Click here to switch to the map view.

The map label for this gene is ispA [H]

Identifier: 182682121

GI number: 182682121

Start: 1773593

End: 1774468

Strand: Reverse

Name: ispA [H]

Synonym: XfasM23_1599

Alternate gene names: 182682121

Gene position: 1774468-1773593 (Counterclockwise)

Preceding gene: 182682122

Following gene: 182682120

Centisome position: 69.98

GC content: 58.33

Gene sequence:

>876_bases
GTGAGCAAAGCGCTGTTCACGCGCTGGTGCCAACGCACCGACAGCTACTTAGAACGAACGTTATCCATCCCCACCCAAGC
ACCACAGCGGCTCCAGGCCGCGATGCGATACACCGTACTGAGTGGCGGCAAACGCATCCGTCCCTTACTGGTTTACGCTG
CCGGCCACCTGTTTCATGTCGATGAACCCCTACTCGACGTACCGGCTGCGGCCGTGGAACTGATCCATGCCTATTCCCTG
GTGCATGATGACCTTCCCGCCATGGATGACGACCTCTTACGCCGAGGGCGTCCCACCGTCCATATCGCCTTCGACGAAGC
CACTGCAATCCTCACTGGCGACGCCTTGCAGACCCTGGCGTTTGAATGCTTAGCCGATGCCCCAGCCGACACCTCCCTGC
GTATCGCCTGGTTACAGACATTGACACACGCCGCAGGAGTTGCCGGCATGTGTGGCGGCCAGGCACTAGATATTGACGCC
ACTGGCCAATCCCAGACACTCAAAGCACTGGAAGCCATGCATGCGTTGAAGAGCGGCACATTGATGCGAGCCGCCGTGAG
AATGGGTGCCCTGGCTGGCGACCCTTCCGCGGAGGATCTGCACTCCCTGGACACCTTTGCGGCCACCCTTGGATTAGCAT
TCCAAGTGCGTGACGACATCCTGGATATCGAGTCTAGTTCCGAACAACTTGGTAAAACGGCTGGCAAAGATGCCATACAG
CAGAAATCCACCTTCCCCGCCCTGCTGAGCGTAGAAGGTGCCAAATGCTATTTACAAGAATTGGCAGAACGCCTGTACAC
CCAATTGCATCCTTACGGCGAACGTGCTGCCCCCCTGACCGCACTGGCACGCTTGGCTGTAGAACGTGCTCACTGA

Upstream 100 bases:

>100_bases
AAGCCCTGGAACAAGCGCAATTGCGCGTCCGGATATTGAGCGATCCAATGCACCCAGATGACGGTGAACCGTTTGATCCC
AGCCTCGTGAGTACATCCCA

Downstream 100 bases:

>100_bases
GGTACTGCCTGACGGCCCATGAATCCAAATAGATGCATCCTGGAGTGGCGCAACTCCTCATCGCCTCCTGCTGTTGAGCA
GCGTCACCTTGCGGCTATAC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSKALFTRWCQRTDSYLERTLSIPTQAPQRLQAAMRYTVLSGGKRIRPLLVYAAGHLFHVDEPLLDVPAAAVELIHAYSL
VHDDLPAMDDDLLRRGRPTVHIAFDEATAILTGDALQTLAFECLADAPADTSLRIAWLQTLTHAAGVAGMCGGQALDIDA
TGQSQTLKALEAMHALKSGTLMRAAVRMGALAGDPSAEDLHSLDTFAATLGLAFQVRDDILDIESSSEQLGKTAGKDAIQ
QKSTFPALLSVEGAKCYLQELAERLYTQLHPYGERAAPLTALARLAVERAH

Sequences:

>Translated_291_residues
MSKALFTRWCQRTDSYLERTLSIPTQAPQRLQAAMRYTVLSGGKRIRPLLVYAAGHLFHVDEPLLDVPAAAVELIHAYSL
VHDDLPAMDDDLLRRGRPTVHIAFDEATAILTGDALQTLAFECLADAPADTSLRIAWLQTLTHAAGVAGMCGGQALDIDA
TGQSQTLKALEAMHALKSGTLMRAAVRMGALAGDPSAEDLHSLDTFAATLGLAFQVRDDILDIESSSEQLGKTAGKDAIQ
QKSTFPALLSVEGAKCYLQELAERLYTQLHPYGERAAPLTALARLAVERAH
>Mature_290_residues
SKALFTRWCQRTDSYLERTLSIPTQAPQRLQAAMRYTVLSGGKRIRPLLVYAAGHLFHVDEPLLDVPAAAVELIHAYSLV
HDDLPAMDDDLLRRGRPTVHIAFDEATAILTGDALQTLAFECLADAPADTSLRIAWLQTLTHAAGVAGMCGGQALDIDAT
GQSQTLKALEAMHALKSGTLMRAAVRMGALAGDPSAEDLHSLDTFAATLGLAFQVRDDILDIESSSEQLGKTAGKDAIQQ
KSTFPALLSVEGAKCYLQELAERLYTQLHPYGERAAPLTALARLAVERAH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI4758430, Length=218, Percent_Identity=28.4403669724771, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI83700220, Length=218, Percent_Identity=28.4403669724771, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786623, Length=256, Percent_Identity=54.296875, Blast_Score=227, Evalue=8e-61,
Organism=Escherichia coli, GI1789578, Length=218, Percent_Identity=31.651376146789, Blast_Score=95, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6325188, Length=237, Percent_Identity=25.3164556962025, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31398; Mature: 31267

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKALFTRWCQRTDSYLERTLSIPTQAPQRLQAAMRYTVLSGGKRIRPLLVYAAGHLFHV
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHEECCCCEEEC
DEPLLDVPAAAVELIHAYSLVHDDLPAMDDDLLRRGRPTVHIAFDEATAILTGDALQTLA
CCCHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEECCCEEEEEHHHHHHHH
FECLADAPADTSLRIAWLQTLTHAAGVAGMCGGQALDIDATGQSQTLKALEAMHALKSGT
HHHHHCCCCCCCHHHHHHHHHHHHHCCHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCH
LMRAAVRMGALAGDPSAEDLHSLDTFAATLGLAFQVRDDILDIESSSEQLGKTAGKDAIQ
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
QKSTFPALLSVEGAKCYLQELAERLYTQLHPYGERAAPLTALARLAVERAH
HHCCCCHHEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKALFTRWCQRTDSYLERTLSIPTQAPQRLQAAMRYTVLSGGKRIRPLLVYAAGHLFHV
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHEECCCCEEEC
DEPLLDVPAAAVELIHAYSLVHDDLPAMDDDLLRRGRPTVHIAFDEATAILTGDALQTLA
CCCHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEECCCEEEEEHHHHHHHH
FECLADAPADTSLRIAWLQTLTHAAGVAGMCGGQALDIDATGQSQTLKALEAMHALKSGT
HHHHHCCCCCCCHHHHHHHHHHHHHCCHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCH
LMRAAVRMGALAGDPSAEDLHSLDTFAATLGLAFQVRDDILDIESSSEQLGKTAGKDAIQ
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
QKSTFPALLSVEGAKCYLQELAERLYTQLHPYGERAAPLTALARLAVERAH
HHCCCCHHEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2089044; 9278503 [H]