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The map label for this gene is erg3 [H]

Identifier: 183220172

GI number: 183220172

Start: 777520

End: 778704

Strand: Direct

Name: erg3 [H]

Synonym: LEPBI_I0761

Alternate gene names: 183220172

Gene position: 777520-778704 (Clockwise)

Preceding gene: 183220171

Following gene: 183220173

Centisome position: 21.6

GC content: 38.06

Gene sequence:

>1185_bases
ATGAGACTGATAGAATCCATTGTTCCTTTTTATTTCCTTTTGATGCTCATTGAGATTCTTTACACTCGATTCAAAAAAAA
AGATTATTACTTTTATGAAGACTCACTTGCTGATTTGAGTTTGGGAGTATTGAGTCGGATCTTTGACGGCCTAATTTTAT
TAGGAATCGTTTATCTTTATTCCAAATTGTATCAATTCTCCATTGGTGCGGAAACACTCGACCACTACTTTCTTGGGACT
TCTTCCTTTTTGCATTGGGTGGTTTTATTTGTTCTTTTGGATTTTTTATTTTATGTAGCCCATCGGTATAGCCATGAAAT
CAAAATCCTTTGGGCATCTCATGTTGTGCACCATTCGAGTGAAGAGTTCAATTTGTCGGTTGCATTAAGGCAATCATTCA
TACGCAATATTGGGATTGGAATGTTTTATCTGCCACTGGCTTTATTGGGTTTTCCCGTGGAGTCCTATCTCATCATTGAT
GCCCTGAACCGAACCTACCAATTTTGGGTTCACACTCGTACCATCAAAAAACTTCCTAACTGGTTTGAAGCTGTGTTTGT
CACACCGTCACACCATCGAGTGCACCATGCGATGAATCCAGAATACATCGATAAAAACTATGGTGGAGTCTTTATCATAT
GGGATAAACTCTTTGGCACCTTTTGTGAGGAAAAATTTGAACCAAGGTATGGACTCACAACTCAATTGCATCATTATGAT
CCAATCCAAGCGAACATTCATGTATTAAAAGATTTGTTTTCCGATTTATTAACAACTAAAAAGAAATGGCAAGGGATTGT
TTCGTTTTTCTCCTATCCTTCTGTGCGCCCTGATGATTTACAAATCGCAGAGGATCGTGGGGTGCGCGATCCTAAAGTTT
GGCTCTCCCACCACCGTTTGGAATTAACCAATAAAGTATACCAACCCGTTCACCGATTGGCATCAGGTCAGTTCCTTTAC
CGAGTGACTCTTTTCTTTCAGTTTATGTTCCCAACCGTAATGACTTTGTATTTTTTAAAGCGGATGCATTTCTATGGTTT
GGCTGAAGTGTGTTCCGTTTTTGTTTTACTTGTGTTTTCTTTTTATTCCTTAGGAAATTTACTCGAAGGGAAAAAAGAAT
GGCTTTCGGTCGAAATTCCTAAGTATTTCTCTTGGCTATTTCTCTTGGTGTATTTTTTTACATAA

Upstream 100 bases:

>100_bases
TTGGTTTCCATAAATTTTTTAGTCCCAATCAAAAACATAGGAAAGATACTTGCTTTCCTATTATGATTCCTATCGATATA
AAAATCTTTAAGGTAAGTTT

Downstream 100 bases:

>100_bases
TAGAGCCATTCACTAATGAAATATTTACACACAATGATTCGTGTTCAAAATTTGGAGAAAGCCCTCCATTTTTTTGTCGA
TGTTTTGGGATTACAAGTTT

Product: putative sterol desaturase

Products: NA

Alternate protein names: Sterol-C5-desaturase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MRLIESIVPFYFLLMLIEILYTRFKKKDYYFYEDSLADLSLGVLSRIFDGLILLGIVYLYSKLYQFSIGAETLDHYFLGT
SSFLHWVVLFVLLDFLFYVAHRYSHEIKILWASHVVHHSSEEFNLSVALRQSFIRNIGIGMFYLPLALLGFPVESYLIID
ALNRTYQFWVHTRTIKKLPNWFEAVFVTPSHHRVHHAMNPEYIDKNYGGVFIIWDKLFGTFCEEKFEPRYGLTTQLHHYD
PIQANIHVLKDLFSDLLTTKKKWQGIVSFFSYPSVRPDDLQIAEDRGVRDPKVWLSHHRLELTNKVYQPVHRLASGQFLY
RVTLFFQFMFPTVMTLYFLKRMHFYGLAEVCSVFVLLVFSFYSLGNLLEGKKEWLSVEIPKYFSWLFLLVYFFT

Sequences:

>Translated_394_residues
MRLIESIVPFYFLLMLIEILYTRFKKKDYYFYEDSLADLSLGVLSRIFDGLILLGIVYLYSKLYQFSIGAETLDHYFLGT
SSFLHWVVLFVLLDFLFYVAHRYSHEIKILWASHVVHHSSEEFNLSVALRQSFIRNIGIGMFYLPLALLGFPVESYLIID
ALNRTYQFWVHTRTIKKLPNWFEAVFVTPSHHRVHHAMNPEYIDKNYGGVFIIWDKLFGTFCEEKFEPRYGLTTQLHHYD
PIQANIHVLKDLFSDLLTTKKKWQGIVSFFSYPSVRPDDLQIAEDRGVRDPKVWLSHHRLELTNKVYQPVHRLASGQFLY
RVTLFFQFMFPTVMTLYFLKRMHFYGLAEVCSVFVLLVFSFYSLGNLLEGKKEWLSVEIPKYFSWLFLLVYFFT
>Mature_394_residues
MRLIESIVPFYFLLMLIEILYTRFKKKDYYFYEDSLADLSLGVLSRIFDGLILLGIVYLYSKLYQFSIGAETLDHYFLGT
SSFLHWVVLFVLLDFLFYVAHRYSHEIKILWASHVVHHSSEEFNLSVALRQSFIRNIGIGMFYLPLALLGFPVESYLIID
ALNRTYQFWVHTRTIKKLPNWFEAVFVTPSHHRVHHAMNPEYIDKNYGGVFIIWDKLFGTFCEEKFEPRYGLTTQLHHYD
PIQANIHVLKDLFSDLLTTKKKWQGIVSFFSYPSVRPDDLQIAEDRGVRDPKVWLSHHRLELTNKVYQPVHRLASGQFLY
RVTLFFQFMFPTVMTLYFLKRMHFYGLAEVCSVFVLLVFSFYSLGNLLEGKKEWLSVEIPKYFSWLFLLVYFFT

Specific function: Unknown

COG id: COG3000

COG function: function code I; Sterol desaturase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sterol desaturase family [H]

Homologues:

Organism=Homo sapiens, GI51972212, Length=400, Percent_Identity=32.75, Blast_Score=171, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25144659, Length=228, Percent_Identity=35.9649122807018, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006694 [H]

Pfam domain/function: PF04116 FA_hydroxylase [H]

EC number: NA

Molecular weight: Translated: 46848; Mature: 46848

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIESIVPFYFLLMLIEILYTRFKKKDYYFYEDSLADLSLGVLSRIFDGLILLGIVYLY
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
SKLYQFSIGAETLDHYFLGTSSFLHWVVLFVLLDFLFYVAHRYSHEIKILWASHVVHHSS
HHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHCCC
EEFNLSVALRQSFIRNIGIGMFYLPLALLGFPVESYLIIDALNRTYQFWVHTRTIKKLPN
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WFEAVFVTPSHHRVHHAMNPEYIDKNYGGVFIIWDKLFGTFCEEKFEPRYGLTTQLHHYD
HHHHEEECCCCHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCC
PIQANIHVLKDLFSDLLTTKKKWQGIVSFFSYPSVRPDDLQIAEDRGVRDPKVWLSHHRL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHH
ELTNKVYQPVHRLASGQFLYRVTLFFQFMFPTVMTLYFLKRMHFYGLAEVCSVFVLLVFS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYSLGNLLEGKKEWLSVEIPKYFSWLFLLVYFFT
HHHHHHHHCCHHHHEEEECHHHHHHHHHHHHHHC
>Mature Secondary Structure
MRLIESIVPFYFLLMLIEILYTRFKKKDYYFYEDSLADLSLGVLSRIFDGLILLGIVYLY
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
SKLYQFSIGAETLDHYFLGTSSFLHWVVLFVLLDFLFYVAHRYSHEIKILWASHVVHHSS
HHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHCCC
EEFNLSVALRQSFIRNIGIGMFYLPLALLGFPVESYLIIDALNRTYQFWVHTRTIKKLPN
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WFEAVFVTPSHHRVHHAMNPEYIDKNYGGVFIIWDKLFGTFCEEKFEPRYGLTTQLHHYD
HHHHEEECCCCHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCC
PIQANIHVLKDLFSDLLTTKKKWQGIVSFFSYPSVRPDDLQIAEDRGVRDPKVWLSHHRL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHH
ELTNKVYQPVHRLASGQFLYRVTLFFQFMFPTVMTLYFLKRMHFYGLAEVCSVFVLLVFS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYSLGNLLEGKKEWLSVEIPKYFSWLFLLVYFFT
HHHHHHHHCCHHHHEEEECHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]