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The map label for this gene is 18311275

Identifier: 18311275

GI number: 18311275

Start: 2637545

End: 2638483

Strand: Reverse

Name: 18311275

Synonym: CPE2293

Alternate gene names: NA

Gene position: 2638483-2637545 (Counterclockwise)

Preceding gene: 18311276

Following gene: 18311272

Centisome position: 87.04

GC content: 29.93

Gene sequence:

>939_bases
ATGGATTTTAAAAGTGTAGAATATGGAGAGAACAAAGTAATATTAAAAGATGCAAAAAACTTTAATATAAAACAAGTTTT
TGAATGTGGTCAATGTTTTAGATGGGAAAGAACAGAAAGTGGTTCATACATAGGAGTTGCCTTTGGAAAGGTTATAGAGT
TAGCTCAAGAAGGCCATGATGTAATAATATACAATACTAACAAAGAAGATTTTGAAAATATTTGGGTTGATTATTTTGAT
TTAGAAAGAGATTATTCAAAAGTAAAAGAAGCTTTATCTTGGGATGAAACATTAAAGAGTGCTGTTGAATTTGGATATGG
AATAAGAATATTAAATCAAGATCCTTTTGAACTTGTTATTTCATTTATAATATCAGCAAGAAATAGTATTCCTGTAATTT
CAAAGACCATAAAGAAAATAAGTGAAAGATGGGGAGAACCAATAGAGTATAAGGGAAATACTTATTATTCATTCCCAACT
CCAGAAAGCCTATCTAAGGCTTCAATAGATGATATAAGAGAGACAGGAGCTTCATTTAGAAGTAAGTATATATGGGATAC
AACTAAAAATATATATAACTGTGAGTTAGCTAAAAAGGGAATACTAGATGCACCAGAAGAAGAGATAGTTGAAATATTAG
AAAAATATGATTTAGAAAAGATAACTAATATGGATGCTGATGGATGTCATAAAGGACTTCAAGAATTTATGGGAGTAGGA
GCAAAGGTAGCAGACTGTATAATGCTATTTTCTATGAAAAAAAGTTCTGCATTCCCAGTAGATGTTTGGGTTAAGAGAGC
AATGATGCATTTTTATGGAGCTGATGATGCTTCATTAAATAAAATAAGAATTTTTGCAAGAGAGAGATTTGGAGAGTATT
CTGGATTTGCTCAACAATATCTATTCTATTATGCTAGAGAAAATGGAATAAAGATCTAA

Upstream 100 bases:

>100_bases
TAAGTACAAAAAAGATGATGACAGAAGATGCATAGTTATGATAGAAACTGCAGCTGAGGTTTTAGATGAAATCGTAAGAA
GAGAAAGATAGGTGAAAAGA

Downstream 100 bases:

>100_bases
TAAAAAACTTACAAACATATTTAGAGGATTACTAAATTTAGCTAAGGATTAAAATTCTAAAGCTTATTTAGATATTCTCT
TTATATTGTTTGTAAGTTTT

Product: 8-oxoguanine DNA glycosylase

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase; AP lyase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MDFKSVEYGENKVILKDAKNFNIKQVFECGQCFRWERTESGSYIGVAFGKVIELAQEGHDVIIYNTNKEDFENIWVDYFD
LERDYSKVKEALSWDETLKSAVEFGYGIRILNQDPFELVISFIISARNSIPVISKTIKKISERWGEPIEYKGNTYYSFPT
PESLSKASIDDIRETGASFRSKYIWDTTKNIYNCELAKKGILDAPEEEIVEILEKYDLEKITNMDADGCHKGLQEFMGVG
AKVADCIMLFSMKKSSAFPVDVWVKRAMMHFYGADDASLNKIRIFARERFGEYSGFAQQYLFYYARENGIKI

Sequences:

>Translated_312_residues
MDFKSVEYGENKVILKDAKNFNIKQVFECGQCFRWERTESGSYIGVAFGKVIELAQEGHDVIIYNTNKEDFENIWVDYFD
LERDYSKVKEALSWDETLKSAVEFGYGIRILNQDPFELVISFIISARNSIPVISKTIKKISERWGEPIEYKGNTYYSFPT
PESLSKASIDDIRETGASFRSKYIWDTTKNIYNCELAKKGILDAPEEEIVEILEKYDLEKITNMDADGCHKGLQEFMGVG
AKVADCIMLFSMKKSSAFPVDVWVKRAMMHFYGADDASLNKIRIFARERFGEYSGFAQQYLFYYARENGIKI
>Mature_312_residues
MDFKSVEYGENKVILKDAKNFNIKQVFECGQCFRWERTESGSYIGVAFGKVIELAQEGHDVIIYNTNKEDFENIWVDYFD
LERDYSKVKEALSWDETLKSAVEFGYGIRILNQDPFELVISFIISARNSIPVISKTIKKISERWGEPIEYKGNTYYSFPT
PESLSKASIDDIRETGASFRSKYIWDTTKNIYNCELAKKGILDAPEEEIVEILEKYDLEKITNMDADGCHKGLQEFMGVG
AKVADCIMLFSMKKSSAFPVDVWVKRAMMHFYGADDASLNKIRIFARERFGEYSGFAQQYLFYYARENGIKI

Specific function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-1 OGG1 family [H]

Homologues:

Organism=Homo sapiens, GI4505495, Length=304, Percent_Identity=26.3157894736842, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI8670534, Length=304, Percent_Identity=25.9868421052632, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI8670542, Length=300, Percent_Identity=26, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI8670540, Length=300, Percent_Identity=26, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI8670530, Length=300, Percent_Identity=26, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI8670532, Length=300, Percent_Identity=26, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI8670536, Length=234, Percent_Identity=24.3589743589744, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323580, Length=327, Percent_Identity=26.2996941896024, Blast_Score=96, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24640654, Length=298, Percent_Identity=28.1879194630872, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR004577
- InterPro:   IPR012904 [H]

Pfam domain/function: PF00730 HhH-GPD; PF07934 OGG_N [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 36047; Mature: 36047

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFKSVEYGENKVILKDAKNFNIKQVFECGQCFRWERTESGSYIGVAFGKVIELAQEGHD
CCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHCCCE
VIIYNTNKEDFENIWVDYFDLERDYSKVKEALSWDETLKSAVEFGYGIRILNQDPFELVI
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHH
SFIISARNSIPVISKTIKKISERWGEPIEYKGNTYYSFPTPESLSKASIDDIRETGASFR
HHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHH
SKYIWDTTKNIYNCELAKKGILDAPEEEIVEILEKYDLEKITNMDADGCHKGLQEFMGVG
HHHHHCCCCCCEECHHHHCCCCCCCHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHCCC
AKVADCIMLFSMKKSSAFPVDVWVKRAMMHFYGADDASLNKIRIFARERFGEYSGFAQQY
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHH
LFYYARENGIKI
HHHHHHCCCCCC
>Mature Secondary Structure
MDFKSVEYGENKVILKDAKNFNIKQVFECGQCFRWERTESGSYIGVAFGKVIELAQEGHD
CCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHCCCE
VIIYNTNKEDFENIWVDYFDLERDYSKVKEALSWDETLKSAVEFGYGIRILNQDPFELVI
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHH
SFIISARNSIPVISKTIKKISERWGEPIEYKGNTYYSFPTPESLSKASIDDIRETGASFR
HHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHH
SKYIWDTTKNIYNCELAKKGILDAPEEEIVEILEKYDLEKITNMDADGCHKGLQEFMGVG
HHHHHCCCCCCEECHHHHCCCCCCCHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHCCC
AKVADCIMLFSMKKSSAFPVDVWVKRAMMHFYGADDASLNKIRIFARERFGEYSGFAQQY
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHH
LFYYARENGIKI
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]