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The map label for this gene is uidB [H]

Identifier: 183220236

GI number: 183220236

Start: 842236

End: 843792

Strand: Direct

Name: uidB [H]

Synonym: LEPBI_I0829

Alternate gene names: 183220236

Gene position: 842236-843792 (Clockwise)

Preceding gene: 183220235

Following gene: 183220237

Centisome position: 23.4

GC content: 40.4

Gene sequence:

>1557_bases
GTGAAACACATGCAAAAACCGTCTTTACCATTTGGAAAACAAATTAGTTATGCAGTAGGCCAACTTGGTTGGTCTACACT
CATCAATATCATCGGCCTCCACCAAGTTTATTTTTATCTCCCTCCAGCACCCAAACCAGGCCAGGACTGTTTCCCTGATT
TAATTGAAAAAATGGCATTTTGGGGCCTTTCCACGATCGGTGTGGTTGCCGCGGTCGGACGATTATGGGATGCGTTCACC
GATCCACTCATTGCAAACTCTTCAGATCGCTTTTTTTCACGATTTGGAAGGAGGATTCCGTTTTTGTTTTTAGGTGGGAT
TCCTTCTGCCGTCTTTTGTTGGTTAATCTTTGTCCCACCACATAACTTCGTTTCTTCGACCAACTTGGTTTGGATGACAA
GTTTCATGTTACTCTTCTATTTATTTTTAACAGTGTATGTCACACCATTCTTTGCTCTCATCCCGGAGTTAGGCCATACC
CCGGAAGAACGACTCAACCTTTCTACTTATATCTCGGTTACGTATGCACTAGGAATCATTGTTGCCTCCACAGAACCAAT
GATTGCCAGTGTCCTGCAGTCTAGTTTTGTTTTTGATGCCGATCCATCTCTGCAAACATTAGTCTCTAGGCAATATGCTC
TTGGTATTCTTTGTATCTTCGCTGCCATTTGTATGTACTTCCCAGTATTCACCATCCACGAAAAAACTTACTGTGAATCG
GAAGCATCCAGTGTTCCATTTAAGGAAGCCATTTTACTCACCTTCAAAAACAAAAACTTTTTGTATTTTGCACTCTCCGA
TTTGTGTTATTTTTTGGCACTCACCATCCTCACAACAGGAATTTCGTATTATGTAACTGTCCTATTAGAATTGGAAAGAG
ACTTCGTGACCCAACTGCTCACCGTCATGTTACTGGTTTCGTTTGCGTTTTACCCCGTTGTGAATTTTGTCGCACGTAAA
ATTGGCAAAAAGAGAACGGTTCTCATTGGGTTTTATCTATTTTTAGCCTTGTTTTTATCCATCTTTTTCATCGGTAAAAA
CAGTTTGCCAATCTCACCGTATATCCAAGGTTATATGATTGTTGCCGTTGCAGCCATCCCAATTGCGATTCTTGGAATAT
TACCAAATGCAATATTAGCAGATATTGCTGAACTTGATTCATTAAAAACAGGATCCAAACGAGAAGGTCTTTTTTATGCA
GGAAGGACCTTTATGCAAAAACTAGGACAAACACTTGCCGTATTGATCTTTAGTTCCGTGATTTTACTTGGTCTCGACAG
AGACTCCAAACAACAAGTTTCACCCAATGTGACAGGCATCATTGCTCCCTCTGTGGCGGATTCTAAGTCAGATCTGAAAA
AAAATAACGAGACTGAGGCAAAAATAAGTAAGGAATCAAGTATTTGCAAAGTCGAAGAAGTAGAAACTGGTGGGGAACTC
GGGGTTCGATTGACAGGACCTTTGGCTTCTGCATTCTGTTTACTTGCAATTTTTCTCTTTGGTAAATACAAAGAGGATGA
AACTTTAGAAGAGATTGCAAAGATACGTGGTAAATAA

Upstream 100 bases:

>100_bases
TTTTATACGACGAGAAAAACTTTCCGGAACTCTATAAACATAAAAAGTAGTTTGCCTTTTTTACTTTTGGCGGTATCATG
CTCCTACTTTACCGCCTCTA

Downstream 100 bases:

>100_bases
ATCCTGGTTTTTGGAGCTATTCAGATGAGATATCGCATTGAGACAACCAAGTTAAAGAACGGGTATATCGAAGCCAAACT
CATCGAGACAACCACAAATA

Product: putative sodium/galactoside symporter

Products: Proton [Cytoplasm]; Glucuronides [Cytoplasm] [C]

Alternate protein names: Glucuronide permease [H]

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MKHMQKPSLPFGKQISYAVGQLGWSTLINIIGLHQVYFYLPPAPKPGQDCFPDLIEKMAFWGLSTIGVVAAVGRLWDAFT
DPLIANSSDRFFSRFGRRIPFLFLGGIPSAVFCWLIFVPPHNFVSSTNLVWMTSFMLLFYLFLTVYVTPFFALIPELGHT
PEERLNLSTYISVTYALGIIVASTEPMIASVLQSSFVFDADPSLQTLVSRQYALGILCIFAAICMYFPVFTIHEKTYCES
EASSVPFKEAILLTFKNKNFLYFALSDLCYFLALTILTTGISYYVTVLLELERDFVTQLLTVMLLVSFAFYPVVNFVARK
IGKKRTVLIGFYLFLALFLSIFFIGKNSLPISPYIQGYMIVAVAAIPIAILGILPNAILADIAELDSLKTGSKREGLFYA
GRTFMQKLGQTLAVLIFSSVILLGLDRDSKQQVSPNVTGIIAPSVADSKSDLKKNNETEAKISKESSICKVEEVETGGEL
GVRLTGPLASAFCLLAIFLFGKYKEDETLEEIAKIRGK

Sequences:

>Translated_518_residues
MKHMQKPSLPFGKQISYAVGQLGWSTLINIIGLHQVYFYLPPAPKPGQDCFPDLIEKMAFWGLSTIGVVAAVGRLWDAFT
DPLIANSSDRFFSRFGRRIPFLFLGGIPSAVFCWLIFVPPHNFVSSTNLVWMTSFMLLFYLFLTVYVTPFFALIPELGHT
PEERLNLSTYISVTYALGIIVASTEPMIASVLQSSFVFDADPSLQTLVSRQYALGILCIFAAICMYFPVFTIHEKTYCES
EASSVPFKEAILLTFKNKNFLYFALSDLCYFLALTILTTGISYYVTVLLELERDFVTQLLTVMLLVSFAFYPVVNFVARK
IGKKRTVLIGFYLFLALFLSIFFIGKNSLPISPYIQGYMIVAVAAIPIAILGILPNAILADIAELDSLKTGSKREGLFYA
GRTFMQKLGQTLAVLIFSSVILLGLDRDSKQQVSPNVTGIIAPSVADSKSDLKKNNETEAKISKESSICKVEEVETGGEL
GVRLTGPLASAFCLLAIFLFGKYKEDETLEEIAKIRGK
>Mature_518_residues
MKHMQKPSLPFGKQISYAVGQLGWSTLINIIGLHQVYFYLPPAPKPGQDCFPDLIEKMAFWGLSTIGVVAAVGRLWDAFT
DPLIANSSDRFFSRFGRRIPFLFLGGIPSAVFCWLIFVPPHNFVSSTNLVWMTSFMLLFYLFLTVYVTPFFALIPELGHT
PEERLNLSTYISVTYALGIIVASTEPMIASVLQSSFVFDADPSLQTLVSRQYALGILCIFAAICMYFPVFTIHEKTYCES
EASSVPFKEAILLTFKNKNFLYFALSDLCYFLALTILTTGISYYVTVLLELERDFVTQLLTVMLLVSFAFYPVVNFVARK
IGKKRTVLIGFYLFLALFLSIFFIGKNSLPISPYIQGYMIVAVAAIPIAILGILPNAILADIAELDSLKTGSKREGLFYA
GRTFMQKLGQTLAVLIFSSVILLGLDRDSKQQVSPNVTGIIAPSVADSKSDLKKNNETEAKISKESSICKVEEVETGGEL
GVRLTGPLASAFCLLAIFLFGKYKEDETLEEIAKIRGK

Specific function: Responsible for the transport of glucuronide into the cell energized by the proton motive force (probably by symport). Import is enhanced by uidC (gusC, AC Q47706) [H]

COG id: COG2211

COG function: function code G; Na+/melibiose symporter and related transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:galactoside symporter (TC 2.A.2) family [H]

Homologues:

Organism=Homo sapiens, GI122937339, Length=361, Percent_Identity=24.3767313019391, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787902, Length=375, Percent_Identity=25.6, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87082306, Length=452, Percent_Identity=21.9026548672566, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI145693206, Length=434, Percent_Identity=23.5023041474654, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI48994989, Length=408, Percent_Identity=23.5294117647059, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001927
- InterPro:   IPR018043 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 57550; Mature: 57550

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHMQKPSLPFGKQISYAVGQLGWSTLINIIGLHQVYFYLPPAPKPGQDCFPDLIEKMAF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHH
WGLSTIGVVAAVGRLWDAFTDPLIANSSDRFFSRFGRRIPFLFLGGIPSAVFCWLIFVPP
HCHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHCCCCCEEEECCCHHHHHHHHHEECC
HNFVSSTNLVWMTSFMLLFYLFLTVYVTPFFALIPELGHTPEERLNLSTYISVTYALGII
CCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHH
VASTEPMIASVLQSSFVFDADPSLQTLVSRQYALGILCIFAAICMYFPVFTIHEKTYCES
EECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHCC
EASSVPFKEAILLTFKNKNFLYFALSDLCYFLALTILTTGISYYVTVLLELERDFVTQLL
CCCCCCHHHEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVMLLVSFAFYPVVNFVARKIGKKRTVLIGFYLFLALFLSIFFIGKNSLPISPYIQGYMI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
VAVAAIPIAILGILPNAILADIAELDSLKTGSKREGLFYAGRTFMQKLGQTLAVLIFSSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ILLGLDRDSKQQVSPNVTGIIAPSVADSKSDLKKNNETEAKISKESSICKVEEVETGGEL
HHHCCCCCCCHHCCCCCCEEECCCCCCCHHHHHCCCCHHHHHHHCCCCEEHHCCCCCCCC
GVRLTGPLASAFCLLAIFLFGKYKEDETLEEIAKIRGK
CEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKHMQKPSLPFGKQISYAVGQLGWSTLINIIGLHQVYFYLPPAPKPGQDCFPDLIEKMAF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHH
WGLSTIGVVAAVGRLWDAFTDPLIANSSDRFFSRFGRRIPFLFLGGIPSAVFCWLIFVPP
HCHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHCCCCCEEEECCCHHHHHHHHHEECC
HNFVSSTNLVWMTSFMLLFYLFLTVYVTPFFALIPELGHTPEERLNLSTYISVTYALGII
CCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHH
VASTEPMIASVLQSSFVFDADPSLQTLVSRQYALGILCIFAAICMYFPVFTIHEKTYCES
EECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHCC
EASSVPFKEAILLTFKNKNFLYFALSDLCYFLALTILTTGISYYVTVLLELERDFVTQLL
CCCCCCHHHEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVMLLVSFAFYPVVNFVARKIGKKRTVLIGFYLFLALFLSIFFIGKNSLPISPYIQGYMI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
VAVAAIPIAILGILPNAILADIAELDSLKTGSKREGLFYAGRTFMQKLGQTLAVLIFSSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ILLGLDRDSKQQVSPNVTGIIAPSVADSKSDLKKNNETEAKISKESSICKVEEVETGGEL
HHHCCCCCCCHHCCCCCCEEECCCCCCCHHHHHCCCCHHHHHHHCCCCEEHHCCCCCCCC
GVRLTGPLASAFCLLAIFLFGKYKEDETLEEIAKIRGK
CEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; Glucuronides [Periplasm] [C]

Specific reaction: Proton [Periplasm] + Glucuronides [Periplasm] = Proton [Cytoplasm] + Glucuronides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3534890 [H]