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The map label for this gene is lip2 [H]

Identifier: 183220076

GI number: 183220076

Start: 667034

End: 668080

Strand: Reverse

Name: lip2 [H]

Synonym: LEPBI_I0663

Alternate gene names: 183220076

Gene position: 668080-667034 (Counterclockwise)

Preceding gene: 183220077

Following gene: 183220075

Centisome position: 18.56

GC content: 46.23

Gene sequence:

>1047_bases
ATGTTAGGTATCAAAAAATCAGTCGCACAACTTGTCTTTTCGTTACCTGAGAATTGGATCTCTGCTCTCACTCGAAAAAA
CAATACCAATGAGTCCAATGCCTTAGACCCACGTTGTGCACTCGCTTGTAACATCGCAAGGTTCCTTCCGAAAATGGAAC
ATATGAGTCCTGAAAAAGCGAGAAAACATTACCGGGACCAAATGAAACTCTTCGAAGAGGGTGAATTTCCGATCGCTCAT
ATCGAAGACAAACTGATCCCCACTCCCAGTGCTTCCTTCATTCCCATCCGCGTTTACAATGCCAACCCTCAAAAAAGAAA
TCTCCCCACCATCCTCTTTTTCCATGGGGGTGGACTCACCATCGGCAACTTAGAGACACATGATTCTTTTTGTCGCAAAT
TGTCTCATTATACCAAAAGCATTGTGATTGCAGTCGATTACCGTTTGGCCCCGGAACACCCTTACCCAGCCGCACACGAT
GATGCTTGGCTTGCCTACCAATATGTTCGTAACTCAGCTTACATCTTTGGTGGGTCTCCGAAAGCCATTGCTGTTTGCGG
GGATAGCGCTGGCGCTCTCCTTGCCACGACCCTTTGCCTACGTGCCAAAAAAAACAATGTCCAAGCCCCCATTTACCAAG
CACTCCTCTATCCCATGCTTGATACTTCCAAAGAATCGGACACCTATGAACTCTTTGGGGAAAATTATGTCTTAACCAAA
ACGCTCATGCGCTGGTTCATCCAAAATTATTTGCCCCAAACCAAGGACCGAAGTTTGATACAGAACTCACCTGTTTTGGC
AGAGACCAAAGAACTGAAGGGTCTCCCACCTACCTACATTGGCATTGCCGGCTTTGATCCCCTCCGTGAAGAAGGGGAAA
CCTATGCCAAACACCTCCAAACAGCTGGTGTGAAGGTGGAAGAACGACATTTTCCTTCCCTTGTGCACGGATACATCCAA
TTGTCGGGGCTCATTCCAAAGGCAAAAGAAGCAGAAGAGGACCTCTTCCAATCCCTATTACGATTTTTTTCCCAAATCAA
AATCTAA

Upstream 100 bases:

>100_bases
AAAAACGTGTCTTGGAGGATTTGATAGCTTACTGCAAATTAGATAGTTACGGTTTGTTTTTAATCTATAGAATGTTACAA
GAAAGATTATCGGTTATTTA

Downstream 100 bases:

>100_bases
TTCACTTCCATTCAAGAATCGACACAGAAAGATTCGATACTATAAAGGACAACATCTAGAGGTATGTCATGATGCTACGA
TTTTCCATTCTTCTCTGTTA

Product: putative triacylglycerol lipase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MLGIKKSVAQLVFSLPENWISALTRKNNTNESNALDPRCALACNIARFLPKMEHMSPEKARKHYRDQMKLFEEGEFPIAH
IEDKLIPTPSASFIPIRVYNANPQKRNLPTILFFHGGGLTIGNLETHDSFCRKLSHYTKSIVIAVDYRLAPEHPYPAAHD
DAWLAYQYVRNSAYIFGGSPKAIAVCGDSAGALLATTLCLRAKKNNVQAPIYQALLYPMLDTSKESDTYELFGENYVLTK
TLMRWFIQNYLPQTKDRSLIQNSPVLAETKELKGLPPTYIGIAGFDPLREEGETYAKHLQTAGVKVEERHFPSLVHGYIQ
LSGLIPKAKEAEEDLFQSLLRFFSQIKI

Sequences:

>Translated_348_residues
MLGIKKSVAQLVFSLPENWISALTRKNNTNESNALDPRCALACNIARFLPKMEHMSPEKARKHYRDQMKLFEEGEFPIAH
IEDKLIPTPSASFIPIRVYNANPQKRNLPTILFFHGGGLTIGNLETHDSFCRKLSHYTKSIVIAVDYRLAPEHPYPAAHD
DAWLAYQYVRNSAYIFGGSPKAIAVCGDSAGALLATTLCLRAKKNNVQAPIYQALLYPMLDTSKESDTYELFGENYVLTK
TLMRWFIQNYLPQTKDRSLIQNSPVLAETKELKGLPPTYIGIAGFDPLREEGETYAKHLQTAGVKVEERHFPSLVHGYIQ
LSGLIPKAKEAEEDLFQSLLRFFSQIKI
>Mature_348_residues
MLGIKKSVAQLVFSLPENWISALTRKNNTNESNALDPRCALACNIARFLPKMEHMSPEKARKHYRDQMKLFEEGEFPIAH
IEDKLIPTPSASFIPIRVYNANPQKRNLPTILFFHGGGLTIGNLETHDSFCRKLSHYTKSIVIAVDYRLAPEHPYPAAHD
DAWLAYQYVRNSAYIFGGSPKAIAVCGDSAGALLATTLCLRAKKNNVQAPIYQALLYPMLDTSKESDTYELFGENYVLTK
TLMRWFIQNYLPQTKDRSLIQNSPVLAETKELKGLPPTYIGIAGFDPLREEGETYAKHLQTAGVKVEERHFPSLVHGYIQ
LSGLIPKAKEAEEDLFQSLLRFFSQIKI

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI68299767, Length=327, Percent_Identity=25.0764525993884, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI157041239, Length=143, Percent_Identity=31.4685314685315, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI206597554, Length=302, Percent_Identity=24.1721854304636, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI61966717, Length=287, Percent_Identity=22.2996515679443, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI21328446, Length=116, Percent_Identity=32.7586206896552, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786682, Length=279, Percent_Identity=29.0322580645161, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17567059, Length=287, Percent_Identity=27.8745644599303, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI72001146, Length=161, Percent_Identity=32.2981366459627, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540028, Length=142, Percent_Identity=31.6901408450704, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71996133, Length=142, Percent_Identity=30.9859154929577, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115533410, Length=98, Percent_Identity=31.6326530612245, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115533412, Length=98, Percent_Identity=31.6326530612245, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24656084, Length=175, Percent_Identity=27.4285714285714, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24656076, Length=175, Percent_Identity=27.4285714285714, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI20130169, Length=175, Percent_Identity=27.4285714285714, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 39304; Mature: 39304

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00122 CARBOXYLESTERASE_B_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGIKKSVAQLVFSLPENWISALTRKNNTNESNALDPRCALACNIARFLPKMEHMSPEKA
CCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
RKHYRDQMKLFEEGEFPIAHIEDKLIPTPSASFIPIRVYNANPQKRNLPTILFFHGGGLT
HHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCEE
IGNLETHDSFCRKLSHYTKSIVIAVDYRLAPEHPYPAAHDDAWLAYQYVRNSAYIFGGSP
ECCCCHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCEEEECCCC
KAIAVCGDSAGALLATTLCLRAKKNNVQAPIYQALLYPMLDTSKESDTYELFGENYVLTK
CEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHH
TLMRWFIQNYLPQTKDRSLIQNSPVLAETKELKGLPPTYIGIAGFDPLREEGETYAKHLQ
HHHHHHHHHHCCCCCCCHHHHCCCCCEEHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHH
TAGVKVEERHFPSLVHGYIQLSGLIPKAKEAEEDLFQSLLRFFSQIKI
HCCCEEHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLGIKKSVAQLVFSLPENWISALTRKNNTNESNALDPRCALACNIARFLPKMEHMSPEKA
CCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
RKHYRDQMKLFEEGEFPIAHIEDKLIPTPSASFIPIRVYNANPQKRNLPTILFFHGGGLT
HHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCEE
IGNLETHDSFCRKLSHYTKSIVIAVDYRLAPEHPYPAAHDDAWLAYQYVRNSAYIFGGSP
ECCCCHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCEEEECCCC
KAIAVCGDSAGALLATTLCLRAKKNNVQAPIYQALLYPMLDTSKESDTYELFGENYVLTK
CEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHH
TLMRWFIQNYLPQTKDRSLIQNSPVLAETKELKGLPPTYIGIAGFDPLREEGETYAKHLQ
HHHHHHHHHHCCCCCCCHHHHCCCCCEEHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHH
TAGVKVEERHFPSLVHGYIQLSGLIPKAKEAEEDLFQSLLRFFSQIKI
HCCCEEHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]