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The map label for this gene is fepA [H]

Identifier: 182681813

GI number: 182681813

Start: 1404470

End: 1406851

Strand: Direct

Name: fepA [H]

Synonym: XfasM23_1277

Alternate gene names: 182681813

Gene position: 1404470-1406851 (Clockwise)

Preceding gene: 182681811

Following gene: 182681815

Centisome position: 55.39

GC content: 54.24

Gene sequence:

>2382_bases
ATGAACCCATTTGTATCTCTCACAGTAGCAAGCGTAACCGCACTCTTTGTTGCCTCCCCTGCGTTCGGTCAGGAGGCCAC
GCAATCTACAACGCTGGATACGATGATCGTTACCGGCACGCACGTGACCGAGCGTACTGTGGTGGAATCCCAATCGCCGA
TTGACATTATCAGCGCTGCACACTTGGCCGCTACGGGTAGTTCAGAACTGGCTACGGCGCTGTCCCGAATGTTGCCATCA
TTAAATTTTCCGCGTCCGGCACTGGCAGATGGCACCTCCGGTATTCGTCCGGCACAGATGCGTGGACTAGCGCCGGATCA
AACATTGGTGCTGATCAATGGCAAGCGCCGCCACCTCTCGGCGCAAATCAATGTCAATGGCACGATTGGGCGCGGCAGTT
CAGCCGTTGATCTGAACACGATTCCCATCACCGCGATTGAGCGTATAGAAGTGCTGCGTGATGGGGCCTCGGCACAATAT
GGCTCAGATGCAATCGCTGGGGTCATCAATATTGTGCTGAAAGGTGCCACTCAGGATGGCAGTTTGGCAGTGGAACACGG
CCAGTACAGCGCCGGCGATGGTGCCACATCCAAGTTATCCGGCGATTCCGGAATCTCTTTCGCTAACGGACGCGGCACGC
TGCACCTGGCAATGGACATCAGTCAACAAGAGCAGACTAATCGTGCTGGTCCCTATCAAGGGAGCGCGCCCAATACCGGC
AACTATCCCGACATTGGACGTACTGCATTTATCTACGGTGATCCACGGGTCAATGCGGTTGCGTTCTCAGCTAATGGCAT
GTTCGATGTTGGGGAGCATGTGAAGGGTTACGCCAACGCCATGCTCAGCAACCGCGACATTACGTCGTTTGCGTTCTATC
GCTCACGCAATCACAACGGGCAAAGCATGTTGCTGGCGCAGCGATATCCAGAGGGTTACGTGCCTGAAATCGAGCAGAAC
AGCAAAGACCGTTCACTGGTTACCGGACTCAAGGGCAGCACCGAGCACGGCTTGAACTGGGATATGAGCTACAACTATGG
AAGCAATCATATCGGCTTCCACACCAACAACAGCATTAACTACAGTCTGGGTGTGGAAAGTCCAAGGGATTTCTACGATG
GTGCGTTGGAGTACACGCAACACTTGCTCAACACCGATTTTACTAAGGTGCTGGATTGGGGACTGACTTATCCAGTCACA
CTCTCCTTCGGCACCGAATACCGCTATGAACAGTGGAATCAGTCCCCTGGCATTCCGGCTTCATATAACGGCATGACCGG
CGGCGCACAGGGATTTGCAGGGTTTTCACCTCTGAATACCGTGCATGCGAACCGTAATAATTACGCTCTGTATGCTGGAC
TGGATGGCGATCTTAGCGAGCACCTATCTGCAGGAGTGGCCGGGCGGTTCGAGCACTACTCTGATTTTGGCAATCAGACA
TCAGGCAAGCTCTCGGCACGCTATGCATTGACTGATCAGGCGGCGCTACGCGCCACCATCGGCAATGGCTTTCGTGCGCC
GTCACTGGCACAGCAACGCTACCAAGTGGTCACCAGTACCTACAGTAACGGTACTTTCTACGAGTCAGGGACGTTCCCGA
CAACGAGTCCCGTTGCGCAAGCACTGGGTGCAGCGCCGCTGCGGGCTGAATCATCGTTGTCCTATAGCCTGGGTTTGGTA
CTACAACCGTTCGAACGGCTTTATTTGACGCTGGATACCTACCAAATCGACATCGCGCACCGGATCTTGCTGTCTTCCAA
TCTTAACGATGCAGCGGTCCTTGCTGCACTACAGCAACAAGGCAATAGCAACGTTACCAGCGTTCGCTATTTCGCAAACG
CGGCCAATACCCGCACCCGTGGTGTCGACTTGGTCGGTACGTATACGATTCCGTTCGCTGTAGGTCAGCTTGATCTGACT
ACAAGCTACAGTGGCATCGCCACCAGGATTCGCAGTGCAGTCACACAGCCAGCAGCACTCTCGGCCATCGGTTCAACGCA
GACGATTGTAGGACGGGACGAAATCGGTCGGCTGGAAGAGAGTTTCCCGAAAGACAAGCTGATCCTCAGCGGTACATGGA
AGCTGACACAGTGGGATCTGATGCTCGCAGCAACACGCTACGGCACGGTAACGGTGCGTAATCCAACGTCCGTCTCACGC
GATCAGACGTACGGCGCTCGCTGGGTAGTCGATGCGTCGGCCAGCTACAAGCCAGACATGCACTGGATGTTGACGTTGGG
TGCAAACAATCTGTTGAATGCTTATCCAGATAAAACAGTCAACGCAATCAACTCGATCTACGGACAGATGCCTTACAGCA
ACTATGCGCCCTTCGGCTTTAACGGGGCCTACGTGTATGCACGTATTGGTTACAGTTGGTAA

Upstream 100 bases:

>100_bases
TTAACGTTATGATTGTTTGGGTTTGGAAAACAGCATAAGACCCTCATTACATGGTTTTGCCATGTCTCTCACACAGCACA
ATTTCATGTTGAAGGTTGCA

Downstream 100 bases:

>100_bases
GCGCCGCGGCCAGACGCTGCTTGACGGGAATCAGGTGCATCTTCAAAACGCGTGATGCTCTGCTTAGGTATCGCATCGCG
TTGCAGTCATCAACGCAGGA

Product: TonB-dependent receptor

Products: NA

Alternate protein names: Enterobactin outer-membrane receptor [H]

Number of amino acids: Translated: 793; Mature: 793

Protein sequence:

>793_residues
MNPFVSLTVASVTALFVASPAFGQEATQSTTLDTMIVTGTHVTERTVVESQSPIDIISAAHLAATGSSELATALSRMLPS
LNFPRPALADGTSGIRPAQMRGLAPDQTLVLINGKRRHLSAQINVNGTIGRGSSAVDLNTIPITAIERIEVLRDGASAQY
GSDAIAGVINIVLKGATQDGSLAVEHGQYSAGDGATSKLSGDSGISFANGRGTLHLAMDISQQEQTNRAGPYQGSAPNTG
NYPDIGRTAFIYGDPRVNAVAFSANGMFDVGEHVKGYANAMLSNRDITSFAFYRSRNHNGQSMLLAQRYPEGYVPEIEQN
SKDRSLVTGLKGSTEHGLNWDMSYNYGSNHIGFHTNNSINYSLGVESPRDFYDGALEYTQHLLNTDFTKVLDWGLTYPVT
LSFGTEYRYEQWNQSPGIPASYNGMTGGAQGFAGFSPLNTVHANRNNYALYAGLDGDLSEHLSAGVAGRFEHYSDFGNQT
SGKLSARYALTDQAALRATIGNGFRAPSLAQQRYQVVTSTYSNGTFYESGTFPTTSPVAQALGAAPLRAESSLSYSLGLV
LQPFERLYLTLDTYQIDIAHRILLSSNLNDAAVLAALQQQGNSNVTSVRYFANAANTRTRGVDLVGTYTIPFAVGQLDLT
TSYSGIATRIRSAVTQPAALSAIGSTQTIVGRDEIGRLEESFPKDKLILSGTWKLTQWDLMLAATRYGTVTVRNPTSVSR
DQTYGARWVVDASASYKPDMHWMLTLGANNLLNAYPDKTVNAINSIYGQMPYSNYAPFGFNGAYVYARIGYSW

Sequences:

>Translated_793_residues
MNPFVSLTVASVTALFVASPAFGQEATQSTTLDTMIVTGTHVTERTVVESQSPIDIISAAHLAATGSSELATALSRMLPS
LNFPRPALADGTSGIRPAQMRGLAPDQTLVLINGKRRHLSAQINVNGTIGRGSSAVDLNTIPITAIERIEVLRDGASAQY
GSDAIAGVINIVLKGATQDGSLAVEHGQYSAGDGATSKLSGDSGISFANGRGTLHLAMDISQQEQTNRAGPYQGSAPNTG
NYPDIGRTAFIYGDPRVNAVAFSANGMFDVGEHVKGYANAMLSNRDITSFAFYRSRNHNGQSMLLAQRYPEGYVPEIEQN
SKDRSLVTGLKGSTEHGLNWDMSYNYGSNHIGFHTNNSINYSLGVESPRDFYDGALEYTQHLLNTDFTKVLDWGLTYPVT
LSFGTEYRYEQWNQSPGIPASYNGMTGGAQGFAGFSPLNTVHANRNNYALYAGLDGDLSEHLSAGVAGRFEHYSDFGNQT
SGKLSARYALTDQAALRATIGNGFRAPSLAQQRYQVVTSTYSNGTFYESGTFPTTSPVAQALGAAPLRAESSLSYSLGLV
LQPFERLYLTLDTYQIDIAHRILLSSNLNDAAVLAALQQQGNSNVTSVRYFANAANTRTRGVDLVGTYTIPFAVGQLDLT
TSYSGIATRIRSAVTQPAALSAIGSTQTIVGRDEIGRLEESFPKDKLILSGTWKLTQWDLMLAATRYGTVTVRNPTSVSR
DQTYGARWVVDASASYKPDMHWMLTLGANNLLNAYPDKTVNAINSIYGQMPYSNYAPFGFNGAYVYARIGYSW
>Mature_793_residues
MNPFVSLTVASVTALFVASPAFGQEATQSTTLDTMIVTGTHVTERTVVESQSPIDIISAAHLAATGSSELATALSRMLPS
LNFPRPALADGTSGIRPAQMRGLAPDQTLVLINGKRRHLSAQINVNGTIGRGSSAVDLNTIPITAIERIEVLRDGASAQY
GSDAIAGVINIVLKGATQDGSLAVEHGQYSAGDGATSKLSGDSGISFANGRGTLHLAMDISQQEQTNRAGPYQGSAPNTG
NYPDIGRTAFIYGDPRVNAVAFSANGMFDVGEHVKGYANAMLSNRDITSFAFYRSRNHNGQSMLLAQRYPEGYVPEIEQN
SKDRSLVTGLKGSTEHGLNWDMSYNYGSNHIGFHTNNSINYSLGVESPRDFYDGALEYTQHLLNTDFTKVLDWGLTYPVT
LSFGTEYRYEQWNQSPGIPASYNGMTGGAQGFAGFSPLNTVHANRNNYALYAGLDGDLSEHLSAGVAGRFEHYSDFGNQT
SGKLSARYALTDQAALRATIGNGFRAPSLAQQRYQVVTSTYSNGTFYESGTFPTTSPVAQALGAAPLRAESSLSYSLGLV
LQPFERLYLTLDTYQIDIAHRILLSSNLNDAAVLAALQQQGNSNVTSVRYFANAANTRTRGVDLVGTYTIPFAVGQLDLT
TSYSGIATRIRSAVTQPAALSAIGSTQTIVGRDEIGRLEESFPKDKLILSGTWKLTQWDLMLAATRYGTVTVRNPTSVSR
DQTYGARWVVDASASYKPDMHWMLTLGANNLLNAYPDKTVNAINSIYGQMPYSNYAPFGFNGAYVYARIGYSW

Specific function: This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to extract iron from the environment. FepA also acts as a receptor for colicins B and D [H]

COG id: COG1629

COG function: function code P; Outer membrane receptor proteins, mostly Fe transport

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1786798, Length=592, Percent_Identity=25.5067567567568, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1788478, Length=660, Percent_Identity=22.5757575757576, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917
- InterPro:   IPR010105 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 85387; Mature: 85387

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPFVSLTVASVTALFVASPAFGQEATQSTTLDTMIVTGTHVTERTVVESQSPIDIISAA
CCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHCCCCCHHHHHHH
HLAATGSSELATALSRMLPSLNFPRPALADGTSGIRPAQMRGLAPDQTLVLINGKRRHLS
HHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEECCCCEEEE
AQINVNGTIGRGSSAVDLNTIPITAIERIEVLRDGASAQYGSDAIAGVINIVLKGATQDG
EEEEECEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCC
SLAVEHGQYSAGDGATSKLSGDSGISFANGRGTLHLAMDISQQEQTNRAGPYQGSAPNTG
CEEEECCCCCCCCCCCCCCCCCCCCEEECCCCEEEEEEECCHHHHCCCCCCCCCCCCCCC
NYPDIGRTAFIYGDPRVNAVAFSANGMFDVGEHVKGYANAMLSNRDITSFAFYRSRNHNG
CCCCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
QSMLLAQRYPEGYVPEIEQNSKDRSLVTGLKGSTEHGLNWDMSYNYGSNHIGFHTNNSIN
CEEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEEECCCCCCCCEECCCEEE
YSLGVESPRDFYDGALEYTQHLLNTDFTKVLDWGLTYPVTLSFGTEYRYEQWNQSPGIPA
EEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEECCCCCCHHHHCCCCCCCC
SYNGMTGGAQGFAGFSPLNTVHANRNNYALYAGLDGDLSEHLSAGVAGRFEHYSDFGNQT
CCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCHHHHHHCCCCHHHHHHHHCCCCC
SGKLSARYALTDQAALRATIGNGFRAPSLAQQRYQVVTSTYSNGTFYESGTFPTTSPVAQ
CCCEEEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHEEECCCCEEEECCCCCCCHHHHH
ALGAAPLRAESSLSYSLGLVLQPFERLYLTLDTYQIDIAHRILLSSNLNDAAVLAALQQQ
HHCCCCCCCCCCCCEEECHHHCCCCEEEEEEEEEEEEHHHEEEECCCCCHHHHHHHHHHC
GNSNVTSVRYFANAANTRTRGVDLVGTYTIPFAVGQLDLTTSYSGIATRIRSAVTQPAAL
CCCCCEEEEEEECCCCCCCCCEEEEEEEEECEEECEEEEECCCHHHHHHHHHHHCCCHHH
SAIGSTQTIVGRDEIGRLEESFPKDKLILSGTWKLTQWDLMLAATRYGTVTVRNPTSVSR
HHCCCCEEEECCHHHHHHHHHCCCCEEEEECCEEEEEEEEEEEEEECCEEEECCCCCCCC
DQTYGARWVVDASASYKPDMHWMLTLGANNLLNAYPDKTVNAINSIYGQMPYSNYAPFGF
CCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCCC
NGAYVYARIGYSW
CCEEEEEEECCCC
>Mature Secondary Structure
MNPFVSLTVASVTALFVASPAFGQEATQSTTLDTMIVTGTHVTERTVVESQSPIDIISAA
CCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHCCCCCHHHHHHH
HLAATGSSELATALSRMLPSLNFPRPALADGTSGIRPAQMRGLAPDQTLVLINGKRRHLS
HHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEECCCCEEEE
AQINVNGTIGRGSSAVDLNTIPITAIERIEVLRDGASAQYGSDAIAGVINIVLKGATQDG
EEEEECEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCC
SLAVEHGQYSAGDGATSKLSGDSGISFANGRGTLHLAMDISQQEQTNRAGPYQGSAPNTG
CEEEECCCCCCCCCCCCCCCCCCCCEEECCCCEEEEEEECCHHHHCCCCCCCCCCCCCCC
NYPDIGRTAFIYGDPRVNAVAFSANGMFDVGEHVKGYANAMLSNRDITSFAFYRSRNHNG
CCCCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
QSMLLAQRYPEGYVPEIEQNSKDRSLVTGLKGSTEHGLNWDMSYNYGSNHIGFHTNNSIN
CEEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEEECCCCCCCCEECCCEEE
YSLGVESPRDFYDGALEYTQHLLNTDFTKVLDWGLTYPVTLSFGTEYRYEQWNQSPGIPA
EEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEECCCCCCHHHHCCCCCCCC
SYNGMTGGAQGFAGFSPLNTVHANRNNYALYAGLDGDLSEHLSAGVAGRFEHYSDFGNQT
CCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCHHHHHHCCCCHHHHHHHHCCCCC
SGKLSARYALTDQAALRATIGNGFRAPSLAQQRYQVVTSTYSNGTFYESGTFPTTSPVAQ
CCCEEEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHEEECCCCEEEECCCCCCCHHHHH
ALGAAPLRAESSLSYSLGLVLQPFERLYLTLDTYQIDIAHRILLSSNLNDAAVLAALQQQ
HHCCCCCCCCCCCCEEECHHHCCCCEEEEEEEEEEEEHHHEEEECCCCCHHHHHHHHHHC
GNSNVTSVRYFANAANTRTRGVDLVGTYTIPFAVGQLDLTTSYSGIATRIRSAVTQPAAL
CCCCCEEEEEEECCCCCCCCCEEEEEEEEECEEECEEEEECCCHHHHHHHHHHHCCCHHH
SAIGSTQTIVGRDEIGRLEESFPKDKLILSGTWKLTQWDLMLAATRYGTVTVRNPTSVSR
HHCCCCEEEECCHHHHHHHHHCCCCEEEEECCEEEEEEEEEEEEEECCEEEECCCCCCCC
DQTYGARWVVDASASYKPDMHWMLTLGANNLLNAYPDKTVNAINSIYGQMPYSNYAPFGF
CCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCCC
NGAYVYARIGYSW
CCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3015941; 8905232; 9278503; 2974033; 2526281; 2201687; 9886293 [H]