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The map label for this gene is fadB2 [H]

Identifier: 183220016

GI number: 183220016

Start: 602104

End: 603414

Strand: Reverse

Name: fadB2 [H]

Synonym: LEPBI_I0599

Alternate gene names: 183220016

Gene position: 603414-602104 (Counterclockwise)

Preceding gene: 183220019

Following gene: 183220015

Centisome position: 16.76

GC content: 43.33

Gene sequence:

>1311_bases
ATGAGAGAAATCAAAACTGTCACGATTTTAGGTGCCAACGGAGCCATGGGTTCTGGAAGTGCAGGCGTCATTGCTGCCTT
CGGTGGTGCTAAAGTCCATATGCTCGCTAGAGATGTAGAAAAAGCAAAACAGGGTATCGAAGCCGCTGTCGCATCCGTCA
AAACGGATACAATTCGCGCTAGAATGATCCCTGGTTCCTACGATGCGGATCTGGAAAAAGCTGTCGCAGAGTCAGATTGG
GTATTCGAACTCGTGGCGGAAAGTTACGAAGTCAAAGAACCGATCAATACTCGTATTGCAAAGGCTCGCCGTCCAGGAAC
CATTGTGTCCACTGTGTCTTCTGGTTTATCCATTGGTCGTTTGGCAAAAGCATACGACGAAGATGGCCAAAAACATTATT
ACGGAACCCATTTTTTTAACCCTCCTTACAAAATGATCCTTTGTGAACTCGTCACTCACTCTGGAAACGATAAAAAAGTC
ACACAAGCGTTAGGTGAATACTTAGACAAAGTACTCGGCCGTGCTGTTGTGTATACAAATGACACTCCTGCTTTCGCTGG
AAACCGCATTGGATTCCAGTTGATGAACGAAGTGGCTCACTTTGCAGAAAAGTATGCTGACAAAGGTGGAATCGCCCTTA
TGGACGAAATCATGTCTGGTTACACGGGCCGTGCTATGGGGCCTTTGGCAACTGCTGACTTCGTAGGACTTGATGTTCAC
AAAGCCATCGTAGACAATATCTATGACAATACAAAAGACGAAGCACACGAAACTTTCAAACTTCCAGGTTACTTCCAAAA
GTTAATCGATGCTGGTAAACTTGGTATGAAATCGGGTGGTGGTCTCACAAAAGTGGTGAAACACGCTGACGGAAAACGTG
AGAAGTTTGTTTATAATATCAAAACTGGCGAGTACGATCCGTACCCAAAATTTGATATTCCTTTTATCAAAGAAGCTCGC
CAAAAAATCAAAGAATCAAACTACAAAGGTGCTATGGACGTTGTGAAAAATGCATCTGGATTTGAAGCAGAGATCGCTCG
TTACTTCATTTCACGTTACATCAGTTATTCGCTCTCTCTCGTAGGAGAAGTTGTGGATACAAAAGAAAACACTGACGGAG
CAATGGGTTTCGGTTTTAACTGGGTACCTGCTTCTGCCTTCGTTGATTTCCTTGGTGGACCAAAAGAAACAATTAAGTTA
ATGGAAGCGTCTAAAATACCAGTTCCAAAACTTTTAAAAGATGCTAAAGAAGGCAAAAAGTTCTACGAACTTGGCGACAA
ACTTGATGCACGGTCTCTCTTCAAAGGTTAA

Upstream 100 bases:

>100_bases
ACCGCCCCTCTTTTGTAACAAATCTGACAAAAAAAAACGATTTTCCTGTCACCTCGGCTTTCTAGAACGGTAAGTAAAAA
TTAGATTCGGAAATTCCTTC

Downstream 100 bases:

>100_bases
TTAGGAGTATCATATGAGTGAAAAAGTATTCGTACTAGGCGGGGAACAAACCGACTTCCAAAGAAACTGGACCAAAGAAG
GAAAAACCTTCATGTCCATG

Product: 3-hydroxyacyl-CoA dehydrogenase FadB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MREIKTVTILGANGAMGSGSAGVIAAFGGAKVHMLARDVEKAKQGIEAAVASVKTDTIRARMIPGSYDADLEKAVAESDW
VFELVAESYEVKEPINTRIAKARRPGTIVSTVSSGLSIGRLAKAYDEDGQKHYYGTHFFNPPYKMILCELVTHSGNDKKV
TQALGEYLDKVLGRAVVYTNDTPAFAGNRIGFQLMNEVAHFAEKYADKGGIALMDEIMSGYTGRAMGPLATADFVGLDVH
KAIVDNIYDNTKDEAHETFKLPGYFQKLIDAGKLGMKSGGGLTKVVKHADGKREKFVYNIKTGEYDPYPKFDIPFIKEAR
QKIKESNYKGAMDVVKNASGFEAEIARYFISRYISYSLSLVGEVVDTKENTDGAMGFGFNWVPASAFVDFLGGPKETIKL
MEASKIPVPKLLKDAKEGKKFYELGDKLDARSLFKG

Sequences:

>Translated_436_residues
MREIKTVTILGANGAMGSGSAGVIAAFGGAKVHMLARDVEKAKQGIEAAVASVKTDTIRARMIPGSYDADLEKAVAESDW
VFELVAESYEVKEPINTRIAKARRPGTIVSTVSSGLSIGRLAKAYDEDGQKHYYGTHFFNPPYKMILCELVTHSGNDKKV
TQALGEYLDKVLGRAVVYTNDTPAFAGNRIGFQLMNEVAHFAEKYADKGGIALMDEIMSGYTGRAMGPLATADFVGLDVH
KAIVDNIYDNTKDEAHETFKLPGYFQKLIDAGKLGMKSGGGLTKVVKHADGKREKFVYNIKTGEYDPYPKFDIPFIKEAR
QKIKESNYKGAMDVVKNASGFEAEIARYFISRYISYSLSLVGEVVDTKENTDGAMGFGFNWVPASAFVDFLGGPKETIKL
MEASKIPVPKLLKDAKEGKKFYELGDKLDARSLFKG
>Mature_436_residues
MREIKTVTILGANGAMGSGSAGVIAAFGGAKVHMLARDVEKAKQGIEAAVASVKTDTIRARMIPGSYDADLEKAVAESDW
VFELVAESYEVKEPINTRIAKARRPGTIVSTVSSGLSIGRLAKAYDEDGQKHYYGTHFFNPPYKMILCELVTHSGNDKKV
TQALGEYLDKVLGRAVVYTNDTPAFAGNRIGFQLMNEVAHFAEKYADKGGIALMDEIMSGYTGRAMGPLATADFVGLDVH
KAIVDNIYDNTKDEAHETFKLPGYFQKLIDAGKLGMKSGGGLTKVVKHADGKREKFVYNIKTGEYDPYPKFDIPFIKEAR
QKIKESNYKGAMDVVKNASGFEAEIARYFISRYISYSLSLVGEVVDTKENTDGAMGFGFNWVPASAFVDFLGGPKETIKL
MEASKIPVPKLLKDAKEGKKFYELGDKLDARSLFKG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=295, Percent_Identity=29.8305084745763, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI296179427, Length=309, Percent_Identity=28.1553398058252, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1787661, Length=291, Percent_Identity=28.5223367697594, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790281, Length=226, Percent_Identity=26.9911504424779, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17549919, Length=303, Percent_Identity=30.03300330033, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17553560, Length=297, Percent_Identity=27.6094276094276, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17508951, Length=371, Percent_Identity=27.7628032345013, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508953, Length=371, Percent_Identity=27.7628032345013, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17563036, Length=297, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558304, Length=449, Percent_Identity=23.6080178173719, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25144276, Length=228, Percent_Identity=28.0701754385965, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921000, Length=446, Percent_Identity=26.6816143497758, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583077, Length=446, Percent_Identity=26.6816143497758, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583079, Length=446, Percent_Identity=26.6816143497758, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 47681; Mature: 47681

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREIKTVTILGANGAMGSGSAGVIAAFGGAKVHMLARDVEKAKQGIEAAVASVKTDTIRA
CCCEEEEEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
RMIPGSYDADLEKAVAESDWVFELVAESYEVKEPINTRIAKARRPGTIVSTVSSGLSIGR
EECCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHCCCHHHH
LAKAYDEDGQKHYYGTHFFNPPYKMILCELVTHSGNDKKVTQALGEYLDKVLGRAVVYTN
HHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEC
DTPAFAGNRIGFQLMNEVAHFAEKYADKGGIALMDEIMSGYTGRAMGPLATADFVGLDVH
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
KAIVDNIYDNTKDEAHETFKLPGYFQKLIDAGKLGMKSGGGLTKVVKHADGKREKFVYNI
HHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCEEEEEE
KTGEYDPYPKFDIPFIKEARQKIKESNYKGAMDVVKNASGFEAEIARYFISRYISYSLSL
ECCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VGEVVDTKENTDGAMGFGFNWVPASAFVDFLGGPKETIKLMEASKIPVPKLLKDAKEGKK
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
FYELGDKLDARSLFKG
HHHHHCCCCHHHHCCC
>Mature Secondary Structure
MREIKTVTILGANGAMGSGSAGVIAAFGGAKVHMLARDVEKAKQGIEAAVASVKTDTIRA
CCCEEEEEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
RMIPGSYDADLEKAVAESDWVFELVAESYEVKEPINTRIAKARRPGTIVSTVSSGLSIGR
EECCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHCCCHHHH
LAKAYDEDGQKHYYGTHFFNPPYKMILCELVTHSGNDKKVTQALGEYLDKVLGRAVVYTN
HHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEC
DTPAFAGNRIGFQLMNEVAHFAEKYADKGGIALMDEIMSGYTGRAMGPLATADFVGLDVH
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
KAIVDNIYDNTKDEAHETFKLPGYFQKLIDAGKLGMKSGGGLTKVVKHADGKREKFVYNI
HHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCEEEEEE
KTGEYDPYPKFDIPFIKEARQKIKESNYKGAMDVVKNASGFEAEIARYFISRYISYSLSL
ECCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VGEVVDTKENTDGAMGFGFNWVPASAFVDFLGGPKETIKLMEASKIPVPKLLKDAKEGKK
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
FYELGDKLDARSLFKG
HHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]