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The map label for this gene is folK [H]

Identifier: 182681265

GI number: 182681265

Start: 839755

End: 840330

Strand: Direct

Name: folK [H]

Synonym: XfasM23_0710

Alternate gene names: 182681265

Gene position: 839755-840330 (Clockwise)

Preceding gene: 182681264

Following gene: 182681267

Centisome position: 33.12

GC content: 50.52

Gene sequence:

>576_bases
ATGCCCATGACGGAGGTTGACGTTGTCTCTGGTTACATGCGCGAATATGGCATGACTAGTGTGCTTCTGAGTTTAGGTAG
TAATGTTCGTCCCAGGTATTACTTGAGTCAGGCAGAAGCTGCATTGCACGCTTTTTTTGGTGAAGTGTTGTTTTCTCCTG
TCTACCGCACTTTGGCTGTGGGTTTTGACGGTCCGGATTTCCTTAATAGTGCTGCCATGGTGCATACCGCTATGTCTCTG
TCAGATTTGCTTGCATGGTTGCAGGTTGCATGGTTGCATGCGTTGGAGGAACGCTATGGCCGTGATCGCGCCGAGCCGCG
TTTTGGTAACCGTACCCTGGATGTGGTGTTCTATGGTGATCTGATCGTGAAAGAACCAGGTGGGGAATACTGTATTCCAC
GCCGTGAGTTGAAGCATAGTTTTGTGCTTAAACCATTAGTGGATGTGGCACCGGATTTTGTCGATCCAGTCAGTGGGCGT
ACCTTGGCGCAGTTGTGGGCGGTGCATCCACACGTCGACGCATGTTTCCAGGCCGTGGATCTTGAAGTACCCGGTGACGA
TAGAGACATGATTTAG

Upstream 100 bases:

>100_bases
CGAGCCGTGGCGTATGCACTGACATAACGTATGACGTAGTGGGCGGAGTTTTGACAGAACACTTAGTGTGCAGCACGAGG
GCAGCAATAACGCTGCATTC

Downstream 100 bases:

>100_bases
GTAAACATGTTCATGTCAGCGTGCGGCCGCCATCCAGGCGCAGGGTATGTCCGGTGATGAAATTGGCACTTTCTAGTAGC
CATAGCACTGCTTCGGCGAT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MPMTEVDVVSGYMREYGMTSVLLSLGSNVRPRYYLSQAEAALHAFFGEVLFSPVYRTLAVGFDGPDFLNSAAMVHTAMSL
SDLLAWLQVAWLHALEERYGRDRAEPRFGNRTLDVVFYGDLIVKEPGGEYCIPRRELKHSFVLKPLVDVAPDFVDPVSGR
TLAQLWAVHPHVDACFQAVDLEVPGDDRDMI

Sequences:

>Translated_191_residues
MPMTEVDVVSGYMREYGMTSVLLSLGSNVRPRYYLSQAEAALHAFFGEVLFSPVYRTLAVGFDGPDFLNSAAMVHTAMSL
SDLLAWLQVAWLHALEERYGRDRAEPRFGNRTLDVVFYGDLIVKEPGGEYCIPRRELKHSFVLKPLVDVAPDFVDPVSGR
TLAQLWAVHPHVDACFQAVDLEVPGDDRDMI
>Mature_190_residues
PMTEVDVVSGYMREYGMTSVLLSLGSNVRPRYYLSQAEAALHAFFGEVLFSPVYRTLAVGFDGPDFLNSAAMVHTAMSLS
DLLAWLQVAWLHALEERYGRDRAEPRFGNRTLDVVFYGDLIVKEPGGEYCIPRRELKHSFVLKPLVDVAPDFVDPVSGRT
LAQLWAVHPHVDACFQAVDLEVPGDDRDMI

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 21408; Mature: 21277

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMTEVDVVSGYMREYGMTSVLLSLGSNVRPRYYLSQAEAALHAFFGEVLFSPVYRTLAV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFDGPDFLNSAAMVHTAMSLSDLLAWLQVAWLHALEERYGRDRAEPRFGNRTLDVVFYGD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECC
LIVKEPGGEYCIPRRELKHSFVLKPLVDVAPDFVDPVSGRTLAQLWAVHPHVDACFQAVD
EEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHCCCCHHHHHHHHC
LEVPGDDRDMI
CCCCCCCCCCC
>Mature Secondary Structure 
PMTEVDVVSGYMREYGMTSVLLSLGSNVRPRYYLSQAEAALHAFFGEVLFSPVYRTLAV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFDGPDFLNSAAMVHTAMSLSDLLAWLQVAWLHALEERYGRDRAEPRFGNRTLDVVFYGD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECC
LIVKEPGGEYCIPRRELKHSFVLKPLVDVAPDFVDPVSGRTLAQLWAVHPHVDACFQAVD
EEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHCCCCHHHHHHHHC
LEVPGDDRDMI
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]