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The map label for this gene is galK [H]

Identifier: 183219500

GI number: 183219500

Start: 72994

End: 74163

Strand: Reverse

Name: galK [H]

Synonym: LEPBI_I0073

Alternate gene names: 183219500

Gene position: 74163-72994 (Counterclockwise)

Preceding gene: 183219502

Following gene: 183219499

Centisome position: 2.06

GC content: 39.15

Gene sequence:

>1170_bases
GTGGATTCATTGAGAAGTAAAGAAAATTTGAATCAATTTGAACATATATTTGGAAAAACAAATTCCAAACCACGAATGTT
TGTTGCACCCGCAAGGATCAATATCATTGGAGAACATGTTGACTATTTGGGTGGAATTGTCCTACCAGCCGCAATTGATT
TTTCGGTTCAGTTGTTTTTGCGTCCCAACCAATCTCCATTCTATCAATTCCATTCCATTACTTATCATGAAACCATTAAG
GTGGAAAAACCTTTCCGACCCAATCCAACTTCTCCTTGGACTGACTATATCACAGGTGTCATCGTAGAAATAGAAGCCCT
AGGTTATCAAGTTCCTGGGTTTGATGTGTTAGTGGATGGAAATATCCCACAAGGATCTGGGCTCTCTTCCTCAGCTGCAT
TAGAAGTGGTAACTGGCTTTGCGATTTCCGAAACATTCAGACTTGGTATTCCAAAAGAACAAATTGCCGTGATTGGACAG
AAAGCCGAAAACAATTTTGTCGGTACCAAATGTGGGATCATGGACCAATTCATCATTGCGGTAGGAAAAGAAAATGATTG
TATCTCACTCAATACAGAAAGTCTGAAATACTCATACCACCATTTTGAATTAGGTGATCATGAATTTTATCTCGTCAATT
CAAACGTAAAACACAACCTCAAAGACAGTGCGTATAACAAACGTAGGCAAGAATGTGAATCCGCATTGGCGAAAATTCAA
ATCAAACACCCAAATATCAAACAATTGTATGATGTCGCTCTCTCTGAAGAAGAAATCAGAGATTGTGGATTAAACTCAGA
AGAACTAAAACGAACCCTTCATGTTGTGACAGAACGAGAGAGAACAAAACTTGTCATCCAAGGTTTGGAAACAAACCAGT
TTGCCCAAGTGGGGGAAGCTTTGTATGGCGCACATGAATCCTTGTCAAAAAATTTTGAAGTGTCTTGCGAAGAAACGGAC
TTCATCGTTTCTACCTTAAAAGGATTGGGAGTCATGGGTGCCAGAATGATTGGAGGTGGGTTTGGTGGGTGCGTACTCGT
ACTAGACAAAAAAGAGCATTTTGTCAAAATAAACCCGGAAATGAAAAAAAGTTATCAACAAAAATTTAACCTTGCGTTAG
ACTTCTACAAGTTTCAAATCTCGGATGGCGTGAGGGAAATTTCCATATGA

Upstream 100 bases:

>100_bases
TTGGATTGGTCAAGAAAGGGTTTCACAAAGCGATCTGAAATTTTTAGATTCGACATAGCACCTGTCCTAAAATAAAGTAT
AGCATCGAAAGGAAGATGAA

Downstream 100 bases:

>100_bases
TTGAAAATTGGGATGATTATACCGTAGAAAGTGGGGATTTCAAAATGGAAGTCCTACAACAGAGATTTGTCCCACTCCCT
GAATCAGCCGTTTATTTCGA

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MDSLRSKENLNQFEHIFGKTNSKPRMFVAPARINIIGEHVDYLGGIVLPAAIDFSVQLFLRPNQSPFYQFHSITYHETIK
VEKPFRPNPTSPWTDYITGVIVEIEALGYQVPGFDVLVDGNIPQGSGLSSSAALEVVTGFAISETFRLGIPKEQIAVIGQ
KAENNFVGTKCGIMDQFIIAVGKENDCISLNTESLKYSYHHFELGDHEFYLVNSNVKHNLKDSAYNKRRQECESALAKIQ
IKHPNIKQLYDVALSEEEIRDCGLNSEELKRTLHVVTERERTKLVIQGLETNQFAQVGEALYGAHESLSKNFEVSCEETD
FIVSTLKGLGVMGARMIGGGFGGCVLVLDKKEHFVKINPEMKKSYQQKFNLALDFYKFQISDGVREISI

Sequences:

>Translated_389_residues
MDSLRSKENLNQFEHIFGKTNSKPRMFVAPARINIIGEHVDYLGGIVLPAAIDFSVQLFLRPNQSPFYQFHSITYHETIK
VEKPFRPNPTSPWTDYITGVIVEIEALGYQVPGFDVLVDGNIPQGSGLSSSAALEVVTGFAISETFRLGIPKEQIAVIGQ
KAENNFVGTKCGIMDQFIIAVGKENDCISLNTESLKYSYHHFELGDHEFYLVNSNVKHNLKDSAYNKRRQECESALAKIQ
IKHPNIKQLYDVALSEEEIRDCGLNSEELKRTLHVVTERERTKLVIQGLETNQFAQVGEALYGAHESLSKNFEVSCEETD
FIVSTLKGLGVMGARMIGGGFGGCVLVLDKKEHFVKINPEMKKSYQQKFNLALDFYKFQISDGVREISI
>Mature_389_residues
MDSLRSKENLNQFEHIFGKTNSKPRMFVAPARINIIGEHVDYLGGIVLPAAIDFSVQLFLRPNQSPFYQFHSITYHETIK
VEKPFRPNPTSPWTDYITGVIVEIEALGYQVPGFDVLVDGNIPQGSGLSSSAALEVVTGFAISETFRLGIPKEQIAVIGQ
KAENNFVGTKCGIMDQFIIAVGKENDCISLNTESLKYSYHHFELGDHEFYLVNSNVKHNLKDSAYNKRRQECESALAKIQ
IKHPNIKQLYDVALSEEEIRDCGLNSEELKRTLHVVTERERTKLVIQGLETNQFAQVGEALYGAHESLSKNFEVSCEETD
FIVSTLKGLGVMGARMIGGGFGGCVLVLDKKEHFVKINPEMKKSYQQKFNLALDFYKFQISDGVREISI

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=395, Percent_Identity=32.1518987341772, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI48527957, Length=427, Percent_Identity=28.3372365339578, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI4503897, Length=435, Percent_Identity=28.5057471264368, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786972, Length=365, Percent_Identity=33.4246575342466, Blast_Score=208, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24661292, Length=437, Percent_Identity=25.4004576659039, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355577, Length=437, Percent_Identity=25.4004576659039, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24661285, Length=437, Percent_Identity=25.4004576659039, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 43680; Mature: 43680

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSLRSKENLNQFEHIFGKTNSKPRMFVAPARINIIGEHVDYLGGIVLPAAIDFSVQLFL
CCCCCCHHHHHHHHHHHCCCCCCCEEEEECCEEEEEHHHHHHHCCCHHHEEECEEEEEEE
RPNQSPFYQFHSITYHETIKVEKPFRPNPTSPWTDYITGVIVEIEALGYQVPGFDVLVDG
ECCCCCCEEEEEEEEEEEEEECCCCCCCCCCCHHHHHHEEEEEEEECCEECCCEEEEEEC
NIPQGSGLSSSAALEVVTGFAISETFRLGIPKEQIAVIGQKAENNFVGTKCGIMDQFIIA
CCCCCCCCCCCHHHHHHHHHHHHHHEECCCCHHHHHEEECCCCCCCCCCCCCHHHEEHEE
VGKENDCISLNTESLKYSYHHFELGDHEFYLVNSNVKHNLKDSAYNKRRQECESALAKIQ
ECCCCCEEEECCHHEEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEE
IKHPNIKQLYDVALSEEEIRDCGLNSEELKRTLHVVTERERTKLVIQGLETNQFAQVGEA
ECCCCHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHH
LYGAHESLSKNFEVSCEETDFIVSTLKGLGVMGARMIGGGFGGCVLVLDKKEHFVKINPE
HHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECHH
MKKSYQQKFNLALDFYKFQISDGVREISI
HHHHHHHHHCEEEEEEEEEECCCEEECCC
>Mature Secondary Structure
MDSLRSKENLNQFEHIFGKTNSKPRMFVAPARINIIGEHVDYLGGIVLPAAIDFSVQLFL
CCCCCCHHHHHHHHHHHCCCCCCCEEEEECCEEEEEHHHHHHHCCCHHHEEECEEEEEEE
RPNQSPFYQFHSITYHETIKVEKPFRPNPTSPWTDYITGVIVEIEALGYQVPGFDVLVDG
ECCCCCCEEEEEEEEEEEEEECCCCCCCCCCCHHHHHHEEEEEEEECCEECCCEEEEEEC
NIPQGSGLSSSAALEVVTGFAISETFRLGIPKEQIAVIGQKAENNFVGTKCGIMDQFIIA
CCCCCCCCCCCHHHHHHHHHHHHHHEECCCCHHHHHEEECCCCCCCCCCCCCHHHEEHEE
VGKENDCISLNTESLKYSYHHFELGDHEFYLVNSNVKHNLKDSAYNKRRQECESALAKIQ
ECCCCCEEEECCHHEEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEE
IKHPNIKQLYDVALSEEEIRDCGLNSEELKRTLHVVTERERTKLVIQGLETNQFAQVGEA
ECCCCHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHH
LYGAHESLSKNFEVSCEETDFIVSTLKGLGVMGARMIGGGFGGCVLVLDKKEHFVKINPE
HHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECHH
MKKSYQQKFNLALDFYKFQISDGVREISI
HHHHHHHHHCEEEEEEEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA