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The map label for this gene is bcd [H]

Identifier: 18311282

GI number: 18311282

Start: 2644531

End: 2645670

Strand: Reverse

Name: bcd [H]

Synonym: CPE2300

Alternate gene names: 18311282

Gene position: 2645670-2644531 (Counterclockwise)

Preceding gene: 18311283

Following gene: 18311281

Centisome position: 87.27

GC content: 34.47

Gene sequence:

>1140_bases
ATGAACTTTCAATTAACAAGAGAACAAGAATTAGTTAAGCAAATGGTTAGAGAATTTGCTCAAAATGAAGTTAAGCCTAT
AGCTGCAGAAATAGATGTAACAGAAAGATTCCCTATGGAAAATGTTAAGAAAATGGCTAAACTAGGAATGATGGGAATTC
CTTTTAGCAAAGAATATGGCGGAGCTGGTGGAGATACTTTATCTTACATCTTAACTGTTGAAGAATTATCAAAAGTTTGT
GCTACTACAGGAGTTATAGTTTCAGCTCATACTTCATTATGTGCTTCATTAATAGATCAATTTGGTACTCCAGCTCAAAA
AGAAAAATATTTAACTCCACTTGCAAAAGGTGAAAAATTAGGTGCTTTTGGATTAACTGAACCAGGAGCAGGTACAGATG
CTGCAGGACAACAAACTACAGCTGTATTAGAAGGAGATAATTACATCTTAAACGGAAGTAAAATCTTCATAACTAATGGT
GGAGTTGCAGATACTTTCATAATCTTTGCTATGACTGATAAGAGTCAAGGTACAAGAGGAATTTCAGCTTTCATAGTTGA
AAAGAATTTCCCAGGATTCTCAATTGGTAAGTTAGAAGAAAAAATGGGTATAAGAGCTTCTTCAACAACTGAGTTAATCA
TGGAAAACTGTGTTGTTCCAAAAGAAAACTTAATCGGAAGAGAAGGAAAAGGATTTGGAATAGCAATGAAAACTTTAGAC
GGTGGTAGAATAGGTATCGCTGCTCAAGCATTAGGTATAGCAGAAGGAGCTTTAGAAGAAGCTGTTGCTTACATGAAAGA
AAGAAAACAATTTGGTAGATCATTATCTGCATTCCAAGGATTACAATGGATGGTAGCAGAAATGGATACTAAAATAGAAG
CTGCAAGATTTTTAGTATATAAAGCAGCTTGTTTAAAAGAAGAGGGTAAACCATATTCTATAGATGCTGCAAGAGCTAAA
TTATTCGCTGCAGATGTAGCTATGGAAGTTACAACTAAGGCAGTTCAATTATTCGGTGGATATGGATATACTAAGGAATA
CCCAGTAGAAAGAATGATGAGAGATGCTAAGATAACTGAGATTTATGAAGGAACTTCAGAAGTTCAAAAAATGGTTATCG
CAGGAAGCATATTAAGATAA

Upstream 100 bases:

>100_bases
GAAGGTATGAGTGCTTTTGTAGAGAGAAGAGAAAAGAACTTTAAAAACAAGTAATTTTTTAAACAAAATGGTTGTGTGGA
TTTAAGGAGGGTAATTAAAA

Downstream 100 bases:

>100_bases
TTTTAGGAGGGCTTTGAGATGAAAATAGTAGTTTGCTTAAAACAAGTGCCAGATACAACAGCTGTTAAAATAGATCCAAA
AACAGGAACTCTTATAAGAG

Product: butyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MNFQLTREQELVKQMVREFAQNEVKPIAAEIDVTERFPMENVKKMAKLGMMGIPFSKEYGGAGGDTLSYILTVEELSKVC
ATTGVIVSAHTSLCASLIDQFGTPAQKEKYLTPLAKGEKLGAFGLTEPGAGTDAAGQQTTAVLEGDNYILNGSKIFITNG
GVADTFIIFAMTDKSQGTRGISAFIVEKNFPGFSIGKLEEKMGIRASSTTELIMENCVVPKENLIGREGKGFGIAMKTLD
GGRIGIAAQALGIAEGALEEAVAYMKERKQFGRSLSAFQGLQWMVAEMDTKIEAARFLVYKAACLKEEGKPYSIDAARAK
LFAADVAMEVTTKAVQLFGGYGYTKEYPVERMMRDAKITEIYEGTSEVQKMVIAGSILR

Sequences:

>Translated_379_residues
MNFQLTREQELVKQMVREFAQNEVKPIAAEIDVTERFPMENVKKMAKLGMMGIPFSKEYGGAGGDTLSYILTVEELSKVC
ATTGVIVSAHTSLCASLIDQFGTPAQKEKYLTPLAKGEKLGAFGLTEPGAGTDAAGQQTTAVLEGDNYILNGSKIFITNG
GVADTFIIFAMTDKSQGTRGISAFIVEKNFPGFSIGKLEEKMGIRASSTTELIMENCVVPKENLIGREGKGFGIAMKTLD
GGRIGIAAQALGIAEGALEEAVAYMKERKQFGRSLSAFQGLQWMVAEMDTKIEAARFLVYKAACLKEEGKPYSIDAARAK
LFAADVAMEVTTKAVQLFGGYGYTKEYPVERMMRDAKITEIYEGTSEVQKMVIAGSILR
>Mature_379_residues
MNFQLTREQELVKQMVREFAQNEVKPIAAEIDVTERFPMENVKKMAKLGMMGIPFSKEYGGAGGDTLSYILTVEELSKVC
ATTGVIVSAHTSLCASLIDQFGTPAQKEKYLTPLAKGEKLGAFGLTEPGAGTDAAGQQTTAVLEGDNYILNGSKIFITNG
GVADTFIIFAMTDKSQGTRGISAFIVEKNFPGFSIGKLEEKMGIRASSTTELIMENCVVPKENLIGREGKGFGIAMKTLD
GGRIGIAAQALGIAEGALEEAVAYMKERKQFGRSLSAFQGLQWMVAEMDTKIEAARFLVYKAACLKEEGKPYSIDAARAK
LFAADVAMEVTTKAVQLFGGYGYTKEYPVERMMRDAKITEIYEGTSEVQKMVIAGSILR

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=378, Percent_Identity=47.8835978835979, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=44.2359249329759, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI7656849, Length=376, Percent_Identity=40.6914893617021, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI226958412, Length=373, Percent_Identity=40.2144772117962, Blast_Score=288, Evalue=4e-78,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=40.7407407407407, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=40.7407407407407, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI226958414, Length=355, Percent_Identity=39.7183098591549, Blast_Score=271, Evalue=8e-73,
Organism=Homo sapiens, GI21361497, Length=367, Percent_Identity=40.3269754768392, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=35.8090185676393, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI76496475, Length=374, Percent_Identity=38.2352941176471, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI4557235, Length=374, Percent_Identity=38.2352941176471, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI4503943, Length=376, Percent_Identity=32.4468085106383, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=32.8729281767956, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI211971008, Length=361, Percent_Identity=28.808864265928, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI48976061, Length=361, Percent_Identity=28.808864265928, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI38505218, Length=413, Percent_Identity=26.634382566586, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI218563752, Length=228, Percent_Identity=26.7543859649123, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=29.7368421052632, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=32.2916666666667, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI87082384, Length=285, Percent_Identity=23.859649122807, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081702, Length=245, Percent_Identity=25.3061224489796, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=43.9353099730458, Blast_Score=322, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI17506239, Length=370, Percent_Identity=41.8918918918919, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=41.3612565445026, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=40.4199475065617, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17533517, Length=376, Percent_Identity=38.8297872340425, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=40.5759162303665, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17538396, Length=373, Percent_Identity=36.9973190348526, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI71990804, Length=276, Percent_Identity=46.3768115942029, Blast_Score=257, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=38.8571428571429, Blast_Score=233, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17534353, Length=376, Percent_Identity=34.0425531914894, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71982178, Length=271, Percent_Identity=39.1143911439114, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71985192, Length=297, Percent_Identity=39.0572390572391, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=40.174672489083, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17505929, Length=359, Percent_Identity=30.08356545961, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17551932, Length=371, Percent_Identity=29.3800539083558, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17531909, Length=237, Percent_Identity=35.4430379746835, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17562446, Length=284, Percent_Identity=31.6901408450704, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17531913, Length=179, Percent_Identity=32.9608938547486, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI86563383, Length=265, Percent_Identity=28.6792452830189, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI86563381, Length=265, Percent_Identity=28.6792452830189, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17540912, Length=305, Percent_Identity=25.5737704918033, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=47.2, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=42.9333333333333, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=42.8954423592493, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI24660351, Length=377, Percent_Identity=39.5225464190981, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI21355753, Length=377, Percent_Identity=38.1962864721485, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI281363737, Length=388, Percent_Identity=35.3092783505155, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=31.6622691292876, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 41048; Mature: 41048

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQLTREQELVKQMVREFAQNEVKPIAAEIDVTERFPMENVKKMAKLGMMGIPFSKEYG
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCHHCCCHHHHHHHHHHCCCCCCCCCCCC
GAGGDTLSYILTVEELSKVCATTGVIVSAHTSLCASLIDQFGTPAQKEKYLTPLAKGEKL
CCCCCHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHCCCCC
GAFGLTEPGAGTDAAGQQTTAVLEGDNYILNGSKIFITNGGVADTFIIFAMTDKSQGTRG
CCCCCCCCCCCCCCCCCCEEEEEECCCEEECCCEEEEECCCCCEEEEEEEEECCCCCCCC
ISAFIVEKNFPGFSIGKLEEKMGIRASSTTELIMENCVVPKENLIGREGKGFGIAMKTLD
EEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHCCCCCCCCEEEEEECC
GGRIGIAAQALGIAEGALEEAVAYMKERKQFGRSLSAFQGLQWMVAEMDTKIEAARFLVY
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KAACLKEEGKPYSIDAARAKLFAADVAMEVTTKAVQLFGGYGYTKEYPVERMMRDAKITE
HHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTSEVQKMVIAGSILR
HHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFQLTREQELVKQMVREFAQNEVKPIAAEIDVTERFPMENVKKMAKLGMMGIPFSKEYG
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCHHCCCHHHHHHHHHHCCCCCCCCCCCC
GAGGDTLSYILTVEELSKVCATTGVIVSAHTSLCASLIDQFGTPAQKEKYLTPLAKGEKL
CCCCCHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHCCCCC
GAFGLTEPGAGTDAAGQQTTAVLEGDNYILNGSKIFITNGGVADTFIIFAMTDKSQGTRG
CCCCCCCCCCCCCCCCCCEEEEEECCCEEECCCEEEEECCCCCEEEEEEEEECCCCCCCC
ISAFIVEKNFPGFSIGKLEEKMGIRASSTTELIMENCVVPKENLIGREGKGFGIAMKTLD
EEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHCCCCCCCCEEEEEECC
GGRIGIAAQALGIAEGALEEAVAYMKERKQFGRSLSAFQGLQWMVAEMDTKIEAARFLVY
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KAACLKEEGKPYSIDAARAKLFAADVAMEVTTKAVQLFGGYGYTKEYPVERMMRDAKITE
HHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTSEVQKMVIAGSILR
HHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]