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The map label for this gene is rnr [H]

Identifier: 183219447

GI number: 183219447

Start: 19860

End: 22052

Strand: Reverse

Name: rnr [H]

Synonym: LEPBI_I0020

Alternate gene names: 183219447

Gene position: 22052-19860 (Counterclockwise)

Preceding gene: 183219448

Following gene: 183219445

Centisome position: 0.61

GC content: 36.75

Gene sequence:

>2193_bases
ATGGATACCTATAAAATACAAAGAAAAATCATCGAATATCTAGACCAAAAGTCAGGTAAAGATATCACAAGACAAGAGAT
CAAAAAAAAATTCATTGAATCCAGTGAATTCAAACGACCCGACCCAAAAACTAAAAAAGTAAAAGCCTTCAAACGAAAAG
AGAAAGTTCCAAGAAAGGAAATCGAATTTCTCATCGATCAACTTTGTAACCTACTGGAAGTCGAAGGATTACTCATTCCC
AATAAAAAATACCTAACTGTTGCTAAACCATTTCGACTCACTGGTAGGATCTCCATTTCAAGAAGAGGTGATGGTTTCAT
TTCCTTACCATCCAAAAACGAAATATTTGTACCAGGCCCACTCACAAACACCGCCATCTCTGGTGATAAAGTGGAAGTGA
TCCCACTCGGTGTTGGTAAAAAAGACCGGCTGGAGGCAGAAGTCACAAAGATTCTCAAACGAGGTCGTATTTTATATCGA
ATGCGAGTCAAAGAAAAAACCAATAAATTTGTTTTTGGGAATTTTTTAGATATGTTAGGTGACGGTAAAGAAGGTGTACT
ACATGTTAAATCGATACTCAAGGATAGTTTCGATGCAATCAACATTGATGATGTACTGATTGTTAAACTGAAAGAAGGTG
CCGAACCACAAGACAATCTTTATGATGTGAGTTTCATACGATTTGAATCAGACACAAAAGAAGATGGCGATTTACAACGG
ATCTTAATGAAATACAATTATGATCCGGTGCATCCCGATTTTATTCCATTGGATTTTCCAGAAGAAGTTACGGAAAAAAC
AGTTTCGGATTGGAATCGCAGAACGGATCTACGTGATCTGTATGCGGTCACAATCGATGGAATCACAGCCAAAGATTTTG
ATGATGCTATCAGTTTTGTTGATGAAGGAAATCGGCTTAGGATTTGGATCCACATTGCAGATGTATCCTATTATGTAGAA
AAGGGATCTGCCTTAGATAAAGAAGCGTATGAAAGGGCTACATCAGTTTATCTAGCCAATCGTGTCGTTCCAATGCTTCC
ACCCATACTATCGGAAGACCTATGTAGTCTTGTCGCCAATACAAATCGATTGGCTTTCACAGTGGAGATGGAAGCGAGTA
AATCAGGTGAAATTTACAATGCCAAGTTTTACAAATCCATCATCAAAGTCAAAAAACGTTACACGTATGAGATGGCCGAA
GAGGAAATAAAGGCACAGGATCCAAATAATTGGATGTACCAAGTTTCGCTCTTCACAGATGCTCTTCGTAAACATAGGAT
GAAAACTGGTCGTATTGACTTAAATTTACGAGAAACAACGATCACTTGGAACGAAAGAAAAGAACCAATTGGAATTGAAA
ATCGTGAACGTCTAACAAGTCATATTTTGATCGAAGAATTGATGTTGTCTGCCAATTTGAAAGTGGATGAATTCCTTCGC
AAAAAAAAGATTCCAACTCTCCACCGAATCCATGAACCTATGGATGAAGAAAAATTAGAAACTCTCAATCACTTCTTACA
ACTCAATGGGTACAATGTTCAAATCCATGATACAAGTTATCCTGAAATCATGAAGGCCGTGAAAGAAATCCAAGACAACT
CTGTTGGAAAAATATTCAATTATTTATTACTACGAAGTTTTATGCAGGCTTATTATGGAGCCGATCCACTCGGACATTGG
GGACTTGGTTTTAAAGACTATTGCCACTTTACATCTCCTATCAGGCGTTATCCTGATTTGATTGTCCACAGAGTTCTTCA
GGCAACTTTGTTAGAAACTGATAAGGAATATTCAGAAAATGAAATTGCAGTGATGGGCCTCCATTGTTCAGAAGAAGAAA
GAAGAGCGGCAGACGCAGAAAGAGACATTGTCAAAATCAAATCATTTCGTTATCTCGAATCAACCGGAATCAAAGAATTT
AAAGGTTTTATCGTAGGGATCCGTCCTTCTCAAATTTTTGTGGAATTAGACATTTCCAATTTGGAAGGAGTTCTTGATAA
ATCAGAGTTTACTGATGAGTTTGAAGTGATGATTAAAAATGATTTTTCTTTTTATTCCAAAAAGTATTCCAAGATTTTTT
TCATCGGAGATCCAGTGACAGTGAGTTTAGATCGAATCGATTTCGAAGAAATCAAAGTCTTTTTAAAACTAAAAGATTTC
AAAAAAGACGATACACCAACCAAAAAGAAGTAA

Upstream 100 bases:

>100_bases
AGTTTGGAACAAATCAAACAAACAAATCTTAAGAATTACGACTATTTATCTCTCCTACCCAATTACATTCGTGGGACCTA
CGTAGATCAAAAATGAATTT

Downstream 100 bases:

>100_bases
GCATTTCCGTCGAATGTATCTTAAAAGGATACATTCGGTATTTCTTCTCGTTTCCAAATTTTTCTAAAAAACTTTCTTTG
TTTAACCTCAATGGATAAAA

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 730; Mature: 730

Protein sequence:

>730_residues
MDTYKIQRKIIEYLDQKSGKDITRQEIKKKFIESSEFKRPDPKTKKVKAFKRKEKVPRKEIEFLIDQLCNLLEVEGLLIP
NKKYLTVAKPFRLTGRISISRRGDGFISLPSKNEIFVPGPLTNTAISGDKVEVIPLGVGKKDRLEAEVTKILKRGRILYR
MRVKEKTNKFVFGNFLDMLGDGKEGVLHVKSILKDSFDAINIDDVLIVKLKEGAEPQDNLYDVSFIRFESDTKEDGDLQR
ILMKYNYDPVHPDFIPLDFPEEVTEKTVSDWNRRTDLRDLYAVTIDGITAKDFDDAISFVDEGNRLRIWIHIADVSYYVE
KGSALDKEAYERATSVYLANRVVPMLPPILSEDLCSLVANTNRLAFTVEMEASKSGEIYNAKFYKSIIKVKKRYTYEMAE
EEIKAQDPNNWMYQVSLFTDALRKHRMKTGRIDLNLRETTITWNERKEPIGIENRERLTSHILIEELMLSANLKVDEFLR
KKKIPTLHRIHEPMDEEKLETLNHFLQLNGYNVQIHDTSYPEIMKAVKEIQDNSVGKIFNYLLLRSFMQAYYGADPLGHW
GLGFKDYCHFTSPIRRYPDLIVHRVLQATLLETDKEYSENEIAVMGLHCSEEERRAADAERDIVKIKSFRYLESTGIKEF
KGFIVGIRPSQIFVELDISNLEGVLDKSEFTDEFEVMIKNDFSFYSKKYSKIFFIGDPVTVSLDRIDFEEIKVFLKLKDF
KKDDTPTKKK

Sequences:

>Translated_730_residues
MDTYKIQRKIIEYLDQKSGKDITRQEIKKKFIESSEFKRPDPKTKKVKAFKRKEKVPRKEIEFLIDQLCNLLEVEGLLIP
NKKYLTVAKPFRLTGRISISRRGDGFISLPSKNEIFVPGPLTNTAISGDKVEVIPLGVGKKDRLEAEVTKILKRGRILYR
MRVKEKTNKFVFGNFLDMLGDGKEGVLHVKSILKDSFDAINIDDVLIVKLKEGAEPQDNLYDVSFIRFESDTKEDGDLQR
ILMKYNYDPVHPDFIPLDFPEEVTEKTVSDWNRRTDLRDLYAVTIDGITAKDFDDAISFVDEGNRLRIWIHIADVSYYVE
KGSALDKEAYERATSVYLANRVVPMLPPILSEDLCSLVANTNRLAFTVEMEASKSGEIYNAKFYKSIIKVKKRYTYEMAE
EEIKAQDPNNWMYQVSLFTDALRKHRMKTGRIDLNLRETTITWNERKEPIGIENRERLTSHILIEELMLSANLKVDEFLR
KKKIPTLHRIHEPMDEEKLETLNHFLQLNGYNVQIHDTSYPEIMKAVKEIQDNSVGKIFNYLLLRSFMQAYYGADPLGHW
GLGFKDYCHFTSPIRRYPDLIVHRVLQATLLETDKEYSENEIAVMGLHCSEEERRAADAERDIVKIKSFRYLESTGIKEF
KGFIVGIRPSQIFVELDISNLEGVLDKSEFTDEFEVMIKNDFSFYSKKYSKIFFIGDPVTVSLDRIDFEEIKVFLKLKDF
KKDDTPTKKK
>Mature_730_residues
MDTYKIQRKIIEYLDQKSGKDITRQEIKKKFIESSEFKRPDPKTKKVKAFKRKEKVPRKEIEFLIDQLCNLLEVEGLLIP
NKKYLTVAKPFRLTGRISISRRGDGFISLPSKNEIFVPGPLTNTAISGDKVEVIPLGVGKKDRLEAEVTKILKRGRILYR
MRVKEKTNKFVFGNFLDMLGDGKEGVLHVKSILKDSFDAINIDDVLIVKLKEGAEPQDNLYDVSFIRFESDTKEDGDLQR
ILMKYNYDPVHPDFIPLDFPEEVTEKTVSDWNRRTDLRDLYAVTIDGITAKDFDDAISFVDEGNRLRIWIHIADVSYYVE
KGSALDKEAYERATSVYLANRVVPMLPPILSEDLCSLVANTNRLAFTVEMEASKSGEIYNAKFYKSIIKVKKRYTYEMAE
EEIKAQDPNNWMYQVSLFTDALRKHRMKTGRIDLNLRETTITWNERKEPIGIENRERLTSHILIEELMLSANLKVDEFLR
KKKIPTLHRIHEPMDEEKLETLNHFLQLNGYNVQIHDTSYPEIMKAVKEIQDNSVGKIFNYLLLRSFMQAYYGADPLGHW
GLGFKDYCHFTSPIRRYPDLIVHRVLQATLLETDKEYSENEIAVMGLHCSEEERRAADAERDIVKIKSFRYLESTGIKEF
KGFIVGIRPSQIFVELDISNLEGVLDKSEFTDEFEVMIKNDFSFYSKKYSKIFFIGDPVTVSLDRIDFEEIKVFLKLKDF
KKDDTPTKKK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=538, Percent_Identity=28.996282527881, Blast_Score=180, Evalue=5e-45,
Organism=Homo sapiens, GI190014625, Length=538, Percent_Identity=28.996282527881, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI134288890, Length=434, Percent_Identity=30.8755760368664, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI219521928, Length=376, Percent_Identity=28.7234042553192, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI19115966, Length=376, Percent_Identity=28.7234042553192, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI156105695, Length=140, Percent_Identity=35.7142857142857, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI156105693, Length=138, Percent_Identity=36.231884057971, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI87082383, Length=690, Percent_Identity=30.4347826086957, Blast_Score=256, Evalue=5e-69,
Organism=Escherichia coli, GI1787542, Length=580, Percent_Identity=25.1724137931034, Blast_Score=129, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI212645896, Length=412, Percent_Identity=31.3106796116505, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17553506, Length=480, Percent_Identity=27.7083333333333, Blast_Score=166, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6324552, Length=385, Percent_Identity=30.3896103896104, Blast_Score=156, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6320499, Length=390, Percent_Identity=23.0769230769231, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323943, Length=365, Percent_Identity=26.027397260274, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24649634, Length=500, Percent_Identity=30.6, Blast_Score=175, Evalue=9e-44,
Organism=Drosophila melanogaster, GI19922976, Length=361, Percent_Identity=31.0249307479224, Blast_Score=139, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24654597, Length=361, Percent_Identity=31.0249307479224, Blast_Score=139, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24654592, Length=361, Percent_Identity=31.0249307479224, Blast_Score=139, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 84949; Mature: 84949

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTYKIQRKIIEYLDQKSGKDITRQEIKKKFIESSEFKRPDPKTKKVKAFKRKEKVPRKE
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHH
IEFLIDQLCNLLEVEGLLIPNKKYLTVAKPFRLTGRISISRRGDGFISLPSKNEIFVPGP
HHHHHHHHHHHHHHCCEEECCCCEEEEECCEEEEEEEEEEECCCCEEECCCCCCEEECCC
LTNTAISGDKVEVIPLGVGKKDRLEAEVTKILKRGRILYRMRVKEKTNKFVFGNFLDMLG
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEHHHCCCEEHHHHHHHHC
DGKEGVLHVKSILKDSFDAINIDDVLIVKLKEGAEPQDNLYDVSFIRFESDTKEDGDLQR
CCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCHHHH
ILMKYNYDPVHPDFIPLDFPEEVTEKTVSDWNRRTDLRDLYAVTIDGITAKDFDDAISFV
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCHHHHHHHH
DEGNRLRIWIHIADVSYYVEKGSALDKEAYERATSVYLANRVVPMLPPILSEDLCSLVAN
CCCCEEEEEEEEECEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHCC
TNRLAFTVEMEASKSGEIYNAKFYKSIIKVKKRYTYEMAEEEIKAQDPNNWMYQVSLFTD
CCEEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHH
ALRKHRMKTGRIDLNLRETTITWNERKEPIGIENRERLTSHILIEELMLSANLKVDEFLR
HHHHHCCCCCCEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
KKKIPTLHRIHEPMDEEKLETLNHFLQLNGYNVQIHDTSYPEIMKAVKEIQDNSVGKIFN
HHCCCHHHHHHCCCCHHHHHHHHHHHEECCEEEEEECCCCHHHHHHHHHHHCCCHHHHHH
YLLLRSFMQAYYGADPLGHWGLGFKDYCHFTSPIRRYPDLIVHRVLQATLLETDKEYSEN
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EIAVMGLHCSEEERRAADAERDIVKIKSFRYLESTGIKEFKGFIVGIRPSQIFVELDISN
CEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCEEEEECCCEEEEEEECCH
LEGVLDKSEFTDEFEVMIKNDFSFYSKKYSKIFFIGDPVTVSLDRIDFEEIKVFLKLKDF
HHHHHCHHHCCCHHHEEEECCHHHHHCCCCEEEEECCCEEEEEECCCHHHHHEEEEEHHC
KKDDTPTKKK
CCCCCCCCCC
>Mature Secondary Structure
MDTYKIQRKIIEYLDQKSGKDITRQEIKKKFIESSEFKRPDPKTKKVKAFKRKEKVPRKE
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHH
IEFLIDQLCNLLEVEGLLIPNKKYLTVAKPFRLTGRISISRRGDGFISLPSKNEIFVPGP
HHHHHHHHHHHHHHCCEEECCCCEEEEECCEEEEEEEEEEECCCCEEECCCCCCEEECCC
LTNTAISGDKVEVIPLGVGKKDRLEAEVTKILKRGRILYRMRVKEKTNKFVFGNFLDMLG
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEHHHCCCEEHHHHHHHHC
DGKEGVLHVKSILKDSFDAINIDDVLIVKLKEGAEPQDNLYDVSFIRFESDTKEDGDLQR
CCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCHHHH
ILMKYNYDPVHPDFIPLDFPEEVTEKTVSDWNRRTDLRDLYAVTIDGITAKDFDDAISFV
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCHHHHHHHH
DEGNRLRIWIHIADVSYYVEKGSALDKEAYERATSVYLANRVVPMLPPILSEDLCSLVAN
CCCCEEEEEEEEECEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHCC
TNRLAFTVEMEASKSGEIYNAKFYKSIIKVKKRYTYEMAEEEIKAQDPNNWMYQVSLFTD
CCEEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHH
ALRKHRMKTGRIDLNLRETTITWNERKEPIGIENRERLTSHILIEELMLSANLKVDEFLR
HHHHHCCCCCCEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
KKKIPTLHRIHEPMDEEKLETLNHFLQLNGYNVQIHDTSYPEIMKAVKEIQDNSVGKIFN
HHCCCHHHHHHCCCCHHHHHHHHHHHEECCEEEEEECCCCHHHHHHHHHHHCCCHHHHHH
YLLLRSFMQAYYGADPLGHWGLGFKDYCHFTSPIRRYPDLIVHRVLQATLLETDKEYSEN
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EIAVMGLHCSEEERRAADAERDIVKIKSFRYLESTGIKEFKGFIVGIRPSQIFVELDISN
CEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCEEEEECCCEEEEEEECCH
LEGVLDKSEFTDEFEVMIKNDFSFYSKKYSKIFFIGDPVTVSLDRIDFEEIKVFLKLKDF
HHHHHCHHHCCCHHHEEEECCHHHHHCCCCEEEEECCCEEEEEECCCHHHHHEEEEEHHC
KKDDTPTKKK
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]