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The map label for this gene is ccmA [H]

Identifier: 182682082

GI number: 182682082

Start: 1734316

End: 1734963

Strand: Direct

Name: ccmA [H]

Synonym: XfasM23_1560

Alternate gene names: 182682082

Gene position: 1734316-1734963 (Clockwise)

Preceding gene: 182682078

Following gene: 182682083

Centisome position: 68.4

GC content: 60.96

Gene sequence:

>648_bases
ATGACCGCCCTTCCCTCCTCCGCACCGCCCCTACTGGCTGCACATGCCCTGACCTACTCGCGCAACGCAATCCCCATCCT
CGGCCCCCTGCATTTCCACATCAATCCCGGTGAAGCCCTCATCGTCCAGGGACCCAACGGCATCGGCAAAACCACCCTAC
TACGCATCCTGGCCGGACTCCTGCACAGCGACAGCGGCCACATCCACATCAACACACACCACAACACCACAGCCCCAGAA
CGCACCCGCCACATTGCCTACCTGAGCCACCTCCCTGGACTGAAACAAGACCTCTCAGCCCTGGAAAACCTCCACTTTCT
GAACGCCTTGCACGGCTGCCACCCCCAACGGACACCCAGCAACGCACTCACCATCGTTGGCCTGACAGACCATGCACAGA
CACTGGTTCGGCAACTTTCAGCCGGCCAGAAAAAACGCCTCAGCCTGGCCCGACTGTGGCTCTCACCAGCCCCGTTATGG
CTCTTGGACGAACCCTACGCCAACCTAGATCCAGAGGGCATCACACTCCTCAACCACATCCTCACCACACACCTTCACAC
CCAAGGCGGCACACTGCTCACCACACCCGGCGCGCTCCCCACACTGCCAGTCCCCACCCGCCTGCTTCACTTACAGAAAG
CTCCATGA

Upstream 100 bases:

>100_bases
ACACCTGCCCACCACACCGCTCCACACACCATGCCGCGATACAATGCCCCCGCATTCACCTGCCTGCCACATATCGCGTG
CTTCCCAATCGCACCCCCTG

Downstream 100 bases:

>100_bases
GCGCACCGCCCCCTCCCCTATCCCTCTGGCAGGCCTCATCTGCCATCATCACCCGAGACCTGCGCCTACTGTGGCGCCGC
CGCGCCGCCGCCATACACCC

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MTALPSSAPPLLAAHALTYSRNAIPILGPLHFHINPGEALIVQGPNGIGKTTLLRILAGLLHSDSGHIHINTHHNTTAPE
RTRHIAYLSHLPGLKQDLSALENLHFLNALHGCHPQRTPSNALTIVGLTDHAQTLVRQLSAGQKKRLSLARLWLSPAPLW
LLDEPYANLDPEGITLLNHILTTHLHTQGGTLLTTPGALPTLPVPTRLLHLQKAP

Sequences:

>Translated_215_residues
MTALPSSAPPLLAAHALTYSRNAIPILGPLHFHINPGEALIVQGPNGIGKTTLLRILAGLLHSDSGHIHINTHHNTTAPE
RTRHIAYLSHLPGLKQDLSALENLHFLNALHGCHPQRTPSNALTIVGLTDHAQTLVRQLSAGQKKRLSLARLWLSPAPLW
LLDEPYANLDPEGITLLNHILTTHLHTQGGTLLTTPGALPTLPVPTRLLHLQKAP
>Mature_214_residues
TALPSSAPPLLAAHALTYSRNAIPILGPLHFHINPGEALIVQGPNGIGKTTLLRILAGLLHSDSGHIHINTHHNTTAPER
TRHIAYLSHLPGLKQDLSALENLHFLNALHGCHPQRTPSNALTIVGLTDHAQTLVRQLSAGQKKRLSLARLWLSPAPLWL
LDEPYANLDPEGITLLNHILTTHLHTQGGTLLTTPGALPTLPVPTRLLHLQKAP

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI105990541, Length=210, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI27262624, Length=149, Percent_Identity=28.1879194630872, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI27262626, Length=149, Percent_Identity=28.1879194630872, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI87082064, Length=186, Percent_Identity=37.6344086021505, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787370, Length=174, Percent_Identity=33.9080459770115, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI87082267, Length=165, Percent_Identity=30.9090909090909, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787182, Length=181, Percent_Identity=31.4917127071823, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1788761, Length=158, Percent_Identity=34.1772151898734, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790467, Length=177, Percent_Identity=28.2485875706215, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1789873, Length=154, Percent_Identity=32.4675324675325, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1786253, Length=175, Percent_Identity=31.4285714285714, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI87081782, Length=153, Percent_Identity=34.640522875817, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1790544, Length=209, Percent_Identity=30.622009569378, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081709, Length=148, Percent_Identity=30.4054054054054, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789593, Length=204, Percent_Identity=27.4509803921569, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786703, Length=197, Percent_Identity=28.9340101522843, Blast_Score=67, Evalue=6e-13,
Organism=Escherichia coli, GI1786563, Length=149, Percent_Identity=32.2147651006711, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87081834, Length=199, Percent_Identity=27.1356783919598, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI87081791, Length=166, Percent_Identity=29.5180722891566, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1786698, Length=191, Percent_Identity=30.8900523560209, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787547, Length=161, Percent_Identity=29.1925465838509, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1786872, Length=165, Percent_Identity=32.1212121212121, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71983523, Length=141, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71983510, Length=141, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71983516, Length=141, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115533608, Length=187, Percent_Identity=29.9465240641711, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17510237, Length=132, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641342, Length=191, Percent_Identity=31.9371727748691, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI85816269, Length=204, Percent_Identity=30.3921568627451, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24580553, Length=204, Percent_Identity=30.3921568627451, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI85724864, Length=204, Percent_Identity=30.3921568627451, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24580555, Length=204, Percent_Identity=30.3921568627451, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574744, Length=192, Percent_Identity=30.2083333333333, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28574533, Length=168, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 23232; Mature: 23101

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALPSSAPPLLAAHALTYSRNAIPILGPLHFHINPGEALIVQGPNGIGKTTLLRILAGL
CCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHH
LHSDSGHIHINTHHNTTAPERTRHIAYLSHLPGLKQDLSALENLHFLNALHGCHPQRTPS
HCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
NALTIVGLTDHAQTLVRQLSAGQKKRLSLARLWLSPAPLWLLDEPYANLDPEGITLLNHI
CCEEEEEECHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHH
LTTHLHTQGGTLLTTPGALPTLPVPTRLLHLQKAP
HHHHEECCCCEEEECCCCCCCCCCCHHHHEEECCC
>Mature Secondary Structure 
TALPSSAPPLLAAHALTYSRNAIPILGPLHFHINPGEALIVQGPNGIGKTTLLRILAGL
CCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHH
LHSDSGHIHINTHHNTTAPERTRHIAYLSHLPGLKQDLSALENLHFLNALHGCHPQRTPS
HCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
NALTIVGLTDHAQTLVRQLSAGQKKRLSLARLWLSPAPLWLLDEPYANLDPEGITLLNHI
CCEEEEEECHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHH
LTTHLHTQGGTLLTTPGALPTLPVPTRLLHLQKAP
HHHHEECCCCEEEECCCCCCCCCCCHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]