATCGAATACACAATCCTAGGTATCAAACCTAGACCCTTCGATCGAGTTGATGCCATTTCGTTTTTGTTTTA
TATGGGATTTTCCTTTGCAGAAGGAATCAAGTCGGACAGTTTGTACACGATCATGGAATCTGAGTTAGCTGGTCGTTCGG
CAAGTGAACTCTTCCCGAGATATGATTTTGAACCAAATGCCTCCATTTTAGAATCCCAACCAGGGATTCTAAAACTCGCT
TCCAATGTTCCAAAAATACAAATCAATTCTCAAAATACGCGCCAAAACGTTCACTCAGAGAAAGAACATCCTGAACAAAT
CAATTCTCAATCCATCCAAGATGTAACCAATTTGAAAGAGCTCGTACGTTTTGTGGGCTCACTCCAGATCCCAATGGAAC
CATTGGAAGGTAGTAATTCTTGGCTTGTAGCACCGAGTCGGTCCGCAAGTGGAGGAGCCGTACTTGCCAATGACCCACAC
ATTGCTTTGTCGAACCCGGGTGCTTGGTATGAAGCCCATATTGAATACCCTGGGTATGAAAACTATGGTTATTTTTTATC
CATCATACCTTTCCCACTCATCGCACACAATCAAGACAAAGCTTGGGGACTGACAATGCTTGAGCAAGATGATGTGAATT
TGTATATGGAAACCATTGATAATGGGAAATACAAATCAGGGTCTACATGGAAAGAATTAAGCCATTATAAAGATGGAATC
AAACAAAAGGATGGATCGATCATTCCTTTCGAAGTTGCCATAACAGGCCACGGTCCTATCATCACCGAACATATCAAAGG
TTATAAAGGTAGACCCGTCAGCTTGTATTGGTCCCACCACCATTTAGAAAATCCTCTTCTAGATGTTTTATATAAAATGG
GTAAATCCAAATCTTTCCAGGAACTAGATTCTGCGTCTTCCATGATCGGAGCACCTGGACTAAATTTTAGTTATGCGGAT
AAGGATGGAAATATCGCTTATTATGCCGTGGGTAGATTTCCTATATTGAAGGGAGGGAATCCAAGGAAAATTTTAGAAGG
TTCCACAGGAGAAAATGATGTGATTGGTTATGTTCCTGTAAAAGACAATCCAAAGATCATCAATCCTAAAAATGGAATTA
TCGTAACAGCCAATAACCTAGTGACAAACCAAAGGTTACCTGGTCTTGGAAAACCGGAAGGGAATTGGCAACCCCCTGAT
CGTTTTCAGAGGTTAGTTGGTATTTTGGAAACCCAAGAGAAATGGAGTTTAGAAGAACTTGCCGCGATCCAAACAGATAC
GGTTTCCTCTTTTGCCCCCGAATACCTTGAAATTGTATTTTCTTCTGCAAAAAAACCAAACTCATTGGGTGGGAAAAAAG
TATTAGAAATTTTAAAACATTGGAACTTTGAACATTTCCCTGATTCGCAAGGTGCTGCTGTGTATGATGTTTTCTTTTAT
TTAACCTTGAAAGAACTTCTCATCGATGAAATGGGCCCTGAACATTTTGAACTGTATGGAGAATTAGCAGAATATTGGAA
TGCGTATCGTCGTTTTATCCGAAATCCCAATTCCAATTATTGGGATGATTTGAGGACTGTTGGTGTGATCGAAACAAGGG
AAGATATTATCAATCGATCCCTTGAAGAAACAGCGAAGTATCTAGAAAAGAATGTCTCTGCCTCTCCAAGCCTTTGGAAA
TGGAAATACTTATACAAAATCAAACACCCACATCCACTTGGAGTATTGCCTTTGATAGGTGGTGTATTTGATATTGGTCC
CATGCCAAGTGCTGGTGGTGCGGAAGTGGTGAATAACTTAAAATACAAATTGATGAAAGAAGATTGGACGGCCACTTCTG
GTCCTTCGAAACGTAGGGTAATTGATTATGGTAGGTTTGAAGAGTCTTTGACCCAACTTCCCATTGGGAACAGTGGGAAT
TTAGGGAGTCCTTTTTATGGAAACACAGTCGAGGATTATAATCATGGAATCCACAGAAAAATATTGTATTCCAAAAGCCA
AGTGGGAGAGGGTAAATTTCGTTTAGAATTCCAACCTAAATAA

Upstream 100 bases:

>100_bases
ATAAAACAAAATACTACAAAGTTGAATCATTCTCAAATGCCGCTTGGGACTCTGCAGATAAACAAAATCGTATCCGTCAA
ATCAAATCACTACAATAACT

Downstream 100 bases:

>100_bases
GAGAATTTTCCCTACCAGAGGCGGTAGGGAATTTTTTTTCTACTCACTGACTTTTGGAATCGGCCGATCCTTAGTATAGA
TGGTTCGGCTCTTCCTTCTT

Product: penicillin G acylase

Products: NA

Alternate protein names: Cephalosporin acylase II; Penicillin acylase II; Penicillin amidase II; Penicillin acylase II small subunit; Penicillin acylase II large subunit [H]

Number of amino acids: Translated: 840; Mature: 840

Protein sequence:

>840_residues
MLQKTKNFIKKRPMISLFLLLILSLPVTLHILFWGLVSLKAPRYQGEIRSEKLSAKATVIRDANGIPHIVGEDAKSAYFA
LGFTMAQDRIFQMELQRRIGKGELTEIFGEKLIPSDQFLKSLLLKQTAEAYANQTKHIYPEAWEQLDWFLDGVNHFLETE
ALPIEYTILGIKPRPFDRVDAISFLFYMGFSFAEGIKSDSLYTIMESELAGRSASELFPRYDFEPNASILESQPGILKLA
SNVPKIQINSQNTRQNVHSEKEHPEQINSQSIQDVTNLKELVRFVGSLQIPMEPLEGSNSWLVAPSRSASGGAVLANDPH
IALSNPGAWYEAHIEYPGYENYGYFLSIIPFPLIAHNQDKAWGLTMLEQDDVNLYMETIDNGKYKSGSTWKELSHYKDGI
KQKDGSIIPFEVAITGHGPIITEHIKGYKGRPVSLYWSHHHLENPLLDVLYKMGKSKSFQELDSASSMIGAPGLNFSYAD
KDGNIAYYAVGRFPILKGGNPRKILEGSTGENDVIGYVPVKDNPKIINPKNGIIVTANNLVTNQRLPGLGKPEGNWQPPD
RFQRLVGILETQEKWSLEELAAIQTDTVSSFAPEYLEIVFSSAKKPNSLGGKKVLEILKHWNFEHFPDSQGAAVYDVFFY
LTLKELLIDEMGPEHFELYGELAEYWNAYRRFIRNPNSNYWDDLRTVGVIETREDIINRSLEETAKYLEKNVSASPSLWK
WKYLYKIKHPHPLGVLPLIGGVFDIGPMPSAGGAEVVNNLKYKLMKEDWTATSGPSKRRVIDYGRFEESLTQLPIGNSGN
LGSPFYGNTVEDYNHGIHRKILYSKSQVGEGKFRLEFQPK

Sequences:

>Translated_840_residues
MLQKTKNFIKKRPMISLFLLLILSLPVTLHILFWGLVSLKAPRYQGEIRSEKLSAKATVIRDANGIPHIVGEDAKSAYFA
LGFTMAQDRIFQMELQRRIGKGELTEIFGEKLIPSDQFLKSLLLKQTAEAYANQTKHIYPEAWEQLDWFLDGVNHFLETE
ALPIEYTILGIKPRPFDRVDAISFLFYMGFSFAEGIKSDSLYTIMESELAGRSASELFPRYDFEPNASILESQPGILKLA
SNVPKIQINSQNTRQNVHSEKEHPEQINSQSIQDVTNLKELVRFVGSLQIPMEPLEGSNSWLVAPSRSASGGAVLANDPH
IALSNPGAWYEAHIEYPGYENYGYFLSIIPFPLIAHNQDKAWGLTMLEQDDVNLYMETIDNGKYKSGSTWKELSHYKDGI
KQKDGSIIPFEVAITGHGPIITEHIKGYKGRPVSLYWSHHHLENPLLDVLYKMGKSKSFQELDSASSMIGAPGLNFSYAD
KDGNIAYYAVGRFPILKGGNPRKILEGSTGENDVIGYVPVKDNPKIINPKNGIIVTANNLVTNQRLPGLGKPEGNWQPPD
RFQRLVGILETQEKWSLEELAAIQTDTVSSFAPEYLEIVFSSAKKPNSLGGKKVLEILKHWNFEHFPDSQGAAVYDVFFY
LTLKELLIDEMGPEHFELYGELAEYWNAYRRFIRNPNSNYWDDLRTVGVIETREDIINRSLEETAKYLEKNVSASPSLWK
WKYLYKIKHPHPLGVLPLIGGVFDIGPMPSAGGAEVVNNLKYKLMKEDWTATSGPSKRRVIDYGRFEESLTQLPIGNSGN
LGSPFYGNTVEDYNHGIHRKILYSKSQVGEGKFRLEFQPK
>Mature_840_residues
MLQKTKNFIKKRPMISLFLLLILSLPVTLHILFWGLVSLKAPRYQGEIRSEKLSAKATVIRDANGIPHIVGEDAKSAYFA
LGFTMAQDRIFQMELQRRIGKGELTEIFGEKLIPSDQFLKSLLLKQTAEAYANQTKHIYPEAWEQLDWFLDGVNHFLETE
ALPIEYTILGIKPRPFDRVDAISFLFYMGFSFAEGIKSDSLYTIMESELAGRSASELFPRYDFEPNASILESQPGILKLA
SNVPKIQINSQNTRQNVHSEKEHPEQINSQSIQDVTNLKELVRFVGSLQIPMEPLEGSNSWLVAPSRSASGGAVLANDPH
IALSNPGAWYEAHIEYPGYENYGYFLSIIPFPLIAHNQDKAWGLTMLEQDDVNLYMETIDNGKYKSGSTWKELSHYKDGI
KQKDGSIIPFEVAITGHGPIITEHIKGYKGRPVSLYWSHHHLENPLLDVLYKMGKSKSFQELDSASSMIGAPGLNFSYAD
KDGNIAYYAVGRFPILKGGNPRKILEGSTGENDVIGYVPVKDNPKIINPKNGIIVTANNLVTNQRLPGLGKPEGNWQPPD
RFQRLVGILETQEKWSLEELAAIQTDTVSSFAPEYLEIVFSSAKKPNSLGGKKVLEILKHWNFEHFPDSQGAAVYDVFFY
LTLKELLIDEMGPEHFELYGELAEYWNAYRRFIRNPNSNYWDDLRTVGVIETREDIINRSLEETAKYLEKNVSASPSLWK
WKYLYKIKHPHPLGVLPLIGGVFDIGPMPSAGGAEVVNNLKYKLMKEDWTATSGPSKRRVIDYGRFEESLTQLPIGNSGN
LGSPFYGNTVEDYNHGIHRKILYSKSQVGEGKFRLEFQPK

Specific function: Unknown

COG id: COG2366

COG function: function code R; Protein related to penicillin acylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S45 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014395
- InterPro:   IPR002692 [H]

Pfam domain/function: PF01804 Penicil_amidase [H]

EC number: =3.5.1.11 [H]

Molecular weight: Translated: 94911; Mature: 94911

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQKTKNFIKKRPMISLFLLLILSLPVTLHILFWGLVSLKAPRYQGEIRSEKLSAKATVI
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEE
RDANGIPHIVGEDAKSAYFALGFTMAQDRIFQMELQRRIGKGELTEIFGEKLIPSDQFLK
ECCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHH
SLLLKQTAEAYANQTKHIYPEAWEQLDWFLDGVNHFLETEALPIEYTILGIKPRPFDRVD
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHH
AISFLFYMGFSFAEGIKSDSLYTIMESELAGRSASELFPRYDFEPNASILESQPGILKLA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHCCCCCCCCCCHHHCCCCCEEECC
SNVPKIQINSQNTRQNVHSEKEHPEQINSQSIQDVTNLKELVRFVGSLQIPMEPLEGSNS
CCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
WLVAPSRSASGGAVLANDPHIALSNPGAWYEAHIEYPGYENYGYFLSIIPFPLIAHNQDK
EEEECCCCCCCCEEEECCCEEEECCCCCEEEEEEECCCCCCCCCEEEECCCCEEECCCCC
AWGLTMLEQDDVNLYMETIDNGKYKSGSTWKELSHYKDGIKQKDGSIIPFEVAITGHGPI
CCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCC
ITEHIKGYKGRPVSLYWSHHHLENPLLDVLYKMGKSKSFQELDSASSMIGAPGLNFSYAD
HHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEECC
KDGNIAYYAVGRFPILKGGNPRKILEGSTGENDVIGYVPVKDNPKIINPKNGIIVTANNL
CCCCEEEEEECCEEEECCCCCCEEECCCCCCCCEEEEEECCCCCCEECCCCCEEEEECCE
VTNQRLPGLGKPEGNWQPPDRFQRLVGILETQEKWSLEELAAIQTDTVSSFAPEYLEIVF
EECCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
SSAKKPNSLGGKKVLEILKHWNFEHFPDSQGAAVYDVFFYLTLKELLIDEMGPEHFELYG
HCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
ELAEYWNAYRRFIRNPNSNYWDDLRTVGVIETREDIINRSLEETAKYLEKNVSASPSLWK
HHHHHHHHHHHHHCCCCCCHHHHHHHCCEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCEE
WKYLYKIKHPHPLGVLPLIGGVFDIGPMPSAGGAEVVNNLKYKLMKEDWTATSGPSKRRV
EEEEEEECCCCCCCHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
IDYGRFEESLTQLPIGNSGNLGSPFYGNTVEDYNHGIHRKILYSKSQVGEGKFRLEFQPK
EECHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MLQKTKNFIKKRPMISLFLLLILSLPVTLHILFWGLVSLKAPRYQGEIRSEKLSAKATVI
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEE
RDANGIPHIVGEDAKSAYFALGFTMAQDRIFQMELQRRIGKGELTEIFGEKLIPSDQFLK
ECCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHH
SLLLKQTAEAYANQTKHIYPEAWEQLDWFLDGVNHFLETEALPIEYTILGIKPRPFDRVD
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHH
AISFLFYMGFSFAEGIKSDSLYTIMESELAGRSASELFPRYDFEPNASILESQPGILKLA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHCCCCCCCCCCHHHCCCCCEEECC
SNVPKIQINSQNTRQNVHSEKEHPEQINSQSIQDVTNLKELVRFVGSLQIPMEPLEGSNS
CCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
WLVAPSRSASGGAVLANDPHIALSNPGAWYEAHIEYPGYENYGYFLSIIPFPLIAHNQDK
EEEECCCCCCCCEEEECCCEEEECCCCCEEEEEEECCCCCCCCCEEEECCCCEEECCCCC
AWGLTMLEQDDVNLYMETIDNGKYKSGSTWKELSHYKDGIKQKDGSIIPFEVAITGHGPI
CCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCC
ITEHIKGYKGRPVSLYWSHHHLENPLLDVLYKMGKSKSFQELDSASSMIGAPGLNFSYAD
HHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEECC
KDGNIAYYAVGRFPILKGGNPRKILEGSTGENDVIGYVPVKDNPKIINPKNGIIVTANNL
CCCCEEEEEECCEEEECCCCCCEEECCCCCCCCEEEEEECCCCCCEECCCCCEEEEECCE
VTNQRLPGLGKPEGNWQPPDRFQRLVGILETQEKWSLEELAAIQTDTVSSFAPEYLEIVF
EECCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
SSAKKPNSLGGKKVLEILKHWNFEHFPDSQGAAVYDVFFYLTLKELLIDEMGPEHFELYG
HCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
ELAEYWNAYRRFIRNPNSNYWDDLRTVGVIETREDIINRSLEETAKYLEKNVSASPSLWK
HHHHHHHHHHHHHCCCCCCHHHHHHHCCEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCEE
WKYLYKIKHPHPLGVLPLIGGVFDIGPMPSAGGAEVVNNLKYKLMKEDWTATSGPSKRRV
EEEEEEECCCCCCCHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
IDYGRFEESLTQLPIGNSGNLGSPFYGNTVEDYNHGIHRKILYSKSQVGEGKFRLEFQPK
EECHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3680178 [H]