Click here to switch to the map view.

The map label for this gene is ilvG [H]

Identifier: 182681650

GI number: 182681650

Start: 1255752

End: 1257503

Strand: Direct

Name: ilvG [H]

Synonym: XfasM23_1108

Alternate gene names: 182681650

Gene position: 1255752-1257503 (Clockwise)

Preceding gene: 182681649

Following gene: 182681651

Centisome position: 49.52

GC content: 54.85

Gene sequence:

>1752_bases
ATGAACAGATCCGCACACAGCGCAACCCGCAATGGTGCGAGCTGGTTGACGCATGCTCTGGAAGCAGAAGGAGTTGATAC
ACTCTTCGGCTATCCGGGTGGCACGATCATGCCGTTTTATGACGCCCTGGTCGATTCTCGCCTCACACATATTCTGGTCC
GCCATGAACAGGGTGCAGCTTTAGCTGCAAATGGCTATGCCCGCGCTAGCGGACGTGTCGGTGTATGCGTAGCGACGTCA
GGTCCAGGTGCCTCCAATCTGATCACTGGCATTGCCGACGCGATGCTAGATTCAGTCCCCATGGTCTGCTTGACTGGCCA
AGTCGCTAGCTCGTTGCTGGGGACCGATGCATTTCAGGAATTGGACGTATTTGGCCTAACCATGCCGATCGTCAAACATA
GCTTCTTGGTGCGTTCGATACAGGATCTGCCAAGCATGGTGCAGGACGCATTCCGTATCGCACGAGAAGGCCGCCCCGGC
CCTGTCCTGATCGATTTACCTAAAGATGTCCAAATGACTGATGCTTCGCACCTACAGGACCATGTGTCGGCCGCCGTGAT
GGCACCGCCGCAAGCAGAAGCAGCGATGATCATCGAAGCTGCAGCAGCAATCGCCTCTGCTGAGAAACCAGTGATCTATG
GCGGCGGCGGCATCGCCCTCGCCGATGCAGTTAACGTCTTCCGTACCTTCGTTGATACCACTAGTATCCCGACCACATTG
ACACTACGCGGTTTGGGGGCGCTGCCACACGCTCATCCTCATTACTTGGGCATGCTGGGCATGCATGGCACCCGCGCGGC
CAACATGGCAATCCAGGAGTGCGATCTACTACTTGTCATTGGCGCCCGTTTCGACGACCGTGCAACCGGGAAGGTGAACG
AATTCGCTCCGTTCGCTCGAATTGTCCACCTTGATGCAGACGCTTACGAAATCAATAAGCTACGTAATGCCGACATCGCG
GTACCAGGCAACTTAGCCACAACACTCACTGCCCTTAGCGCCTTGCTGTCACCCAGTACAGCCGACCCACACATAAGCTC
ATCCAGATATGAATGGCACGAGCGCTGCATAGGCAACCGCGAACGTTTTGGCGTGCGTTACGATGCGCCAGGCAATGATA
TCTACGCACCGGCCCTACTTAAACGCCTGAGCGAAATGGCGCCCGTTGATACCATCATTGCTTGCGATGTTGGCCAGCAT
CAAATGTGGGTGGCGCAACACTGCAAATTCGAAGATCCACGTAATCACCTGACCAGCGGTGGGCTAGGCACAATGGGGTT
CGGCTTGCCTGCGGCAATGGGTGCGCAGTTTGCCTATCCGGAACGCACTGTAGTACTGGTTTCTGGCGATGGCAGTTTCA
TGATGAATGTACAAGAACTGACCACAATCGCACGGTGCAAGCTACCTTTGAAGATTGTCCTGCTTGATAACAACTCGCTA
GGCATGGTTCGGCAATGGCAAGAGCTGTTCTTCGCGGAGCGATACAGTGAAATTGACCTGTCTGACAATCCCGATTTCAC
TGCATTGGTACAGGTATTTGGAATTCCTGCAAAACGCATCACGGTTCGCAGCGACGTCGAACAAGGCTTAGCCTATTTAC
TAGCACAACCAGGTCCAGCATTACTGCACGTGCAGATTGATGCACGCGCCAACGTATGGCCCCTTGTGCCACCGAACACC
GCCAACAGCACCATGCTGGAAAGCAATCCGGCCCACGTTCAGAAGGAAACGCCCCATGCAATACCGGCTTGA

Upstream 100 bases:

>100_bases
AACAGCGAAAAAACAAATGACACAACGCATCCCATGAGTTCGAAGGTGGTTTAAACCTTCCGCCCTCCTCTCACTGCAAC
ATATAGAAGGCCGCTACCAC

Downstream 100 bases:

>100_bases
TCTGATCCTCAGACCCGCCGAAGGTGCAGTATTACGTGTGCTAGGCATGACTGAACGTCGGGGCTTCCGCGCCTGCGCGA
TCCACGGCAGTACTGTCGTC

Product: acetolactate synthase 2 catalytic subunit

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MNRSAHSATRNGASWLTHALEAEGVDTLFGYPGGTIMPFYDALVDSRLTHILVRHEQGAALAANGYARASGRVGVCVATS
GPGASNLITGIADAMLDSVPMVCLTGQVASSLLGTDAFQELDVFGLTMPIVKHSFLVRSIQDLPSMVQDAFRIAREGRPG
PVLIDLPKDVQMTDASHLQDHVSAAVMAPPQAEAAMIIEAAAAIASAEKPVIYGGGGIALADAVNVFRTFVDTTSIPTTL
TLRGLGALPHAHPHYLGMLGMHGTRAANMAIQECDLLLVIGARFDDRATGKVNEFAPFARIVHLDADAYEINKLRNADIA
VPGNLATTLTALSALLSPSTADPHISSSRYEWHERCIGNRERFGVRYDAPGNDIYAPALLKRLSEMAPVDTIIACDVGQH
QMWVAQHCKFEDPRNHLTSGGLGTMGFGLPAAMGAQFAYPERTVVLVSGDGSFMMNVQELTTIARCKLPLKIVLLDNNSL
GMVRQWQELFFAERYSEIDLSDNPDFTALVQVFGIPAKRITVRSDVEQGLAYLLAQPGPALLHVQIDARANVWPLVPPNT
ANSTMLESNPAHVQKETPHAIPA

Sequences:

>Translated_583_residues
MNRSAHSATRNGASWLTHALEAEGVDTLFGYPGGTIMPFYDALVDSRLTHILVRHEQGAALAANGYARASGRVGVCVATS
GPGASNLITGIADAMLDSVPMVCLTGQVASSLLGTDAFQELDVFGLTMPIVKHSFLVRSIQDLPSMVQDAFRIAREGRPG
PVLIDLPKDVQMTDASHLQDHVSAAVMAPPQAEAAMIIEAAAAIASAEKPVIYGGGGIALADAVNVFRTFVDTTSIPTTL
TLRGLGALPHAHPHYLGMLGMHGTRAANMAIQECDLLLVIGARFDDRATGKVNEFAPFARIVHLDADAYEINKLRNADIA
VPGNLATTLTALSALLSPSTADPHISSSRYEWHERCIGNRERFGVRYDAPGNDIYAPALLKRLSEMAPVDTIIACDVGQH
QMWVAQHCKFEDPRNHLTSGGLGTMGFGLPAAMGAQFAYPERTVVLVSGDGSFMMNVQELTTIARCKLPLKIVLLDNNSL
GMVRQWQELFFAERYSEIDLSDNPDFTALVQVFGIPAKRITVRSDVEQGLAYLLAQPGPALLHVQIDARANVWPLVPPNT
ANSTMLESNPAHVQKETPHAIPA
>Mature_583_residues
MNRSAHSATRNGASWLTHALEAEGVDTLFGYPGGTIMPFYDALVDSRLTHILVRHEQGAALAANGYARASGRVGVCVATS
GPGASNLITGIADAMLDSVPMVCLTGQVASSLLGTDAFQELDVFGLTMPIVKHSFLVRSIQDLPSMVQDAFRIAREGRPG
PVLIDLPKDVQMTDASHLQDHVSAAVMAPPQAEAAMIIEAAAAIASAEKPVIYGGGGIALADAVNVFRTFVDTTSIPTTL
TLRGLGALPHAHPHYLGMLGMHGTRAANMAIQECDLLLVIGARFDDRATGKVNEFAPFARIVHLDADAYEINKLRNADIA
VPGNLATTLTALSALLSPSTADPHISSSRYEWHERCIGNRERFGVRYDAPGNDIYAPALLKRLSEMAPVDTIIACDVGQH
QMWVAQHCKFEDPRNHLTSGGLGTMGFGLPAAMGAQFAYPERTVVLVSGDGSFMMNVQELTTIARCKLPLKIVLLDNNSL
GMVRQWQELFFAERYSEIDLSDNPDFTALVQVFGIPAKRITVRSDVEQGLAYLLAQPGPALLHVQIDARANVWPLVPPNT
ANSTMLESNPAHVQKETPHAIPA

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=560, Percent_Identity=24.6428571428571, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI21361361, Length=522, Percent_Identity=25.095785440613, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI1790104, Length=570, Percent_Identity=44.7368421052632, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI87081685, Length=554, Percent_Identity=41.5162454873646, Blast_Score=435, Evalue=1e-123,
Organism=Escherichia coli, GI1786717, Length=552, Percent_Identity=31.8840579710145, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1787096, Length=544, Percent_Identity=27.7573529411765, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1788716, Length=555, Percent_Identity=25.5855855855856, Blast_Score=139, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17531301, Length=494, Percent_Identity=27.9352226720648, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17531299, Length=494, Percent_Identity=27.9352226720648, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17542570, Length=513, Percent_Identity=27.0955165692008, Blast_Score=149, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6323755, Length=595, Percent_Identity=40.5042016806723, Blast_Score=430, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6320816, Length=475, Percent_Identity=24.4210526315789, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320588, Length=586, Percent_Identity=20.9897610921502, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323163, Length=483, Percent_Identity=25.0517598343685, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323073, Length=500, Percent_Identity=24.6, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321524, Length=486, Percent_Identity=23.4567901234568, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19922626, Length=501, Percent_Identity=27.1457085828343, Blast_Score=174, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 62514; Mature: 62514

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRSAHSATRNGASWLTHALEAEGVDTLFGYPGGTIMPFYDALVDSRLTHILVRHEQGAA
CCCCCCCCCCCCHHHHHHHHHCCCCHHEECCCCCCHHHHHHHHHHHHHHEEEEEECCCCE
LAANGYARASGRVGVCVATSGPGASNLITGIADAMLDSVPMVCLTGQVASSLLGTDAFQE
EEECCCEECCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCHHHHH
LDVFGLTMPIVKHSFLVRSIQDLPSMVQDAFRIAREGRPGPVLIDLPKDVQMTDASHLQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHH
HVSAAVMAPPQAEAAMIIEAAAAIASAEKPVIYGGGGIALADAVNVFRTFVDTTSIPTTL
HHHHEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEE
TLRGLGALPHAHPHYLGMLGMHGTRAANMAIQECDLLLVIGARFDDRATGKVNEFAPFAR
EEECCCCCCCCCCHHHEECCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHCCEEE
IVHLDADAYEINKLRNADIAVPGNLATTLTALSALLSPSTADPHISSSRYEWHERCIGNR
EEEECCCHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCH
ERFGVRYDAPGNDIYAPALLKRLSEMAPVDTIIACDVGQHQMWVAQHCKFEDPRNHLTSG
HHCCEEECCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCCHHHHCCC
GLGTMGFGLPAAMGAQFAYPERTVVLVSGDGSFMMNVQELTTIARCKLPLKIVLLDNNSL
CCCCCCCCCHHHHCCCCCCCCEEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEECCCCC
GMVRQWQELFFAERYSEIDLSDNPDFTALVQVFGIPAKRITVRSDVEQGLAYLLAQPGPA
CHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHEEEEHHHHHHHHHHHHCCCCCE
LLHVQIDARANVWPLVPPNTANSTMLESNPAHVQKETPHAIPA
EEEEEEECCCCEECCCCCCCCCCCEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNRSAHSATRNGASWLTHALEAEGVDTLFGYPGGTIMPFYDALVDSRLTHILVRHEQGAA
CCCCCCCCCCCCHHHHHHHHHCCCCHHEECCCCCCHHHHHHHHHHHHHHEEEEEECCCCE
LAANGYARASGRVGVCVATSGPGASNLITGIADAMLDSVPMVCLTGQVASSLLGTDAFQE
EEECCCEECCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCHHHHH
LDVFGLTMPIVKHSFLVRSIQDLPSMVQDAFRIAREGRPGPVLIDLPKDVQMTDASHLQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHH
HVSAAVMAPPQAEAAMIIEAAAAIASAEKPVIYGGGGIALADAVNVFRTFVDTTSIPTTL
HHHHEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEE
TLRGLGALPHAHPHYLGMLGMHGTRAANMAIQECDLLLVIGARFDDRATGKVNEFAPFAR
EEECCCCCCCCCCHHHEECCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHCCEEE
IVHLDADAYEINKLRNADIAVPGNLATTLTALSALLSPSTADPHISSSRYEWHERCIGNR
EEEECCCHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCH
ERFGVRYDAPGNDIYAPALLKRLSEMAPVDTIIACDVGQHQMWVAQHCKFEDPRNHLTSG
HHCCEEECCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCCHHHHCCC
GLGTMGFGLPAAMGAQFAYPERTVVLVSGDGSFMMNVQELTTIARCKLPLKIVLLDNNSL
CCCCCCCCCHHHHCCCCCCCCEEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEECCCCC
GMVRQWQELFFAERYSEIDLSDNPDFTALVQVFGIPAKRITVRSDVEQGLAYLLAQPGPA
CHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHEEEEHHHHHHHHHHHHCCCCCE
LLHVQIDARANVWPLVPPNTANSTMLESNPAHVQKETPHAIPA
EEEEEEECCCCEECCCCCCCCCCCEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]