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The map label for this gene is upp

Identifier: 18311179

GI number: 18311179

Start: 2517959

End: 2518588

Strand: Reverse

Name: upp

Synonym: CPE2197

Alternate gene names: 18311179

Gene position: 2518588-2517959 (Counterclockwise)

Preceding gene: 18311180

Following gene: 18311178

Centisome position: 83.08

GC content: 33.49

Gene sequence:

>630_bases
ATGAGTAAAGTAACAGAAATAACACATCCACTTATATTACATAAGTTAGCGTTTATAAGAGATAAAAATACAGGGTCTAA
GGATTTTAGAGAACTAGTAAGTGAAGTTTCTATGCTTATGGCTTATGAGGTAACAAGAAATCTTCCTATGGAAGAAATAG
AAATAGAAACTCCAGTTTGTAAAACTAAATGTAAAGTTTTAGCTGGTAAAAAAGTTGCTATAGTTCCAATATTAAGAGCA
GGATTAGGTATGGTAGATGGTATGCTACAACTTATTCCAGCAGCAAAAGTAGGGCATATAGGATTATACAGAGATGAAGA
AACTCTTCAACCTGTAGAATATTTCTGTAAGTTACCACAAGATATAGCTGAAAGAGATGTAATAGTTGTTGATCCAATGT
TAGCTACAGGTGGTTCAGCTGCAGATGCTATAACTCTTTTAAAGAAAAGAGGAGCTAAGCAAATAAGACTTATGTGTTTA
ATTTCTTCACCAGAAGGAATAGAGTTTGTACAAAAAGCTCACCCAGATGTTGATATATATGTGGCATGTATTGATGAGAA
ATTAAACGATCATGGATACATCGTTCCTGGATTAGGTGATGCAGGAGATAGACTATTTGGAACAAAATAG

Upstream 100 bases:

>100_bases
GACACCAAAATAGAATAGATAAAATAACAGCTATTGAAGAAAAGTATTCAAAATAATTTGATAAAAAATATTTTTATATA
AATTTTAGGAGGAAGATACA

Downstream 100 bases:

>100_bases
TTATAATTTAAATAGCTACTTAATTTTAAGTAGCTATTAATTATTTTTGGAGGTAAATGATTCATGGAAAAGATAAAAGT
TTTAACTATCTTTGGAACAA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSKVTEITHPLILHKLAFIRDKNTGSKDFRELVSEVSMLMAYEVTRNLPMEEIEIETPVCKTKCKVLAGKKVAIVPILRA
GLGMVDGMLQLIPAAKVGHIGLYRDEETLQPVEYFCKLPQDIAERDVIVVDPMLATGGSAADAITLLKKRGAKQIRLMCL
ISSPEGIEFVQKAHPDVDIYVACIDEKLNDHGYIVPGLGDAGDRLFGTK

Sequences:

>Translated_209_residues
MSKVTEITHPLILHKLAFIRDKNTGSKDFRELVSEVSMLMAYEVTRNLPMEEIEIETPVCKTKCKVLAGKKVAIVPILRA
GLGMVDGMLQLIPAAKVGHIGLYRDEETLQPVEYFCKLPQDIAERDVIVVDPMLATGGSAADAITLLKKRGAKQIRLMCL
ISSPEGIEFVQKAHPDVDIYVACIDEKLNDHGYIVPGLGDAGDRLFGTK
>Mature_208_residues
SKVTEITHPLILHKLAFIRDKNTGSKDFRELVSEVSMLMAYEVTRNLPMEEIEIETPVCKTKCKVLAGKKVAIVPILRAG
LGMVDGMLQLIPAAKVGHIGLYRDEETLQPVEYFCKLPQDIAERDVIVVDPMLATGGSAADAITLLKKRGAKQIRLMCLI
SSPEGIEFVQKAHPDVDIYVACIDEKLNDHGYIVPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=193, Percent_Identity=31.0880829015544, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI57863312, Length=193, Percent_Identity=31.0880829015544, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI21450816, Length=163, Percent_Identity=30.0613496932515, Blast_Score=74, Evalue=7e-14,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=52.6570048309179, Blast_Score=238, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17539892, Length=202, Percent_Identity=26.7326732673267, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17539894, Length=202, Percent_Identity=26.7326732673267, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321920, Length=190, Percent_Identity=41.0526315789474, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45550449, Length=196, Percent_Identity=30.1020408163265, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28573516, Length=196, Percent_Identity=30.1020408163265, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28573514, Length=196, Percent_Identity=30.1020408163265, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28573512, Length=196, Percent_Identity=30.1020408163265, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21358379, Length=195, Percent_Identity=25.1282051282051, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_CLOP1 (Q0TNB4)

Other databases:

- EMBL:   CP000246
- RefSeq:   YP_696876.1
- ProteinModelPortal:   Q0TNB4
- SMR:   Q0TNB4
- STRING:   Q0TNB4
- GeneID:   4201005
- GenomeReviews:   CP000246_GR
- KEGG:   cpf:CPF_2462
- TIGR:   CPF_2462
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   IQHKLSH
- ProtClustDB:   PRK00129
- BioCyc:   CPER195103:CPF_2462-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22986; Mature: 22855

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVTEITHPLILHKLAFIRDKNTGSKDFRELVSEVSMLMAYEVTRNLPMEEIEIETPVC
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCHH
KTKCKVLAGKKVAIVPILRAGLGMVDGMLQLIPAAKVGHIGLYRDEETLQPVEYFCKLPQ
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCH
DIAERDVIVVDPMLATGGSAADAITLLKKRGAKQIRLMCLISSPEGIEFVQKAHPDVDIY
HHHHCCEEEECCHHHCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHCCCCCEEE
VACIDEKLNDHGYIVPGLGDAGDRLFGTK
EEEEECCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SKVTEITHPLILHKLAFIRDKNTGSKDFRELVSEVSMLMAYEVTRNLPMEEIEIETPVC
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCHH
KTKCKVLAGKKVAIVPILRAGLGMVDGMLQLIPAAKVGHIGLYRDEETLQPVEYFCKLPQ
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCH
DIAERDVIVVDPMLATGGSAADAITLLKKRGAKQIRLMCLISSPEGIEFVQKAHPDVDIY
HHHHCCEEEECCHHHCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHCCCCCEEE
VACIDEKLNDHGYIVPGLGDAGDRLFGTK
EEEEECCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA