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The map label for this gene is fixB [H]

Identifier: 18311280

GI number: 18311280

Start: 2642704

End: 2643711

Strand: Reverse

Name: fixB [H]

Synonym: CPE2298

Alternate gene names: 18311280

Gene position: 2643711-2642704 (Counterclockwise)

Preceding gene: 18311281

Following gene: 18311279

Centisome position: 87.21

GC content: 33.04

Gene sequence:

>1008_bases
ATGAATAAAGCAGATTTCAATGGCGTTTGGGTTTTTGCAGAGCAAAGAGAAGGTCAATTACAAAAAGTTTCATTAGAATT
ATTAGGTGAAGGTAGAAAAATCGCTGATAAATTAGGATCAAAATTAACAGCGTTATTAATAGGAAATAAAGTTCAAAATT
TAGTTGAAGATTTATCAAGACATGGTGCTGATGAAGTACTAGTTGTTGATGCTCCAGAATTAGAACATTACACAACTGAT
GGATATACAAAAGCTATATGTGAATTAGCTAATGCTAAAAAACCAAATATAATTTTCATAGGAGCAACATTCATAGGAAG
AGACTTAGGTCCAAGAGTTGCTGCAAGATTAGAAACTGGTTTAACTGCTGACTGTACATCTTTAGATGTTGATGTTGAAA
GTGGGGATTTATTAGCAACAAGACCAGCATTTGGTGGTAACTTAATGGCTACAATAGTATGTCCAGATCATAGACCACAA
ATGGCTACAGTAAGACCTGGAGTTTTTGAAAAACTTCCACTAGGAGAAAATGATGCAACTGTAGAAAATGTTGAAATAAA
ATTCAACTCTAATGATATAAGAACAAAAATTGTTGAAATAATTAAAGAACATAAAGATATTGTTGATATATCAGAAGCTA
ACGTATTAGTTGCAGGTGGTAGAGGTATTGGTTCAGAAGAAAACTTCAAAATGCTTAAGGAATTAGCAGAAGTTATGAAT
GGATCAATAGCAGCTTCAAGAGCAGCAGTAGAAAAAGGATGGGTAGATAAAGATTACCAAGTTGGACAAACAGGAAAAAC
TGTTAGACCAAATATATATGTAGCTTGTGGTATATCAGGAGCTATTCAACATGCCGCTGGTATGCAAGATTCAGATATGA
TAATAGCTATAAATAAAGATGCTAATGCTCCAATAATGAAGATTGCTGATTATGCAATAGTTGGGGATGTAAATAAAGTT
GTTCCAGAATTCATAGCTCAATTAAAAGCTATGAAGGAAGAAGCTTAA

Upstream 100 bases:

>100_bases
AGGAGAAATAGTTAAAGAATCACCTAAAGATTCAGTTACTTATGTACTAGGCAAATTAAAAGAAAAACACTACATCTAAG
GATTATGGGAGGTATTTAAG

Downstream 100 bases:

>100_bases
TTAATAAATAATATAACAAGGGTAAACTTATAAAATTTTTCAATTAATGGTGTAGGACTTTTCTGTTAAGTCAGAAAAGT
CCAATTAAAGAGAGTATTTA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MNKADFNGVWVFAEQREGQLQKVSLELLGEGRKIADKLGSKLTALLIGNKVQNLVEDLSRHGADEVLVVDAPELEHYTTD
GYTKAICELANAKKPNIIFIGATFIGRDLGPRVAARLETGLTADCTSLDVDVESGDLLATRPAFGGNLMATIVCPDHRPQ
MATVRPGVFEKLPLGENDATVENVEIKFNSNDIRTKIVEIIKEHKDIVDISEANVLVAGGRGIGSEENFKMLKELAEVMN
GSIAASRAAVEKGWVDKDYQVGQTGKTVRPNIYVACGISGAIQHAAGMQDSDMIIAINKDANAPIMKIADYAIVGDVNKV
VPEFIAQLKAMKEEA

Sequences:

>Translated_335_residues
MNKADFNGVWVFAEQREGQLQKVSLELLGEGRKIADKLGSKLTALLIGNKVQNLVEDLSRHGADEVLVVDAPELEHYTTD
GYTKAICELANAKKPNIIFIGATFIGRDLGPRVAARLETGLTADCTSLDVDVESGDLLATRPAFGGNLMATIVCPDHRPQ
MATVRPGVFEKLPLGENDATVENVEIKFNSNDIRTKIVEIIKEHKDIVDISEANVLVAGGRGIGSEENFKMLKELAEVMN
GSIAASRAAVEKGWVDKDYQVGQTGKTVRPNIYVACGISGAIQHAAGMQDSDMIIAINKDANAPIMKIADYAIVGDVNKV
VPEFIAQLKAMKEEA
>Mature_335_residues
MNKADFNGVWVFAEQREGQLQKVSLELLGEGRKIADKLGSKLTALLIGNKVQNLVEDLSRHGADEVLVVDAPELEHYTTD
GYTKAICELANAKKPNIIFIGATFIGRDLGPRVAARLETGLTADCTSLDVDVESGDLLATRPAFGGNLMATIVCPDHRPQ
MATVRPGVFEKLPLGENDATVENVEIKFNSNDIRTKIVEIIKEHKDIVDISEANVLVAGGRGIGSEENFKMLKELAEVMN
GSIAASRAAVEKGWVDKDYQVGQTGKTVRPNIYVACGISGAIQHAAGMQDSDMIIAINKDANAPIMKIADYAIVGDVNKV
VPEFIAQLKAMKEEA

Specific function: May play a role in a redox process [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=330, Percent_Identity=37.5757575757576, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI189181759, Length=246, Percent_Identity=42.2764227642276, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1787990, Length=331, Percent_Identity=31.7220543806647, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1786226, Length=237, Percent_Identity=30.8016877637131, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI87082157, Length=241, Percent_Identity=25.3112033195021, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17506929, Length=334, Percent_Identity=37.125748502994, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6325261, Length=301, Percent_Identity=31.2292358803987, Blast_Score=160, Evalue=4e-40,
Organism=Drosophila melanogaster, GI17136898, Length=323, Percent_Identity=35.6037151702786, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24652801, Length=323, Percent_Identity=35.6037151702786, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 36142; Mature: 36142

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKADFNGVWVFAEQREGQLQKVSLELLGEGRKIADKLGSKLTALLIGNKVQNLVEDLSR
CCCCCCCCEEEEEECCCCCHHEEEHHHHCCCHHHHHHHCCCEEEEHHHHHHHHHHHHHHH
HGADEVLVVDAPELEHYTTDGYTKAICELANAKKPNIIFIGATFIGRDLGPRVAARLETG
CCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHCCCCCHHHHHHHHCC
LTADCTSLDVDVESGDLLATRPAFGGNLMATIVCPDHRPQMATVRPGVFEKLPLGENDAT
CCCCCCEEEEECCCCCEEEECCCCCCCEEEEEECCCCCCCEEEECCCCHHCCCCCCCCCE
VENVEIKFNSNDIRTKIVEIIKEHKDIVDISEANVLVAGGRGIGSEENFKMLKELAEVMN
EEEEEEEECCCHHHHHHHHHHHHHCCEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHC
GSIAASRAAVEKGWVDKDYQVGQTGKTVRPNIYVACGISGAIQHAAGMQDSDMIIAINKD
CCHHHHHHHHHHCCCCCCCEECCCCCEECCCEEEEECCCHHHHHHCCCCCCCEEEEEECC
ANAPIMKIADYAIVGDVNKVVPEFIAQLKAMKEEA
CCCCHHHHHCEEEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKADFNGVWVFAEQREGQLQKVSLELLGEGRKIADKLGSKLTALLIGNKVQNLVEDLSR
CCCCCCCCEEEEEECCCCCHHEEEHHHHCCCHHHHHHHCCCEEEEHHHHHHHHHHHHHHH
HGADEVLVVDAPELEHYTTDGYTKAICELANAKKPNIIFIGATFIGRDLGPRVAARLETG
CCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHCCCCCHHHHHHHHCC
LTADCTSLDVDVESGDLLATRPAFGGNLMATIVCPDHRPQMATVRPGVFEKLPLGENDAT
CCCCCCEEEEECCCCCEEEECCCCCCCEEEEEECCCCCCCEEEECCCCHHCCCCCCCCCE
VENVEIKFNSNDIRTKIVEIIKEHKDIVDISEANVLVAGGRGIGSEENFKMLKELAEVMN
EEEEEEEECCCHHHHHHHHHHHHHCCEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHC
GSIAASRAAVEKGWVDKDYQVGQTGKTVRPNIYVACGISGAIQHAAGMQDSDMIIAINKD
CCHHHHHHHHHHCCCCCCCEECCCCCEECCCEEEEECCCHHHHHHCCCCCCCEEEEEECC
ANAPIMKIADYAIVGDVNKVVPEFIAQLKAMKEEA
CCCCHHHHHCEEEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7875566 [H]