Click here to switch to the map view.

The map label for this gene is tktA [H]

Identifier: 182681459

GI number: 182681459

Start: 1081029

End: 1083089

Strand: Direct

Name: tktA [H]

Synonym: XfasM23_0910

Alternate gene names: 182681459

Gene position: 1081029-1083089 (Clockwise)

Preceding gene: 182681458

Following gene: 182681464

Centisome position: 42.63

GC content: 52.5

Gene sequence:

>2061_bases
ATGACCAAACCCACACGCCGCCAGTTGGCCAACGCAATCCGTTTCCTTGCCGCTGATGCAGTACAAGCTGCTCATTCTGG
GCACCCGGGCATGCCGATGGGAATGGCAGATATCGCTGAAGTTCTTTGGAACGATTTCCTACGCCATAACCCTAACAACC
CGAACTGGTTTAACCGTGACCGCTTCATTCTTTCCAACGGTCACGGCTCGATGTTGCAATATGCATTGCTGCATTTAAGT
GGCTATGACCTGCCGTTAGATGAACTCAAGCAATTCCGTCAGCTGCATAGCAAAACAGCTGGTCATCCTGAGCGTAGCGA
GACCCCAGGGATTGAGACGACTACTGGGCCGCTTGGTCAGGGGTTTGCTAACGCAGTGGGTTTTGCCTTGGCCGAGAAAC
TTCTAGCGCAACGCTACAACCGTCCGGAACATCTCATTGTCGATCACCGCACCTGGGTGTTCATGGGCGACGGCTGTCTC
ATGGAAGGTATCTCACATGAAGCAGCCGCGCTGGCGGGTACCTGGAACTTAGGCAAATTGATTTGTTTCTGGGATGACAA
CAATATTTCTATTGATGGCAATACTGCGGGTTGGTTTACCGAAGACACTCCAGCACGATTCGAAGCCTATGGTTGGCATG
TAATCCGCGATATTGATGGCCATGATGCGGAAAAAATCGCAACCGCAATCCAAGCCGCCGTTGCTCAAGAGAACAAGCCC
TCATTGCTATGCTGCCGTACCGTGATCGGATTTGGCTCACCAAATAAAGCTGGTAAAGAATCTTCGCATGGTGCCCCACT
AGGAGCGGAGGAACTGGAGGCCACGCGTAAGATGTTGGATTGGCCATACGGCCCGTTCGAGATTCCGTCCGAGATTTACG
ATGGTTGGCGTGCTAACGGCACAGGCATGCTACGTCAAGCTGAGTGGGAGCAGGCGTTCGACAACTATGCCCGACAGTAT
CCTAAGGAAGCAGCTGAATTAACCCGGCGCTCCCACGCTGAGTTACCTACTGATTTTCTCAGCCAATTGGATGCTTACAT
TGCCAAAGTTCACGCTGTGGGGCCCTGCATTGCTTCCCGTAAAGCATCGCAGATGGCGATTGAAGCATTTGCACCTTTAC
TTCCCGAGTTAATTGGTGGCTCGGCTGACTTGGCACATTCCAATCTAACGTTGTGGAAAGGGAGCCAAACAGTTGTTGGC
GACGCCCCCAACGCCAACTATGCCTATTACGGCGTACGTGAGTTTGGGATGAGTGCCATCGCAAATGGACTTGCATTGCA
TGGCGGCTTTATCCCCTTCGACGCGACATTTCTAGTATTCAGTGATTACGCCCGCAACGCAGTGCGTATGAGTGCATTGA
TCCCAGCACATGTGATTCACGTTTACACACATGATTCAATCGGACTTGGCGAAGACGGTCCAACGCATCAGCCTGTTGAA
CACTTAGCCGCACTGCGCTATATCCCGAACAATGACGTGTGGCGTCCCTGTGACGCAGTTGAATCTGCAGTGGCATGGAA
GGCGGCGATCACTCGCAATAACGGCCCGAGCTGTTTGGTGTTCAGCCGCCAAAACTTGCCGCACCAACCGCGCCATGATG
CACAACTTGAGCAGATTGCACGCGGTGGCTATATCTTGGCTGACGCGGCGAGCAGCATCCCAGACATCATTTTGATCGCG
ACCGGCTCGGAAGTCAGCCTAGCGATCGAAGCGAAAAAGACACTTGATGCGATGCAGCTAAAAACACGCGTGGTCTCGAT
GCCATCGACCAATGTGTTTGAACGTCAGGACCCCACCTACCGTGAGTCGGTCCTCCCATCGAAAGTCCACAAGCGTGTTG
CAATAGAAGCTGGCGTCACTGGTTTTTGGTGGCAATACGTAGGGTTACATGGTGCCGTGATTGGCCTGGACACCTTTGGT
GCATCAGCCCCAGCGGATGTGTTGTACAAACATTTTAATATCACTGCAGAACACGTGGTCGAAGTCGCAAAGGCACTATG
TGGAAGAGCTGAGACAACACTATCTCTTCCGTACTATCACCAAATGCCGCTCTCCGGTTAG

Upstream 100 bases:

>100_bases
ATGGAATCAGTGGGCCTTGATCTGAGATCGTGTCACTGTGGGACAATAGTGGGGCATCGTATGACTTTCACGATGCCCCT
TTCTCTACCGTCGATGCATC

Downstream 100 bases:

>100_bases
CTTGGGGACTTGCAATCGGTGTACTGCTTCGACAACCCAATGGGGTGGCAACATGGCGATCTCCTCATGAGGATAGGCAC
CCTTCATCGCCAGCAACGTC

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 686; Mature: 685

Protein sequence:

>686_residues
MTKPTRRQLANAIRFLAADAVQAAHSGHPGMPMGMADIAEVLWNDFLRHNPNNPNWFNRDRFILSNGHGSMLQYALLHLS
GYDLPLDELKQFRQLHSKTAGHPERSETPGIETTTGPLGQGFANAVGFALAEKLLAQRYNRPEHLIVDHRTWVFMGDGCL
MEGISHEAAALAGTWNLGKLICFWDDNNISIDGNTAGWFTEDTPARFEAYGWHVIRDIDGHDAEKIATAIQAAVAQENKP
SLLCCRTVIGFGSPNKAGKESSHGAPLGAEELEATRKMLDWPYGPFEIPSEIYDGWRANGTGMLRQAEWEQAFDNYARQY
PKEAAELTRRSHAELPTDFLSQLDAYIAKVHAVGPCIASRKASQMAIEAFAPLLPELIGGSADLAHSNLTLWKGSQTVVG
DAPNANYAYYGVREFGMSAIANGLALHGGFIPFDATFLVFSDYARNAVRMSALIPAHVIHVYTHDSIGLGEDGPTHQPVE
HLAALRYIPNNDVWRPCDAVESAVAWKAAITRNNGPSCLVFSRQNLPHQPRHDAQLEQIARGGYILADAASSIPDIILIA
TGSEVSLAIEAKKTLDAMQLKTRVVSMPSTNVFERQDPTYRESVLPSKVHKRVAIEAGVTGFWWQYVGLHGAVIGLDTFG
ASAPADVLYKHFNITAEHVVEVAKALCGRAETTLSLPYYHQMPLSG

Sequences:

>Translated_686_residues
MTKPTRRQLANAIRFLAADAVQAAHSGHPGMPMGMADIAEVLWNDFLRHNPNNPNWFNRDRFILSNGHGSMLQYALLHLS
GYDLPLDELKQFRQLHSKTAGHPERSETPGIETTTGPLGQGFANAVGFALAEKLLAQRYNRPEHLIVDHRTWVFMGDGCL
MEGISHEAAALAGTWNLGKLICFWDDNNISIDGNTAGWFTEDTPARFEAYGWHVIRDIDGHDAEKIATAIQAAVAQENKP
SLLCCRTVIGFGSPNKAGKESSHGAPLGAEELEATRKMLDWPYGPFEIPSEIYDGWRANGTGMLRQAEWEQAFDNYARQY
PKEAAELTRRSHAELPTDFLSQLDAYIAKVHAVGPCIASRKASQMAIEAFAPLLPELIGGSADLAHSNLTLWKGSQTVVG
DAPNANYAYYGVREFGMSAIANGLALHGGFIPFDATFLVFSDYARNAVRMSALIPAHVIHVYTHDSIGLGEDGPTHQPVE
HLAALRYIPNNDVWRPCDAVESAVAWKAAITRNNGPSCLVFSRQNLPHQPRHDAQLEQIARGGYILADAASSIPDIILIA
TGSEVSLAIEAKKTLDAMQLKTRVVSMPSTNVFERQDPTYRESVLPSKVHKRVAIEAGVTGFWWQYVGLHGAVIGLDTFG
ASAPADVLYKHFNITAEHVVEVAKALCGRAETTLSLPYYHQMPLSG
>Mature_685_residues
TKPTRRQLANAIRFLAADAVQAAHSGHPGMPMGMADIAEVLWNDFLRHNPNNPNWFNRDRFILSNGHGSMLQYALLHLSG
YDLPLDELKQFRQLHSKTAGHPERSETPGIETTTGPLGQGFANAVGFALAEKLLAQRYNRPEHLIVDHRTWVFMGDGCLM
EGISHEAAALAGTWNLGKLICFWDDNNISIDGNTAGWFTEDTPARFEAYGWHVIRDIDGHDAEKIATAIQAAVAQENKPS
LLCCRTVIGFGSPNKAGKESSHGAPLGAEELEATRKMLDWPYGPFEIPSEIYDGWRANGTGMLRQAEWEQAFDNYARQYP
KEAAELTRRSHAELPTDFLSQLDAYIAKVHAVGPCIASRKASQMAIEAFAPLLPELIGGSADLAHSNLTLWKGSQTVVGD
APNANYAYYGVREFGMSAIANGLALHGGFIPFDATFLVFSDYARNAVRMSALIPAHVIHVYTHDSIGLGEDGPTHQPVEH
LAALRYIPNNDVWRPCDAVESAVAWKAAITRNNGPSCLVFSRQNLPHQPRHDAQLEQIARGGYILADAASSIPDIILIAT
GSEVSLAIEAKKTLDAMQLKTRVVSMPSTNVFERQDPTYRESVLPSKVHKRVAIEAGVTGFWWQYVGLHGAVIGLDTFGA
SAPADVLYKHFNITAEHVVEVAKALCGRAETTLSLPYYHQMPLSG

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=603, Percent_Identity=26.3681592039801, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4507521, Length=603, Percent_Identity=26.3681592039801, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI133778974, Length=586, Percent_Identity=26.4505119453925, Blast_Score=150, Evalue=6e-36,
Organism=Homo sapiens, GI225637459, Length=591, Percent_Identity=23.0118443316413, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI225637461, Length=487, Percent_Identity=24.0246406570842, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI225637463, Length=487, Percent_Identity=24.0246406570842, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=64.0483383685801, Blast_Score=898, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=664, Percent_Identity=61.2951807228916, Blast_Score=849, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=683, Percent_Identity=23.8653001464129, Blast_Score=157, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=669, Percent_Identity=47.6831091180867, Blast_Score=568, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6319593, Length=682, Percent_Identity=44.574780058651, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45551847, Length=672, Percent_Identity=26.1904761904762, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI45550715, Length=672, Percent_Identity=26.1904761904762, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24666278, Length=583, Percent_Identity=25.557461406518, Blast_Score=147, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24645119, Length=638, Percent_Identity=25.2351097178683, Blast_Score=142, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 75198; Mature: 75066

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPTRRQLANAIRFLAADAVQAAHSGHPGMPMGMADIAEVLWNDFLRHNPNNPNWFNRD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
RFILSNGHGSMLQYALLHLSGYDLPLDELKQFRQLHSKTAGHPERSETPGIETTTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GFANAVGFALAEKLLAQRYNRPEHLIVDHRTWVFMGDGCLMEGISHEAAALAGTWNLGKL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECEEEEEECCCHHHHCCCCHHHHEEECCCCCEE
ICFWDDNNISIDGNTAGWFTEDTPARFEAYGWHVIRDIDGHDAEKIATAIQAAVAQENKP
EEEEECCEEEECCCCCCCCCCCCCCHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCCC
SLLCCRTVIGFGSPNKAGKESSHGAPLGAEELEATRKMLDWPYGPFEIPSEIYDGWRANG
CEEEHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCC
TGMLRQAEWEQAFDNYARQYPKEAAELTRRSHAELPTDFLSQLDAYIAKVHAVGPCIASR
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KASQMAIEAFAPLLPELIGGSADLAHSNLTLWKGSQTVVGDAPNANYAYYGVREFGMSAI
HHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCCEEECCCCCCCEEEECHHHHHHHHH
ANGLALHGGFIPFDATFLVFSDYARNAVRMSALIPAHVIHVYTHDSIGLGEDGPTHQPVE
HCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCHHHH
HLAALRYIPNNDVWRPCDAVESAVAWKAAITRNNGPSCLVFSRQNLPHQPRHDAQLEQIA
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCCHHHHHHHH
RGGYILADAASSIPDIILIATGSEVSLAIEAKKTLDAMQLKTRVVSMPSTNVFERQDPTY
CCCEEEEECCCCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHEECCCCCCCCCCCCCH
RESVLPSKVHKRVAIEAGVTGFWWQYVGLHGAVIGLDTFGASAPADVLYKHFNITAEHVV
HHHCCHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHCCCHHHHH
EVAKALCGRAETTLSLPYYHQMPLSG
HHHHHHHCCCCCEEECCCCCCCCCCC
>Mature Secondary Structure 
TKPTRRQLANAIRFLAADAVQAAHSGHPGMPMGMADIAEVLWNDFLRHNPNNPNWFNRD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
RFILSNGHGSMLQYALLHLSGYDLPLDELKQFRQLHSKTAGHPERSETPGIETTTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GFANAVGFALAEKLLAQRYNRPEHLIVDHRTWVFMGDGCLMEGISHEAAALAGTWNLGKL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECEEEEEECCCHHHHCCCCHHHHEEECCCCCEE
ICFWDDNNISIDGNTAGWFTEDTPARFEAYGWHVIRDIDGHDAEKIATAIQAAVAQENKP
EEEEECCEEEECCCCCCCCCCCCCCHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCCC
SLLCCRTVIGFGSPNKAGKESSHGAPLGAEELEATRKMLDWPYGPFEIPSEIYDGWRANG
CEEEHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCC
TGMLRQAEWEQAFDNYARQYPKEAAELTRRSHAELPTDFLSQLDAYIAKVHAVGPCIASR
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KASQMAIEAFAPLLPELIGGSADLAHSNLTLWKGSQTVVGDAPNANYAYYGVREFGMSAI
HHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCCEEECCCCCCCEEEECHHHHHHHHH
ANGLALHGGFIPFDATFLVFSDYARNAVRMSALIPAHVIHVYTHDSIGLGEDGPTHQPVE
HCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCHHHH
HLAALRYIPNNDVWRPCDAVESAVAWKAAITRNNGPSCLVFSRQNLPHQPRHDAQLEQIA
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCCHHHHHHHH
RGGYILADAASSIPDIILIATGSEVSLAIEAKKTLDAMQLKTRVVSMPSTNVFERQDPTY
CCCEEEEECCCCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHEECCCCCCCCCCCCCH
RESVLPSKVHKRVAIEAGVTGFWWQYVGLHGAVIGLDTFGASAPADVLYKHFNITAEHVV
HHHCCHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHCCCHHHHH
EVAKALCGRAETTLSLPYYHQMPLSG
HHHHHHHCCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]