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The map label for this gene is nadC [H]

Identifier: 182681468

GI number: 182681468

Start: 1088516

End: 1089382

Strand: Reverse

Name: nadC [H]

Synonym: XfasM23_0920

Alternate gene names: 182681468

Gene position: 1089382-1088516 (Counterclockwise)

Preceding gene: 182681469

Following gene: 182681466

Centisome position: 42.96

GC content: 51.1

Gene sequence:

>867_bases
ATGAACCTCGTTTCTCTTCCACGTATCATCATTGAACCGATGGTACGCCATGCGCTTGCAGAAGATTTAGGACTTGCAGG
CGACATTACCTCAGCCGCAGTTATCCCTGAAAAACATCGTTCCACAGTGATCATCGTGGCGCGTCAGGCGGGAGTCATCG
CGGGATTGGATATGGCCGAGCTGGCATTCCAGCTCATTGATGCCGAACTTGTCATGATGCGGCATGTGCATGATGGCATG
AAAGTAGAACCGGGCGATGTGATTGCTACCATCACCGGTTGCTCACGGGCATTGCTCACTGCCGAACGTACAGCACTCAA
TTTTCTGAGCCATCTCTCAGGCATTGCAACAGCGACTGCATCGATCGCTACAGCCATTGCAGGAACAAAAACAATCGTTG
TCTGCACACGTAAAACGCTCCCGGGAATACGTACCTTACAAAAATATGCAGTCCGGGCCGGTGGTGGCATGAACCATCGA
TTTGCTCTGTACGATGCGATGTTGATCAAGGACAACCATATCGCAATTGCAGGCAGTGTCCGCGAAGCACTGCGCCATGC
AAAAGCCATGGCCGGTCATCTGGTGAACATTGAGATTGAGGTCGATACTCTTGAACAGCTACATGAAGCGATGGAAATAG
GAGTAGACGCGGTCTTACTTGACAATATGCAGCCCTCCGAATTGCGAGAGGCGGTGAACATTGTTGCAGGGCGAGCGATC
ACCGAAGCATCTGGACGCATTACTCCAGAAACAGCGATCAACATTGCCGCTTCTGGTGTCGATCTGATCTCTGTCGGCTG
GATCACTCATAGCGCCCCCATCCTTGATATCGGCCTAGATTTTAAGAGTGCTGCATCAGATCGATAA

Upstream 100 bases:

>100_bases
CTCAAACATGACACAACACAGCGGCGCAACATGACACTTGAGGATGTTCTTGAAATCGCCCACTCCCGTATTGCACAACG
CAAAGAAAAGATCTCCTGAC

Downstream 100 bases:

>100_bases
AATCGAGGTCGAAATCCTATTGGATTCTGGTATTAACTAGTACGGTGCCGTAGGCATTACCACCGACAACACATATCCCT
GCCCTTCCCTCTTGATACAA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MNLVSLPRIIIEPMVRHALAEDLGLAGDITSAAVIPEKHRSTVIIVARQAGVIAGLDMAELAFQLIDAELVMMRHVHDGM
KVEPGDVIATITGCSRALLTAERTALNFLSHLSGIATATASIATAIAGTKTIVVCTRKTLPGIRTLQKYAVRAGGGMNHR
FALYDAMLIKDNHIAIAGSVREALRHAKAMAGHLVNIEIEVDTLEQLHEAMEIGVDAVLLDNMQPSELREAVNIVAGRAI
TEASGRITPETAINIAASGVDLISVGWITHSAPILDIGLDFKSAASDR

Sequences:

>Translated_288_residues
MNLVSLPRIIIEPMVRHALAEDLGLAGDITSAAVIPEKHRSTVIIVARQAGVIAGLDMAELAFQLIDAELVMMRHVHDGM
KVEPGDVIATITGCSRALLTAERTALNFLSHLSGIATATASIATAIAGTKTIVVCTRKTLPGIRTLQKYAVRAGGGMNHR
FALYDAMLIKDNHIAIAGSVREALRHAKAMAGHLVNIEIEVDTLEQLHEAMEIGVDAVLLDNMQPSELREAVNIVAGRAI
TEASGRITPETAINIAASGVDLISVGWITHSAPILDIGLDFKSAASDR
>Mature_288_residues
MNLVSLPRIIIEPMVRHALAEDLGLAGDITSAAVIPEKHRSTVIIVARQAGVIAGLDMAELAFQLIDAELVMMRHVHDGM
KVEPGDVIATITGCSRALLTAERTALNFLSHLSGIATATASIATAIAGTKTIVVCTRKTLPGIRTLQKYAVRAGGGMNHR
FALYDAMLIKDNHIAIAGSVREALRHAKAMAGHLVNIEIEVDTLEQLHEAMEIGVDAVLLDNMQPSELREAVNIVAGRAI
TEASGRITPETAINIAASGVDLISVGWITHSAPILDIGLDFKSAASDR

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=279, Percent_Identity=33.3333333333333, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1786299, Length=273, Percent_Identity=42.4908424908425, Blast_Score=185, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6321162, Length=249, Percent_Identity=32.9317269076305, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30549; Mature: 30549

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVSLPRIIIEPMVRHALAEDLGLAGDITSAAVIPEKHRSTVIIVARQAGVIAGLDMAE
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHEECCCCCCCEEEEEEECCCEEECCCHHH
LAFQLIDAELVMMRHVHDGMKVEPGDVIATITGCSRALLTAERTALNFLSHLSGIATATA
HHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SIATAIAGTKTIVVCTRKTLPGIRTLQKYAVRAGGGMNHRFALYDAMLIKDNHIAIAGSV
HHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCEEEEHHH
REALRHAKAMAGHLVNIEIEVDTLEQLHEAMEIGVDAVLLDNMQPSELREAVNIVAGRAI
HHHHHHHHHHHCEEEEEEEEHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCE
TEASGRITPETAINIAASGVDLISVGWITHSAPILDIGLDFKSAASDR
ECCCCCCCCHHHEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MNLVSLPRIIIEPMVRHALAEDLGLAGDITSAAVIPEKHRSTVIIVARQAGVIAGLDMAE
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHEECCCCCCCEEEEEEECCCEEECCCHHH
LAFQLIDAELVMMRHVHDGMKVEPGDVIATITGCSRALLTAERTALNFLSHLSGIATATA
HHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SIATAIAGTKTIVVCTRKTLPGIRTLQKYAVRAGGGMNHRFALYDAMLIKDNHIAIAGSV
HHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCEEEEHHH
REALRHAKAMAGHLVNIEIEVDTLEQLHEAMEIGVDAVLLDNMQPSELREAVNIVAGRAI
HHHHHHHHHHHCEEEEEEEEHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCE
TEASGRITPETAINIAASGVDLISVGWITHSAPILDIGLDFKSAASDR
ECCCCCCCCHHHEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]