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The map label for this gene is acdA1 [H]

Identifier: 183219531

GI number: 183219531

Start: 105216

End: 106343

Strand: Direct

Name: acdA1 [H]

Synonym: LEPBI_I0104

Alternate gene names: 183219531

Gene position: 105216-106343 (Clockwise)

Preceding gene: 183219530

Following gene: 183219532

Centisome position: 2.92

GC content: 39.8

Gene sequence:

>1128_bases
ATGAATTTCTATTTTTCAGAAGAACAAAACAAATTAAGGGATGCCGTTGCTGCATATTCTAAAATCGCAGGAAGTGACCC
GCAAAGAGACATCGAAGAAAGAGATAGTGAGTTTTCTTGGGATGTTTTACGCGCGCTAGGTGACAAAGGTTGGACTGGTG
TAATCGTACCAGAAGAGTATGGTGGTATGGGTAAAGGTGCAATGGAATACACTATCATCATGGAAGAGACTGCCAAAGAA
TTAATTTATGGGCCACAAAATTTAATCCAAGCACAACAAGGACTTCTAGCTGTTGGAACAGAAGAACAAAAAAGGAAATG
GTTACCGGAACTTGCCAAAGGAAAAATGATGGCGGCCCAAGCAATTTCAGAGCCAGATGCTGGATCATCATTCCAAAACA
TTCAAACGACTGCAGTGAAAGATGAGAACGAATGGGTCTTAAATGGTCTTAAAGTACACATCAACTTGGGAAAAGAAGCT
CAATTGATGATGGTATTGGCAAAAACCGATAAGGGATTAACGGAATTTTTAGTCGATCGAGATTCAAAAGGGATTCGTTA
TGAAAAACAAGATCCGATTGGCTTACGATCTGCACCTATGTATGATGTTCACTTTGAAGATTGTCGAATCCCACTCGATA
GTGTTTTGGGTAGAGAAGGTAGGGGGATCGAAACCTTTATGTCTATTTTTAAATTGAGTCGATTGGGAGTTGCATCGCAA
TTGATTGGAATTGCTAGAGGGTGTTTGGATCATGCTGTCTCGTTTACAAAGTCAAGAAAAGTCGGCGAAAACCGCGTTTC
AGATTTTCAGGGGATACAATGGATCATTGCAAAGTTAACATCTGAATTAGAAGCAGCAAAATTAGCAAGAAACCAAGCCG
CATGGTTGCATGATCAAAAGGTAAATCATAACTTAGAAACATCGATTGCAAAATATCTTGCTGGTGTGGTTGCAGATGAA
GTTGTGAACAAAGCTTTTACTTTGACTGGATCCCATGCTTGTTATCGAAACAAGCCATATGATAGATATGTGCGTGAAGT
AAAATCGTTATTAGCTGGCGGTGGAAGTTCGGAAGTGATGTTAAATAATGTCGCTAGAGAAATCCTTCGGCCTTCCTACC
AATATTAA

Upstream 100 bases:

>100_bases
GATGCCACTTTTATATGCATTGTTTGTGCCCATTACCTCTTCAATCGCTACTTACTATTTTTATTTAAAATCAAAACAAG
AATCAAAAGGACAAGTTTGA

Downstream 100 bases:

>100_bases
AATGAAATATACTGGAATCACTTTGATCACTGGAGCCAATGGATTCATTGGATTTGAACTTTTGAAAGAGCTCTCAAAAG
ATTCAAATCTAAAGATTCGT

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MNFYFSEEQNKLRDAVAAYSKIAGSDPQRDIEERDSEFSWDVLRALGDKGWTGVIVPEEYGGMGKGAMEYTIIMEETAKE
LIYGPQNLIQAQQGLLAVGTEEQKRKWLPELAKGKMMAAQAISEPDAGSSFQNIQTTAVKDENEWVLNGLKVHINLGKEA
QLMMVLAKTDKGLTEFLVDRDSKGIRYEKQDPIGLRSAPMYDVHFEDCRIPLDSVLGREGRGIETFMSIFKLSRLGVASQ
LIGIARGCLDHAVSFTKSRKVGENRVSDFQGIQWIIAKLTSELEAAKLARNQAAWLHDQKVNHNLETSIAKYLAGVVADE
VVNKAFTLTGSHACYRNKPYDRYVREVKSLLAGGGSSEVMLNNVAREILRPSYQY

Sequences:

>Translated_375_residues
MNFYFSEEQNKLRDAVAAYSKIAGSDPQRDIEERDSEFSWDVLRALGDKGWTGVIVPEEYGGMGKGAMEYTIIMEETAKE
LIYGPQNLIQAQQGLLAVGTEEQKRKWLPELAKGKMMAAQAISEPDAGSSFQNIQTTAVKDENEWVLNGLKVHINLGKEA
QLMMVLAKTDKGLTEFLVDRDSKGIRYEKQDPIGLRSAPMYDVHFEDCRIPLDSVLGREGRGIETFMSIFKLSRLGVASQ
LIGIARGCLDHAVSFTKSRKVGENRVSDFQGIQWIIAKLTSELEAAKLARNQAAWLHDQKVNHNLETSIAKYLAGVVADE
VVNKAFTLTGSHACYRNKPYDRYVREVKSLLAGGGSSEVMLNNVAREILRPSYQY
>Mature_375_residues
MNFYFSEEQNKLRDAVAAYSKIAGSDPQRDIEERDSEFSWDVLRALGDKGWTGVIVPEEYGGMGKGAMEYTIIMEETAKE
LIYGPQNLIQAQQGLLAVGTEEQKRKWLPELAKGKMMAAQAISEPDAGSSFQNIQTTAVKDENEWVLNGLKVHINLGKEA
QLMMVLAKTDKGLTEFLVDRDSKGIRYEKQDPIGLRSAPMYDVHFEDCRIPLDSVLGREGRGIETFMSIFKLSRLGVASQ
LIGIARGCLDHAVSFTKSRKVGENRVSDFQGIQWIIAKLTSELEAAKLARNQAAWLHDQKVNHNLETSIAKYLAGVVADE
VVNKAFTLTGSHACYRNKPYDRYVREVKSLLAGGGSSEVMLNNVAREILRPSYQY

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=377, Percent_Identity=31.2997347480106, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=31.1170212765957, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI4557233, Length=361, Percent_Identity=31.8559556786704, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI226958414, Length=347, Percent_Identity=31.9884726224784, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4557231, Length=382, Percent_Identity=28.0104712041885, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI187960098, Length=382, Percent_Identity=28.0104712041885, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI21361497, Length=339, Percent_Identity=29.7935103244838, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=28.4574468085106, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI7656849, Length=348, Percent_Identity=26.7241379310345, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI76496475, Length=379, Percent_Identity=26.9129287598945, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4557235, Length=379, Percent_Identity=26.9129287598945, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI48976061, Length=330, Percent_Identity=27.8787878787879, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI211971008, Length=330, Percent_Identity=27.8787878787879, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI4503943, Length=285, Percent_Identity=24.9122807017544, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI7669494, Length=285, Percent_Identity=24.9122807017544, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI38505218, Length=331, Percent_Identity=23.2628398791541, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1786223, Length=347, Percent_Identity=27.6657060518732, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=25.78125, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=29.7587131367292, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17534899, Length=385, Percent_Identity=29.6103896103896, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17569725, Length=384, Percent_Identity=30.46875, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17506239, Length=375, Percent_Identity=30.4, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71990804, Length=293, Percent_Identity=30.7167235494881, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17538396, Length=374, Percent_Identity=28.6096256684492, Blast_Score=150, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17570075, Length=387, Percent_Identity=26.3565891472868, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17533517, Length=362, Percent_Identity=27.3480662983425, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI32563615, Length=244, Percent_Identity=33.1967213114754, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=277, Percent_Identity=30.6859205776173, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=28.328611898017, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71985192, Length=304, Percent_Identity=29.2763157894737, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17505929, Length=333, Percent_Identity=27.3273273273273, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17551932, Length=333, Percent_Identity=27.027027027027, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=28.2786885245902, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17562446, Length=333, Percent_Identity=26.1261261261261, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17534353, Length=311, Percent_Identity=24.4372990353698, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24666513, Length=379, Percent_Identity=28.7598944591029, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24660351, Length=385, Percent_Identity=28.051948051948, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21356377, Length=357, Percent_Identity=28.8515406162465, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24646207, Length=358, Percent_Identity=30.4469273743017, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=28.0205655526992, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI281363737, Length=366, Percent_Identity=27.8688524590164, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI19920834, Length=308, Percent_Identity=27.5974025974026, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24652780, Length=348, Percent_Identity=25.2873563218391, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41863; Mature: 41863

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFYFSEEQNKLRDAVAAYSKIAGSDPQRDIEERDSEFSWDVLRALGDKGWTGVIVPEEY
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHCCCCCEEEECCHHC
GGMGKGAMEYTIIMEETAKELIYGPQNLIQAQQGLLAVGTEEQKRKWLPELAKGKMMAAQ
CCCCCCCEEEEEEHHHHHHHHHCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHCHHHHHH
AISEPDAGSSFQNIQTTAVKDENEWVLNGLKVHINLGKEAQLMMVLAKTDKGLTEFLVDR
HHCCCCCCCCHHHCHHHEECCCCCEEEEEEEEEEECCCCCEEEEEEECCCCCHHHHHHCC
DSKGIRYEKQDPIGLRSAPMYDVHFEDCRIPLDSVLGREGRGIETFMSIFKLSRLGVASQ
CCCCCCCCCCCCCCCCCCCEEEEEHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LIGIARGCLDHAVSFTKSRKVGENRVSDFQGIQWIIAKLTSELEAAKLARNQAAWLHDQK
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNHNLETSIAKYLAGVVADEVVNKAFTLTGSHACYRNKPYDRYVREVKSLLAGGGSSEVM
CCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHCCCCHHHHHHHHHHHHHCCCCCHHH
LNNVAREILRPSYQY
HHHHHHHHHCCCCCC
>Mature Secondary Structure
MNFYFSEEQNKLRDAVAAYSKIAGSDPQRDIEERDSEFSWDVLRALGDKGWTGVIVPEEY
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHCCCCCEEEECCHHC
GGMGKGAMEYTIIMEETAKELIYGPQNLIQAQQGLLAVGTEEQKRKWLPELAKGKMMAAQ
CCCCCCCEEEEEEHHHHHHHHHCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHCHHHHHH
AISEPDAGSSFQNIQTTAVKDENEWVLNGLKVHINLGKEAQLMMVLAKTDKGLTEFLVDR
HHCCCCCCCCHHHCHHHEECCCCCEEEEEEEEEEECCCCCEEEEEEECCCCCHHHHHHCC
DSKGIRYEKQDPIGLRSAPMYDVHFEDCRIPLDSVLGREGRGIETFMSIFKLSRLGVASQ
CCCCCCCCCCCCCCCCCCCEEEEEHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LIGIARGCLDHAVSFTKSRKVGENRVSDFQGIQWIIAKLTSELEAAKLARNQAAWLHDQK
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNHNLETSIAKYLAGVVADEVVNKAFTLTGSHACYRNKPYDRYVREVKSLLAGGGSSEVM
CCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHCCCCHHHHHHHHHHHHHCCCCCHHH
LNNVAREILRPSYQY
HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]