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The map label for this gene is prs [H]

Identifier: 182682630

GI number: 182682630

Start: 2388594

End: 2389562

Strand: Reverse

Name: prs [H]

Synonym: XfasM23_2118

Alternate gene names: 182682630

Gene position: 2389562-2388594 (Counterclockwise)

Preceding gene: 182682631

Following gene: 182682629

Centisome position: 94.24

GC content: 48.5

Gene sequence:

>969_bases
ATGCCTACCATTCAAGACGAACGCAATTTGATGGTCTTTTCGGGCAATGCCAATAAACCACTGACTCAAAGTATTTGTAA
GGAGTTAGGGGTGCGTATGGGTAAATCGTTAGTGTCGCGTTTTTCCGATGGAGAGGAGCAGGTCGAAATTGAGGAAAGTG
TGCGTCGTCAGGAAGTATTTGTGGTGCAGCCGACCTGTGCGCCAAGTGCTGAAAATTTGATGGAACTGTTGGTTATCATT
GATGCGCTCAAGCGTGCCAGTGTTTCTAGTGTCACTGCCGTGATTCCGTACTTCGGTTATTCGCGTCAGGATCGCCGAAT
GCGTTCTTTGCGTGTACCGATTACCGCAAAGGTTGCGGCAAAAATGATCAGTGCGATTGGTGCTGATCGTGTGTTGACCA
TTGATTTGCACGCTGATCAAATCCAGGGTTTTTTTGATGTGCCGGTAGATAACGTTTATGCTTCGCCGCTGTTACTGGCT
GATATTTGGCGTGCTTATGGCACTGACAATATAATTGTGGTTTCCCCGGATGTGGGGGGGGTGGTCAGAGCCCGTGCCAT
GGCTAAGCGTTTAGGCGATACCGATCTGGCAATCATTGATAAGCGCCGTCCTCGTGCCAATGTTGCTACGGTAATGAATA
TTATCGGGGAGGTTAACGGTAAGACCTGTGTACTGGTCGATGATTTAGTGGATACTGCCGGTACTTTGTGTGCGGCGGCC
GTAGCACTTAAGCAAAATGGTGCTACTAAGGTTGTTGCTTATATCACGCATCCGGTGCTGTCCGGCCCTGCTATGGACAA
TATTAATAACTCTGAGCTTGACGAGCTTGTGGTGACGGATACCATTCCTTTGTCTGATGCCGCTCGGGAATGCCGAAAAA
TTCGCCAGCTTAGTGTGGCTGAGTTGCTTGCTGAGACTATTCGGCGTATTGCTTTTGGTGAATCAGTCAGTTCACTGTAT
GTGGATTGA

Upstream 100 bases:

>100_bases
CATGTGTTCCCGTTTGGAGTGGGCAGGGCGCTTGGGTTTGTAGTGTTCCTGGTAATTCGGTTTTACTCTCTTAACCTTAC
TCTTCGTTGCTGCCTGATAG

Downstream 100 bases:

>100_bases
TTGCATGGCCCATCGGGCTGTTTTTAAAAACGACTCTTTTGGTCGCGAGAGGGTCGCCTTCTATCGCTGCGAGGCGGTTT
CTCAACTTTTATAAGGTAGT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MPTIQDERNLMVFSGNANKPLTQSICKELGVRMGKSLVSRFSDGEEQVEIEESVRRQEVFVVQPTCAPSAENLMELLVII
DALKRASVSSVTAVIPYFGYSRQDRRMRSLRVPITAKVAAKMISAIGADRVLTIDLHADQIQGFFDVPVDNVYASPLLLA
DIWRAYGTDNIIVVSPDVGGVVRARAMAKRLGDTDLAIIDKRRPRANVATVMNIIGEVNGKTCVLVDDLVDTAGTLCAAA
VALKQNGATKVVAYITHPVLSGPAMDNINNSELDELVVTDTIPLSDAARECRKIRQLSVAELLAETIRRIAFGESVSSLY
VD

Sequences:

>Translated_322_residues
MPTIQDERNLMVFSGNANKPLTQSICKELGVRMGKSLVSRFSDGEEQVEIEESVRRQEVFVVQPTCAPSAENLMELLVII
DALKRASVSSVTAVIPYFGYSRQDRRMRSLRVPITAKVAAKMISAIGADRVLTIDLHADQIQGFFDVPVDNVYASPLLLA
DIWRAYGTDNIIVVSPDVGGVVRARAMAKRLGDTDLAIIDKRRPRANVATVMNIIGEVNGKTCVLVDDLVDTAGTLCAAA
VALKQNGATKVVAYITHPVLSGPAMDNINNSELDELVVTDTIPLSDAARECRKIRQLSVAELLAETIRRIAFGESVSSLY
VD
>Mature_321_residues
PTIQDERNLMVFSGNANKPLTQSICKELGVRMGKSLVSRFSDGEEQVEIEESVRRQEVFVVQPTCAPSAENLMELLVIID
ALKRASVSSVTAVIPYFGYSRQDRRMRSLRVPITAKVAAKMISAIGADRVLTIDLHADQIQGFFDVPVDNVYASPLLLAD
IWRAYGTDNIIVVSPDVGGVVRARAMAKRLGDTDLAIIDKRRPRANVATVMNIIGEVNGKTCVLVDDLVDTAGTLCAAAV
ALKQNGATKVVAYITHPVLSGPAMDNINNSELDELVVTDTIPLSDAARECRKIRQLSVAELLAETIRRIAFGESVSSLYV
D

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=318, Percent_Identity=47.7987421383648, Blast_Score=295, Evalue=3e-80,
Organism=Homo sapiens, GI4506129, Length=318, Percent_Identity=47.1698113207547, Blast_Score=295, Evalue=4e-80,
Organism=Homo sapiens, GI84875539, Length=320, Percent_Identity=46.5625, Blast_Score=292, Evalue=2e-79,
Organism=Homo sapiens, GI28557709, Length=318, Percent_Identity=46.5408805031447, Blast_Score=288, Evalue=7e-78,
Organism=Homo sapiens, GI194018537, Length=344, Percent_Identity=37.5, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=35.3623188405797, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI310128524, Length=149, Percent_Identity=29.5302013422819, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI310115209, Length=149, Percent_Identity=29.5302013422819, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI310118259, Length=149, Percent_Identity=29.5302013422819, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI310119946, Length=149, Percent_Identity=29.5302013422819, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=60.2564102564103, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17554702, Length=313, Percent_Identity=45.6869009584665, Blast_Score=280, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI25149168, Length=313, Percent_Identity=45.6869009584665, Blast_Score=280, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI71989924, Length=313, Percent_Identity=45.6869009584665, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17554704, Length=310, Percent_Identity=45.8064516129032, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17570245, Length=350, Percent_Identity=33.1428571428571, Blast_Score=181, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6321776, Length=321, Percent_Identity=43.613707165109, Blast_Score=263, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6319403, Length=315, Percent_Identity=42.5396825396825, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=42.0382165605096, Blast_Score=246, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6322667, Length=203, Percent_Identity=36.9458128078818, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324511, Length=267, Percent_Identity=32.5842696629214, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21355239, Length=318, Percent_Identity=47.4842767295598, Blast_Score=281, Evalue=4e-76,
Organism=Drosophila melanogaster, GI45551540, Length=341, Percent_Identity=44.574780058651, Blast_Score=271, Evalue=6e-73,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=34.0845070422535, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=34.0845070422535, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=34.0845070422535, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=34.0845070422535, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24651462, Length=374, Percent_Identity=32.3529411764706, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24651464, Length=374, Percent_Identity=32.3529411764706, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI45552010, Length=374, Percent_Identity=31.5508021390374, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35013; Mature: 34882

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTIQDERNLMVFSGNANKPLTQSICKELGVRMGKSLVSRFSDGEEQVEIEESVRRQEVF
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCEEE
VVQPTCAPSAENLMELLVIIDALKRASVSSVTAVIPYFGYSRQDRRMRSLRVPITAKVAA
EECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHH
KMISAIGADRVLTIDLHADQIQGFFDVPVDNVYASPLLLADIWRAYGTDNIIVVSPDVGG
HHHHHHCCCCEEEEEEEHHHHCCEECCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCH
VVRARAMAKRLGDTDLAIIDKRRPRANVATVMNIIGEVNGKTCVLVDDLVDTAGTLCAAA
HHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHH
VALKQNGATKVVAYITHPVLSGPAMDNINNSELDELVVTDTIPLSDAARECRKIRQLSVA
HHHHCCCCCEEEEEEHHHHHCCCCCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHHHH
ELLAETIRRIAFGESVSSLYVD
HHHHHHHHHHHHCCCHHHHCCC
>Mature Secondary Structure 
PTIQDERNLMVFSGNANKPLTQSICKELGVRMGKSLVSRFSDGEEQVEIEESVRRQEVF
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCEEE
VVQPTCAPSAENLMELLVIIDALKRASVSSVTAVIPYFGYSRQDRRMRSLRVPITAKVAA
EECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHH
KMISAIGADRVLTIDLHADQIQGFFDVPVDNVYASPLLLADIWRAYGTDNIIVVSPDVGG
HHHHHHCCCCEEEEEEEHHHHCCEECCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCH
VVRARAMAKRLGDTDLAIIDKRRPRANVATVMNIIGEVNGKTCVLVDDLVDTAGTLCAAA
HHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHH
VALKQNGATKVVAYITHPVLSGPAMDNINNSELDELVVTDTIPLSDAARECRKIRQLSVA
HHHHCCCCCEEEEEEHHHHHCCCCCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHHHH
ELLAETIRRIAFGESVSSLYVD
HHHHHHHHHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]