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The map label for this gene is gpo [C]

Identifier: 183220205

GI number: 183220205

Start: 814822

End: 815307

Strand: Direct

Name: gpo [C]

Synonym: LEPBI_I0796

Alternate gene names: 183220205

Gene position: 814822-815307 (Clockwise)

Preceding gene: 183220202

Following gene: 183220206

Centisome position: 22.64

GC content: 36.01

Gene sequence:

>486_bases
ATGGCGGAAGAATTTTACAATATTAAAGTGAAACGTGGATCGGAAGAGATTCCTATGGAACAATTTAAAGATAAGGTATT
GTTGATTGTGAATACCGCAAGTCAGTGTGGCTTCACTCCACAATATAAAGGCCTGCAAGAAACTTATGATCGTTGGAAAG
GCAAAGGTTTGGAAATTTTAGCTTTCCCTTGTAACCAGTTCGGAGAACAAGAACCTGGCTCCGATGCAGATATAAAATTG
TTTTGTGAAAAAACATTTTCTACAACTTTCCCAATCTTTTCTAAGCTCGAAGTGAACGGTCCAAATACGGATGCACTTTA
TATGCATTTAAAAAAGAATGCACCAGGAATTTTTGGTTCTCTTGATATCAAATGGAATTTTACAAAGTTCTTAGTCGATA
AAAATGGAAAGGTTGTTAAAAGATATGCACCGATTACAAAACCTGAAGCAATCGAGAAGGATATCGAAAAGCTTGTCCAA
GGTTAA

Upstream 100 bases:

>100_bases
AATTTTTCAGAATTTGTTTGTATTTTAATCAGAACTTCAAATAAAAAGATTGAACAAAATTAAATTGTGCACAATCTAAT
TTACAACAACGGAGAGTAAC

Downstream 100 bases:

>100_bases
ATCATCGAAAGAAGAGGTTCTTTTGTTGAAGAACCAAATTTGTTTTTCGATGTATTCCTCAATGCATCGATTGATGAAAC
TCTATCGTCCGCTTCTTGCG

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 161; Mature: 160

Protein sequence:

>161_residues
MAEEFYNIKVKRGSEEIPMEQFKDKVLLIVNTASQCGFTPQYKGLQETYDRWKGKGLEILAFPCNQFGEQEPGSDADIKL
FCEKTFSTTFPIFSKLEVNGPNTDALYMHLKKNAPGIFGSLDIKWNFTKFLVDKNGKVVKRYAPITKPEAIEKDIEKLVQ
G

Sequences:

>Translated_161_residues
MAEEFYNIKVKRGSEEIPMEQFKDKVLLIVNTASQCGFTPQYKGLQETYDRWKGKGLEILAFPCNQFGEQEPGSDADIKL
FCEKTFSTTFPIFSKLEVNGPNTDALYMHLKKNAPGIFGSLDIKWNFTKFLVDKNGKVVKRYAPITKPEAIEKDIEKLVQ
G
>Mature_160_residues
AEEFYNIKVKRGSEEIPMEQFKDKVLLIVNTASQCGFTPQYKGLQETYDRWKGKGLEILAFPCNQFGEQEPGSDADIKLF
CEKTFSTTFPIFSKLEVNGPNTDALYMHLKKNAPGIFGSLDIKWNFTKFLVDKNGKVVKRYAPITKPEAIEKDIEKLVQG

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=142, Percent_Identity=46.4788732394366, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI90903240, Length=142, Percent_Identity=46.4788732394366, Blast_Score=121, Evalue=3e-28,
Organism=Homo sapiens, GI15618997, Length=160, Percent_Identity=36.875, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI192455698, Length=158, Percent_Identity=36.7088607594937, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI4557629, Length=161, Percent_Identity=34.7826086956522, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI33186887, Length=169, Percent_Identity=34.3195266272189, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI6006001, Length=162, Percent_Identity=35.8024691358025, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI90903238, Length=117, Percent_Identity=42.7350427350427, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI41406084, Length=179, Percent_Identity=31.2849162011173, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI32967607, Length=185, Percent_Identity=29.7297297297297, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1788003, Length=150, Percent_Identity=46, Blast_Score=138, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17535473, Length=158, Percent_Identity=46.8354430379747, Blast_Score=140, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17506887, Length=155, Percent_Identity=45.8064516129032, Blast_Score=133, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71993584, Length=146, Percent_Identity=43.1506849315069, Blast_Score=123, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI193210707, Length=161, Percent_Identity=41.6149068322981, Blast_Score=116, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17550320, Length=177, Percent_Identity=29.9435028248588, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193209493, Length=181, Percent_Identity=27.6243093922652, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17507603, Length=113, Percent_Identity=40.7079646017699, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71993573, Length=81, Percent_Identity=37.037037037037, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319721, Length=160, Percent_Identity=51.25, Blast_Score=179, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322228, Length=158, Percent_Identity=51.8987341772152, Blast_Score=172, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322826, Length=158, Percent_Identity=45.5696202531646, Blast_Score=145, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24656772, Length=162, Percent_Identity=43.8271604938272, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24656767, Length=162, Percent_Identity=43.8271604938272, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24656777, Length=162, Percent_Identity=43.8271604938272, Blast_Score=126, Evalue=7e-30,
Organism=Drosophila melanogaster, GI85726443, Length=145, Percent_Identity=41.3793103448276, Blast_Score=110, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 18338; Mature: 18207

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEEFYNIKVKRGSEEIPMEQFKDKVLLIVNTASQCGFTPQYKGLQETYDRWKGKGLEIL
CCCCEEEEEEECCCCCCCHHHCCCEEEEEEECHHHCCCCCCCCCHHHHHHHHCCCCEEEE
AFPCNQFGEQEPGSDADIKLFCEKTFSTTFPIFSKLEVNGPNTDALYMHLKKNAPGIFGS
EECCHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCEEE
LDIKWNFTKFLVDKNGKVVKRYAPITKPEAIEKDIEKLVQG
EEEEECEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AEEFYNIKVKRGSEEIPMEQFKDKVLLIVNTASQCGFTPQYKGLQETYDRWKGKGLEIL
CCCEEEEEEECCCCCCCHHHCCCEEEEEEECHHHCCCCCCCCCHHHHHHHHCCCCEEEE
AFPCNQFGEQEPGSDADIKLFCEKTFSTTFPIFSKLEVNGPNTDALYMHLKKNAPGIFGS
EECCHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCEEE
LDIKWNFTKFLVDKNGKVVKRYAPITKPEAIEKDIEKLVQG
EEEEECEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]