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The map label for this gene is pyrD [H]

Identifier: 183219519

GI number: 183219519

Start: 92561

End: 93634

Strand: Reverse

Name: pyrD [H]

Synonym: LEPBI_I0092

Alternate gene names: 183219519

Gene position: 93634-92561 (Counterclockwise)

Preceding gene: 183219522

Following gene: 183219518

Centisome position: 2.6

GC content: 40.32

Gene sequence:

>1074_bases
TTGTTTTACCACCAACTGATCAAACCCATATTATTTCATTTAGACCCTGAATCGGCTCACCATTTAGTCGCTACCTTTCT
TTCTTTATCCAAAAAAATCCCATTTTTCCATAAAACACTTTCTGCCATCTTTCAATTTTCATCCAAACGATTGGAACAAA
CCATCCAAGGCATCCATTTCCCAAATCCTGTGGGACTTGCCGCTGGATTTGACAAAACGACCGAACTCTTCCCTACCATG
ATCCATATGGGTTTTGGTTTTATCGAAATCGGAACCATCACAGCCAAAGCACAACCAGGGAATGAAAAACCAAGACTCTT
TCGTTACCCCAAAGTGAAAGCACTCATCAATCGAATGGGATTCAACAACCCAGGTGCTGACCAAGCAGAAATCAATTTAA
AGAACCAACAAAAGTTGGGTGTGCGTGGGATCAATGCTGGCAAATCCAAGGTCACAGCCTTGGAAGACGCAGTGGGTGAT
TATGTTTATACTTTAAAAAAATTAGTCCCTTTCGGTGATTATGCAGTCATCAATATCAGTTCCCCGAATACACCTGGTCT
TCGATCGTTACAAACCAAACAAAGTTTGATCGATCTCATCCAAGGCATTCAAAAGGAATTCCAAAACTCGTTTCCCATTC
CCTTGTATTTAAAATTTGCACCTGATTTAACAGAAGAAGAACTCATCGAAAATCTGAAAGTGTGTTTGGAGTATAAAATC
AGTGGTGTCATCCTTACAAACACAACACTCGACAAACAAAGTTTAGGTGAATTGAATCCCGAGGAAGGTGGCCTTTCTGG
TGGACCATTATTCCAAAAATCCTTACGTTTTGTTTCTCTCGCTTACCAAACCTTACAAGGAAAAATTCCGATCATCGGTG
TCGGAGGAATCGATTCGGGTGAAAAAGCCTTACAAATGATGGAGATGGGTGCTAACTTAATTCAAATTTATACTGGTTAT
ATCTATGAAGGTCCGTTTTTGCCGTATCAAATTTGTTCTTACCTAGACAAAGTGGTGAAAGATCGAGGATACCAAACGAT
CAGCGAACTGGTAGGCTCGGGGAATTCAAAATGA

Upstream 100 bases:

>100_bases
CAAGTACTGACCTCATTAGGAATATTGGAAACAATCTCATTTTCGGAAAGAAATTGTAAGAAATCATGGGGAAAAAAGAA
TCAACGTAAGGATTTTTCCC

Downstream 100 bases:

>100_bases
CGACAACAAAAACTGGCAATTCGATCTGTACCCACTTTGGCACTTGTGGTGGATGTAATTATCTCGACATTGATTATACG
AAAGAACTTCGCAAAAAAGA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MFYHQLIKPILFHLDPESAHHLVATFLSLSKKIPFFHKTLSAIFQFSSKRLEQTIQGIHFPNPVGLAAGFDKTTELFPTM
IHMGFGFIEIGTITAKAQPGNEKPRLFRYPKVKALINRMGFNNPGADQAEINLKNQQKLGVRGINAGKSKVTALEDAVGD
YVYTLKKLVPFGDYAVINISSPNTPGLRSLQTKQSLIDLIQGIQKEFQNSFPIPLYLKFAPDLTEEELIENLKVCLEYKI
SGVILTNTTLDKQSLGELNPEEGGLSGGPLFQKSLRFVSLAYQTLQGKIPIIGVGGIDSGEKALQMMEMGANLIQIYTGY
IYEGPFLPYQICSYLDKVVKDRGYQTISELVGSGNSK

Sequences:

>Translated_357_residues
MFYHQLIKPILFHLDPESAHHLVATFLSLSKKIPFFHKTLSAIFQFSSKRLEQTIQGIHFPNPVGLAAGFDKTTELFPTM
IHMGFGFIEIGTITAKAQPGNEKPRLFRYPKVKALINRMGFNNPGADQAEINLKNQQKLGVRGINAGKSKVTALEDAVGD
YVYTLKKLVPFGDYAVINISSPNTPGLRSLQTKQSLIDLIQGIQKEFQNSFPIPLYLKFAPDLTEEELIENLKVCLEYKI
SGVILTNTTLDKQSLGELNPEEGGLSGGPLFQKSLRFVSLAYQTLQGKIPIIGVGGIDSGEKALQMMEMGANLIQIYTGY
IYEGPFLPYQICSYLDKVVKDRGYQTISELVGSGNSK
>Mature_357_residues
MFYHQLIKPILFHLDPESAHHLVATFLSLSKKIPFFHKTLSAIFQFSSKRLEQTIQGIHFPNPVGLAAGFDKTTELFPTM
IHMGFGFIEIGTITAKAQPGNEKPRLFRYPKVKALINRMGFNNPGADQAEINLKNQQKLGVRGINAGKSKVTALEDAVGD
YVYTLKKLVPFGDYAVINISSPNTPGLRSLQTKQSLIDLIQGIQKEFQNSFPIPLYLKFAPDLTEEELIENLKVCLEYKI
SGVILTNTTLDKQSLGELNPEEGGLSGGPLFQKSLRFVSLAYQTLQGKIPIIGVGGIDSGEKALQMMEMGANLIQIYTGY
IYEGPFLPYQICSYLDKVVKDRGYQTISELVGSGNSK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=370, Percent_Identity=39.4594594594595, Blast_Score=244, Evalue=1e-64,
Organism=Escherichia coli, GI1787177, Length=342, Percent_Identity=43.5672514619883, Blast_Score=258, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI17509475, Length=370, Percent_Identity=35.4054054054054, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI281361352, Length=368, Percent_Identity=36.4130434782609, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI17137316, Length=368, Percent_Identity=36.4130434782609, Blast_Score=228, Evalue=6e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 39568; Mature: 39568

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYHQLIKPILFHLDPESAHHLVATFLSLSKKIPFFHKTLSAIFQFSSKRLEQTIQGIHF
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PNPVGLAAGFDKTTELFPTMIHMGFGFIEIGTITAKAQPGNEKPRLFRYPKVKALINRMG
CCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCEEECHHHHHHHHHHC
FNNPGADQAEINLKNQQKLGVRGINAGKSKVTALEDAVGDYVYTLKKLVPFGDYAVINIS
CCCCCCCCEEEECCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
SPNTPGLRSLQTKQSLIDLIQGIQKEFQNSFPIPLYLKFAPDLTEEELIENLKVCLEYKI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHC
SGVILTNTTLDKQSLGELNPEEGGLSGGPLFQKSLRFVSLAYQTLQGKIPIIGVGGIDSG
CEEEEECCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCH
EKALQMMEMGANLIQIYTGYIYEGPFLPYQICSYLDKVVKDRGYQTISELVGSGNSK
HHHHHHHHHCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MFYHQLIKPILFHLDPESAHHLVATFLSLSKKIPFFHKTLSAIFQFSSKRLEQTIQGIHF
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PNPVGLAAGFDKTTELFPTMIHMGFGFIEIGTITAKAQPGNEKPRLFRYPKVKALINRMG
CCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCEEECHHHHHHHHHHC
FNNPGADQAEINLKNQQKLGVRGINAGKSKVTALEDAVGDYVYTLKKLVPFGDYAVINIS
CCCCCCCCEEEECCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
SPNTPGLRSLQTKQSLIDLIQGIQKEFQNSFPIPLYLKFAPDLTEEELIENLKVCLEYKI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHC
SGVILTNTTLDKQSLGELNPEEGGLSGGPLFQKSLRFVSLAYQTLQGKIPIIGVGGIDSG
CEEEEECCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCH
EKALQMMEMGANLIQIYTGYIYEGPFLPYQICSYLDKVVKDRGYQTISELVGSGNSK
HHHHHHHHHCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]