Click here to switch to the map view.

The map label for this gene is fadA2 [C]

Identifier: 183220015

GI number: 183220015

Start: 600825

End: 602090

Strand: Reverse

Name: fadA2 [C]

Synonym: LEPBI_I0598

Alternate gene names: 183220015

Gene position: 602090-600825 (Counterclockwise)

Preceding gene: 183220016

Following gene: 183220014

Centisome position: 16.73

GC content: 43.6

Gene sequence:

>1266_bases
ATGAGTGAAAAAGTATTCGTACTAGGCGGGGAACAAACCGACTTCCAAAGAAACTGGACCAAAGAAGGAAAAACCTTCAT
GTCCATGATGCGTGAAGTGTTAGATGATGCTCTTGAAAAAGTTGGCATCAGTTATGATGAAATCAAACGATTGAACAAAG
AAAACAAAGTAGCTGTTTTCGTTGGTAACTTTGATGCAGAACAGTATGCGAACCAAGGTCACTTGGGTGCTTTTTTAACA
GAAGTAAACCCTGCTCTTTTTGGTGTGCCTGGTGCACGTTACGAAGCAGCTTGTGCTTCTGGATCTGTTGCCCTTGATGC
TGCCATCACACACATCCGTGCCGAAGATTATGATCTAGCGATCGTTCTAGGTGTGGAAGTGATGAAAACCGTTTCTTCTT
CTGTGGGTGGTGACTTTCTTGGAACTGCTGCGTATTATGATAAAGAAGCGAAAGGGGTTCAATTTCCTTTCCCTAAACTT
TTCGGAAAACTAGCAGATGTGATCTTAGAAAGATACGAACTGAAAGAAGAACGATTTATGGATGCACTTGCTGAAATTTC
TCGTATCAATTACGCAAACGCAAAACGGAACCCAAAAGCTCAAACTCGCACTTGGTTCATGAACAAAGAACATGCAATGG
CTCGTGGTGGTGCAAACAATATGGCAGTTGGTGGAAGGCTTTGTATCACTGACTGTTCCCAAGTCACAGACGGTGCTGCT
GTTACCATCCTTGCTTCTAAAGACTACACCAAAGAATACGCTAAAAAAACAGGCCGTAAAATTGATGACATCCCTCGTGT
GAAAGGATGGGGTCACCGAGTGGCGCCGATTACCTTTGAAGCAAAAAAACAAGAATCCGTTGGGGACAAATACATCCTTC
CATGGACTCGCCAAACAGTAAAAGATGCTTACAAACGTGCTGACCTCGATGTAAAAAACATTGATGTGTTTGAAACACAT
GACTGTTTTACTTCTTCTGAGTATGCTGCGATTTCTGCTTTCGGAATCTCAGAACCAGGAAAAGAACACGTCGCGATCGA
AGAAGGAACGATTGACTTCGGTGGTAAAAAACCAATCAATCCATCCGGCGGACTCATCGGTGTGGGTCACCCAGTAGGTG
CATCCGGTGTTCGTATGATGCTTGACCTTTACAAACAAGTCACGAATACCGCAGGCGACTACCAAGTGAAAGGAGCAAAG
AACGGTCTTATGCTCAACATTGGTGGATCTGCTACTACGAACTTCGTGTTCATCTTAGGAAAGTAA

Upstream 100 bases:

>100_bases
CCAAAACTTTTAAAAGATGCTAAAGAAGGCAAAAAGTTCTACGAACTTGGCGACAAACTTGATGCACGGTCTCTCTTCAA
AGGTTAATTAGGAGTATCAT

Downstream 100 bases:

>100_bases
TCCAGTGAATTCGCTGAATACAGAAAAATGGAATCGGATACTCGTCCGGTTCCTTCTCGCCTTTTCGTTTTGGGAAGCCG
TATCCATCCCGGTTCGAATG

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSEKVFVLGGEQTDFQRNWTKEGKTFMSMMREVLDDALEKVGISYDEIKRLNKENKVAVFVGNFDAEQYANQGHLGAFLT
EVNPALFGVPGARYEAACASGSVALDAAITHIRAEDYDLAIVLGVEVMKTVSSSVGGDFLGTAAYYDKEAKGVQFPFPKL
FGKLADVILERYELKEERFMDALAEISRINYANAKRNPKAQTRTWFMNKEHAMARGGANNMAVGGRLCITDCSQVTDGAA
VTILASKDYTKEYAKKTGRKIDDIPRVKGWGHRVAPITFEAKKQESVGDKYILPWTRQTVKDAYKRADLDVKNIDVFETH
DCFTSSEYAAISAFGISEPGKEHVAIEEGTIDFGGKKPINPSGGLIGVGHPVGASGVRMMLDLYKQVTNTAGDYQVKGAK
NGLMLNIGGSATTNFVFILGK

Sequences:

>Translated_421_residues
MSEKVFVLGGEQTDFQRNWTKEGKTFMSMMREVLDDALEKVGISYDEIKRLNKENKVAVFVGNFDAEQYANQGHLGAFLT
EVNPALFGVPGARYEAACASGSVALDAAITHIRAEDYDLAIVLGVEVMKTVSSSVGGDFLGTAAYYDKEAKGVQFPFPKL
FGKLADVILERYELKEERFMDALAEISRINYANAKRNPKAQTRTWFMNKEHAMARGGANNMAVGGRLCITDCSQVTDGAA
VTILASKDYTKEYAKKTGRKIDDIPRVKGWGHRVAPITFEAKKQESVGDKYILPWTRQTVKDAYKRADLDVKNIDVFETH
DCFTSSEYAAISAFGISEPGKEHVAIEEGTIDFGGKKPINPSGGLIGVGHPVGASGVRMMLDLYKQVTNTAGDYQVKGAK
NGLMLNIGGSATTNFVFILGK
>Mature_420_residues
SEKVFVLGGEQTDFQRNWTKEGKTFMSMMREVLDDALEKVGISYDEIKRLNKENKVAVFVGNFDAEQYANQGHLGAFLTE
VNPALFGVPGARYEAACASGSVALDAAITHIRAEDYDLAIVLGVEVMKTVSSSVGGDFLGTAAYYDKEAKGVQFPFPKLF
GKLADVILERYELKEERFMDALAEISRINYANAKRNPKAQTRTWFMNKEHAMARGGANNMAVGGRLCITDCSQVTDGAAV
TILASKDYTKEYAKKTGRKIDDIPRVKGWGHRVAPITFEAKKQESVGDKYILPWTRQTVKDAYKRADLDVKNIDVFETHD
CFTSSEYAAISAFGISEPGKEHVAIEEGTIDFGGKKPINPSGGLIGVGHPVGASGVRMMLDLYKQVTNTAGDYQVKGAKN
GLMLNIGGSATTNFVFILGK

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=426, Percent_Identity=27.4647887323944, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI302344767, Length=344, Percent_Identity=29.0697674418605, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI302344760, Length=344, Percent_Identity=29.0697674418605, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI302344762, Length=264, Percent_Identity=30.6818181818182, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI55956775, Length=219, Percent_Identity=30.1369863013699, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17537653, Length=421, Percent_Identity=26.3657957244656, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24585051, Length=438, Percent_Identity=24.4292237442922, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI19921506, Length=438, Percent_Identity=24.2009132420091, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 46056; Mature: 45925

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKVFVLGGEQTDFQRNWTKEGKTFMSMMREVLDDALEKVGISYDEIKRLNKENKVAVF
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEE
VGNFDAEQYANQGHLGAFLTEVNPALFGVPGARYEAACASGSVALDAAITHIRAEDYDLA
EECCCHHHHCCCCCCCHHHHHCCHHHCCCCCCCHHHHHCCCCEEHHHHHHHHCCCCCCEE
IVLGVEVMKTVSSSVGGDFLGTAAYYDKEAKGVQFPFPKLFGKLADVILERYELKEERFM
EEEHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DALAEISRINYANAKRNPKAQTRTWFMNKEHAMARGGANNMAVGGRLCITDCSQVTDGAA
HHHHHHHHCCCCCCCCCCCCHHHEEECCCHHHHHCCCCCCCEECCEEEECCHHHCCCCCE
VTILASKDYTKEYAKKTGRKIDDIPRVKGWGHRVAPITFEAKKQESVGDKYILPWTRQTV
EEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCEECEEEEECCHHHCCCCCEECCCCHHHH
KDAYKRADLDVKNIDVFETHDCFTSSEYAAISAFGISEPGKEHVAIEEGTIDFGGKKPIN
HHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCEEEECCEEECCCCCCCC
PSGGLIGVGHPVGASGVRMMLDLYKQVTNTAGDYQVKGAKNGLMLNIGGSATTNFVFILG
CCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCCCEEEEEEE
K
C
>Mature Secondary Structure 
SEKVFVLGGEQTDFQRNWTKEGKTFMSMMREVLDDALEKVGISYDEIKRLNKENKVAVF
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEE
VGNFDAEQYANQGHLGAFLTEVNPALFGVPGARYEAACASGSVALDAAITHIRAEDYDLA
EECCCHHHHCCCCCCCHHHHHCCHHHCCCCCCCHHHHHCCCCEEHHHHHHHHCCCCCCEE
IVLGVEVMKTVSSSVGGDFLGTAAYYDKEAKGVQFPFPKLFGKLADVILERYELKEERFM
EEEHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DALAEISRINYANAKRNPKAQTRTWFMNKEHAMARGGANNMAVGGRLCITDCSQVTDGAA
HHHHHHHHCCCCCCCCCCCCHHHEEECCCHHHHHCCCCCCCEECCEEEECCHHHCCCCCE
VTILASKDYTKEYAKKTGRKIDDIPRVKGWGHRVAPITFEAKKQESVGDKYILPWTRQTV
EEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCEECEEEEECCHHHCCCCCEECCCCHHHH
KDAYKRADLDVKNIDVFETHDCFTSSEYAAISAFGISEPGKEHVAIEEGTIDFGGKKPIN
HHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCEEEECCEEECCCCCCCC
PSGGLIGVGHPVGASGVRMMLDLYKQVTNTAGDYQVKGAKNGLMLNIGGSATTNFVFILG
CCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCCCEEEEEEE
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]