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The map label for this gene is dhaT [H]

Identifier: 18309918

GI number: 18309918

Start: 1133756

End: 1134913

Strand: Direct

Name: dhaT [H]

Synonym: CPE0936

Alternate gene names: 18309918

Gene position: 1133756-1134913 (Clockwise)

Preceding gene: 18309917

Following gene: 18309919

Centisome position: 37.4

GC content: 35.66

Gene sequence:

>1158_bases
ATGAGAATGTACGATTATTTAGTACCAAGTGTAAACTTTATGGGAGCTAACTCAATATCAGTAGTTGGTGAAAGATGTAA
AATATTAGGTGGAAAGAAAGCTTTAATAGTTACAGATAAATTCTTAAGAGGATTAAAAGGTGGAGCAGTTGAATTAACTG
AAAAATACCTAAAAGAAGCAGGAATCGAAGTTGCTTATTATGATGGAGTTGAACCAAACCCAAAAGATACAAACGTTAAA
GATGGTTTAAAAATATTCCAAGACGAAAACTGTGATATGATCGTTACAGTTGGTGGAGGAAGCTCACATGACTGTGGTAA
AGGAATAGGTATAGCTGCAACTCACGAAGGAGATCTTTATGACTATGCTGGAATAGAAACTTTAACAAATCCACTTCCTC
CAATAGTAGCAGTAAACACTACAGCTGGAACTGCAAGTGAAGTAACTAGACACTGTGTTATAACAAACACTAAAACTAAA
GTTAAATTCGTTATAGTAAGCTGGAGAAACTTACCTTTAGTTTCAATCAATGACCCAATGTTAATGGTTGGAAAACCAGC
AGGATTAACAGCTGCAACAGGAATGGACGCTTTAACTCATGCTGTAGAAGCATACGTATCAAAAGATGCTAACCCTGTAA
CAGATGCTGCTGCAATACAAGCTATAAAATTAATATCAAGCAATTTAAGACAAGCTGTTGCTTTAGGAGAAAACTTAGTA
GCTAGAGAAAACATGGCTTACGGTTCATTATTAGCTGGTATGGCATTCAACAATGCTAACTTAGGATATGTACATGCTAT
GGCTCACCAATTAGGCGGATTATATGATATGCCTCATGGAGTAGCTAACGCTATGTTATTACCACACGTATGTAAATATA
ACTTAATATCTAACCCACAAAAATTCGCTGATATAGCTGAATTTATGGGAGAAAACATAGAAGGATTATCAGTAATGGAC
GCTGCTCAAAAAGCTATAGATGCAATGTTCAGATTATCAACTGATATCGGAATACCAGCAAAATTAAGAGACATGGGAGT
AAAAGAAGAAGACTTCGGATACATGGCTGAAATGGCTCTTAAAGATGGTAATGCATTCAGTAACCCAAGAAAAGGTAACG
AAAGAGACATCGTTGAAATATTCAAAGCTGCATTCTAA

Upstream 100 bases:

>100_bases
TAAGTAATAAAAAGCTAATAATATTTAACCTATATAATAGATTAAATATTTAAAATATATTTTAATAGATATAAAATGTT
TGAAAATGGAGGAAAATGAA

Downstream 100 bases:

>100_bases
TAAAAGATTAGCTTTATAATAAAAAAATAATTAAAAATATAATAAGTGCTAGCTCTAATAATTAGAGCTAGCAAATAATA
AAAGGCATAAATACAATAGA

Product: 1,3-propanediol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MRMYDYLVPSVNFMGANSISVVGERCKILGGKKALIVTDKFLRGLKGGAVELTEKYLKEAGIEVAYYDGVEPNPKDTNVK
DGLKIFQDENCDMIVTVGGGSSHDCGKGIGIAATHEGDLYDYAGIETLTNPLPPIVAVNTTAGTASEVTRHCVITNTKTK
VKFVIVSWRNLPLVSINDPMLMVGKPAGLTAATGMDALTHAVEAYVSKDANPVTDAAAIQAIKLISSNLRQAVALGENLV
ARENMAYGSLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAMLLPHVCKYNLISNPQKFADIAEFMGENIEGLSVMD
AAQKAIDAMFRLSTDIGIPAKLRDMGVKEEDFGYMAEMALKDGNAFSNPRKGNERDIVEIFKAAF

Sequences:

>Translated_385_residues
MRMYDYLVPSVNFMGANSISVVGERCKILGGKKALIVTDKFLRGLKGGAVELTEKYLKEAGIEVAYYDGVEPNPKDTNVK
DGLKIFQDENCDMIVTVGGGSSHDCGKGIGIAATHEGDLYDYAGIETLTNPLPPIVAVNTTAGTASEVTRHCVITNTKTK
VKFVIVSWRNLPLVSINDPMLMVGKPAGLTAATGMDALTHAVEAYVSKDANPVTDAAAIQAIKLISSNLRQAVALGENLV
ARENMAYGSLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAMLLPHVCKYNLISNPQKFADIAEFMGENIEGLSVMD
AAQKAIDAMFRLSTDIGIPAKLRDMGVKEEDFGYMAEMALKDGNAFSNPRKGNERDIVEIFKAAF
>Mature_385_residues
MRMYDYLVPSVNFMGANSISVVGERCKILGGKKALIVTDKFLRGLKGGAVELTEKYLKEAGIEVAYYDGVEPNPKDTNVK
DGLKIFQDENCDMIVTVGGGSSHDCGKGIGIAATHEGDLYDYAGIETLTNPLPPIVAVNTTAGTASEVTRHCVITNTKTK
VKFVIVSWRNLPLVSINDPMLMVGKPAGLTAATGMDALTHAVEAYVSKDANPVTDAAAIQAIKLISSNLRQAVALGENLV
ARENMAYGSLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAMLLPHVCKYNLISNPQKFADIAEFMGENIEGLSVMD
AAQKAIDAMFRLSTDIGIPAKLRDMGVKEEDFGYMAEMALKDGNAFSNPRKGNERDIVEIFKAAF

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=409, Percent_Identity=27.1393643031785, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI48994951, Length=385, Percent_Identity=48.8311688311688, Blast_Score=370, Evalue=1e-104,
Organism=Escherichia coli, GI1789163, Length=375, Percent_Identity=44, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI87082107, Length=383, Percent_Identity=35.509138381201, Blast_Score=221, Evalue=5e-59,
Organism=Escherichia coli, GI1787493, Length=399, Percent_Identity=32.3308270676692, Blast_Score=191, Evalue=5e-50,
Organism=Escherichia coli, GI1789386, Length=294, Percent_Identity=24.8299319727891, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17537053, Length=396, Percent_Identity=23.4848484848485, Blast_Score=111, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321181, Length=382, Percent_Identity=42.4083769633508, Blast_Score=308, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24657991, Length=400, Percent_Identity=24.75, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 41288; Mature: 41288

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2 ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMYDYLVPSVNFMGANSISVVGERCKILGGKKALIVTDKFLRGLKGGAVELTEKYLKEA
CCCHHHHCCCCEECCCCHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHC
GIEVAYYDGVEPNPKDTNVKDGLKIFQDENCDMIVTVGGGSSHDCGKGIGIAATHEGDLY
CCEEEEECCCCCCCCCCCHHHHHHHEECCCCCEEEEECCCCCCCCCCCCCEEEECCCCCC
DYAGIETLTNPLPPIVAVNTTAGTASEVTRHCVITNTKTKVKFVIVSWRNLPLVSINDPM
HHCCHHHHCCCCCCEEEEECCCCCHHHHHCEEEEECCCCEEEEEEEEECCCEEEEECCCE
LMVGKPAGLTAATGMDALTHAVEAYVSKDANPVTDAAAIQAIKLISSNLRQAVALGENLV
EEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
ARENMAYGSLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAMLLPHVCKYNLISNPQ
HHCCCHHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHH
KFADIAEFMGENIEGLSVMDAAQKAIDAMFRLSTDIGIPAKLRDMGVKEEDFGYMAEMAL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHH
KDGNAFSNPRKGNERDIVEIFKAAF
CCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MRMYDYLVPSVNFMGANSISVVGERCKILGGKKALIVTDKFLRGLKGGAVELTEKYLKEA
CCCHHHHCCCCEECCCCHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHC
GIEVAYYDGVEPNPKDTNVKDGLKIFQDENCDMIVTVGGGSSHDCGKGIGIAATHEGDLY
CCEEEEECCCCCCCCCCCHHHHHHHEECCCCCEEEEECCCCCCCCCCCCCEEEECCCCCC
DYAGIETLTNPLPPIVAVNTTAGTASEVTRHCVITNTKTKVKFVIVSWRNLPLVSINDPM
HHCCHHHHCCCCCCEEEEECCCCCHHHHHCEEEEECCCCEEEEEEEEECCCEEEEECCCE
LMVGKPAGLTAATGMDALTHAVEAYVSKDANPVTDAAAIQAIKLISSNLRQAVALGENLV
EEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
ARENMAYGSLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAMLLPHVCKYNLISNPQ
HHCCCHHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHH
KFADIAEFMGENIEGLSVMDAAQKAIDAMFRLSTDIGIPAKLRDMGVKEEDFGYMAEMAL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHH
KDGNAFSNPRKGNERDIVEIFKAAF
CCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]