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The map label for this gene is hbd [H]

Identifier: 18311279

GI number: 18311279

Start: 2641742

End: 2642590

Strand: Reverse

Name: hbd [H]

Synonym: CPE2297

Alternate gene names: 18311279

Gene position: 2642590-2641742 (Counterclockwise)

Preceding gene: 18311280

Following gene: 18311278

Centisome position: 87.17

GC content: 33.22

Gene sequence:

>849_bases
ATGGAAAAGATTTTTGTAATTGGTGCAGGTACAATGGGTGCTGGAATAGTTCAAGCATTTGCACAAAAAGGATATGAAGT
TATCGTTAGAGATATCAAAGACGAGTTTGTTGATAGAGGAATAGCTGGAATCAACAAAGGTCTTACTAAATTAGTTTCTA
AAGGAAAAATAACTGAAGAAGATAAAGAAGCAGTATTATCAAAAATCACTGGAACTACTGATTTAGGATTAGCTGCTGAC
TGTGATTTAGTTATAGAAGCTGCAGTTGAAAATATGGAAATCAAAAAACAAATTTTCGCTGAATTAGATAAAATCTGTAA
AGAAGAAACTATATTAGCTTCAAATACATCTTCATTATCAATAACAGAAGTAGCATCAGCTACAAACAGACCTGATAGAG
TTATAGGAATGCATTTCTTTAACCCTGCAACAATAATGAAACTTGTTGAAGTAATAAGAGGTATGGCTACTTCACAAGAA
ACTTTTGACAAAGTAAAAGCTATGTCAGAAGCTATAGGAAAGACTCCAGTAGAAGTTGCTGAAGCACCAGGATTTGTAGT
TAATAGAATACTTATCCCTATGATAAACGAAGCTATTGGAATATATGCAGAAGGAATAGCTTCCGTTGAAGATATAGATA
CTTCAATGAAATTAGGAGCTAATCATCCAATGGGACCTTTAGCTTTAGGAGATTTAATAGGATTAGATGTTTGCTTAGCT
ATAATGGACGTATTATTTAAAGAAACTGGAGACAGTAAATACAGAGCTCACAGTCTTTTAAGAAAATATGTTAGAGCAGG
ATGGTTAGGTAGAAAAACTGGTAGAGGATTCTACAACTACAACGCATAA

Upstream 100 bases:

>100_bases
TAACAAGGGTAAACTTATAAAATTTTTCAATTAATGGTGTAGGACTTTTCTGTTAAGTCAGAAAAGTCCAATTAAAGAGA
GTATTTAGGAGGAACTTAAT

Downstream 100 bases:

>100_bases
TATTGAAAGTTTAAAAAGTTTATAAGGTATAAATTTTCTATAGTATAAATCTGATATTATTAAATATTTTAAAGTATATA
TTATAGGAAGAGATTGAAGT

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MEKIFVIGAGTMGAGIVQAFAQKGYEVIVRDIKDEFVDRGIAGINKGLTKLVSKGKITEEDKEAVLSKITGTTDLGLAAD
CDLVIEAAVENMEIKKQIFAELDKICKEETILASNTSSLSITEVASATNRPDRVIGMHFFNPATIMKLVEVIRGMATSQE
TFDKVKAMSEAIGKTPVEVAEAPGFVVNRILIPMINEAIGIYAEGIASVEDIDTSMKLGANHPMGPLALGDLIGLDVCLA
IMDVLFKETGDSKYRAHSLLRKYVRAGWLGRKTGRGFYNYNA

Sequences:

>Translated_282_residues
MEKIFVIGAGTMGAGIVQAFAQKGYEVIVRDIKDEFVDRGIAGINKGLTKLVSKGKITEEDKEAVLSKITGTTDLGLAAD
CDLVIEAAVENMEIKKQIFAELDKICKEETILASNTSSLSITEVASATNRPDRVIGMHFFNPATIMKLVEVIRGMATSQE
TFDKVKAMSEAIGKTPVEVAEAPGFVVNRILIPMINEAIGIYAEGIASVEDIDTSMKLGANHPMGPLALGDLIGLDVCLA
IMDVLFKETGDSKYRAHSLLRKYVRAGWLGRKTGRGFYNYNA
>Mature_282_residues
MEKIFVIGAGTMGAGIVQAFAQKGYEVIVRDIKDEFVDRGIAGINKGLTKLVSKGKITEEDKEAVLSKITGTTDLGLAAD
CDLVIEAAVENMEIKKQIFAELDKICKEETILASNTSSLSITEVASATNRPDRVIGMHFFNPATIMKLVEVIRGMATSQE
TFDKVKAMSEAIGKTPVEVAEAPGFVVNRILIPMINEAIGIYAEGIASVEDIDTSMKLGANHPMGPLALGDLIGLDVCLA
IMDVLFKETGDSKYRAHSLLRKYVRAGWLGRKTGRGFYNYNA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=45.4861111111111, Blast_Score=240, Evalue=8e-64,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=42.9508196721311, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI20127408, Length=279, Percent_Identity=36.2007168458781, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI261878539, Length=291, Percent_Identity=36.426116838488, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI68989263, Length=291, Percent_Identity=36.426116838488, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI115430219, Length=222, Percent_Identity=31.5315315315315, Blast_Score=108, Evalue=5e-24,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=42.756183745583, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI1790281, Length=263, Percent_Identity=38.4030418250951, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1788682, Length=258, Percent_Identity=38.3720930232558, Blast_Score=168, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17553560, Length=286, Percent_Identity=42.3076923076923, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=39.0243902439024, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17563036, Length=286, Percent_Identity=38.4615384615385, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25144276, Length=281, Percent_Identity=36.6548042704626, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17508951, Length=281, Percent_Identity=36.6548042704626, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17508953, Length=281, Percent_Identity=36.6548042704626, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17558304, Length=284, Percent_Identity=34.8591549295775, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71985923, Length=283, Percent_Identity=34.2756183745583, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71985930, Length=278, Percent_Identity=32.0143884892086, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI115533614, Length=202, Percent_Identity=27.7227722772277, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193203623, Length=202, Percent_Identity=27.7227722772277, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19921000, Length=279, Percent_Identity=35.84229390681, Blast_Score=180, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24583077, Length=279, Percent_Identity=35.84229390681, Blast_Score=180, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24583079, Length=279, Percent_Identity=35.84229390681, Blast_Score=180, Evalue=9e-46,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=32.5, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20129993, Length=223, Percent_Identity=26.0089686098655, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30494; Mature: 30494

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIFVIGAGTMGAGIVQAFAQKGYEVIVRDIKDEFVDRGIAGINKGLTKLVSKGKITEE
CCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
DKEAVLSKITGTTDLGLAADCDLVIEAAVENMEIKKQIFAELDKICKEETILASNTSSLS
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCH
ITEVASATNRPDRVIGMHFFNPATIMKLVEVIRGMATSQETFDKVKAMSEAIGKTPVEVA
HHHHHHCCCCCCEEEEEHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHH
EAPGFVVNRILIPMINEAIGIYAEGIASVEDIDTSMKLGANHPMGPLALGDLIGLDVCLA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
IMDVLFKETGDSKYRAHSLLRKYVRAGWLGRKTGRGFYNYNA
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEKIFVIGAGTMGAGIVQAFAQKGYEVIVRDIKDEFVDRGIAGINKGLTKLVSKGKITEE
CCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
DKEAVLSKITGTTDLGLAADCDLVIEAAVENMEIKKQIFAELDKICKEETILASNTSSLS
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCH
ITEVASATNRPDRVIGMHFFNPATIMKLVEVIRGMATSQETFDKVKAMSEAIGKTPVEVA
HHHHHHCCCCCCEEEEEHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHH
EAPGFVVNRILIPMINEAIGIYAEGIASVEDIDTSMKLGANHPMGPLALGDLIGLDVCLA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
IMDVLFKETGDSKYRAHSLLRKYVRAGWLGRKTGRGFYNYNA
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]