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The map label for this gene is gmk

Identifier: 182681309

GI number: 182681309

Start: 893320

End: 893934

Strand: Reverse

Name: gmk

Synonym: XfasM23_0756

Alternate gene names: 182681309

Gene position: 893934-893320 (Counterclockwise)

Preceding gene: 182681310

Following gene: 182681308

Centisome position: 35.25

GC content: 52.36

Gene sequence:

>615_bases
ATGCGCGGCACCCTCTACATCGTTTCAGCCTCTTCCGGCACTGGTAAAAGCAGCATCGTCAACGCCACTCTGGAACGCGA
TCAACAAATCGCTCTGTCGATCTCCTTCACCTCACGTCAGCCCAGACCCAATGAGCGCCATGCACAGCACTACTATTTCG
TCTCAGCCGATGAATTTCAGCGCATGATTGAGGCAGGCGACTTTTTTGAATACGCATTGGTCCATGGCGATTGGAAAGGC
ACCGCCCGCCAATCGGTGGAGCCACAACTGGCTGCCGGTCACGATGTACTGTTAGAAATCGACTGGCAGGGTGCACGCCA
AGTGCGCAGCAAGATCCCTGATGCAATCAGCATATTTATATTGCCGCCCTCACGCGCCGCACTGGAAGAACGCCTGCGTA
AACGCGGCCAAGACAGTGAAGAGGTCATCCATCTGCGCTTAGCTGCCGCCCACGAAGAAATGGCGCACTACGATGAATTC
GACTACACGATTATTAATGAGCATTTCGAAACTGCAGTTTCAGAAATGAGCGCTATCTTCACGGCAAGTCGGTTGCGGCG
CCAAACCCAAAAAATACGGCATGCCAATCTGATCCAAACCTTATTAACTCCATAA

Upstream 100 bases:

>100_bases
AGTGCAGAACATCGAATAACCGTAATAGTGCCTTTAACGGCAGTGACATCGCACACCAAGTATCCACCTGATCCATTGTC
CACTGAGCAATCTCTATTCT

Downstream 100 bases:

>100_bases
AGCATGTTGGGGTTTTTCTTTAACGTGCATGTGGCATGCATACTGGTAAAGCCTCATTGGGATTCATCAGCAAGAAAAAT
CTGCGAAAGCAGGAAGTTCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MRGTLYIVSASSGTGKSSIVNATLERDQQIALSISFTSRQPRPNERHAQHYYFVSADEFQRMIEAGDFFEYALVHGDWKG
TARQSVEPQLAAGHDVLLEIDWQGARQVRSKIPDAISIFILPPSRAALEERLRKRGQDSEEVIHLRLAAAHEEMAHYDEF
DYTIINEHFETAVSEMSAIFTASRLRRQTQKIRHANLIQTLLTP

Sequences:

>Translated_204_residues
MRGTLYIVSASSGTGKSSIVNATLERDQQIALSISFTSRQPRPNERHAQHYYFVSADEFQRMIEAGDFFEYALVHGDWKG
TARQSVEPQLAAGHDVLLEIDWQGARQVRSKIPDAISIFILPPSRAALEERLRKRGQDSEEVIHLRLAAAHEEMAHYDEF
DYTIINEHFETAVSEMSAIFTASRLRRQTQKIRHANLIQTLLTP
>Mature_204_residues
MRGTLYIVSASSGTGKSSIVNATLERDQQIALSISFTSRQPRPNERHAQHYYFVSADEFQRMIEAGDFFEYALVHGDWKG
TARQSVEPQLAAGHDVLLEIDWQGARQVRSKIPDAISIFILPPSRAALEERLRKRGQDSEEVIHLRLAAAHEEMAHYDEF
DYTIINEHFETAVSEMSAIFTASRLRRQTQKIRHANLIQTLLTP

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=174, Percent_Identity=37.9310344827586, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4504221, Length=174, Percent_Identity=37.9310344827586, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI226874831, Length=174, Percent_Identity=37.9310344827586, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4505237, Length=180, Percent_Identity=28.3333333333333, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI262118255, Length=180, Percent_Identity=28.3333333333333, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI262118259, Length=180, Percent_Identity=28.3333333333333, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI262118263, Length=180, Percent_Identity=28.3333333333333, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI52630447, Length=207, Percent_Identity=27.0531400966184, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=205, Percent_Identity=54.6341463414634, Blast_Score=221, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI193203132, Length=175, Percent_Identity=37.7142857142857, Blast_Score=120, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17508835, Length=175, Percent_Identity=37.7142857142857, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=36.0655737704918, Blast_Score=116, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21356141, Length=195, Percent_Identity=33.8461538461538, Blast_Score=101, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23236; Mature: 23236

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGTLYIVSASSGTGKSSIVNATLERDQQIALSISFTSRQPRPNERHAQHYYFVSADEFQ
CCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEEECHHHHH
RMIEAGDFFEYALVHGDWKGTARQSVEPQLAAGHDVLLEIDWQGARQVRSKIPDAISIFI
HHHHHCCCEEEEEEECCCCCCHHCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCEEEEEE
LPPSRAALEERLRKRGQDSEEVIHLRLAAAHEEMAHYDEFDYTIINEHFETAVSEMSAIF
ECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHH
TASRLRRQTQKIRHANLIQTLLTP
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRGTLYIVSASSGTGKSSIVNATLERDQQIALSISFTSRQPRPNERHAQHYYFVSADEFQ
CCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEEECHHHHH
RMIEAGDFFEYALVHGDWKGTARQSVEPQLAAGHDVLLEIDWQGARQVRSKIPDAISIFI
HHHHHCCCEEEEEEECCCCCCHHCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCEEEEEE
LPPSRAALEERLRKRGQDSEEVIHLRLAAAHEEMAHYDEFDYTIINEHFETAVSEMSAIF
ECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHH
TASRLRRQTQKIRHANLIQTLLTP
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]