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The map label for this gene is ilvC [H]

Identifier: 182681649

GI number: 182681649

Start: 1254698

End: 1255705

Strand: Direct

Name: ilvC [H]

Synonym: XfasM23_1107

Alternate gene names: 182681649

Gene position: 1254698-1255705 (Clockwise)

Preceding gene: 182681648

Following gene: 182681650

Centisome position: 49.48

GC content: 50.3

Gene sequence:

>1008_bases
ATGAGAAACACAAAGTCCACTTTGAAAATTGCAATCATCGGTTATGGAAGTCAGGGTCGGGCACATGCTCTGAACCTGCG
TGACTCTGGTTTTGACATTATCGTCGGCCTGCGTCCAGGTGGAGCAACCGAAGCTAAAGCTCAGGCTGACGGTTTCACAG
TGCAGTCTCCGGACCAAGCAGCGAAACATGCCGATTTAGTTGCTGTACTGACCCCAGACATGGTCCAAAAGAAACTCTAC
GAAGAGGTTTTAGCACCAAACATAAAGCAAGGTGCTTGCCTATTATTCGCACATGGCCTAAACGTCCACTACAGCTTGAT
TACCCCACGGAGCGATCTAGATGTGGTGCTCGTTGCCCCCAAGGGTCCTGGTGCACTGGTACGCCGCGAATACGAAATCG
GACGTGGGGTGCCATGTATCTATGCAGTACATCAAGATCTCAGCAGCCATGCCGAGCAGCTGGCTTTAACCTACGCTGGT
GGCCTAGGTGGTGCCCGTGCCAACATCATCAAAACAACTTTCAAGGAAGAAACTGAGACCGACTTGTTCGGTGAGCAAGC
TGTGCTGTGCGGCGGTGTTTCCTCGCTAGTGCAAGCCGGCTTTGAAACCTTGGTTGAAGCCGGTTACCAGCCGGAAATCG
CCTATTACGAAGTACTGCACGAATTGAAGTTAATCGTGGATCTGTTCTACGAAGGTGGCATCACCCGAATGCTGGAATTT
GTCTCTGAAACCGCACAGTATGGCGACTATGTCAGTGGCCCACGCGTGATCGACCGCAGCACCAAGGAACGTATGAAAGC
TGTGCTGAAGGATATCCAAGATGGCACCTTCACCAAACATTGGATTGCCGAATACCAAGCCGGCTTACCAAACTACAAGA
AATATAAGCAAGCCGACCTGGAACACCCCATTGAAAAAGTCGGTAAGCAACTGCGTGCCAAGATGGTCTGGTTAAACAGC
GAAAAAACAAATGACACAACGCATCCCATGAGTTCGAAGGTGGTTTAA

Upstream 100 bases:

>100_bases
CGTTGCGCATCTCGTTCTCAGACATTAATAAACAGCCAACATATGCTATGCACTGTTGGTTAACGTTTCCATCACCACAG
ATTATTCAAGGATGCTATTT

Downstream 100 bases:

>100_bases
ACCTTCCGCCCTCCTCTCACTGCAACATATAGAAGGCCGCTACCACATGAACAGATCCGCACACAGCGCAACCCGCAATG
GTGCGAGCTGGTTGACGCAT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MRNTKSTLKIAIIGYGSQGRAHALNLRDSGFDIIVGLRPGGATEAKAQADGFTVQSPDQAAKHADLVAVLTPDMVQKKLY
EEVLAPNIKQGACLLFAHGLNVHYSLITPRSDLDVVLVAPKGPGALVRREYEIGRGVPCIYAVHQDLSSHAEQLALTYAG
GLGGARANIIKTTFKEETETDLFGEQAVLCGGVSSLVQAGFETLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEF
VSETAQYGDYVSGPRVIDRSTKERMKAVLKDIQDGTFTKHWIAEYQAGLPNYKKYKQADLEHPIEKVGKQLRAKMVWLNS
EKTNDTTHPMSSKVV

Sequences:

>Translated_335_residues
MRNTKSTLKIAIIGYGSQGRAHALNLRDSGFDIIVGLRPGGATEAKAQADGFTVQSPDQAAKHADLVAVLTPDMVQKKLY
EEVLAPNIKQGACLLFAHGLNVHYSLITPRSDLDVVLVAPKGPGALVRREYEIGRGVPCIYAVHQDLSSHAEQLALTYAG
GLGGARANIIKTTFKEETETDLFGEQAVLCGGVSSLVQAGFETLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEF
VSETAQYGDYVSGPRVIDRSTKERMKAVLKDIQDGTFTKHWIAEYQAGLPNYKKYKQADLEHPIEKVGKQLRAKMVWLNS
EKTNDTTHPMSSKVV
>Mature_335_residues
MRNTKSTLKIAIIGYGSQGRAHALNLRDSGFDIIVGLRPGGATEAKAQADGFTVQSPDQAAKHADLVAVLTPDMVQKKLY
EEVLAPNIKQGACLLFAHGLNVHYSLITPRSDLDVVLVAPKGPGALVRREYEIGRGVPCIYAVHQDLSSHAEQLALTYAG
GLGGARANIIKTTFKEETETDLFGEQAVLCGGVSSLVQAGFETLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEF
VSETAQYGDYVSGPRVIDRSTKERMKAVLKDIQDGTFTKHWIAEYQAGLPNYKKYKQADLEHPIEKVGKQLRAKMVWLNS
EKTNDTTHPMSSKVV

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=292, Percent_Identity=35.6164383561644, Blast_Score=147, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6323387, Length=318, Percent_Identity=33.0188679245283, Blast_Score=132, Evalue=6e-32,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36766; Mature: 36766

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNTKSTLKIAIIGYGSQGRAHALNLRDSGFDIIVGLRPGGATEAKAQADGFTVQSPDQA
CCCCCCEEEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCEECCCHHH
AKHADLVAVLTPDMVQKKLYEEVLAPNIKQGACLLFAHGLNVHYSLITPRSDLDVVLVAP
HHHCCEEEEECHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCCCCCCEEEECC
KGPGALVRREYEIGRGVPCIYAVHQDLSSHAEQLALTYAGGLGGARANIIKTTFKEETET
CCCCHHHEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHH
DLFGEQAVLCGGVSSLVQAGFETLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEF
HHCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VSETAQYGDYVSGPRVIDRSTKERMKAVLKDIQDGTFTKHWIAEYQAGLPNYKKYKQADL
HHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHH
EHPIEKVGKQLRAKMVWLNSEKTNDTTHPMSSKVV
CCHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRNTKSTLKIAIIGYGSQGRAHALNLRDSGFDIIVGLRPGGATEAKAQADGFTVQSPDQA
CCCCCCEEEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCEECCCHHH
AKHADLVAVLTPDMVQKKLYEEVLAPNIKQGACLLFAHGLNVHYSLITPRSDLDVVLVAP
HHHCCEEEEECHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCCCCCCEEEECC
KGPGALVRREYEIGRGVPCIYAVHQDLSSHAEQLALTYAGGLGGARANIIKTTFKEETET
CCCCHHHEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHH
DLFGEQAVLCGGVSSLVQAGFETLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEF
HHCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VSETAQYGDYVSGPRVIDRSTKERMKAVLKDIQDGTFTKHWIAEYQAGLPNYKKYKQADL
HHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHH
EHPIEKVGKQLRAKMVWLNSEKTNDTTHPMSSKVV
CCHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]