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The map label for this gene is flp [H]

Identifier: 182681772

GI number: 182681772

Start: 1366155

End: 1367522

Strand: Direct

Name: flp [H]

Synonym: XfasM23_1230

Alternate gene names: 182681772

Gene position: 1366155-1367522 (Clockwise)

Preceding gene: 182681766

Following gene: 182681774

Centisome position: 53.88

GC content: 52.7

Gene sequence:

>1368_bases
ATGAAGCAACAGGGCTGGCACCGGAATTTGCGTCTAATTGTAACTGGACTACTGGGCAGCTTAATGCCCTTCACTCTCAG
TTCCACAGATCAAACTCCAGTCCTCAAGCCGCAGTCGTTACCGCTGATCACTAGCTCAGACGACACACAAGACAAGGTGG
CACTGCTGACGCACCGTTTCGATATCAAAGCAATCGAATCGATGGCCGAGCAACTGACCTATGGCCAAAAAGTCCCGGGG
TTGGCAATGGCAATTGTCCAAGGGGGGCACATCCTTAGCATGCGCGGCTATGGAGTTAACGATGTCAGCAACCCGCAGCC
TGTGAATGCACACACCGTTTTTCGCCTTGCTTCACTTTCCAAAGCCTTTGCCAGCGCCATGACCGGTTTACTTGTCAACG
ATGGCATCCTCAGTTGGAACAGCAAGATTGTGGATTACGTCCCCGGCTTCCACCTAAGCAACCCAACCGCAACAAACAAA
TTGACTGTTGCCGATGTCCTCAGCCATCGCGTCGGCCTGAGCCGCAATGCCTATGACGGCGAAATCGAGTCGAATGCCGA
CTATTATTCACTGAATCGCAAACTCGCCTATGCACCACTCATCTGTTCCCCAGGTGAGTGTTACTCCTACCAAAACGTGG
CCTTCAGCCTGATCGGCGACGTCGTGTTTGCTGCCTCCGGAGACTTTTATGAACAGGCGGTGGAACGCCGCATCTTTAAG
CCATTGGGAATGAATGATGCCAGCCTTGGTCTAGCTGGCATTCGATCCAGTCAAAGTTGGGCACGACCACATACACGTAC
CAAAAAGGGATGGAGGCCCGTCGTCGTCAAACAAACGTATTACCACTTAGCACCAGCCGCCGGTGTCAACGCCAGTGCAA
GCGATATGGCTCAATGGCTACTGGCACAAACAGGACATAAGCCGGAAGTGCTACCCGCACCATTGCTCGTGACATTACAC
ACACCACTTGTCAGCACACCCAGTGAAGTCCGCCCAGGCTGGCGCGAACAACGTTTATTGGCAGCAAGCTACGCATTGGG
CTGGCGCCTGTTCAACTACAATGGACACACACTCGTATTCCATGCCGGCGCGGTACAAGGCTACCGCGGTTTAGTCGCAC
TGCTACCAGAACGCGATTTTGGGGTGGCCATCTTATGTAATGGTGAAACCGGCCTACCTTCCGGGCTGCTACTCACTATC
CTGGACCGGGTACTCGGTCTACGGGGACAACACCGACTGGATCTTGAAACTGATAGCGACTTCAGCAGCGAAAACATGCT
AGCTAAGAAATCAACAAACGAATCGAATTCCCAGAGCAGTTTAGAAAACAAACCGTCACCACCACCACCTTCAACGCAAC
TACATTAG

Upstream 100 bases:

>100_bases
AATGGGATATGAAATTTTTCTAAGTGTGATTTGTGGAACAGGAAAAAGCGACGGTAGAATCCGACCAGTCACAAATCATT
GATTACTCTGGAGAGCCACA

Downstream 100 bases:

>100_bases
TGTCCCTTTCTTTTCTTGCCACATCCGTTCGAGAAACATCGAGAATCATGATCTGGAACCTATCGAACTTTTTAGACCAT
ATTTCAAATGATCTTGAATA

Product: beta-lactamase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKQQGWHRNLRLIVTGLLGSLMPFTLSSTDQTPVLKPQSLPLITSSDDTQDKVALLTHRFDIKAIESMAEQLTYGQKVPG
LAMAIVQGGHILSMRGYGVNDVSNPQPVNAHTVFRLASLSKAFASAMTGLLVNDGILSWNSKIVDYVPGFHLSNPTATNK
LTVADVLSHRVGLSRNAYDGEIESNADYYSLNRKLAYAPLICSPGECYSYQNVAFSLIGDVVFAASGDFYEQAVERRIFK
PLGMNDASLGLAGIRSSQSWARPHTRTKKGWRPVVVKQTYYHLAPAAGVNASASDMAQWLLAQTGHKPEVLPAPLLVTLH
TPLVSTPSEVRPGWREQRLLAASYALGWRLFNYNGHTLVFHAGAVQGYRGLVALLPERDFGVAILCNGETGLPSGLLLTI
LDRVLGLRGQHRLDLETDSDFSSENMLAKKSTNESNSQSSLENKPSPPPPSTQLH

Sequences:

>Translated_455_residues
MKQQGWHRNLRLIVTGLLGSLMPFTLSSTDQTPVLKPQSLPLITSSDDTQDKVALLTHRFDIKAIESMAEQLTYGQKVPG
LAMAIVQGGHILSMRGYGVNDVSNPQPVNAHTVFRLASLSKAFASAMTGLLVNDGILSWNSKIVDYVPGFHLSNPTATNK
LTVADVLSHRVGLSRNAYDGEIESNADYYSLNRKLAYAPLICSPGECYSYQNVAFSLIGDVVFAASGDFYEQAVERRIFK
PLGMNDASLGLAGIRSSQSWARPHTRTKKGWRPVVVKQTYYHLAPAAGVNASASDMAQWLLAQTGHKPEVLPAPLLVTLH
TPLVSTPSEVRPGWREQRLLAASYALGWRLFNYNGHTLVFHAGAVQGYRGLVALLPERDFGVAILCNGETGLPSGLLLTI
LDRVLGLRGQHRLDLETDSDFSSENMLAKKSTNESNSQSSLENKPSPPPPSTQLH
>Mature_455_residues
MKQQGWHRNLRLIVTGLLGSLMPFTLSSTDQTPVLKPQSLPLITSSDDTQDKVALLTHRFDIKAIESMAEQLTYGQKVPG
LAMAIVQGGHILSMRGYGVNDVSNPQPVNAHTVFRLASLSKAFASAMTGLLVNDGILSWNSKIVDYVPGFHLSNPTATNK
LTVADVLSHRVGLSRNAYDGEIESNADYYSLNRKLAYAPLICSPGECYSYQNVAFSLIGDVVFAASGDFYEQAVERRIFK
PLGMNDASLGLAGIRSSQSWARPHTRTKKGWRPVVVKQTYYHLAPAAGVNASASDMAQWLLAQTGHKPEVLPAPLLVTLH
TPLVSTPSEVRPGWREQRLLAASYALGWRLFNYNGHTLVFHAGAVQGYRGLVALLPERDFGVAILCNGETGLPSGLLLTI
LDRVLGLRGQHRLDLETDSDFSSENMLAKKSTNESNSQSSLENKPSPPPPSTQLH

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790593, Length=388, Percent_Identity=23.7113402061856, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1786574, Length=246, Percent_Identity=26.0162601626016, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87082101, Length=284, Percent_Identity=25.7042253521127, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17550934, Length=210, Percent_Identity=27.1428571428571, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115533026, Length=211, Percent_Identity=26.5402843601896, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 49598; Mature: 49598

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQQGWHRNLRLIVTGLLGSLMPFTLSSTDQTPVLKPQSLPLITSSDDTQDKVALLTHRF
CCCCCCCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHC
DIKAIESMAEQLTYGQKVPGLAMAIVQGGHILSMRGYGVNDVSNPQPVNAHTVFRLASLS
HHHHHHHHHHHHHCCCCCCCCEEHEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
KAFASAMTGLLVNDGILSWNSKIVDYVPGFHLSNPTATNKLTVADVLSHRVGLSRNAYDG
HHHHHHHHHHHHCCCEECCCCCHHHHCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCCC
EIESNADYYSLNRKLAYAPLICSPGECYSYQNVAFSLIGDVVFAASGDFYEQAVERRIFK
CCCCCCCEEECCCEEEECCEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
PLGMNDASLGLAGIRSSQSWARPHTRTKKGWRPVVVKQTYYHLAPAAGVNASASDMAQWL
CCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCEEEEECHHHHHCCCCCCCCCHHHHHHHH
LAQTGHKPEVLPAPLLVTLHTPLVSTPSEVRPGWREQRLLAASYALGWRLFNYNGHTLVF
HHHCCCCCCCCCCCEEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHEEEEEECCCCEEEE
HAGAVQGYRGLVALLPERDFGVAILCNGETGLPSGLLLTILDRVLGLRGQHRLDLETDSD
ECCCCCCCCCEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCC
FSSENMLAKKSTNESNSQSSLENKPSPPPPSTQLH
CCCCCEEEECCCCCCCCHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKQQGWHRNLRLIVTGLLGSLMPFTLSSTDQTPVLKPQSLPLITSSDDTQDKVALLTHRF
CCCCCCCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHC
DIKAIESMAEQLTYGQKVPGLAMAIVQGGHILSMRGYGVNDVSNPQPVNAHTVFRLASLS
HHHHHHHHHHHHHCCCCCCCCEEHEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
KAFASAMTGLLVNDGILSWNSKIVDYVPGFHLSNPTATNKLTVADVLSHRVGLSRNAYDG
HHHHHHHHHHHHCCCEECCCCCHHHHCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCCC
EIESNADYYSLNRKLAYAPLICSPGECYSYQNVAFSLIGDVVFAASGDFYEQAVERRIFK
CCCCCCCEEECCCEEEECCEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
PLGMNDASLGLAGIRSSQSWARPHTRTKKGWRPVVVKQTYYHLAPAAGVNASASDMAQWL
CCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCEEEEECHHHHHCCCCCCCCCHHHHHHHH
LAQTGHKPEVLPAPLLVTLHTPLVSTPSEVRPGWREQRLLAASYALGWRLFNYNGHTLVF
HHHCCCCCCCCCCCEEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHEEEEEECCCCEEEE
HAGAVQGYRGLVALLPERDFGVAILCNGETGLPSGLLLTILDRVLGLRGQHRLDLETDSD
ECCCCCCCCCEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCC
FSSENMLAKKSTNESNSQSSLENKPSPPPPSTQLH
CCCCCEEEECCCCCCCCHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA