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The map label for this gene is hemH

Identifier: 182682185

GI number: 182682185

Start: 1842259

End: 1843221

Strand: Reverse

Name: hemH

Synonym: XfasM23_1664

Alternate gene names: 182682185

Gene position: 1843221-1842259 (Counterclockwise)

Preceding gene: 182682190

Following gene: 182682180

Centisome position: 72.69

GC content: 55.56

Gene sequence:

>963_bases
ATGAATCACACTTCTGATACTGCTTTACTGATTGTTAATCTTGGTACTCCTGAGGCGCCGACTGCGGCGGCGGTGCGCCG
TTATCTGGGCGAATTCCTGAGTGATCGCCGCGTGGTATCCATTCCGCCGTTGTTTTGGAAGCCATTGCTGCATATGGTGA
TTTTGCCGATTCGCGGCCCGCGTTCAGCCAGCAAATACGCCAAAGTGTGGTTGCAGGAAGGCTCTCCCCTCAGTGTGTAT
ACCCGCCGTATTGCTGAAGGGCTGACGCAACATCTGCCTGATTGGCGTGTGGCTTGGGCGATGCGTTACGGTGCTCCAGC
ATTGACAAAGGCGCTAGATGCGCTGCAAGCGCAGCAGGTACGCCGCATCGTGATACTGCCGTTATATCCTCAATATTCGA
CCACCACCACGGCCTCAGTACAGGATGTGGTGGAAGCGTGGTGTAAGCGTACTCCCCAAGTGCAGGTTGAATGCATTCAA
GACTATGCCGAGGACCCAGCGTGGGTCGCTGCGGTGGCTGCTTCGATCCGTAGGCATTGGCAAGCACATGGCCGCAGTGA
GAAGTTGATGTTCTCTTTCCATGGACTGCCGCAGCGTGTGGCCAATAACGGTGATCCCTATCCGCAGCGCTGCCAGGTGA
GTGCGTCTTTGATTGCCGCAGCATTGAATTTGAATGAGAGTGAGTGGGTGCTCGGTTATCAGTCGCGCTTTGGTGCTGAG
CGTTGGTTACAACCATATGCTGAGCCAACGCTCTGGGCGCTTGCTGAGTCTGGCATACGTCGCTTTGATCTTGTCTGCCC
AGGTTTTTCCGTTGATTGCCTGGAAACATTGGAGGAAGTGGCGCTCGGTTTTTCAGAAACGCTGGCAGCGCGTGGTGCAA
CGATGCGCTACATTCCCTGTCTCAATGATGACCCTGCACATGTGCAGGCGTTGGCTGGACTGGCGCAACGTGCGTTGCCG
TGA

Upstream 100 bases:

>100_bases
GCTGAATCGGTAATGAGTGTGACTACGTTCCTTGTGTTATCGGTATGACTTGCCGATTTGCATGCGGCAAGTGAGGTCAC
GTTGAGTCACAATAGCACAT

Downstream 100 bases:

>100_bases
ATGCAGCAGCGTTCTCAGTGCATTGCCCTGTGTTGTAGTGCAGCGTTGCCAATGCTGCATTTTAGTGCATTTGATGTTGC
GGCTGATCAGGGGATGTGCC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MNHTSDTALLIVNLGTPEAPTAAAVRRYLGEFLSDRRVVSIPPLFWKPLLHMVILPIRGPRSASKYAKVWLQEGSPLSVY
TRRIAEGLTQHLPDWRVAWAMRYGAPALTKALDALQAQQVRRIVILPLYPQYSTTTTASVQDVVEAWCKRTPQVQVECIQ
DYAEDPAWVAAVAASIRRHWQAHGRSEKLMFSFHGLPQRVANNGDPYPQRCQVSASLIAAALNLNESEWVLGYQSRFGAE
RWLQPYAEPTLWALAESGIRRFDLVCPGFSVDCLETLEEVALGFSETLAARGATMRYIPCLNDDPAHVQALAGLAQRALP

Sequences:

>Translated_320_residues
MNHTSDTALLIVNLGTPEAPTAAAVRRYLGEFLSDRRVVSIPPLFWKPLLHMVILPIRGPRSASKYAKVWLQEGSPLSVY
TRRIAEGLTQHLPDWRVAWAMRYGAPALTKALDALQAQQVRRIVILPLYPQYSTTTTASVQDVVEAWCKRTPQVQVECIQ
DYAEDPAWVAAVAASIRRHWQAHGRSEKLMFSFHGLPQRVANNGDPYPQRCQVSASLIAAALNLNESEWVLGYQSRFGAE
RWLQPYAEPTLWALAESGIRRFDLVCPGFSVDCLETLEEVALGFSETLAARGATMRYIPCLNDDPAHVQALAGLAQRALP
>Mature_320_residues
MNHTSDTALLIVNLGTPEAPTAAAVRRYLGEFLSDRRVVSIPPLFWKPLLHMVILPIRGPRSASKYAKVWLQEGSPLSVY
TRRIAEGLTQHLPDWRVAWAMRYGAPALTKALDALQAQQVRRIVILPLYPQYSTTTTASVQDVVEAWCKRTPQVQVECIQ
DYAEDPAWVAAVAASIRRHWQAHGRSEKLMFSFHGLPQRVANNGDPYPQRCQVSASLIAAALNLNESEWVLGYQSRFGAE
RWLQPYAEPTLWALAESGIRRFDLVCPGFSVDCLETLEEVALGFSETLAARGATMRYIPCLNDDPAHVQALAGLAQRALP

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=327, Percent_Identity=28.1345565749235, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI60499021, Length=327, Percent_Identity=28.1345565749235, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786681, Length=312, Percent_Identity=46.474358974359, Blast_Score=281, Evalue=3e-77,
Organism=Drosophila melanogaster, GI17864156, Length=329, Percent_Identity=24.0121580547112, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_XYLF2 (B2I7H7)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830345.1
- ProteinModelPortal:   B2I7H7
- SMR:   B2I7H7
- GeneID:   6202585
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1664
- HOGENOM:   HBG697135
- OMA:   TIEEIGM
- ProtClustDB:   PRK00035
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 35657; Mature: 35657

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHTSDTALLIVNLGTPEAPTAAAVRRYLGEFLSDRRVVSIPPLFWKPLLHMVILPIRGP
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCC
RSASKYAKVWLQEGSPLSVYTRRIAEGLTQHLPDWRVAWAMRYGAPALTKALDALQAQQV
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHC
RRIVILPLYPQYSTTTTASVQDVVEAWCKRTPQVQVECIQDYAEDPAWVAAVAASIRRHW
CEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
QAHGRSEKLMFSFHGLPQRVANNGDPYPQRCQVSASLIAAALNLNESEWVLGYQSRFGAE
HHCCCCCEEEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCHH
RWLQPYAEPTLWALAESGIRRFDLVCPGFSVDCLETLEEVALGFSETLAARGATMRYIPC
HHHHHCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCHHHHHHHCCCCEEEECC
LNDDPAHVQALAGLAQRALP
CCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNHTSDTALLIVNLGTPEAPTAAAVRRYLGEFLSDRRVVSIPPLFWKPLLHMVILPIRGP
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCC
RSASKYAKVWLQEGSPLSVYTRRIAEGLTQHLPDWRVAWAMRYGAPALTKALDALQAQQV
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHC
RRIVILPLYPQYSTTTTASVQDVVEAWCKRTPQVQVECIQDYAEDPAWVAAVAASIRRHW
CEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
QAHGRSEKLMFSFHGLPQRVANNGDPYPQRCQVSASLIAAALNLNESEWVLGYQSRFGAE
HHCCCCCEEEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCHH
RWLQPYAEPTLWALAESGIRRFDLVCPGFSVDCLETLEEVALGFSETLAARGATMRYIPC
HHHHHCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCHHHHHHHCCCCEEEECC
LNDDPAHVQALAGLAQRALP
CCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA