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The map label for this gene is ribA [H]

Identifier: 182681414

GI number: 182681414

Start: 1014375

End: 1015571

Strand: Reverse

Name: ribA [H]

Synonym: XfasM23_0864

Alternate gene names: 182681414

Gene position: 1015571-1014375 (Counterclockwise)

Preceding gene: 182681420

Following gene: 182681410

Centisome position: 40.05

GC content: 57.06

Gene sequence:

>1197_bases
ATGAATACTCCCACACACACTCACCCACATCCGTTCGGCTCCACGGCAACGATCCGCTGCGAACGTGCCGCTGCCGAACT
GCGTACTGGTCGGCCTGTCCTGTTGATTGATGCTCATGCGCGTCGGCATGCGGTCATGGCTCTGGATAGCATGACCGCTC
AAAGCTTTGCGACATTTGCGAACGCTGTCGGCAACACTCACTACCTATTCCTGACTCCAGTACGCTCCAACGTGCTCGGC
CTGGAGGCTCCCCAAGGCGCACGCATCCCACTGGCGACCCTGTCCTACGACAGCCTGGCCAAGCTCGCCTACCTGCGTCA
GCCAACACGCCCAACAGCATGGGCGCCTGGAGACATCATGGATGCAGCAGCGACAGAGATCACTCGACTTGCCCTGCTCC
TGCCAGCAATCGTCGCCGCCCCATTAACCCAGCATACCGAACATGCCTTTGCAGATTGCCAAACACTTGACTTAGCAGAT
CTCGATACCGCTGCCGCGTGCGCCTCCACAACAGAGTACGAATTGGTCACACGTACTCCGGTGCCACTACGTGATCTAGG
CATGAGCGAATTCATCGTATTCCGTGGTGGCATTGCACAGCGCGACCAAGTTGCGATCCTGATCGGTCGACCCGACCTAA
GCAGTGCAGTCCCCGTGCGCGTGCATTCCTCCTGCCTAACCGGTGACCTCTTTGGCTCGCTCAAGTGTGACTGCGGCGAC
CAATTGCGTCATAGCTTGGCCACACTAAAAGCCCTTGGCGGTGGTGTGCTGCTGTACTTGGACCAAGAAGGACGTGGAAA
CGGAATTGCCGCAAAAATACGCGCCTACGGCTACCAACATGTAGGACTGGATACGATCGACGCAGATGCACAGCTCGGAT
TCGGTCCGGACGAACGCCGCTACACCGGTGCAGTGATGATGCTACGCGCGCTAGGCATCACCCGGATACAACTGCTATCC
AATAATCCCGCAAAAGCAGAGCGCTTACGCGCGGCAGGAATCATCGTCAAGCAACGCATCTCGGTGATAGGACAGATCAC
CAAACAGAACGAACACTACCTGCGCACCAAAGTCAGCCGTGCCGGCCACGACCTGGACATAGATGCCTTAATCATGACAT
CACAGAGACCTCAAGACCCATCGGAAACTGTCGATGGAGAGACCGTAAAACCCATCGCAAAAACCGGCCACGCATAA

Upstream 100 bases:

>100_bases
TTAAGTGCAGACTGACGACCAACATCGAAAATAATCACTCTTGCACACGGCCTAACATACACACAGCAGTTGCCAATACC
GCTGCCCTCTGGATTCACTC

Downstream 100 bases:

>100_bases
TGCACCTATATTCCCTTCCACCCTGACGATAAACACCATCTCATCTCCTTGGTGACACTCGACAACAGCATTACCGTGGC
ATTGCCTGCACATACTGCCG

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MNTPTHTHPHPFGSTATIRCERAAAELRTGRPVLLIDAHARRHAVMALDSMTAQSFATFANAVGNTHYLFLTPVRSNVLG
LEAPQGARIPLATLSYDSLAKLAYLRQPTRPTAWAPGDIMDAAATEITRLALLLPAIVAAPLTQHTEHAFADCQTLDLAD
LDTAAACASTTEYELVTRTPVPLRDLGMSEFIVFRGGIAQRDQVAILIGRPDLSSAVPVRVHSSCLTGDLFGSLKCDCGD
QLRHSLATLKALGGGVLLYLDQEGRGNGIAAKIRAYGYQHVGLDTIDADAQLGFGPDERRYTGAVMMLRALGITRIQLLS
NNPAKAERLRAAGIIVKQRISVIGQITKQNEHYLRTKVSRAGHDLDIDALIMTSQRPQDPSETVDGETVKPIAKTGHA

Sequences:

>Translated_398_residues
MNTPTHTHPHPFGSTATIRCERAAAELRTGRPVLLIDAHARRHAVMALDSMTAQSFATFANAVGNTHYLFLTPVRSNVLG
LEAPQGARIPLATLSYDSLAKLAYLRQPTRPTAWAPGDIMDAAATEITRLALLLPAIVAAPLTQHTEHAFADCQTLDLAD
LDTAAACASTTEYELVTRTPVPLRDLGMSEFIVFRGGIAQRDQVAILIGRPDLSSAVPVRVHSSCLTGDLFGSLKCDCGD
QLRHSLATLKALGGGVLLYLDQEGRGNGIAAKIRAYGYQHVGLDTIDADAQLGFGPDERRYTGAVMMLRALGITRIQLLS
NNPAKAERLRAAGIIVKQRISVIGQITKQNEHYLRTKVSRAGHDLDIDALIMTSQRPQDPSETVDGETVKPIAKTGHA
>Mature_398_residues
MNTPTHTHPHPFGSTATIRCERAAAELRTGRPVLLIDAHARRHAVMALDSMTAQSFATFANAVGNTHYLFLTPVRSNVLG
LEAPQGARIPLATLSYDSLAKLAYLRQPTRPTAWAPGDIMDAAATEITRLALLLPAIVAAPLTQHTEHAFADCQTLDLAD
LDTAAACASTTEYELVTRTPVPLRDLGMSEFIVFRGGIAQRDQVAILIGRPDLSSAVPVRVHSSCLTGDLFGSLKCDCGD
QLRHSLATLKALGGGVLLYLDQEGRGNGIAAKIRAYGYQHVGLDTIDADAQLGFGPDERRYTGAVMMLRALGITRIQLLS
NNPAKAERLRAAGIIVKQRISVIGQITKQNEHYLRTKVSRAGHDLDIDALIMTSQRPQDPSETVDGETVKPIAKTGHA

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=191, Percent_Identity=45.0261780104712, Blast_Score=154, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319438, Length=185, Percent_Identity=34.5945945945946, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 42830; Mature: 42830

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPTHTHPHPFGSTATIRCERAAAELRTGRPVLLIDAHARRHAVMALDSMTAQSFATFA
CCCCCCCCCCCCCCEEEEEEHHHHHHHHCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHH
NAVGNTHYLFLTPVRSNVLGLEAPQGARIPLATLSYDSLAKLAYLRQPTRPTAWAPGDIM
HHCCCEEEEEEEECCCCEEECCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCHHH
DAAATEITRLALLLPAIVAAPLTQHTEHAFADCQTLDLADLDTAAACASTTEYELVTRTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCEEEEECCC
VPLRDLGMSEFIVFRGGIAQRDQVAILIGRPDLSSAVPVRVHSSCLTGDLFGSLKCDCGD
CCHHHCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCEEECCCHHCHHHCCCEECCCHH
QLRHSLATLKALGGGVLLYLDQEGRGNGIAAKIRAYGYQHVGLDTIDADAQLGFGPDERR
HHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCEEECCCEEECCCCCCCCCCCCCH
YTGAVMMLRALGITRIQLLSNNPAKAERLRAAGIIVKQRISVIGQITKQNEHYLRTKVSR
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AGHDLDIDALIMTSQRPQDPSETVDGETVKPIAKTGHA
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCC
>Mature Secondary Structure
MNTPTHTHPHPFGSTATIRCERAAAELRTGRPVLLIDAHARRHAVMALDSMTAQSFATFA
CCCCCCCCCCCCCCEEEEEEHHHHHHHHCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHH
NAVGNTHYLFLTPVRSNVLGLEAPQGARIPLATLSYDSLAKLAYLRQPTRPTAWAPGDIM
HHCCCEEEEEEEECCCCEEECCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCHHH
DAAATEITRLALLLPAIVAAPLTQHTEHAFADCQTLDLADLDTAAACASTTEYELVTRTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCEEEEECCC
VPLRDLGMSEFIVFRGGIAQRDQVAILIGRPDLSSAVPVRVHSSCLTGDLFGSLKCDCGD
CCHHHCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCEEECCCHHCHHHCCCEECCCHH
QLRHSLATLKALGGGVLLYLDQEGRGNGIAAKIRAYGYQHVGLDTIDADAQLGFGPDERR
HHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCEEECCCEEECCCCCCCCCCCCCH
YTGAVMMLRALGITRIQLLSNNPAKAERLRAAGIIVKQRISVIGQITKQNEHYLRTKVSR
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AGHDLDIDALIMTSQRPQDPSETVDGETVKPIAKTGHA
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]