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The map label for this gene is trxA [H]

Identifier: 182682667

GI number: 182682667

Start: 2436914

End: 2437255

Strand: Direct

Name: trxA [H]

Synonym: XfasM23_2157

Alternate gene names: 182682667

Gene position: 2436914-2437255 (Clockwise)

Preceding gene: 182682659

Following gene: 182682668

Centisome position: 96.1

GC content: 46.78

Gene sequence:

>342_bases
TTGAGCGACTATGTTCTACATATCAGCGATGCCAATTTCGATGCCATGGTGCTGCTATCCGATCAGCCTGTATTAGTGGA
CTTCTGGGCTAAATGGTGCGGCCCATGCAAAATTATCTCTACCCTACTTGATGATTTAGCCCAAAGCTACGAAGGGAGAT
TAAAAATTGCCAAAGTCGACATCGACGAGAACCGCGCACTAGCGATTAAATATCACGTGTGTTCTATCCCCATGCTGCTA
CTGTTCAAAGATGGTCAAGTTCAAATTACCCAGACCGGCGCCGTCGGAAAGGGTCGTCTAACCCAAATGATTGACAAAGT
GCTGGCAAACACCGACTCATGA

Upstream 100 bases:

>100_bases
ACTTCAGGTTGAGCCATTGATCAATCGCACGGACCCCAGCTTACCGTAATGTAACAATCTGTCTAACTGGCAATTACCTT
CACGTCCAAGGAAATATCAA

Downstream 100 bases:

>100_bases
TGCCTCGCACCGTTCATACCTCATAATTTACCCTATACTATTATGAATGCAGAAAAATAACTCGCGTTGCCGCCGCTTGC
TTGGCAACACGGACAATGAT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 113; Mature: 112

Protein sequence:

>113_residues
MSDYVLHISDANFDAMVLLSDQPVLVDFWAKWCGPCKIISTLLDDLAQSYEGRLKIAKVDIDENRALAIKYHVCSIPMLL
LFKDGQVQITQTGAVGKGRLTQMIDKVLANTDS

Sequences:

>Translated_113_residues
MSDYVLHISDANFDAMVLLSDQPVLVDFWAKWCGPCKIISTLLDDLAQSYEGRLKIAKVDIDENRALAIKYHVCSIPMLL
LFKDGQVQITQTGAVGKGRLTQMIDKVLANTDS
>Mature_112_residues
SDYVLHISDANFDAMVLLSDQPVLVDFWAKWCGPCKIISTLLDDLAQSYEGRLKIAKVDIDENRALAIKYHVCSIPMLLL
FKDGQVQITQTGAVGKGRLTQMIDKVLANTDS

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=77, Percent_Identity=44.1558441558442, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082331, Length=109, Percent_Identity=50.4587155963303, Blast_Score=126, Evalue=3e-31,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=36.9565217391304, Blast_Score=83, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71998175, Length=104, Percent_Identity=37.5, Blast_Score=71, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=98, Percent_Identity=32.6530612244898, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=87, Percent_Identity=34.4827586206897, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=96, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=84, Percent_Identity=38.0952380952381, Blast_Score=64, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573567, Length=76, Percent_Identity=44.7368421052632, Blast_Score=82, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24639826, Length=91, Percent_Identity=39.5604395604396, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664269, Length=106, Percent_Identity=34.9056603773585, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17648013, Length=85, Percent_Identity=35.2941176470588, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583090, Length=85, Percent_Identity=35.2941176470588, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358065, Length=63, Percent_Identity=46.031746031746, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12558; Mature: 12427

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDYVLHISDANFDAMVLLSDQPVLVDFWAKWCGPCKIISTLLDDLAQSYEGRLKIAKVD
CCCEEEEEECCCCEEEEEECCCCCCEEHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEE
IDENRALAIKYHVCSIPMLLLFKDGQVQITQTGAVGKGRLTQMIDKVLANTDS
ECCCCEEEEEEEECCCCEEEEEECCEEEEEECCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SDYVLHISDANFDAMVLLSDQPVLVDFWAKWCGPCKIISTLLDDLAQSYEGRLKIAKVD
CCEEEEEECCCCEEEEEECCCCCCEEHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEE
IDENRALAIKYHVCSIPMLLLFKDGQVQITQTGAVGKGRLTQMIDKVLANTDS
ECCCCEEEEEEEECCCCEEEEEECCEEEEEECCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]