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The map label for this gene is cyaA [H]

Identifier: 183220008

GI number: 183220008

Start: 590724

End: 592304

Strand: Reverse

Name: cyaA [H]

Synonym: LEPBI_I0591

Alternate gene names: 183220008

Gene position: 592304-590724 (Counterclockwise)

Preceding gene: 183220009

Following gene: 183220007

Centisome position: 16.45

GC content: 37.38

Gene sequence:

>1581_bases
TTGAATCCCATGGTGCCAAAACAAAGACTTCAATTCCTAGCCTTCTTACTCATTTATTTTATTGTCCCATTCTCTGCCTG
TTTCTTCACTTTAATCTTTGCCAACTATACTTCCACAGCCTTCTTACCTGAAAAATTTTTAATTCTTTTCGAAGCAACAA
GAGTGACTCAAGACTTCACCTTATTTGCGTTAACCTGGGCACCATTTCCAATCATTACATTCATTTTATTTTTTTATAGT
TTGCCTGTTGCCAATTATCTCTTCAAAAAAGACAAATGTAATTATCTATCGGAAGAGAAAGCTCGCCATCGAATTGTGCA
CTCTCCCATCATCATCAGTTTGTTTGGTTTTTTTGGTTGGGAACTTTCCACCATTTTATCAGTTTTACGCATTGATACTC
TTTATCCGGAAGCACCACCACAAAGTATCTTGACTGTCACGATTTTGTTTGCATTTTGGGGACTTTTTTTGTTTGCCTTT
TCTTATTCTGCAACCAATTTTCTCAATAAAAAATTGATCATTCCATGTGTGTTCCCTGATGGTGGACTTGGAAAATACGC
AAAAGGAAAACAATTTTCCATTGTTACAAAACAAATTATTTTTTGGACAGCATCCACATTATTTCCTATCGTACTTTTGA
TTTTTGGATTATTGCTTAGGACAAATCAAAATCTATTCGATTTACACCAATTGGTTCATAACGATGTATTATTCGAAGTG
ATCGCAATTATGCTTTTCTTTTCTTTTATATTTTCAGTTACCTTTGCCATTAGTTTACAACATCCACTCAACAAAATTGA
AGAAGCAACAGAACTCATCAAAGAACAAAAGTTTGATACAAGAGTCACTATCTTTAGTTCCGACGAACTGGGACTTCTCG
GAGATGCTGTCAATGAAATGGCAGAAGGCCTTGCGGAAAGAGAAAGGATTAAGGATACTTTTGGGAGAATTGTAGATCCA
AGAGTAAGGGATTACCTTCTCTCCAATGAACATAGTTTAGGTGGAAAAGTGGTTGATGCCACGATCCTCTTTTCGGACTT
AAGGGATTTTACAAAACTATCAGAAAAAAGAACCCCTGAAGAAGTTTTGTATATCCTCAATCGGTACTTCCAAGAAATGA
GTAATGCCATCGAAATCCATGGTGGATTTATTAACAAATTCATCGGAGATGCAATTTTGGCTGTTTTTGGAACACCAATG
CCCATGACCGACCATGTGGATCGTGCCTTTCAAACTGCTCTTCAAATGCAAAAGAATTTAGACCTTCTCAACAAACAATT
CTTAGGGGAAGGTTTAACCGAACTCAAAATGGGAATTGGGATCCATACTGGTAGTTTGCTTGTGGGAAACATTGGTTCCG
CCAATCGTATGGAATTCACAGTCATTGGTGATACCGTGAACACTGCCTCAAGGGTCGAAGGACTTTGTAAGGGATTACAA
AAAAATCTACTGATCACTGAAAACACGGCCAATCTATTACCTGATGTGATCCGATCTCGATTGCAGTCAGAAGGTGAATT
TGAACTGAAAGGCAGAGAATCGAAAGAGAAAATTTATTCCTATCCTGTGGCCTTGGGTTAG

Upstream 100 bases:

>100_bases
ATCATCTTTTTGTTTTTTCCATTAACGGATGCAAAACACATCCAAGTCCAACGAATCTTGACAAAAAGAACATTGAAAAA
GGAAACTAGGTAAGTAAGAT

Downstream 100 bases:

>100_bases
GTCAAAAAAACCGAATAAAGGGTTGAATCCATTTTTGAAACGAGTCAAAATGGTGATTATGAGATTTGTTTTAAGTTTAC
TAGGATTCTGTATGTACTTC

Product: putative adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MNPMVPKQRLQFLAFLLIYFIVPFSACFFTLIFANYTSTAFLPEKFLILFEATRVTQDFTLFALTWAPFPIITFILFFYS
LPVANYLFKKDKCNYLSEEKARHRIVHSPIIISLFGFFGWELSTILSVLRIDTLYPEAPPQSILTVTILFAFWGLFLFAF
SYSATNFLNKKLIIPCVFPDGGLGKYAKGKQFSIVTKQIIFWTASTLFPIVLLIFGLLLRTNQNLFDLHQLVHNDVLFEV
IAIMLFFSFIFSVTFAISLQHPLNKIEEATELIKEQKFDTRVTIFSSDELGLLGDAVNEMAEGLAERERIKDTFGRIVDP
RVRDYLLSNEHSLGGKVVDATILFSDLRDFTKLSEKRTPEEVLYILNRYFQEMSNAIEIHGGFINKFIGDAILAVFGTPM
PMTDHVDRAFQTALQMQKNLDLLNKQFLGEGLTELKMGIGIHTGSLLVGNIGSANRMEFTVIGDTVNTASRVEGLCKGLQ
KNLLITENTANLLPDVIRSRLQSEGEFELKGRESKEKIYSYPVALG

Sequences:

>Translated_526_residues
MNPMVPKQRLQFLAFLLIYFIVPFSACFFTLIFANYTSTAFLPEKFLILFEATRVTQDFTLFALTWAPFPIITFILFFYS
LPVANYLFKKDKCNYLSEEKARHRIVHSPIIISLFGFFGWELSTILSVLRIDTLYPEAPPQSILTVTILFAFWGLFLFAF
SYSATNFLNKKLIIPCVFPDGGLGKYAKGKQFSIVTKQIIFWTASTLFPIVLLIFGLLLRTNQNLFDLHQLVHNDVLFEV
IAIMLFFSFIFSVTFAISLQHPLNKIEEATELIKEQKFDTRVTIFSSDELGLLGDAVNEMAEGLAERERIKDTFGRIVDP
RVRDYLLSNEHSLGGKVVDATILFSDLRDFTKLSEKRTPEEVLYILNRYFQEMSNAIEIHGGFINKFIGDAILAVFGTPM
PMTDHVDRAFQTALQMQKNLDLLNKQFLGEGLTELKMGIGIHTGSLLVGNIGSANRMEFTVIGDTVNTASRVEGLCKGLQ
KNLLITENTANLLPDVIRSRLQSEGEFELKGRESKEKIYSYPVALG
>Mature_526_residues
MNPMVPKQRLQFLAFLLIYFIVPFSACFFTLIFANYTSTAFLPEKFLILFEATRVTQDFTLFALTWAPFPIITFILFFYS
LPVANYLFKKDKCNYLSEEKARHRIVHSPIIISLFGFFGWELSTILSVLRIDTLYPEAPPQSILTVTILFAFWGLFLFAF
SYSATNFLNKKLIIPCVFPDGGLGKYAKGKQFSIVTKQIIFWTASTLFPIVLLIFGLLLRTNQNLFDLHQLVHNDVLFEV
IAIMLFFSFIFSVTFAISLQHPLNKIEEATELIKEQKFDTRVTIFSSDELGLLGDAVNEMAEGLAERERIKDTFGRIVDP
RVRDYLLSNEHSLGGKVVDATILFSDLRDFTKLSEKRTPEEVLYILNRYFQEMSNAIEIHGGFINKFIGDAILAVFGTPM
PMTDHVDRAFQTALQMQKNLDLLNKQFLGEGLTELKMGIGIHTGSLLVGNIGSANRMEFTVIGDTVNTASRVEGLCKGLQ
KNLLITENTANLLPDVIRSRLQSEGEFELKGRESKEKIYSYPVALG

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI50959205, Length=206, Percent_Identity=27.6699029126214, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI167830411, Length=182, Percent_Identity=31.3186813186813, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI4580422, Length=182, Percent_Identity=30.2197802197802, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71989822, Length=253, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71989805, Length=253, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17508769, Length=220, Percent_Identity=28.6363636363636, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI193206632, Length=217, Percent_Identity=29.9539170506912, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17551720, Length=157, Percent_Identity=29.9363057324841, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86564713, Length=235, Percent_Identity=24.6808510638298, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193207841, Length=223, Percent_Identity=29.1479820627803, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17568383, Length=201, Percent_Identity=32.8358208955224, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71990146, Length=194, Percent_Identity=25.2577319587629, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71982300, Length=177, Percent_Identity=29.3785310734463, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17561802, Length=227, Percent_Identity=29.0748898678414, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983004, Length=200, Percent_Identity=26.5, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17534659, Length=224, Percent_Identity=27.6785714285714, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17534657, Length=175, Percent_Identity=31.4285714285714, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561800, Length=174, Percent_Identity=31.6091954022989, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193206054, Length=202, Percent_Identity=30.1980198019802, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561810, Length=237, Percent_Identity=24.4725738396624, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17534649, Length=184, Percent_Identity=28.804347826087, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI212645052, Length=223, Percent_Identity=28.2511210762332, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17561804, Length=223, Percent_Identity=26.9058295964126, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193205840, Length=174, Percent_Identity=28.1609195402299, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI62484298, Length=235, Percent_Identity=28.936170212766, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62484477, Length=235, Percent_Identity=28.936170212766, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI116008008, Length=235, Percent_Identity=28.936170212766, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI62473752, Length=158, Percent_Identity=29.746835443038, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17137448, Length=158, Percent_Identity=29.746835443038, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221330468, Length=208, Percent_Identity=27.8846153846154, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221330470, Length=208, Percent_Identity=27.8846153846154, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161078020, Length=221, Percent_Identity=27.6018099547511, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161076872, Length=230, Percent_Identity=28.695652173913, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574512, Length=230, Percent_Identity=28.695652173913, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI85725044, Length=173, Percent_Identity=28.9017341040462, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366320, Length=179, Percent_Identity=27.3743016759777, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 59734; Mature: 59734

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS50885 HAMP ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPMVPKQRLQFLAFLLIYFIVPFSACFFTLIFANYTSTAFLPEKFLILFEATRVTQDFT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHHCCCCE
LFALTWAPFPIITFILFFYSLPVANYLFKKDKCNYLSEEKARHRIVHSPIIISLFGFFGW
EEEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
ELSTILSVLRIDTLYPEAPPQSILTVTILFAFWGLFLFAFSYSATNFLNKKLIIPCVFPD
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
GGLGKYAKGKQFSIVTKQIIFWTASTLFPIVLLIFGLLLRTNQNLFDLHQLVHNDVLFEV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
IAIMLFFSFIFSVTFAISLQHPLNKIEEATELIKEQKFDTRVTIFSSDELGLLGDAVNEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHH
AEGLAERERIKDTFGRIVDPRVRDYLLSNEHSLGGKVVDATILFSDLRDFTKLSEKRTPE
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHH
EVLYILNRYFQEMSNAIEIHGGFINKFIGDAILAVFGTPMPMTDHVDRAFQTALQMQKNL
HHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DLLNKQFLGEGLTELKMGIGIHTGSLLVGNIGSANRMEFTVIGDTVNTASRVEGLCKGLQ
HHHHHHHHHCCHHHHHHHCCEEECCEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
KNLLITENTANLLPDVIRSRLQSEGEFELKGRESKEKIYSYPVALG
HCEEEECCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHCCCCCC
>Mature Secondary Structure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HCEEEECCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]