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The map label for this gene is capA [H]

Identifier: 183219445

GI number: 183219445

Start: 17076

End: 18080

Strand: Reverse

Name: capA [H]

Synonym: LEPBI_I0018

Alternate gene names: 183219445

Gene position: 18080-17076 (Counterclockwise)

Preceding gene: 183219447

Following gene: 183219441

Centisome position: 0.5

GC content: 35.72

Gene sequence:

>1005_bases
GTGCGAATTAAATTTGTTGGGGACCTCATGTGCCATTCCTCTCAAATTTCTGCCTATTTGGATTCAAAAACTAAGATCTA
TGATTCATTCAAAAGTTTCGAATACGTTGCAGATTCTCTACAAAATGCTAATCTAACTTTGGGAAATTTAGAAACGACCA
TAACCGAACTCCAAAGTGAATATTCAGGTTATCCAAGGTTTGGTAGCCCAAGTGGATACTTAACTGGGTTAAAGAATGCA
GGTTTTGATATCCTTTCTACTGCAAACAATCATTCCGCAGACAAAGGATCCTATGGCATTGATACTACAATTCAATCCGT
TTTTAATCATGAGATGATTCCGATTGGAACTTATACTTCCTTATTAGACTTTCAAAATCGAAAAGACTTCATTCAGGATG
TGAATGGAATTAAAATTGCGATCTATAATTATACATATTCGACAAATGGAATACCGGTACGTGATGGAAGGATTGTACGT
TTGTTAAATGAAGATCAAATCCGATCCGATGTCATTTTTGCAAAAAATGAAGGAGCTCACTTTATCATTTTATGGTACCA
TTTTGGAAATGAGTACGAAGAAAAACCATCTCAGTCGCAAACAAAATGGGTGAATGTTGGTTTAGAAGCAGGTGCTGACA
TCATCATTGGTGGCCACCCACATGTTGTGCAAAAGATAGACTTTTACCAAGATCCAAAAACAAATGAAGACAGGCTTATC
GCCTATTCTTTAGGAAATTTTTTATCTGCTCAGAACAGACAATACACAGATGGGGGAATTATTCTTTCATTAACACTCGA
GATAAACAAAGAAAATCAGAAAAAAATTTTGAATGTGCAATCCGAACCTGTTTGGGTGAATCCAAGAAACTATTCCATCA
TCCCAATCCAAAAGTATTCGAATTCAGAATTGCCGATCAAACTTCCAAAACATTTAGAAAAACGGATGTTTGAATTTGAA
TCCCATTTAAAGAAGATTCCTGGTTTGGGAATTCGTTCACTCTAG

Upstream 100 bases:

>100_bases
AACAATGCATAATACGATCAAAAATTTATCTTTCACTCTGGTTTTCACAATCACTTACCTTTCCTGCTACACACTCCCTG
ATTTTATACCAACTAGGCAA

Downstream 100 bases:

>100_bases
GTGTTGGATATCATTTTGGATCAGTTCATATCCTTTTCCCGCACGGATGAGTTCGAGGGAATCATCATGAATTTGAATCA
TAGTTGATAATTCAATTTTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MRIKFVGDLMCHSSQISAYLDSKTKIYDSFKSFEYVADSLQNANLTLGNLETTITELQSEYSGYPRFGSPSGYLTGLKNA
GFDILSTANNHSADKGSYGIDTTIQSVFNHEMIPIGTYTSLLDFQNRKDFIQDVNGIKIAIYNYTYSTNGIPVRDGRIVR
LLNEDQIRSDVIFAKNEGAHFIILWYHFGNEYEEKPSQSQTKWVNVGLEAGADIIIGGHPHVVQKIDFYQDPKTNEDRLI
AYSLGNFLSAQNRQYTDGGIILSLTLEINKENQKKILNVQSEPVWVNPRNYSIIPIQKYSNSELPIKLPKHLEKRMFEFE
SHLKKIPGLGIRSL

Sequences:

>Translated_334_residues
MRIKFVGDLMCHSSQISAYLDSKTKIYDSFKSFEYVADSLQNANLTLGNLETTITELQSEYSGYPRFGSPSGYLTGLKNA
GFDILSTANNHSADKGSYGIDTTIQSVFNHEMIPIGTYTSLLDFQNRKDFIQDVNGIKIAIYNYTYSTNGIPVRDGRIVR
LLNEDQIRSDVIFAKNEGAHFIILWYHFGNEYEEKPSQSQTKWVNVGLEAGADIIIGGHPHVVQKIDFYQDPKTNEDRLI
AYSLGNFLSAQNRQYTDGGIILSLTLEINKENQKKILNVQSEPVWVNPRNYSIIPIQKYSNSELPIKLPKHLEKRMFEFE
SHLKKIPGLGIRSL
>Mature_334_residues
MRIKFVGDLMCHSSQISAYLDSKTKIYDSFKSFEYVADSLQNANLTLGNLETTITELQSEYSGYPRFGSPSGYLTGLKNA
GFDILSTANNHSADKGSYGIDTTIQSVFNHEMIPIGTYTSLLDFQNRKDFIQDVNGIKIAIYNYTYSTNGIPVRDGRIVR
LLNEDQIRSDVIFAKNEGAHFIILWYHFGNEYEEKPSQSQTKWVNVGLEAGADIIIGGHPHVVQKIDFYQDPKTNEDRLI
AYSLGNFLSAQNRQYTDGGIILSLTLEINKENQKKILNVQSEPVWVNPRNYSIIPIQKYSNSELPIKLPKHLEKRMFEFE
SHLKKIPGLGIRSL

Specific function: Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC [H]

COG id: COG2843

COG function: function code M; Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CapA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019079 [H]

Pfam domain/function: PF09587 PGA_cap [H]

EC number: NA

Molecular weight: Translated: 37908; Mature: 37908

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIKFVGDLMCHSSQISAYLDSKTKIYDSFKSFEYVADSLQNANLTLGNLETTITELQSE
CEEEEEEHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHH
YSGYPRFGSPSGYLTGLKNAGFDILSTANNHSADKGSYGIDTTIQSVFNHEMIPIGTYTS
HCCCCCCCCCCCCEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEECCHHH
LLDFQNRKDFIQDVNGIKIAIYNYTYSTNGIPVRDGRIVRLLNEDQIRSDVIFAKNEGAH
HHHHCCHHHHHHCCCCEEEEEEEEEEECCCEEECCCCEEEEECCCCCCCCEEEEECCCCE
FIILWYHFGNEYEEKPSQSQTKWVNVGLEAGADIIIGGHPHVVQKIDFYQDPKTNEDRLI
EEEEEEECCCCHHCCCCCCCCEEEEEECCCCCEEEECCCCHHHHEECCCCCCCCCCCCEE
AYSLGNFLSAQNRQYTDGGIILSLTLEINKENQKKILNVQSEPVWVNPRNYSIIPIQKYS
EEEHHHHHHCCCCEECCCCEEEEEEEEECCCCCCEEEEECCCCEEECCCCEEEEEEECCC
NSELPIKLPKHLEKRMFEFESHLKKIPGLGIRSL
CCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRIKFVGDLMCHSSQISAYLDSKTKIYDSFKSFEYVADSLQNANLTLGNLETTITELQSE
CEEEEEEHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHH
YSGYPRFGSPSGYLTGLKNAGFDILSTANNHSADKGSYGIDTTIQSVFNHEMIPIGTYTS
HCCCCCCCCCCCCEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEECCHHH
LLDFQNRKDFIQDVNGIKIAIYNYTYSTNGIPVRDGRIVRLLNEDQIRSDVIFAKNEGAH
HHHHCCHHHHHHCCCCEEEEEEEEEEECCCEEECCCCEEEEECCCCCCCCEEEEECCCCE
FIILWYHFGNEYEEKPSQSQTKWVNVGLEAGADIIIGGHPHVVQKIDFYQDPKTNEDRLI
EEEEEEECCCCHHCCCCCCCCEEEEEECCCCCEEEECCCCHHHHEECCCCCCCCCCCCEE
AYSLGNFLSAQNRQYTDGGIILSLTLEINKENQKKILNVQSEPVWVNPRNYSIIPIQKYS
EEEHHHHHHCCCCEECCCCEEEEEEEEECCCCCCEEEEECCCCEEECCCCEEEEEEECCC
NSELPIKLPKHLEKRMFEFESHLKKIPGLGIRSL
CCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2536679; 10475962; 12004073 [H]