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The map label for this gene is glmS [H]

Identifier: 182681273

GI number: 182681273

Start: 846830

End: 847870

Strand: Direct

Name: glmS [H]

Synonym: XfasM23_0718

Alternate gene names: 182681273

Gene position: 846830-847870 (Clockwise)

Preceding gene: 182681272

Following gene: 182681274

Centisome position: 33.4

GC content: 56.48

Gene sequence:

>1041_bases
ATGACGTTACCGATCCCTTTGCTTGAACCAGAACAAACACTGATGTTTCGTGAGGCAGCACAGGCTGCCGCAGTGATTGC
CACACAGTTCGAACGTAACGCAGCAACGATTGCCACACTGGTACGGGCATTGCGTGCTGATCCCCCTCCATTTGTGGTGA
CATGCGCGCGTGGCAGTTCTGACCACGTGGCCACCTATGCCAAGTATTTGTTGGAAACGCAGTTGGGTTTGGTGACGGCT
TCGGCCTCCTTGTCAGTGGGGTCAATCTATGCTGCGTCGCTACAGTTGCGTGGTGCGCTCTATCTGGTGATCTCGCAGTC
AGGGAAGAGTCCGGATCTGTTGCGCAATGTGGAAGCGGCTAAGGCAGCCGGTGCACGTGTGGTGGCTTTGGTCAACGTCG
AAGACTCGCCCTTGGCATCGCTGGCTGACACTGTATTGCCACTGTGCGCTGGTCCGGAGCAGAGTGTCGCTGCGACCAAA
AGCTATCTGGCCTCGTTATCTGCGGTGTTGCAGTTAGTAGCAGTATGGAAGGCTGAATCGGGGTTGCTGGCGGCGTTGGA
TGGTATGTCTGATGCGTTGCGCACTGCTTGGGAGTGCGATTGGACAAGCTTAATTGATGGCTTGGTCAATGCTCGCAATC
TGTTCGTGCTTGGTCGTGGCTTTGGCTTGGCGACTGCTCAGGAAGCGGCACTCAAGTTCAAGGAAACCTGTGGCCTGCAT
GCTGAAGCGTATAGCGCGGCGGAGGTCAAGCATGGGCCAATGGCTCTGGTGGGTTCGGGGTTCCCAGTGCTGGTGTTTGC
TCAGTCGGATGGGACCGAAGCGGCGGTACGTGCATTAGCCCATGAGTTTCGAGGGCGCGGCTCCCTGGTATGGCTGGCAG
CACCGGAGGGTGATTTGCCCGTTGGGGTGGCCGCACACCCGGTGTGTGCGCCTTTGTTGTCGATCCAGAGTTTTTATCGC
GCCATTAATACGCTGGCATTATGCCGAGGGTATAACCCTGATCTGCCACCACATTTGAAAAAAGTCACGGAAACGGTGTG
A

Upstream 100 bases:

>100_bases
TGTTACAAAATCGCGGCTTTGTGCCGCAGTTAGTGGTACGCGCTTCTACCGCGCCAGTGCGACAGACACCCTTTATTAAA
ACTCCCTCTCACGATCTGTC

Downstream 100 bases:

>100_bases
TGGGTGTTTCTTCTGGCATCACAGGGTTCATCAATGGCCGCATTCTGACCGATACCGGGTTCCGTCATGATCTGGCGGTG
TTGTTGCGTGAGGGCAGCAT

Product: glutamine--fructose-6-phosphate transaminase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTLPIPLLEPEQTLMFREAAQAAAVIATQFERNAATIATLVRALRADPPPFVVTCARGSSDHVATYAKYLLETQLGLVTA
SASLSVGSIYAASLQLRGALYLVISQSGKSPDLLRNVEAAKAAGARVVALVNVEDSPLASLADTVLPLCAGPEQSVAATK
SYLASLSAVLQLVAVWKAESGLLAALDGMSDALRTAWECDWTSLIDGLVNARNLFVLGRGFGLATAQEAALKFKETCGLH
AEAYSAAEVKHGPMALVGSGFPVLVFAQSDGTEAAVRALAHEFRGRGSLVWLAAPEGDLPVGVAAHPVCAPLLSIQSFYR
AINTLALCRGYNPDLPPHLKKVTETV

Sequences:

>Translated_346_residues
MTLPIPLLEPEQTLMFREAAQAAAVIATQFERNAATIATLVRALRADPPPFVVTCARGSSDHVATYAKYLLETQLGLVTA
SASLSVGSIYAASLQLRGALYLVISQSGKSPDLLRNVEAAKAAGARVVALVNVEDSPLASLADTVLPLCAGPEQSVAATK
SYLASLSAVLQLVAVWKAESGLLAALDGMSDALRTAWECDWTSLIDGLVNARNLFVLGRGFGLATAQEAALKFKETCGLH
AEAYSAAEVKHGPMALVGSGFPVLVFAQSDGTEAAVRALAHEFRGRGSLVWLAAPEGDLPVGVAAHPVCAPLLSIQSFYR
AINTLALCRGYNPDLPPHLKKVTETV
>Mature_345_residues
TLPIPLLEPEQTLMFREAAQAAAVIATQFERNAATIATLVRALRADPPPFVVTCARGSSDHVATYAKYLLETQLGLVTAS
ASLSVGSIYAASLQLRGALYLVISQSGKSPDLLRNVEAAKAAGARVVALVNVEDSPLASLADTVLPLCAGPEQSVAATKS
YLASLSAVLQLVAVWKAESGLLAALDGMSDALRTAWECDWTSLIDGLVNARNLFVLGRGFGLATAQEAALKFKETCGLHA
EAYSAAEVKHGPMALVGSGFPVLVFAQSDGTEAAVRALAHEFRGRGSLVWLAAPEGDLPVGVAAHPVCAPLLSIQSFYRA
INTLALCRGYNPDLPPHLKKVTETV

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG2222

COG function: function code M; Predicted phosphosugar isomerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=265, Percent_Identity=27.1698113207547, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI4826742, Length=335, Percent_Identity=25.9701492537313, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1790167, Length=310, Percent_Identity=27.741935483871, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17532899, Length=270, Percent_Identity=26.2962962962963, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17532897, Length=270, Percent_Identity=26.2962962962963, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17539970, Length=270, Percent_Identity=25.9259259259259, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323731, Length=231, Percent_Identity=24.2424242424242, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21357745, Length=303, Percent_Identity=28.7128712871287, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 36244; Mature: 36113

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPIPLLEPEQTLMFREAAQAAAVIATQFERNAATIATLVRALRADPPPFVVTCARGSS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCC
DHVATYAKYLLETQLGLVTASASLSVGSIYAASLQLRGALYLVISQSGKSPDLLRNVEAA
CHHHHHHHHHHHHHHHEEEECCCCCCCHHEEEHEEECCEEEEEEECCCCCHHHHHHHHHH
KAAGARVVALVNVEDSPLASLADTVLPLCAGPEQSVAATKSYLASLSAVLQLVAVWKAES
HCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
GLLAALDGMSDALRTAWECDWTSLIDGLVNARNLFVLGRGFGLATAQEAALKFKETCGLH
CCEEECCCHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCC
AEAYSAAEVKHGPMALVGSGFPVLVFAQSDGTEAAVRALAHEFRGRGSLVWLAAPEGDLP
HHHHHHHHCCCCCEEEEECCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
VGVAAHPVCAPLLSIQSFYRAINTLALCRGYNPDLPPHLKKVTETV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TLPIPLLEPEQTLMFREAAQAAAVIATQFERNAATIATLVRALRADPPPFVVTCARGSS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCC
DHVATYAKYLLETQLGLVTASASLSVGSIYAASLQLRGALYLVISQSGKSPDLLRNVEAA
CHHHHHHHHHHHHHHHEEEECCCCCCCHHEEEHEEECCEEEEEEECCCCCHHHHHHHHHH
KAAGARVVALVNVEDSPLASLADTVLPLCAGPEQSVAATKSYLASLSAVLQLVAVWKAES
HCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
GLLAALDGMSDALRTAWECDWTSLIDGLVNARNLFVLGRGFGLATAQEAALKFKETCGLH
CCEEECCCHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCC
AEAYSAAEVKHGPMALVGSGFPVLVFAQSDGTEAAVRALAHEFRGRGSLVWLAAPEGDLP
HHHHHHHHCCCCCEEEEECCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
VGVAAHPVCAPLLSIQSFYRAINTLALCRGYNPDLPPHLKKVTETV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]