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The map label for this gene is trxA [H]

Identifier: 18311337

GI number: 18311337

Start: 2714056

End: 2714370

Strand: Reverse

Name: trxA [H]

Synonym: CPE2355

Alternate gene names: 18311337

Gene position: 2714370-2714056 (Counterclockwise)

Preceding gene: 18311338

Following gene: 18311336

Centisome position: 89.54

GC content: 30.79

Gene sequence:

>315_bases
ATGGTAAAACATATAAATGATCAAGATTTTAATACAGAAGTAATAGAAGCAAGTGAAGTAGTAGTTGTTGATTTCTGGGC
AACTTGGTGTGGACCTTGTAAAATGATAGCACCAGTTATAGAAGAATTAGCAAATGAAATGGAAAATGTTAAGTTTGTAA
AGGTTGATGTTGATAAAAACCCAGGTTCAGCTGGAAAATATCAAATACAAAGCATACCAACTTTATTAATATTTAAAGAT
GGAAAAGTTGTTGATACTTTAGTTGGCTTTAGACCAAAGGCTGCATTAGTTGAAGCTATCAAAAAATACGTTTAA

Upstream 100 bases:

>100_bases
AGATAATAATTATTATTTGTAACATTGACTTAATTTTTTAAATATAATATAATTGTAAATAATAAAGTACCCCTTAGGGG
TATATCGGGAGGCGTATATA

Downstream 100 bases:

>100_bases
TAAGCTTCTTAAGGAGATGAATAATTTTGAGCGAAAGATATGATATAGCTATAATAGGAAGCGGACCAGCTGGCCTTTCA
GCTGCATTAAATGCAAAAAT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 104

Protein sequence:

>104_residues
MVKHINDQDFNTEVIEASEVVVVDFWATWCGPCKMIAPVIEELANEMENVKFVKVDVDKNPGSAGKYQIQSIPTLLIFKD
GKVVDTLVGFRPKAALVEAIKKYV

Sequences:

>Translated_104_residues
MVKHINDQDFNTEVIEASEVVVVDFWATWCGPCKMIAPVIEELANEMENVKFVKVDVDKNPGSAGKYQIQSIPTLLIFKD
GKVVDTLVGFRPKAALVEAIKKYV
>Mature_104_residues
MVKHINDQDFNTEVIEASEVVVVDFWATWCGPCKMIAPVIEELANEMENVKFVKVDVDKNPGSAGKYQIQSIPTLLIFKD
GKVVDTLVGFRPKAALVEAIKKYV

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=39.1752577319588, Blast_Score=77, Evalue=2e-15,
Organism=Homo sapiens, GI50592994, Length=91, Percent_Identity=41.7582417582418, Blast_Score=74, Evalue=2e-14,
Organism=Homo sapiens, GI95113651, Length=75, Percent_Identity=40, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI21361657, Length=104, Percent_Identity=32.6923076923077, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=96, Percent_Identity=50, Blast_Score=110, Evalue=2e-26,
Organism=Escherichia coli, GI1788936, Length=77, Percent_Identity=49.3506493506493, Blast_Score=83, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71998175, Length=100, Percent_Identity=37, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17510299, Length=99, Percent_Identity=40.4040404040404, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71980562, Length=82, Percent_Identity=40.2439024390244, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71980565, Length=82, Percent_Identity=40.2439024390244, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17507705, Length=91, Percent_Identity=34.0659340659341, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=86, Percent_Identity=40.6976744186046, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=83, Percent_Identity=38.5542168674699, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=94, Percent_Identity=38.2978723404255, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=71, Percent_Identity=39.4366197183099, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=71, Percent_Identity=39.4366197183099, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=71, Percent_Identity=39.4366197183099, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=97, Percent_Identity=44.3298969072165, Blast_Score=89, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=50, Blast_Score=87, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319925, Length=101, Percent_Identity=37.6237623762376, Blast_Score=80, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=38.7755102040816, Blast_Score=79, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17648013, Length=96, Percent_Identity=42.7083333333333, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24583090, Length=96, Percent_Identity=42.7083333333333, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24639826, Length=86, Percent_Identity=41.8604651162791, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24658597, Length=90, Percent_Identity=38.8888888888889, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664269, Length=70, Percent_Identity=45.7142857142857, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358065, Length=85, Percent_Identity=37.6470588235294, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639068, Length=82, Percent_Identity=31.7073170731707, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11612; Mature: 11612

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKHINDQDFNTEVIEASEVVVVDFWATWCGPCKMIAPVIEELANEMENVKFVKVDVDKN
CCCCCCCCCCCCEEECCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEEECCC
PGSAGKYQIQSIPTLLIFKDGKVVDTLVGFRPKAALVEAIKKYV
CCCCCCEECCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVKHINDQDFNTEVIEASEVVVVDFWATWCGPCKMIAPVIEELANEMENVKFVKVDVDKN
CCCCCCCCCCCCEEECCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEEECCC
PGSAGKYQIQSIPTLLIFKDGKVVDTLVGFRPKAALVEAIKKYV
CCCCCCEECCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]