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The map label for this gene is hemB [H]

Identifier: 182681943

GI number: 182681943

Start: 1572635

End: 1573639

Strand: Direct

Name: hemB [H]

Synonym: XfasM23_1414

Alternate gene names: 182681943

Gene position: 1572635-1573639 (Clockwise)

Preceding gene: 182681940

Following gene: 182681946

Centisome position: 62.02

GC content: 51.64

Gene sequence:

>1005_bases
ATGGCCTATCCACATTACCGTCCACGGCGTATGCGCCGTCATCCCTTTATTCGACGACTGATACGCGAATACACCTTGAC
TGTGGATGACCTAATCTGGCCGGTCTTCGTGCATGGCCTACCCGGGCGGACACCCATCGCATCAATGCCTGGTGTAGAGC
GGCTCTCACTGGATGCACTGCTCCATGAGGCCGAACACGCATTAACTTTAGGTATTCCACTCATCAGCTTATTCCCGGTC
ATTGATCCGGCATTGAAAAGCCTTGACGCCGCCGAAGCATGGAACCCAGATGGCTTAGTACAACATGCAGTACGTGCACT
TAAAACACGCTTCCCAGAGATCGGCGTCATGACAGATGTCGCACTAGATCCATACACCACACACGGGCAAGACGGAATCA
TCAACTCACAAGGCTACGTACTCAACGACATCACCGTAGAAGCACTGGTAAAACAATCACTCTCGCATGCACAAGCAGGT
GCAGACATCATCTCACCCTCTGACATGATGGATGGCCGCATCGGTGCGATTCGCAAAGCCCTAGACACTCATCCAAACTT
CGTAGATACCAGCATCATGGCTTATTCGGCCAAATACGCATCGGCATTCTACAACCCGTTTCGGGATGCAGTGGGCAGCG
CGACCAACCTTGGTAAAGCCGACAAAAAAACCTATCAGATGGACCCGGCTAACAGTGACGAAGCACTCCGTGAGATTGCC
TTGGACATCGAAGAAGGCGCAGATATGGTGATCGTCAAACCTGGATTGCTTTGCTTGGATGTAGTACGCCGGGTAAAAGA
GACATTCCGGATGCCCACTTACGCATATCAAGTCAGCGGCGAGTACGCCATGATCAAGGCTGCTGTATCCAACGGCTGGT
TAGAAGAACGCAGCGGTGTGCTGGAAACGTTAATAGCATTCAAACGTGCCGGTGCAGATGGCATATTGACCTACTTCGCA
CCACAAGTAGCAAGCTGGTTGCGTGAAGGTAAATCGGAGGATTAA

Upstream 100 bases:

>100_bases
GCCCTTAAAAACACTGGCACAAAATATTGCTTTCCCAATCGTGACAACCACATAACAACTGAATGTCACGCCCCACCCCA
TCATTCACATCAACTCAATC

Downstream 100 bases:

>100_bases
AGACGCACGCTCAACAATGGGAATATCACCTCACCACCTGGAAACACAGCGACACTGCATCGGCCATACACGCTTGATCA
AATCAGAGGATAGCTCCACT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MAYPHYRPRRMRRHPFIRRLIREYTLTVDDLIWPVFVHGLPGRTPIASMPGVERLSLDALLHEAEHALTLGIPLISLFPV
IDPALKSLDAAEAWNPDGLVQHAVRALKTRFPEIGVMTDVALDPYTTHGQDGIINSQGYVLNDITVEALVKQSLSHAQAG
ADIISPSDMMDGRIGAIRKALDTHPNFVDTSIMAYSAKYASAFYNPFRDAVGSATNLGKADKKTYQMDPANSDEALREIA
LDIEEGADMVIVKPGLLCLDVVRRVKETFRMPTYAYQVSGEYAMIKAAVSNGWLEERSGVLETLIAFKRAGADGILTYFA
PQVASWLREGKSED

Sequences:

>Translated_334_residues
MAYPHYRPRRMRRHPFIRRLIREYTLTVDDLIWPVFVHGLPGRTPIASMPGVERLSLDALLHEAEHALTLGIPLISLFPV
IDPALKSLDAAEAWNPDGLVQHAVRALKTRFPEIGVMTDVALDPYTTHGQDGIINSQGYVLNDITVEALVKQSLSHAQAG
ADIISPSDMMDGRIGAIRKALDTHPNFVDTSIMAYSAKYASAFYNPFRDAVGSATNLGKADKKTYQMDPANSDEALREIA
LDIEEGADMVIVKPGLLCLDVVRRVKETFRMPTYAYQVSGEYAMIKAAVSNGWLEERSGVLETLIAFKRAGADGILTYFA
PQVASWLREGKSED
>Mature_333_residues
AYPHYRPRRMRRHPFIRRLIREYTLTVDDLIWPVFVHGLPGRTPIASMPGVERLSLDALLHEAEHALTLGIPLISLFPVI
DPALKSLDAAEAWNPDGLVQHAVRALKTRFPEIGVMTDVALDPYTTHGQDGIINSQGYVLNDITVEALVKQSLSHAQAGA
DIISPSDMMDGRIGAIRKALDTHPNFVDTSIMAYSAKYASAFYNPFRDAVGSATNLGKADKKTYQMDPANSDEALREIAL
DIEEGADMVIVKPGLLCLDVVRRVKETFRMPTYAYQVSGEYAMIKAAVSNGWLEERSGVLETLIAFKRAGADGILTYFAP
QVASWLREGKSED

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=319, Percent_Identity=38.871473354232, Blast_Score=224, Evalue=6e-59,
Organism=Escherichia coli, GI87081728, Length=319, Percent_Identity=45.4545454545455, Blast_Score=251, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6321398, Length=319, Percent_Identity=36.3636363636364, Blast_Score=199, Evalue=5e-52,
Organism=Drosophila melanogaster, GI21358291, Length=295, Percent_Identity=40.3389830508475, Blast_Score=213, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36926; Mature: 36795

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYPHYRPRRMRRHPFIRRLIREYTLTVDDLIWPVFVHGLPGRTPIASMPGVERLSLDAL
CCCCCCCHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
LHEAEHALTLGIPLISLFPVIDPALKSLDAAEAWNPDGLVQHAVRALKTRFPEIGVMTDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHCCCCCCCEECC
ALDPYTTHGQDGIINSQGYVLNDITVEALVKQSLSHAQAGADIISPSDMMDGRIGAIRKA
CCCCCCCCCCCCEECCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHH
LDTHPNFVDTSIMAYSAKYASAFYNPFRDAVGSATNLGKADKKTYQMDPANSDEALREIA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCEEECCCCCHHHHHHHHH
LDIEEGADMVIVKPGLLCLDVVRRVKETFRMPTYAYQVSGEYAMIKAAVSNGWLEERSGV
HHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHCCCHHHHHHH
LETLIAFKRAGADGILTYFAPQVASWLREGKSED
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AYPHYRPRRMRRHPFIRRLIREYTLTVDDLIWPVFVHGLPGRTPIASMPGVERLSLDAL
CCCCCCHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
LHEAEHALTLGIPLISLFPVIDPALKSLDAAEAWNPDGLVQHAVRALKTRFPEIGVMTDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHCCCCCCCEECC
ALDPYTTHGQDGIINSQGYVLNDITVEALVKQSLSHAQAGADIISPSDMMDGRIGAIRKA
CCCCCCCCCCCCEECCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHH
LDTHPNFVDTSIMAYSAKYASAFYNPFRDAVGSATNLGKADKKTYQMDPANSDEALREIA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCEEECCCCCHHHHHHHHH
LDIEEGADMVIVKPGLLCLDVVRRVKETFRMPTYAYQVSGEYAMIKAAVSNGWLEERSGV
HHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHCCCHHHHHHH
LETLIAFKRAGADGILTYFAPQVASWLREGKSED
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]